Compounds > n(6)-carboxymethyllysine
Page last updated: 2024-09-03

n(6)-carboxymethyllysine and pyruvaldehyde

n(6)-carboxymethyllysine has been researched along with pyruvaldehyde in 58 studies

Compound Research Comparison

Studies
(n(6)-carboxymethyllysine)		Trials
(n(6)-carboxymethyllysine)		Recent Studies (post-2010)
(n(6)-carboxymethyllysine)		Studies
(pyruvaldehyde)		Trials
(pyruvaldehyde)		Recent Studies (post-2010) (pyruvaldehyde)
803443652,458341,447

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (6.90)18.2507
2000's17 (29.31)29.6817
2010's27 (46.55)24.3611
2020's10 (17.24)2.80

Authors

AuthorsStudies
Ahmed, MU; Baynes, JW; Brinkmann Frye, E; Degenhardt, TP; Thorpe, SR1
Beisswenger, P; Brownlee, M; Giardino, I; Onorato, J; Shinohara, M; Thornalley, PJ; Thorpe, SR1
Aoyama, I; Hirasawa, Y; Miyazaki, S; Miyazaki, T; Morita, T; Niwa, T; Shimokata, K; Takayama, F; Tsukushi, S1
Bretzel, RG; Brownlee, M; Hammes, HP; Lin, J; Schleicher, E1
Bucala, R; Kameda, Y; Koike, T; Makita, Z; Suzuki, T; Takeuchi, M1
Asahi, K; Inagi, R; Izuhara, Y; Kurokawa, K; Miyata, T; Saito, A; Ueda, Y; VAN Ypersele DE Strihou, C1
Becker, CM; Humeny, A; Kislinger, T; Pischetsrieder, M1
Cai, W; Crandall, J; Dardaine, V; Goldberg, T; Oberstein, R; Peppa, M; Rayfield, EJ; Vlassara, H1
Bahner, U; Deppisch, R; Haug, U; Henle, T; Ritz, E; Schneider, H; Schwenger, V; Wanner, C; Weigel, K; Zeier, M1
Berg, TJ; Birkeland, KI; Brownlee, M; Giardino, I; Hanssen, KF; Kilhovd, BK; Thornalley, PJ; Torjesen, PA1
Biswas, J; Kumar, SK; Miriam, KC; Nagaraj, RH; Ramakrishnan, S; Sulochana, KN; Swamy-Mruthinti, S1
Hattori, M; He, C; McEvoy, R; Peppa, M; Vlassara, H; Zheng, F1
Baliga, S; Cai, W; Goldberg, T; Lu, M; Peppa, M; Uribarri, J; Vassalotti, JA; Vlassara, H1
Hoekman, K; Niessen, HW; Schalkwijk, CG; van Heijst, JW1
Funk, RH; Knels, L; Kniep, EM; Ozkucur, N; Reber, F; Roehlecke, C; Steinberg, A1
Cai, W; Ferrucci, L; Goodman, S; Peppa, M; Striker, G; Uribarri, J; Vlassara, H1
Cai, W; Chen, X; He, JC; Striker, GE; Vlassara, H; Zhu, L1
Fujiwara, Y; Mera, K; Nagai, R; Sakashita, N; Takeya, M; Yamagata, K1
Cai, W; He, JC; Li, Z; Linden, E; Uribarri, J; Vlassara, H; Winston, J; Xue, C1
Chang, T; Desai, K; Jia, X; Wang, X; Wu, L1
Davidge, ST; Jiang, Y; Sankaralingam, S; Sawamura, T; Xu, H1
Cai, W; Chen, X; He, JC; Striker, GE; Torreggiani, M; Vlassara, H; Zhu, L1
Cai, W; Chen, X; Mericq, V; Piccardo, C; Striker, GE; Uribarri, J; Vlassara, H; Zhu, L1
Chan, LY; Cheng, AS; Lai, KN; Lan, HY; Leung, JC; Lin, M; Tang, SC1
Glomb, MA; Salzwedel, G; Spanneberg, R1
Chang, CT; Chang, YM; Chen, SM; Huang, TC; Huang, YP; Lee, JA; Li, YC; Tsai, SH1
