Compounds > n(6)-carboxymethyllysine
Page last updated: 2024-09-03

n(6)-carboxymethyllysine and glyoxal

n(6)-carboxymethyllysine has been researched along with glyoxal in 33 studies

Compound Research Comparison

Studies
(n(6)-carboxymethyllysine)		Trials
(n(6)-carboxymethyllysine)		Recent Studies (post-2010)
(n(6)-carboxymethyllysine)		Studies
(glyoxal)		Trials
(glyoxal)		Recent Studies (post-2010) (glyoxal)
803443651,1197458

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (24.24)18.2507
2000's9 (27.27)29.6817
2010's9 (27.27)24.3611
2020's7 (21.21)2.80

Authors

AuthorsStudies
Baynes, JW; Bichler, J; Reddy, S; Thorpe, SR; Wells-Knecht, KJ1
Glomb, MA; Monnier, VM1
Baynes, JW; Litchfield, JE; Thorpe, SR; Wells-Knecht, KJ; Zyzak, DV1
Baynes, JW; Fu, MX; Jenkins, AJ; Lyons, TJ; Requena, JR; Thorpe, SR1
Beisswenger, P; Brownlee, M; Giardino, I; Onorato, J; Shinohara, M; Thornalley, PJ; Thorpe, SR1
Kurokawa, K; Mitsuma, T; Miyata, T; Niwa, H; Sobue, G; Takeda, A; Wakai, M; Yasuda, Y1
Aoyama, I; Hirasawa, Y; Miyazaki, S; Miyazaki, T; Morita, T; Niwa, T; Shimokata, K; Takayama, F; Tsukushi, S1
Fehrenbach, H; Funk, RH; Hofer, A; Kasper, M; Münch, G; Niwa, T; Pehlke, K; Schinzel, R; Wilsch-Bräuninger, M; Witt, M1
Bucala, R; Kameda, Y; Koike, T; Makita, Z; Suzuki, T; Takeuchi, M1
Asahi, K; Inagi, R; Izuhara, Y; Kurokawa, K; Miyata, T; Saito, A; Ueda, Y; VAN Ypersele DE Strihou, C1
Chellan, P; Duve, Y; Glomb, MA; Jiang, CL; Madhun, Z; Nagaraj, RH; Sady, C1
Fehrenbach, H; Funk, RH; Kasper, M; Kuhnt, AK; Roehlecke, C; Werner, C1
Hayase, F; Hayashi, MC; Horiuchi, S; Kinae, N; Masuda, S; Nagai, R; Unno, Y1
Funk, RH; Geffarth, R; Kasper, M; Reber, F; Reichenbach, A; Schleicher, ED; Siegner, A1
Aimoto, S; Kawakami, T; Murata, M; Niwa, S; Oishi, T; Sasaki, T; Yamada, H1
Horiuchi, S; Kawaguchi, M; Kobayashi, M; Shibata, N1
Funk, RH; Knels, L; Kniep, EM; Ozkucur, N; Reber, F; Roehlecke, C; Steinberg, A1
Han, L; Li, B; Li, L; Li, Y; Liu, G; Xu, Z; Zhao, D1
Frau, J; Hernández-Laguna, A; Muñoz, F; Ortega-Castro, J; Solís-Calero, C1
André-Frei, V; Bechetoille, N; Berthod, F; Cadau, S; Leoty-Okombi, S; Pain, S1
Morales, FJ; Navarro, M1
Hans, J; Holik, AK; Kretschy, N; Ley, JP; Lieder, B; Somoza, MM; Somoza, V1
Ahmed, N; Brison, D; Carroll, M; McNeil, L; Murgatroyd, C; Nevin, C1
Holik, AK; Hölz, K; Somoza, MM; Somoza, V; Stöger, V1
Chen, J; Gao, D; He, J; He, Z; Jiao, Y; Qin, F; Xie, M; Zeng, M1
Broers, NJH; Canaud, B; Christiaans, MHL; Cornelis, T; Gauly, A; Hermans, MMH; Konings, CJAM; Kooman, JP; Martens, RJH; Schalkwijk, CG; Scheijen, JLJM; Stifft, F; van der Sande, FM; Wirtz, JJJM1
Liu, H; Wang, Y; Zhang, D1
Chern, C; Deo, P; Peake, B; Tan, SY1
Bast, A; Opperhuizen, A; van der Lugt, T; van Leeuwen, S; Venema, K; Vrolijk, MF1
Baldensperger, T; Dau, T; Di Sanzo, S; Glomb, MA; Heller, R; Henning, C; Kirkpatrick, JM; Leheis, A; Marx, C; Ori, A; Parca, L; Rändler, TL; Spengler, K; Wang, ZQ1
Baskal, S; Tsikas, D1
Ha, SK; Jeong, YJ; Kang, J; Lee, HH; Lee, KW1
Chen, J; Hao, S; Li, M; Li, N; Liu, H; Lu, Z; Quan, W; Wu, X; Xie, D; Xu, H1

