Page last updated: 2024-09-03

n(6)-carboxymethyllysine and n(6)-(1-carboxyethyl)lysine

n(6)-carboxymethyllysine has been researched along with n(6)-(1-carboxyethyl)lysine in 33 studies

Compound Research Comparison

Studies
(n(6)-carboxymethyllysine)
Trials
(n(6)-carboxymethyllysine)
Recent Studies (post-2010)
(n(6)-carboxymethyllysine)
Studies
(n(6)-(1-carboxyethyl)lysine)
Trials
(n(6)-(1-carboxyethyl)lysine)
Recent Studies (post-2010) (n(6)-(1-carboxyethyl)lysine)
8034436555322

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.03)18.2507
2000's18 (54.55)29.6817
2010's14 (42.42)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ahmed, MU; Baynes, JW; Brinkmann Frye, E; Degenhardt, TP; Thorpe, SR1
Bank, RA; Bayliss, MT; Baynes, JW; Bijlsma, JW; DeGroot, J; Lafeber, FP; Oldehinkel, E; Tekoppele, JM; Thorpe, SR; Verzijl, N1
Bank, RA; Baynes, JW; Bijlsma, JW; DeGroot, J; Lafeber, FP; Lyons, TJ; Shaw, JN; TeKoppele, JM; Thorpe, SR; Verzijl, N1
Ahmed, N; Argirov, OK; Cordeiro, CA; Minhas, HS; Thornalley, PJ1
Barja, G; Bellmun, MJ; Gredilla, R; Pamplona, R; Portero-Otín, M1
Barja, G; Gredilla, R; Pamplona, R; Portero-Otín, M; Requena, J1
Barto, R; Lieuw-A-Fa, ML; Schalkwijk, CG; Stehouwer, CD; Teerlink, T; Twisk, J; van Hinsbergh, VW1
Cheriex, EC; Konings, CJ; Kooman, JP; Leunissen, KM; Schalkwijk, CG; Scheffer, PG; ter Wee, PM; van de Kerkhof, J; van der Sande, FM1
Barto, R; Schalkwijk, CG; Teerlink, T; Ten Brink, HJ1
Baynes, JW1
Araki, T; Horiuchi, S; Koito, W; Nagai, R1
Chandoga, J; Futas, J; Jakus, V; Petrovic, R1
Bootsma, AH; Chaturvedi, N; Fuller, JH; Schalkwijk, CG; Schram, MT; Stehouwer, CD1
Amano, S; Fukayama, M; Kaji, Y; Nagai, R; Oshika, T; Takazawa, Y1
Baynes, JW; den Hollander, NC; Graaff, R; Mulder, DJ; Smit, AJ; Smit, GP; Thorpe, SR1
Bakker, SJ; Damman, K; Hartog, JW; Schalkwijk, CG; Scheijen, J; Smilde, TD; Smit, AJ; van Veldhuisen, DJ; Voors, AA1
Bijl, M; Bijzet, J; de Leeuw, K; Graaff, R; Kallenberg, CG; Nienhuis, HL; Schalkwijk, CG; Smit, A1
Choi, YG; Lim, S1
't Hart, LM; Blaak, EE; de Groot, PG; Dekker, JM; Ferreira, I; Feskens, EJ; Gaens, KH; Heine, RJ; Nijpels, G; Schalkwijk, CG; Stehouwer, CD; van der Kallen, CJ; van Greevenbroek, MM1
Ames, JM; Connolly, L; del Castillo, MD; Elliott, CT; Hull, GL; Srey, C1
Engelen, L; Ferreira, I; Hovind, P; Parving, HH; Persson, F; Rossing, P; Schalkwijk, CG; Stehouwer, CD; Teerlink, T1
Izumi, M; Maruyama, T; Mera, K; Nagai, R; Otagiri, M; Takeo, K1
Akileshwari, C; Muthenna, P; Reddy, GB1
Andrades, MÉ; Dal-Pizzol, F; Lorenzi, R; Moreira, JC; Nagai, R; Ritter, C1
Du, R; Jing, Y; Lu, L; Yang, K; Zhang, R; Zhu, J; Zhu, Z1
Brimble, MA; Cooper, GJ; Woods, TM1
Engelen, L; Franssen, FM; Gopal, P; Reynaert, NL; Rutten, EP; Schalkwijk, CG; Scheijen, JL; Wouters, EF1
Dekker, JM; Engelen, L; Ferreira, I; Hanssen, NM; Huijberts, MS; Nijpels, G; Schalkwijk, CG; Scheijen, JL; Stehouwer, CD; van der Kallen, CJ; van Greevenbroek, MM1
Fahlgren, C; Forslund, A; Lindh, CH; Östman, E; Tareke, E1
Cheng, L; Dai, M; Jin, C; Lin, Q; Zhang, Y; Zheng, X; Zhou, Y1
Fiore, A; Fogliano, V; Troise, AD; Wiltafsky, M1
Fiore, A; Troise, AD; Tsang, C; Vitiello, D1
Fogliano, V; Troise, AD; Vitaglione, P; Wiltafsky, M1