Abetew, D; Christianson, C; Enquobahrie, DA; Hevner, K; Qiu, CF; Sheaff, C; Williams, MA; Zimmer, J1
Cai, W; Castillo, A; Gallardo, M; Landy, DC; Livingstone, A; Manning, R; Namias, N; Schulman, CI; Striker, GE; Uribarri, J; Vlassara, H1
Dahl-Jørgensen, K; Fagerland, MW; Hanssen, KF; Jørum, E; Karimé, B; Mellgren, SI; Monnier, VM; Sveen, KA1
Barzilay, JI; Fonseca, V; Goldfine, AB; Jablonski, KA; Monnier, VM; Shoelson, SE; Strauch, C1
Chen, SM; Huang, TC; Lee, JA; Li, YC1
Cai, W; Díaz-Cisneros, FJ; Garay-Sevilla, ME; Macías-Cervantes, MH; Rodríguez-Soto, JM; Uribarri, J1
Poretsky, L; Striker, GE; Vlassara, H; Woodward, M; Yubero-Serrano, EM1
Ahmedna, M; Sampath, C; Sang, S; Zhu, Y1
Chand, V; Cooper, ME; de Courten, B; de Courten, MP; Dougherty, SL; Forbes, JM; Kingwell, BA; Schalkwijk, CG; Scheijen, JL; Schlaich, M; Soldatos, G; Sourris, KC; Straznicky, N; Walker, KZ1
Brings, S; Ejdesjö, A; Eriksson, UJ; Fleming, T; Fred, RG; Nawroth, PP1
Beelman, RB; Cai, W; Calvo, MS; Goh, BC; Kalaras, MD; Mehrotra, A; Nadkarni, G; Uribarri, J; Wang, L1
Beisswenger, PJ; Howell, S; Knowler, WC; Lemley, KV; Mauer, M; Nelson, RG; Saulnier, PJ; Tanamas, SK; Weil, EJ; Wheelock, KM; Yee, B1
Xu, XB; Yu, P; Yu, SJ1
Bahn, G; Beisswenger, PJ; Howell, S; Reaven, PD; Saremi, A; Schwenke, DC1
Morales, FJ; Navarro, M1
Alizadeh, M; Kheirouri, S1
Dai, S; Dong, Q; Feng, C; Li, X; Wu, Z; Yang, L; Zhang, T1
Ahmed, N; Brison, D; Carroll, M; McNeil, L; Murgatroyd, C; Nevin, C1
Alfonso, H; Almeida, OP; Davis, TME; Flicker, L; Forbes, J; Golledge, J; Hankey, GJ; Irrgang, F; Lamb, LS; Müench, G; Norman, PE; Yeap, BB1
Chen, J; Gao, D; He, Z; Jiao, Y; Qin, F; Quan, W; Zeng, M1
Dong, L; Wang, S; Wang, W; Wu, Y; Zhang, Y1
Chen, J; Gao, D; He, J; He, Z; Jiao, Y; Qin, F; Xie, M; Zeng, M1
Ahmad, S; Alatar, AA; Faisal, M; Rehman, S1
Cardelo, MP; de la Cruz-Ares, S; García-Rios, A; Gutiérrez-Mariscal, FM; Katsiki, N; López-Miranda, J; Malagón, MM; Pérez-Martínez, P; Torres-Peña, JD; Yubero-Serrano, EM1
Bast, A; Opperhuizen, A; van der Lugt, T; van Leeuwen, S; Venema, K; Vrolijk, MF1
Chen, J; He, Z; Jiao, Y; Li, Y; Liu, G; Qin, F; Quan, W; Wang, Z; Xue, C; Zeng, M1
Ye, Y; Zhang, B; Zhang, W; Zhu, H1
Ahmad, S; Akashah, R; Alouffi, S; Faisal, M; Khan, M; Khan, MS; Khan, S; Shahab, U1
Banerjee, S1
Jakhotia, S; Reddy Addi, U; Reddy, GB; Reddy, SS1
Baskal, S; Tsikas, D1
Ha, SK; Jeong, YJ; Kang, J; Lee, HH; Lee, KW1

Reviews

1 review(s) available for n(6)-carboxymethyllysine and pyruvaldehyde

ArticleYear
Curcumin against advanced glycation end products (AGEs) and AGEs-induced detrimental agents.
    Critical reviews in food science and nutrition, 2019, Volume: 59, Issue:7