Trials

1 trial(s) available for n(6)-carboxymethyllysine and glyoxal

ArticleYear
Relations of advanced glycation endproducts and dicarbonyls with endothelial dysfunction and low-grade inflammation in individuals with end-stage renal disease in the transition to renal replacement therapy: A cross-sectional observational study.
    PloS one, 2019, Volume: 14, Issue:8

    Topics: Adult; Aged; Biomarkers; Cross-Sectional Studies; Deoxyglucose; Diabetes Mellitus; Endothelium, Vascular; Female; Glycation End Products, Advanced; Glyoxal; Humans; Kidney Failure, Chronic; Lysine; Male; Middle Aged; Ornithine; Renal Dialysis

2019

Other Studies

32 other study(ies) available for n(6)-carboxymethyllysine and glyoxal

ArticleYear
N epsilon-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins.
    Biochemistry, 1995, Aug-29, Volume: 34, Issue:34

    Topics: Aging; Antigens; Chromatography, Gel; Crystallins; Enzyme-Linked Immunosorbent Assay; Fructose; Glucose; Glycation End Products, Advanced; Glyoxal; Humans; Kinetics; Lysine; Maillard Reaction; Serum Albumin, Bovine

1995
Mechanism of protein modification by glyoxal and glycolaldehyde, reactive intermediates of the Maillard reaction.
    The Journal of biological chemistry, 1995, Apr-28, Volume: 270, Issue:17

    Topics: Acetaldehyde; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Gas Chromatography-Mass Spectrometry; Glyoxal; Lysine; Maillard Reaction; Oxidation-Reduction; Proteins

1995
Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose.
    Biochemistry, 1995, Mar-21, Volume: 34, Issue:11

    Topics: Arabinose; Glucose; Glycosylation; Glyoxal; Ketoses; Kinetics; Lysine; Oxidation-Reduction; Proteins

1995
The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions.
    The Journal of biological chemistry, 1996, Apr-26, Volume: 271, Issue:17

    Topics: Arachidonic Acid; Copper; Glycation End Products, Advanced; Glyoxal; Humans; Lipid Peroxides; Lipoproteins, LDL; Lysine; Oxidation-Reduction

1996
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.
    The Journal of clinical investigation, 1998, Mar-01, Volume: 101, Issue:5

    Topics: Acetone; Aldehydes; Animals; Cattle; Endocytosis; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Glucose; Glutathione; Glycation End Products, Advanced; Glyoxal; Hyperglycemia; Ketones; Lactic Acid; Lactoylglutathione Lyase; Lysine; Pyruvaldehyde; Transfection; Tumor Cells, Cultured

1998
Accelerated formation of N epsilon-(carboxymethyl) lysine, an advanced glycation end product, by glyoxal and 3-deoxyglucosone in cultured rat sensory neurons.
    Biochemical and biophysical research communications, 1998, Jul-09, Volume: 248, Issue:1

    Topics: Animals; Apoptosis; Culture Techniques; Deoxyglucose; Dose-Response Relationship, Drug; Ganglia, Spinal; Glycation End Products, Advanced; Glyoxal; Guanidines; Lysine; Neurons, Afferent; Rats; Rats, Sprague-Dawley