Trials

1 trial(s) available for n(6)-carboxymethyllysine and n(6)-(1-carboxyethyl)lysine

ArticleYear
Irbesartan treatment does not influence plasma levels of the advanced glycation end products N(epsilon)(1-carboxymethyl)lysine and N(epsilon)(1-carboxyethyl)lysine in patients with type 2 diabetes and microalbuminuria. A randomized controlled trial.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:11

    Topics: Adult; Aged; Albuminuria; Angiotensin Receptor Antagonists; Biomarkers; Biphenyl Compounds; Diabetes Complications; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glycation End Products, Advanced; Humans; Hypertension; Irbesartan; Lysine; Male; Middle Aged; Prognosis; Tetrazoles

2011

Other Studies

32 other study(ies) available for n(6)-carboxymethyllysine and n(6)-(1-carboxyethyl)lysine

ArticleYear
N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins.
    The Biochemical journal, 1997, Jun-01, Volume: 324 ( Pt 2)

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Carbohydrate Metabolism; Child; Collagen; Crystallins; Humans; Lens, Crystalline; Lysine; Middle Aged; Oxidative Stress; Pyruvaldehyde; Ribonucleases; Skin

1997
Age-related accumulation of Maillard reaction products in human articular cartilage collagen.
    The Biochemical journal, 2000, Sep-01, Volume: 350 Pt 2

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Arginine; Cartilage, Articular; Child; Child, Preschool; Collagen; Collagenases; Cross-Linking Reagents; Female; Femur; Glycation End Products, Advanced; Humans; Lysine; Maillard Reaction; Male; Middle Aged; Skin; Spectrometry, Fluorescence

2000
Effect of collagen turnover on the accumulation of advanced glycation end products.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arginine; Aspartic Acid; Cartilage, Articular; Child; Child, Preschool; Chondrocytes; Collagen; Glycation End Products, Advanced; Humans; Kinetics; Lysine; Middle Aged; Skin

2000
Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified a
    The Biochemical journal, 2002, May-15, Volume: 364, Issue:Pt 1

    Topics: Aminoquinolines; Biochemistry; Carbamates; Chromatography; Chromatography, High Pressure Liquid; Glucose; Glycation End Products, Advanced; Indicators and Reagents; Lysine; Magnetic Resonance Spectroscopy; Models, Chemical; Temperature; Time Factors

2002
Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins.
    Free radical research, 2002, Volume: 36, Issue:1

    Topics: Aging; Animals; Enzyme-Linked Immunosorbent Assay; Fatty Acids; Food Deprivation; Gas Chromatography-Mass Spectrometry; Lysine; Male; Malondialdehyde; Mitochondria; Models, Statistical; Myocardium; Oxidative Stress; Phospholipids; Rats; Rats, Wistar; Reactive Oxygen Species; Time Factors

2002
Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.
    Mechanisms of ageing and development, 2002, Volume: 123, Issue:11

    Topics: Aldehydes; Animals; Biomarkers; Energy Intake; Glutamates; Lysine; Male; Mitochondria, Heart; Mitochondrial Proteins; Oxidative Stress; Rats; Rats, Wistar; Reference Values; Time Factors

2002
Increased levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine in type 1 diabetic patients with impaired renal function: correlation with markers of endothelial dysfunction.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:3

    Topics: Adult; Aged; Blood Coagulation Factors; C-Reactive Protein; Case-Control Studies; Diabetes Mellitus, Type 1; E-Selectin; Endothelium, Vascular; Female; Glomerular Filtration Rate; Humans; Kidney; Lysine; Male; Middle Aged; Thrombomodulin; Vascular Cell Adhesion Molecule-1

2004
Nepsilon-(carboxymethyl)lysine, Nepsilon-(carboxyethyl)lysine and vascular cell adhesion molecule-1 (VCAM-1) in relation to peritoneal glucose prescription and residual renal function; a study in peritoneal dialysis patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:4

    Topics: Cross-Sectional Studies; Female; Glomerular Filtration Rate; Glucose; Glycation End Products, Advanced; Humans; Kidney Failure, Chronic; Lysine; Male; Middle Aged; Peritoneal Dialysis; Vascular Cell Adhesion Molecule-1

2004
Measurement of Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine in human plasma protein by stable-isotope-dilution tandem mass spectrometry.
    Clinical chemistry, 2004, Volume: 50, Issue:7