    Topics: Animals; Antioxidants; Apoptosis; Arginine; Cell Death; Cell Proliferation; Curcumin; Databases, Factual; DNA Damage; Glycation End Products, Advanced; Humans; Lysine; NF-kappa B; Oxidative Stress; Pyruvaldehyde; Receptor for Advanced Glycation End Products

2019

Trials

8 trial(s) available for n(6)-carboxymethyllysine and pyruvaldehyde

ArticleYear
Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Nov-26, Volume: 99, Issue:24

    Topics: Biomarkers; C-Reactive Protein; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Female; Food Analysis; Food, Formulated; Gene Expression Regulation; Glycation End Products, Advanced; Humans; Inflammation Mediators; Lipid Peroxidation; Lysine; Male; Middle Aged; Pyruvaldehyde; Risk Factors; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2002
Glucose degradation products in PD fluids: do they disappear from the peritoneal cavity and enter the systemic circulation?
    Kidney international, 2003, Volume: 63, Issue:1

    Topics: Adult; Ascitic Fluid; CA-125 Antigen; Cross-Over Studies; Deoxyglucose; Female; Fluorescence; Glucose; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Lysine; Male; Middle Aged; Norleucine; Oxidative Stress; Peritoneal Dialysis; Prospective Studies; Pyrroles; Pyruvaldehyde

2003
The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes.
    Diabetes care, 2014, Volume: 37, Issue:4

    Topics: Adiponectin; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Pyruvaldehyde; Salicylates

2014
Effect of an advanced glycation end product-restricted diet and exercise on metabolic parameters in adult overweight men.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:3

    Topics: Adipose Tissue; Adult; Blood Glucose; Body Mass Index; Diet; Diet, Reducing; Energy Intake; Exercise; Feeding Behavior; Glycation End Products, Advanced; Humans; Lipids; Lipoproteins, HDL; Lysine; Male; Middle Aged; Obesity; Overweight; Oxygen Consumption; Pyruvaldehyde; Triglycerides; Waist Circumference; Weight Loss

2015
Effects of sevelamer carbonate on advanced glycation end products and antioxidant/pro-oxidant status in patients with diabetic kidney disease.
    Clinical journal of the American Society of Nephrology : CJASN, 2015, May-07, Volume: 10, Issue:5

    Topics: Adiponectin; Age Factors; Aged; Albuminuria; Chelating Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dinoprost; Estrogen Receptor alpha; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Hypoglycemic Agents; Intention to Treat Analysis; Lysine; Male; Metformin; Middle Aged; NF-E2-Related Factor 2; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Sevelamer; Sex Factors; Single-Blind Method; Sirtuin 1; White People

2015
Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial.
    The American journal of clinical nutrition, 2016, Volume: 103, Issue:6

    Topics: Adult; Blood Glucose; Cross-Over Studies; Diet; Double-Blind Method; Female; Glucose Clamp Technique; Glucose Tolerance Test; Glycation End Products, Advanced; Humans; Imidazolidines; Insulin; Insulin Resistance; Lysine; Male; Middle Aged; Overweight; Pyruvaldehyde

2016
Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:12

    Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Imidazoles; Indians, North American; Kidney; Kidney Glomerulus; Losartan; Lysine; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Pyruvaldehyde

2016
Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study.
    Nutrients, 2020, Jan-16, Volume: 12, Issue:1

    Topics: Biomarkers; Carotid Artery Diseases; Coronary Disease; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diet, Healthy; Endothelium, Vascular; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Olive Oil; Pyruvaldehyde; Single-Blind Method; Vasodilation

2020

Other Studies

49 other study(ies) available for n(6)-carboxymethyllysine and pyruvaldehyde

ArticleYear
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.
    The Biochemical journal, 1997, Jun-01, Volume: 324 ( Pt 2)

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Carbohydrate Metabolism; Child; Collagen; Crystallins; Humans; Lens, Crystalline; Lysine; Middle Aged; Oxidative Stress; Pyruvaldehyde; Ribonucleases; Skin

1997
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.
    The Journal of clinical investigation, 1998, Mar-01, Volume: 101, Issue:5

    Topics: Acetone; Aldehydes; Animals; Cattle; Endocytosis; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Glucose; Glutathione; Glycation End Products, Advanced; Glyoxal; Hyperglycemia; Ketones; Lactic Acid; Lactoylglutathione Lyase; Lysine; Pyruvaldehyde; Transfection; Tumor Cells, Cultured