1998
Immunohistochemical detection of imidazolone and N(epsilon)-(carboxymethyl)lysine in aortas of hemodialysis patients.
    Cellular and molecular biology (Noisy-le-Grand, France), 1998, Volume: 44, Issue:7

    Topics: Aged; Aorta; Arginine; Arteriosclerosis; Deoxyglucose; Female; Glyoxal; Humans; Imidazoles; Immunohistochemistry; Lysine; Male; Middle Aged; Pyruvaldehyde; Renal Dialysis; Uremia

1998
Experimental induction of AGEs in fetal L132 lung cells changes the level of intracellular cathepsin D.
    Biochemical and biophysical research communications, 1999, Jul-22, Volume: 261, Issue:1

    Topics: Antibodies; Cathepsin D; Cell Line; Cell Membrane; Cell Nucleus; Cell Size; Cytosol; Epithelial Cells; Gene Expression Regulation, Enzymologic; Glycation End Products, Advanced; Glyoxal; Humans; Imidazoles; Immunohistochemistry; Lung; Lysine; Lysosomes; Microscopy, Electron; Pulmonary Fibrosis; RNA, Messenger

1999
Immunological evidence that non-carboxymethyllysine advanced glycation end-products are produced from short chain sugars and dicarbonyl compounds in vivo.
    Molecular medicine (Cambridge, Mass.), 2000, Volume: 6, Issue:2

    Topics: Animals; Antibodies; Cattle; Chromatography, Affinity; Cross Reactions; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Glyceraldehyde; Glyoxal; Humans; Immunoblotting; Kidney Failure, Chronic; Lysine; Maillard Reaction; Oxidation-Reduction; Pyruvaldehyde; Rabbits; Renal Dialysis

2000
Mechanism of the inhibitory effect of OPB-9195 [(+/-)-2-isopropylidenehydrazono-4-oxo-thiazolidin-5-yla cetanilide] on advanced glycation end product and advanced lipoxidation end product formation.
    Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:9

    Topics: Aldehydes; Arachidonic Acid; Arginine; Deoxyglucose; Dialysis Solutions; Glycation End Products, Advanced; Glyoxal; Guanidines; Lipid Metabolism; Lysine; Malondialdehyde; Oxidation-Reduction; Peritoneal Dialysis; Prodrugs; Pyruvaldehyde; Thiadiazoles; Thiazolidines

2000
Maillard reactions by alpha-oxoaldehydes: detection of glyoxal-modified proteins.
    Biochimica et biophysica acta, 2000, Sep-29, Volume: 1481, Issue:2

    Topics: Aged; Aging; Antibodies; Cataract; Diabetes Mellitus; Enzyme-Linked Immunosorbent Assay; Glycation End Products, Advanced; Glycosylation; Glyoxal; Humans; Lens, Crystalline; Lysine; Maillard Reaction; Proteins; Serum Albumin; Serum Albumin, Bovine; Serum Albumin, Human

2000
Resistance of L132 lung cell clusters to glyoxal-induced apoptosis.
    Histochemistry and cell biology, 2000, Volume: 114, Issue:4

    Topics: Anoikis; Apoptosis; Caspase 3; Caspases; Cell Line; Dose-Response Relationship, Drug; Drug Resistance; Epithelial Cells; Glycation End Products, Advanced; Glyoxal; Humans; Hyaluronan Receptors; Integrin beta1; Lung; Lysine; Spheroids, Cellular

2000
Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite.
    Diabetes, 2002, Volume: 51, Issue:9

    Topics: 2-Naphthylamine; Aldehydes; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glucose; Glyoxal; Guanidines; Ketoses; Lysine; Mice; Mice, Inbred BALB C; Peroxynitrous Acid; Serum Albumin; Tyrosine

2002
Graded sensitiveness of the various retinal neuron populations on the glyoxal-mediated formation of advanced glycation end products and ways of protection.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2003, Volume: 241, Issue:3