    Topics: Biomarkers; Blood Proteins; Chromatography, Liquid; Glycation End Products, Advanced; Humans; Hydrolysis; Indicator Dilution Techniques; Lipids; Lysine; Mass Spectrometry; Oxidation-Reduction; Renal Dialysis; Renal Insufficiency

2004
The clinical chemome: a tool for the diagnosis and management of chronic disease.
    Clinical chemistry, 2004, Volume: 50, Issue:7

    Topics: Biomarkers; Chromatography, Liquid; Chronic Disease; Glycation End Products, Advanced; Humans; Lipid Metabolism; Lipids; Lysine; Mass Spectrometry; Oxidation-Reduction; Renal Dialysis; Renal Insufficiency

2004
Conventional antibody against Nepsilon-(carboxymethyl)lysine (CML) shows cross-reaction to Nepsilon-(carboxyethyl)lysine (CEL): immunochemical quantification of CML with a specific antibody.
    Journal of biochemistry, 2004, Volume: 136, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Cattle; Cross Reactions; Eye Proteins; Glycation End Products, Advanced; Immunization; Immunoglobulin G; Lysine; Rabbits; Serum Albumin, Bovine

2004
Rapid and simple method for determination of Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine in urine using gas chromatography/mass spectrometry.
    Biomedical chromatography : BMC, 2005, Volume: 19, Issue:9

    Topics: Child; Gas Chromatography-Mass Spectrometry; Glycation End Products, Advanced; Humans; Lysine; Reproducibility of Results; Time Factors

2005
Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study.
    Hypertension (Dallas, Tex. : 1979), 2005, Volume: 46, Issue:1

    Topics: Adult; Blood Pressure; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Linear Models; Lysine; Male; Middle Aged; Multicenter Studies as Topic; Platelet Activating Factor; Prospective Studies

2005
Advanced glycation end product deposits in climatic droplet keratopathy.
    The British journal of ophthalmology, 2007, Volume: 91, Issue:1

    Topics: Antibodies, Monoclonal; Arginine; Cornea; Corneal Diseases; Cross-Linking Reagents; Female; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lysine; Male; Middle Aged; Pyrroles

2007
Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia.
    Journal of inherited metabolic disease, 2007, Volume: 30, Issue:6

    Topics: Adolescent; Adult; Arginine; Atherosclerosis; Carotid Arteries; Collagen; Female; Glycation End Products, Advanced; Glycogen Storage Disease Type I; Humans; Lysine; Male; Oxidative Stress; Risk; Skin; Tunica Intima; Tunica Media

2007
Clinical and prognostic value of advanced glycation end-products in chronic heart failure.
    European heart journal, 2007, Volume: 28, Issue:23

    Topics: Aged; Biomarkers; Female; Follow-Up Studies; Glycation End Products, Advanced; Heart Failure; Humans; Lysine; Male; Middle Aged; Prognosis; Risk Assessment; Risk Factors; Survival Analysis

2007
Skin autofluorescence is increased in systemic lupus erythematosus but is not reflected by elevated plasma levels of advanced glycation endproducts.
    Rheumatology (Oxford, England), 2008, Volume: 47, Issue:10

    Topics: Adult; Case-Control Studies; Female; Fluorescence; Glycation End Products, Advanced; Humans; Lupus Erythematosus, Systemic; Lysine; Male; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Severity of Illness Index; Skin; Vascular Cell Adhesion Molecule-1

2008
Characterization of anti-advanced glycation end product antibodies to nonenzymatically lysine-derived and arginine-derived glycated products.
    Journal of immunoassay & immunochemistry, 2009, Volume: 30, Issue:4

    Topics: Animals; Antibodies; Arginine; Cattle; Cross Reactions; Glycation End Products, Advanced; Lysine; Rabbits; Serum Albumin, Bovine

2009
Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels.
    The Journal of clinical endocrinology and metabolism, 2009, Volume: 94, Issue:12

    Topics: Aged; Blotting, Western; Cohort Studies; Creatine; Enzyme-Linked Immunosorbent Assay; Female; Gene Frequency; Glycation End Products, Advanced; Humans; Kidney Function Tests; Lysine; Male; Middle Aged; Netherlands; Phenotype; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptor for Advanced Glycation End Products; Receptors, Immunologic

2009
Effect of inhibitor compounds on Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL) formation in model foods.
    Journal of agricultural and food chemistry, 2010, Nov-24, Volume: 58, Issue:22

    Topics: Food Analysis; Food Handling; Lysine

2010
An autoantibody against N(ε)-(carboxyethyl)lysine (CEL): possible involvement in the removal of CEL-modified proteins by macrophages.
    Biochemical and biophysical research communications, 2011, Apr-08, Volume: 407, Issue:2