1998
Immunohistochemical detection of imidazolone and N(epsilon)-(carboxymethyl)lysine in aortas of hemodialysis patients.
    Cellular and molecular biology (Noisy-le-Grand, France), 1998, Volume: 44, Issue:7

    Topics: Aged; Aorta; Arginine; Arteriosclerosis; Deoxyglucose; Female; Glyoxal; Humans; Imidazoles; Immunohistochemistry; Lysine; Male; Middle Aged; Pyruvaldehyde; Renal Dialysis; Uremia

1998
Diabetic retinopathy risk correlates with intracellular concentrations of the glycoxidation product Nepsilon-(carboxymethyl) lysine independently of glycohaemoglobin concentrations.
    Diabetologia, 1999, Volume: 42, Issue:5

    Topics: Adult; Deoxyglucose; Diabetes Mellitus, Type 1; Diabetic Retinopathy; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Leukocyte Common Antigens; Lysine; Male; Middle Aged; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyruvaldehyde; Risk Factors; T-Lymphocytes

1999
Immunological evidence that non-carboxymethyllysine advanced glycation end-products are produced from short chain sugars and dicarbonyl compounds in vivo.
    Molecular medicine (Cambridge, Mass.), 2000, Volume: 6, Issue:2

    Topics: Animals; Antibodies; Cattle; Chromatography, Affinity; Cross Reactions; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Glyceraldehyde; Glyoxal; Humans; Immunoblotting; Kidney Failure, Chronic; Lysine; Maillard Reaction; Oxidation-Reduction; Pyruvaldehyde; Rabbits; Renal Dialysis

2000
Mechanism of the inhibitory effect of OPB-9195 [(+/-)-2-isopropylidenehydrazono-4-oxo-thiazolidin-5-yla cetanilide] on advanced glycation end product and advanced lipoxidation end product formation.
    Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:9

    Topics: Aldehydes; Arachidonic Acid; Arginine; Deoxyglucose; Dialysis Solutions; Glycation End Products, Advanced; Glyoxal; Guanidines; Lipid Metabolism; Lysine; Malondialdehyde; Oxidation-Reduction; Peritoneal Dialysis; Prodrugs; Pyruvaldehyde; Thiadiazoles; Thiazolidines

2000
Qualitative determination of specific protein glycation products by matrix-assisted laser desorption/ionization mass spectrometry Peptide mapping.
    Journal of agricultural and food chemistry, 2002, Mar-27, Volume: 50, Issue:7

    Topics: Deoxyglucose; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Glucose; Glycoproteins; Glycosylation; Lysine; Maillard Reaction; Muramidase; Peptide Mapping; Pyruvaldehyde; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship

2002
Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes.
    Metabolism: clinical and experimental, 2003, Volume: 52, Issue:2

    Topics: Diabetes Mellitus, Type 2; Humans; Imidazoles; Immunoassay; Lysine; Pyruvaldehyde; Sensitivity and Specificity

2003
Immunolocalization and quantification of advanced glycation end products in retinal neovascular membranes and serum: a possible role in ocular neovascularization.
    Current eye research, 2002, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Blood Glucose; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Epiretinal Membrane; Female; Glycation End Products, Advanced; Humans; Immunoenzyme Techniques; Lysine; Male; Middle Aged; Pyruvaldehyde; Retinal Neovascularization; Retinal Vasculitis

2002
Fetal or neonatal low-glycotoxin environment prevents autoimmune diabetes in NOD mice.
    Diabetes, 2003, Volume: 52, Issue:6

    Topics: Administration, Oral; Aging; Albuminuria; Animals; Animals, Newborn; Blood Glucose; Creatinine; Crosses, Genetic; Diabetes Mellitus, Type 1; Female; Glycation End Products, Advanced; Islets of Langerhans; Lysine; Male; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Pyruvaldehyde

2003
Dietary glycotoxins correlate with circulating advanced glycation end product levels in renal failure patients.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 42, Issue:3

    Topics: Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus; Diet; Diet Records; Food Analysis; Food Handling; Glycation End Products, Advanced; Humans; Hypertension; Kidney Failure, Chronic; Lysine; Metabolic Clearance Rate; New York City; Peritoneal Dialysis; Pyruvaldehyde; Renal Dialysis; Smoking; Surveys and Questionnaires; Uremia

2003
Advanced glycation end products in human cancer tissues: detection of Nepsilon-(carboxymethyl)lysine and argpyrimidine.
    Annals of the New York Academy of Sciences, 2005, Volume: 1043