    Topics: Acetylcysteine; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Dose-Response Relationship, Drug; Female; Glycation End Products, Advanced; Glyoxal; Guanidines; Immunoenzyme Techniques; In Situ Nick-End Labeling; Lysine; Male; Neurons; Niacinamide; Organ Culture Techniques; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Retina; Thioctic Acid; Vanadates

2003
Intact glycation end products containing carboxymethyl-lysine and glyoxal lysine dimer obtained from synthetic collagen model peptide.
    Bioorganic & medicinal chemistry letters, 2004, Nov-15, Volume: 14, Issue:22

    Topics: Amino Acid Sequence; Collagen Type I; Dimerization; Glycation End Products, Advanced; Glyoxal; Humans; Lysine; Molecular Sequence Data; Molecular Structure; Peptide Fragments; Protein Structure, Tertiary

2004
Glyoxal inactivates glutamate transporter-1 in cultured rat astrocytes.
    Neuropathology : official journal of the Japanese Society of Neuropathology, 2005, Volume: 25, Issue:1

    Topics: Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Chromatography, High Pressure Liquid; Glutamic Acid; Glyoxal; Immunoblotting; Immunohistochemistry; Lysine; Rats

2005
Inhibition of apoptosis and reduction of intracellular pH decrease in retinal neural cell cultures by a blocker of carbonic anhydrase.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:3

    Topics: Animals; Annexin A5; Apoptosis; Carbonic Anhydrase Inhibitors; Caspase 3; Caspases; Cell Culture Techniques; Cell Survival; Flow Cytometry; Glyoxal; Hydrogen Peroxide; Hydrogen-Ion Concentration; In Situ Nick-End Labeling; Lysine; Neurons; Neuroprotective Agents; Pyruvaldehyde; Rats; Reactive Oxygen Species; Retina; Sulfonamides; Thiophenes

2006
Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 60

    Topics: Chromatography, High Pressure Liquid; Diet; Food Handling; Glyoxal; Hydroxyl Radical; Linoleic Acid; Lipid Metabolism; Lysine; Maillard Reaction; Models, Biological; Oleic Acid; Triolein

2013
A DFT study of the carboxymethyl-phosphatidylethanolamine formation from glyoxal and phosphatidylethanolamine surface. Comparison with the formation of N(ε)-(carboxymethyl)lysine from glyoxal and L-lysine.
    Physical chemistry chemical physics : PCCP, 2015, Mar-28, Volume: 17, Issue:12

    Topics: Glycation End Products, Advanced; Glyoxal; Hydrogen Bonding; Lysine; Models, Molecular; Phosphatidylethanolamines; Thermodynamics

2015
In vitro glycation of an endothelialized and innervated tissue-engineered skin to screen anti-AGE molecules.
    Biomaterials, 2015, Volume: 51

    Topics: Animals; Capillaries; Cattle; Cell Differentiation; Cells, Cultured; Collagen; Cytoskeleton; Dermis; Endothelial Cells; Fibroblasts; Filaggrin Proteins; Glycation End Products, Advanced; Glycosylation; Glyoxal; Guanidines; Humans; Keratinocytes; Lysine; Mice; Neurons; Protective Agents; Skin; Thiazoles; Tissue Engineering

2015
Evaluation of an olive leaf extract as a natural source of antiglycative compounds.
    Food research international (Ottawa, Ont.), 2017, Volume: 92

    Topics: Chromatography, Liquid; Deoxyglucose; Fructosamine; Galactose; Glycation End Products, Advanced; Glycosylation; Glyoxal; Lysine; Olea; Ornithine; Phenols; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Pyrimidines; Pyruvaldehyde; Tandem Mass Spectrometry

2017
The advanced glycation end product N
    Journal of cellular biochemistry, 2018, Volume: 119, Issue:3

    Topics: Caco-2 Cells; Glycation End Products, Advanced; Glyoxal; Humans; Lysine; Serotonin

2018
Investigating the Glycating Effects of Glucose, Glyoxal and Methylglyoxal on Human Sperm.
    Scientific reports, 2018, 06-13, Volume: 8, Issue:1