    Topics: Animals; Arginine; Autoantibodies; Glycation End Products, Advanced; Humans; Lysine; Macrophages, Peritoneal; Mice; Rabbits; Serum Albumin

2011
Ellagic acid, a new antiglycating agent: its inhibition of Nϵ-(carboxymethyl)lysine.
    The Biochemical journal, 2012, Feb-15, Volume: 442, Issue:1

    Topics: Animals; Crystallins; Diabetes Complications; Ellagic Acid; Gluconates; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lactones; Lens, Crystalline; Lysine; Male; Muramidase; Organ Culture Techniques; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2012
Plasma glycation levels are associated with severity in sepsis.
    European journal of clinical investigation, 2012, Volume: 42, Issue:10

    Topics: Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Glycation End Products, Advanced; Humans; Kidney Diseases; Lysine; Male; Middle Aged; Prognosis; ROC Curve; Sepsis

2012
The effects of low-dose nepsilon-(carboxymethyl)lysine (CML) and nepsilon-(carboxyethyl)lysine (CEL), two main glycation free adducts considered as potential uremic toxins, on endothelial progenitor cell function.
    Cardiovascular diabetology, 2012, Aug-01, Volume: 11

    Topics: Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Glycation End Products, Advanced; Humans; Lysine; Mitogen-Activated Protein Kinases; Neovascularization, Physiologic; Phosphorylation; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Stem Cells; Time Factors; Toxins, Biological; Uremia

2012
Synthesis of stable isotope-labelled monolysyl advanced glycation endproducts.
    Amino acids, 2013, Volume: 45, Issue:2

    Topics: Diabetes Mellitus; Glycation End Products, Advanced; Isotope Labeling; Lysine; Mass Spectrometry; Norleucine; Pyrroles

2013
Plasma advanced glycation end-products and skin autofluorescence are increased in COPD.
    The European respiratory journal, 2014, Volume: 43, Issue:2

    Topics: Aged; Arginine; Case-Control Studies; Female; Fluorescence; Glycation End Products, Advanced; Humans; Inflammation; Lung; Lysine; Male; Middle Aged; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Skin; Smoking; Spirometry

2014
Plasma levels of advanced glycation endproducts Nε-(carboxymethyl)lysine, Nε-(carboxyethyl)lysine, and pentosidine are not independently associated with cardiovascular disease in individuals with or without type 2 diabetes: the Hoorn and CODAM studies.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:8

    Topics: Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Glucose; Humans; Lysine; Male; Middle Aged

2013
Isotope dilution ESI-LC-MS/MS for quantification of free and total Nε-(1-Carboxymethyl)-L-Lysine and free Nε-(1-Carboxyethyl)-L-Lysine: comparison of total Nε-(1-Carboxymethyl)-L-Lysine levels measured with new method to ELISA assay in gruel samples.
    Food chemistry, 2013, Dec-15, Volume: 141, Issue:4

    Topics: Beverages; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Isotope Labeling; Lysine; Tandem Mass Spectrometry

2013
Simultaneous analysis of N(ε) -(carboxymethyl)Lysine and N(ε) -(carboxyethyl)lysine in foods by ultra-performance liquid chromatography-mass spectrometry with derivatization by 9-fluorenylmethyl chloroformate.
    Journal of food science, 2015, Volume: 80, Issue:2

    Topics: Chromatography, Liquid; Fluorenes; Food Analysis; Glycation End Products, Advanced; Humans; Indicators and Reagents; Lysine; Mass Spectrometry; Reproducibility of Results

2015
Quantification of Nε-(2-Furoylmethyl)-L-lysine (furosine), Nε-(Carboxymethyl)-L-lysine (CML), Nε-(Carboxyethyl)-L-lysine (CEL) and total lysine through stable isotope dilution assay and tandem mass spectrometry.
    Food chemistry, 2015, Dec-01, Volume: 188

    Topics: Chromatography, Liquid; Food Analysis; Indicator Dilution Techniques; Isotopes; Lysine; Protein Conformation; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry

2015
Encapsulation of ascorbic acid promotes the reduction of Maillard reaction products in UHT milk.
    Food & function, 2016, Jun-15, Volume: 7, Issue:6

    Topics: Animals; Ascorbic Acid; Food Handling; Food, Fortified; Glycation End Products, Advanced; Lysine; Maillard Reaction; Mass Spectrometry; Milk

2016
The quantification of free Amadori compounds and amino acids allows to model the bound Maillard reaction products formation in soybean products.
    Food chemistry, 2018, May-01, Volume: 247

    Topics: Amino Acids; Discriminant Analysis; Food Analysis; Food Handling; Glycation End Products, Advanced; Glycine max; Lysine; Maillard Reaction; Mass Spectrometry; Plant Proteins

2018