    Topics: Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Glycolysis; Humans; Lysine; Neoplasm Proteins; Neoplasms; Pyruvaldehyde

2005
Inhibition of apoptosis and reduction of intracellular pH decrease in retinal neural cell cultures by a blocker of carbonic anhydrase.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:3

    Topics: Animals; Annexin A5; Apoptosis; Carbonic Anhydrase Inhibitors; Caspase 3; Caspases; Cell Culture Techniques; Cell Survival; Flow Cytometry; Glyoxal; Hydrogen Peroxide; Hydrogen-Ion Concentration; In Situ Nick-End Labeling; Lysine; Neurons; Neuroprotective Agents; Pyruvaldehyde; Rats; Reactive Oxygen Species; Retina; Sulfonamides; Thiophenes

2006
Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2007, Volume: 62, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; C-Reactive Protein; Diet; Dinoprost; Energy Intake; Female; Glycation End Products, Advanced; Humans; Inflammation; Insulin Resistance; Lysine; Male; Middle Aged; Oxidative Stress; Pyruvaldehyde

2007
AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.
    American journal of physiology. Cell physiology, 2008, Volume: 294, Issue:1

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Antioxidants; Cell Line; Chromones; Down-Regulation; Forkhead Box Protein O3; Forkhead Transcription Factors; Glycation End Products, Advanced; Humans; Lysine; Morpholines; Mutation; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyruvaldehyde; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; RNA, Small Interfering; Serine; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Superoxide Dismutase; Transfection

2008
Immunochemical detection of Nepsilon-(carboxyethyl)lysine using a specific antibody.
    Journal of immunological methods, 2008, Mar-20, Volume: 332, Issue:1-2

    Topics: Aldehydes; Animals; Antibodies, Monoclonal; Antibody Specificity; Antigen-Antibody Reactions; Cattle; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Kidney; Lysine; Male; Pyruvaldehyde; Rats; Rats, Wistar; Sensitivity and Specificity; Serum Albumin

2008
Endothelial dysfunction in patients with chronic kidney disease results from advanced glycation end products (AGE)-mediated inhibition of endothelial nitric oxide synthase through RAGE activation.
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:3

    Topics: Adult; Aged; Case-Control Studies; Cells, Cultured; Cross-Sectional Studies; Endothelial Cells; Endothelium, Vascular; Female; Glomerular Filtration Rate; Glycation End Products, Advanced; Humans; Hyperemia; Lysine; Male; Middle Aged; Nitric Oxide Synthase Type III; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Regional Blood Flow; Renal Insufficiency, Chronic; RNA Interference; RNA, Messenger; RNA, Small Interfering; Severity of Illness Index; Skin; Up-Regulation

2008
Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats.
    Journal of hypertension, 2008, Volume: 26, Issue:4

    Topics: Animals; Aorta; Dietary Carbohydrates; Fructose; Glutathione; Glycation End Products, Advanced; Hydrogen Peroxide; Hypertension; Hypoglycemic Agents; Lysine; Male; Mesenteric Arteries; Metformin; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Pyruvaldehyde; Rats; Rats, Sprague-Dawley

2008
Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
    Hypertension (Dallas, Tex. : 1979), 2009, Volume: 54, Issue:4

    Topics: Adult; Arginase; Arteries; Case-Control Studies; Cells, Cultured; Endothelium, Vascular; Female; Glutathione Peroxidase; Glutathione Reductase; Humans; Lactoylglutathione Lyase; Lysine; Nitric Oxide Synthase; Oxidative Stress; Peroxynitrous Acid; Pre-Eclampsia; Pregnancy; Pyruvaldehyde; Scavenger Receptors, Class E; Thiolester Hydrolases

2009
AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease.
    American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:3

    Topics: Active Transport, Cell Nucleus; Age Factors; Animals; Cell Line; Endothelial Cells; ErbB Receptors; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; NADP; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Phosphorylation; Protein Kinase C-delta; Protein Subunits; Pyruvaldehyde; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; Signal Transduction; Time Factors; Transcription Factor RelA; Transfection; Vascular Diseases

2010
Maternally transmitted and food-derived glycotoxins: a factor preconditioning the young to diabetes?
    Diabetes care, 2010, Volume: 33, Issue:10