    Topics: DNA Damage; Fertility; Glucose; Glycation End Products, Advanced; Glycosylation; Glyoxal; Humans; Lysine; Male; Pyruvaldehyde; Semen Analysis; Sperm Count; Sperm Motility; Spermatozoa

2018
Impact of free N
    Food & function, 2018, Jul-17, Volume: 9, Issue:7

    Topics: Caco-2 Cells; Gene Expression Regulation; Glycation End Products, Advanced; Glyoxal; Humans; Lysine; Maillard Reaction; Receptors, Serotonin; Serotonin; Serum Albumin, Bovine

2018
Formation of N
    Food research international (Ottawa, Ont.), 2019, Volume: 121

    Topics: Camellia sinensis; Catechin; Food Analysis; Food Handling; Gallic Acid; Glyoxal; Lysine; Plant Leaves; Polyphenols; Pyruvaldehyde; Tea

2019
Corn silk extract inhibit the formation of N
    Food chemistry, 2020, Mar-30, Volume: 309

    Topics: Antioxidants; Caseins; Chromatography, High Pressure Liquid; Fatty Acids; Flavonoids; Glucose; Glyoxal; Lysine; Models, Biological; Plant Extracts; Silk; Tandem Mass Spectrometry; Zea mays

2020
Non-nutritive sweeteners are in concomitant with the formation of endogenous and exogenous advanced glycation end-products.
    International journal of food sciences and nutrition, 2020, Volume: 71, Issue:6

    Topics: Cooking; Electrophoresis, Polyacrylamide Gel; Fructosamine; Glycation End Products, Advanced; Glyoxal; Hot Temperature; Lysine; Non-Nutritive Sweeteners; Proof of Concept Study; Sorbitol; Sucrose; Xylitol

2020
Gastrointestinal digestion of dietary advanced glycation endproducts using an in vitro model of the gastrointestinal tract (TIM-1).
    Food & function, 2020, Jul-22, Volume: 11, Issue:7

    Topics: Animals; Arginine; Chromatography, Liquid; Digestion; Fruit and Vegetable Juices; Gastrointestinal Tract; Glycation End Products, Advanced; Glyoxal; Hepatitis A Virus Cellular Receptor 1; Humans; Lysine; Milk; Pyruvaldehyde; Tandem Mass Spectrometry; Zingiber officinale

2020
Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation.
    Nature communications, 2021, 11-18, Volume: 12, Issue:1

    Topics: Aging; Animals; Cell Line; Cell Proliferation; Endothelial Cells; Glycosylation; Glyoxal; Humans; Lysine; Methylation; Mice; Mice, Inbred C57BL; Microtubules; Primary Cell Culture; Protein Processing, Post-Translational; Proteins; Proteomics; Proteostasis; Tubulin

2021
Free L-Lysine and Its Methyl Ester React with Glyoxal and Methylglyoxal in Phosphate Buffer (100 mM, pH 7.4) to Form
    International journal of molecular sciences, 2022, Mar-22, Volume: 23, Issue:7

    Topics: Esters; Gas Chromatography-Mass Spectrometry; Glycation End Products, Advanced; Glyoxal; Hydrogen-Ion Concentration; Lysine; Magnesium Oxide; Phosphates; Pyruvaldehyde; Schiff Bases

2022
Glyoxal-derived advanced glycation end-products, N
    Molecular biology reports, 2023, Volume: 50, Issue:3

    Topics: Apoptosis; Gene Expression; Glycation End Products, Advanced; Glyoxal; Hepatocytes; Humans; Lysine; Maillard Reaction; Proteins; Pyruvaldehyde; Reactive Oxygen Species

2023
Effect of edible oil type on the formation of protein-bound N
    Food research international (Ottawa, Ont.), 2023, Volume: 174, Issue:Pt 1

    Topics: Animals; Corn Oil; Glyoxal; Humans; Linoleic Acid; Linolenic Acids; Linseed Oil; Lysine; Oleic Acid; Olive Oil; Palmitic Acid; Plant Oils; Pork Meat; Red Meat; Swine; Tandem Mass Spectrometry

2023