    Topics: Adiponectin; Adolescent; Adult; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glycation End Products, Advanced; Humans; Infant; Infant Food; Infant, Newborn; Insulin; Isoprostanes; Lysine; Pyruvaldehyde; Risk Factors; Young Adult

2010
Differential effects of advanced glycation end-products on renal tubular cell inflammation.
    Nephrology (Carlton, Vic.), 2011, Volume: 16, Issue:4

    Topics: Anti-Inflammatory Agents; Cells, Cultured; Chemokine CCL2; Connective Tissue Growth Factor; Epithelial Cells; Glycated Serum Albumin; Glycation End Products, Advanced; Humans; Inflammation Mediators; Interleukin-6; Kidney Tubules, Proximal; Lysine; Nephritis, Interstitial; NF-kappa B; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Rosiglitazone; Serum Albumin; Serum Albumin, Bovine; Signal Transduction; Thiazolidinediones; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

2011
Formation of early and advanced Maillard reaction products correlates to the ripening of cheese.
    Journal of agricultural and food chemistry, 2012, Jan-18, Volume: 60, Issue:2

    Topics: Caseins; Cheese; Chymosin; Food Handling; Food Technology; Lysine; Maillard Reaction; Protein Modification, Translational; Pyruvaldehyde; Time Factors

2012
Aristolochic acid-induced accumulation of methylglyoxal and Nε-(carboxymethyl)lysine: an important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy.
    Biochemical and biophysical research communications, 2012, Jul-13, Volume: 423, Issue:4

    Topics: Animals; Aristolochic Acids; Creatine; Disease Models, Animal; Female; Kidney; Lysine; Mice; Mice, Inbred C3H; Nephritis, Interstitial; Pyruvaldehyde

2012
Maternal plasma advanced glycation end products concentrations in response to oral 50-gram glucose load in mid-pregnancy: a pilot study.
    Clinical laboratory, 2012, Volume: 58, Issue:9-10

    Topics: Adult; Arginine; Chromatography, High Pressure Liquid; Female; Glucose; Glucose Tolerance Test; Glycation End Products, Advanced; Humans; Hyperglycemia; Lysine; Mass Spectrometry; Pilot Projects; Pregnancy; Pregnancy Trimester, Second; Prospective Studies; Pyruvaldehyde

2012
Increased circulating advanced glycation endproducts (AGEs) in acute trauma patients.
    Clinical chemistry and laboratory medicine, 2014, Jan-01, Volume: 52, Issue:1

    Topics: Acute Disease; Adult; Female; Glycation End Products, Advanced; Humans; Intensive Care Units; Kinetics; Longitudinal Studies; Lysine; Male; Middle Aged; Pyruvaldehyde; Severity of Illness Index; Wounds and Injuries

2014
Small- and large-fiber neuropathy after 40 years of type 1 diabetes: associations with glycemic control and advanced protein glycation: the Oslo Study.
    Diabetes care, 2013, Volume: 36, Issue:11

    Topics: Adolescent; Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Follow-Up Studies; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Imidazoles; Lysine; Male; Middle Aged; Nerve Fibers; Pyruvaldehyde; Sensory Thresholds; Young Adult

2013
Increased renal semicarbazide-sensitive amine oxidase activity and methylglyoxal levels in aristolochic acid-induced nephrotoxicity.
    Life sciences, 2014, Sep-26, Volume: 114, Issue:1

    Topics: Amine Oxidase (Copper-Containing); Animals; Aristolochic Acids; Dose-Response Relationship, Drug; Kidney; Kidney Diseases; Lysine; Male; Metformin; Mice; Mice, Inbred C57BL; Pyruvaldehyde

2014
Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Feb-15, Volume: 23, Issue:2

    Topics: Catechin; Catechols; Cell Line; Epithelial Cells; Fatty Alcohols; Glutathione; Glycation End Products, Advanced; Heme Oxygenase-1; Humans; Lysine; Malus; NF-E2-Related Factor 2; Phloretin; Phytochemicals; Protective Agents; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Retinal Pigment Epithelium; Tea; Zingiber officinale

2016
Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy.
    Reproductive toxicology (Elmsford, N.Y.), 2016, Volume: 62

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dinoprost; Embryo, Mammalian; Embryonic Development; Female; Fetal Development; Fetal Resorption; Gene Expression; Liver; Lysine; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Pregnancy; Pregnancy in Diabetics; Pyruvaldehyde; Receptor for Advanced Glycation End Products

2016
A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms).
    Plant foods for human nutrition (Dordrecht, Netherlands), 2016, Volume: 71, Issue:3

    Topics: Adiponectin; Adult; Agaricus; Antioxidants; beta-Glucans; Biomarkers; Body Mass Index; Chitin; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Diet; Dinoprost; Ergothioneine; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Insulin Resistance; Leptin; Linear Models; Lysine; Male; Metabolic Syndrome; Middle Aged; Multivariate Analysis; Oxidative Stress; Polyphenols; Pyruvaldehyde; Retrospective Studies; Risk Factors; Triglycerides; Vitamin D

2016
Inhibitory effect of sugarcane molasses extract on the formation of N
    Food chemistry, 2017, Apr-15, Volume: 221

    Topics: Antioxidants; Glucose; Glycation End Products, Advanced; Lysine; Maillard Reaction; Molasses; Pyruvaldehyde; Saccharum

2017
Advanced Glycation End Products, Oxidation Products, and the Extent of Atherosclerosis During the VA Diabetes Trial and Follow-up Study.
    Diabetes care, 2017, Volume: 40, Issue:4

    Topics: Aged; Atherosclerosis; Blood Glucose; Carotid Intima-Media Thickness; Cholesterol; Deoxyglucose; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycation End Products, Advanced; Humans; Imidazoles; Lysine; Male; Middle Aged; Oxidation-Reduction; Pyruvaldehyde; Triglycerides

2017
Evaluation of an olive leaf extract as a natural source of antiglycative compounds.
    Food research international (Ottawa, Ont.), 2017, Volume: 92

    Topics: Chromatography, Liquid; Deoxyglucose; Fructosamine; Galactose; Glycation End Products, Advanced; Glycosylation; Glyoxal; Lysine; Olea; Ornithine; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Pyrimidines; Pyruvaldehyde; Tandem Mass Spectrometry

2017
Inhibition of Methylglyoxal-Induced Histone H1 N
    Journal of agricultural and food chemistry, 2018, Jun-13, Volume: 66, Issue:23

    Topics: Catechin; Glycation End Products, Advanced; Histones; Hydrogen Peroxide; Lysine; Pyruvaldehyde; Schiff Bases

2018
Investigating the Glycating Effects of Glucose, Glyoxal and Methylglyoxal on Human Sperm.
    Scientific reports, 2018, 06-13, Volume: 8, Issue:1

    Topics: DNA Damage; Fertility; Glucose; Glycation End Products, Advanced; Glycosylation; Glyoxal; Humans; Lysine; Male; Pyruvaldehyde; Semen Analysis; Sperm Count; Sperm Motility; Spermatozoa

2018
Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men.
    The Journal of clinical endocrinology and metabolism, 2018, 11-01, Volume: 103, Issue:11

    Topics: Age Factors; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Bone Density; Bone Remodeling; Diabetes Mellitus; Follow-Up Studies; Glycation End Products, Advanced; Hip Fractures; Humans; Incidence; Lysine; Male; Predictive Value of Tests; Prognosis; Pyruvaldehyde; Receptor for Advanced Glycation End Products; Risk Factors

2018
Effects of Catechins on N
    Journal of agricultural and food chemistry, 2019, Jan-30, Volume: 67, Issue:4

    Topics: Camellia sinensis; Catechin; Food Handling; Lysine; Models, Chemical; Molecular Structure; Plant Leaves; Pyruvaldehyde; Tea

2019
Structural modification and digestibility change of β-lactoglobulin modified by methylglyoxal with the simulated reheating of dairy products.
    Food chemistry, 2019, Aug-01, Volume: 288

    Topics: Chromatography, High Pressure Liquid; Dairy Products; Electrophoresis, Polyacrylamide Gel; Lactoglobulins; Lysine; Pepsin A; Pyruvaldehyde; Tandem Mass Spectrometry; Temperature

2019
Formation of N
    Food research international (Ottawa, Ont.), 2019, Volume: 121

    Topics: Camellia sinensis; Catechin; Food Analysis; Food Handling; Gallic Acid; Glyoxal; Lysine; Plant Leaves; Polyphenols; Pyruvaldehyde; Tea

2019
Physico-chemical Changes Induced in the Serum Proteins Immunoglobulin G and Fibrinogen Mediated by Methylglyoxal.
    Current protein & peptide science, 2020, Volume: 21, Issue:9

    Topics: Arginine; Benzothiazoles; Fibrinogen; Furaldehyde; Glycation End Products, Advanced; Glycosylation; Humans; Immunoglobulin G; Kinetics; Lysine; Malondialdehyde; Oxidation-Reduction; Protein Carbonylation; Pyruvaldehyde; Solutions; Spectrometry, Fluorescence

2020
Gastrointestinal digestion of dietary advanced glycation endproducts using an in vitro model of the gastrointestinal tract (TIM-1).
    Food & function, 2020, Jul-22, Volume: 11, Issue:7

    Topics: Animals; Arginine; Chromatography, Liquid; Digestion; Fruit and Vegetable Juices; Gastrointestinal Tract; Glycation End Products, Advanced; Glyoxal; Hepatitis A Virus Cellular Receptor 1; Humans; Lysine; Milk; Pyruvaldehyde; Tandem Mass Spectrometry; Zingiber officinale

2020
Simultaneous generation of acrylamide, β-carboline heterocyclic amines and advanced glycation ends products in an aqueous Maillard reaction model system.
    Food chemistry, 2020, Dec-01, Volume: 332

    Topics: Acrylamide; Amines; Asparagine; Carbolines; Chromatography, Gas; Chromatography, High Pressure Liquid; Glucose; Glycation End Products, Advanced; Harmine; Hot Temperature; Lysine; Maillard Reaction; Models, Biological; Pyruvaldehyde

2020
Methylglyoxal-hydroimidazolones (MG-Hs) instead of Nɛ-(carboxymethyl)-l-lysine (CML) is the major advanced glycation end-product during drying process in black tea.
    Food chemistry, 2020, Dec-15, Volume: 333

    Topics: Camellia sinensis; Chromatography, High Pressure Liquid; Desiccation; Food Handling; Glycation End Products, Advanced; Humans; Imidazoles; Isomerism; Lysine; Plant Extracts; Plant Leaves; Pyruvaldehyde; Tandem Mass Spectrometry; Tea

2020
Gold Nanoparticle-Bioconjugated Aminoguanidine Inhibits Glycation Reaction: An
    BioMed research international, 2021, Volume: 2021

    Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Glycation End Products, Advanced; Glycosylation; Gold; Guanidines; Lysine; Male; Metal Nanoparticles; Proteins; Pyruvaldehyde; Rats; Rats, Wistar

2021
Biophysical and mass spectrometry based characterization of methylglyoxal-modified myoglobin: Role of advanced glycation end products in inducing protein structural alterations.
    International journal of biological macromolecules, 2021, Dec-15, Volume: 193, Issue:Pt B

    Topics: Glycation End Products, Advanced; Heme; Hydrophobic and Hydrophilic Interactions; Lysine; Mass Spectrometry; Myoglobin; Norleucine; Protein Conformation, alpha-Helical; Protein Structure, Tertiary; Pyrroles; Pyruvaldehyde

2021
Age-related neuronal damage by advanced glycation end products through altered proteostasis.
    Chemico-biological interactions, 2022, Mar-01, Volume: 355

    Topics: Aging; Animals; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Brain; Brain-Derived Neurotrophic Factor; Endoplasmic Reticulum Stress; Glycation End Products, Advanced; Lysine; Neurons; Proteostasis; Pyruvaldehyde; Rats; Rats, Wistar; Ubiquitin; Unfolded Protein Response

2022
Free L-Lysine and Its Methyl Ester React with Glyoxal and Methylglyoxal in Phosphate Buffer (100 mM, pH 7.4) to Form
    International journal of molecular sciences, 2022, Mar-22, Volume: 23, Issue:7

    Topics: Esters; Gas Chromatography-Mass Spectrometry; Glycation End Products, Advanced; Glyoxal; Hydrogen-Ion Concentration; Lysine; Magnesium Oxide; Phosphates; Pyruvaldehyde; Schiff Bases

2022
Glyoxal-derived advanced glycation end-products, N
    Molecular biology reports, 2023, Volume: 50, Issue:3

    Topics: Apoptosis; Gene Expression; Glycation End Products, Advanced; Glyoxal; Hepatocytes; Humans; Lysine; Maillard Reaction; Proteins; Pyruvaldehyde; Reactive Oxygen Species

2023