Page last updated: 2024-09-03

n(6)-carboxymethyllysine and fructosyl-lysine

n(6)-carboxymethyllysine has been researched along with fructosyl-lysine in 25 studies

Compound Research Comparison

Studies
(n(6)-carboxymethyllysine)
Trials
(n(6)-carboxymethyllysine)
Recent Studies (post-2010)
(n(6)-carboxymethyllysine)
Studies
(fructosyl-lysine)
Trials
(fructosyl-lysine)
Recent Studies (post-2010) (fructosyl-lysine)
8034436596322

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.00)18.7374
1990's7 (28.00)18.2507
2000's8 (32.00)29.6817
2010's6 (24.00)24.3611
2020's2 (8.00)2.80

Authors

AuthorsStudies
Baynes, JW; Dunn, JA; Knecht, KJ; Lyons, TJ; McCance, DR; McFarland, KF; Thorpe, SR1
Bailie, KE; Baynes, JW; Dunn, JA; Dyer, DG; Lyons, TJ1
Baynes, JW; Dunn, JA; Dyer, DG; Lyons, TJ; Silvestri, G1
Baynes, JW; Dunn, JA; Patrick, JS; Thorpe, SR1
Ahmed, MU; Baynes, JW; Thorpe, SR1
Baynes, JW; Thorpe, SR; Wells-Knecht, MC1
Bailie, KE; Baynes, JW; Dunn, JA; Dyer, DG; Lyons, TJ; McCance, DR; Thorpe, SR1
Baynes, JW; Lyons, TJ; McCance, DR; Thorpe, SR; Wells-Knecht, MC1
Barja, G; Baynes, JW; Bellmunt, MJ; López-Torres, M; Pamplona, R; Portero-Otín, M; Requena, JR; Romero, M; Ruiz, C; Thorpe, SR1
Araki, A; Deoreo, PB; Erhard, P; Glomb, MA; Kader-Attia, FA; Monnier, VM; Weiss, MF; Wu, YC1
Bank, RA; Bayliss, MT; Baynes, JW; Bijlsma, JW; DeGroot, J; Lafeber, FP; Oldehinkel, E; Tekoppele, JM; Thorpe, SR; Verzijl, N1
Erbersdobler, HF; Faist, V; Tasto, S; Wenzel, E1
Hudson, BG; Jacob, J; Khalifah, RG; Serianni, AS; Thibaudeau, C; Voziyan, PA; Yildiz, A1
Gloe, K; Henle, T; Krause, R; Seifert, ST1
Clawin-Rädecker, I; Erbersdobler, HF; Grübel, N; Somoza, V; Weiss, C; Wenzel, E1
Deussen, A; Henle, T; Krause, R; Lauer, T; Planitz, C; Preuss, R; Rassaf, T1
Crabb, JW; Gu, J; Gu, X; Nagaraj, RH; Ni, J; Yuan, X; Yue, X1
Hellwig, M; Henle, T; Löbner, J; Matthes, R; Peto, A1
Han, L; Li, B; Li, L; Li, Y; Liu, G; Xu, Z; Zhao, D1
Barzilay, JI; Fonseca, V; Goldfine, AB; Jablonski, KA; Monnier, VM; Shoelson, SE; Strauch, C1
Bunzel, D; Franz, CM; Hellwig, M; Henle, T; Huch, M; Kulling, SE1
Alexander, L; Bosch, G; Butré, CI; Hendriks, WH; van der Poel, AF; van Rooijen, C; Wierenga, PA1
Chen, J; Gao, D; He, J; He, Z; Jiao, Y; Qin, F; Xie, M; Zeng, M1
Bakker, W; Beekmann, K; Belzer, C; Rietjens, IMCM; van Dongen, KCW1
Friedrich, S; Grune, T; Hellwig, A; Henle, T; Müller, SK; Raupbach, J; Schnell, V1

Trials

2 trial(s) available for n(6)-carboxymethyllysine and fructosyl-lysine

ArticleYear
The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes.
    Diabetes care, 2014, Volume: 37, Issue:4

    Topics: Adiponectin; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Lysine; Male; Middle Aged; Pyruvaldehyde; Salicylates

2014
Urinary excretion of dietary Maillard reaction products in healthy adult female cats.
    Journal of animal science, 2016, Volume: 94, Issue:1

    Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cats; Dairy Products; Diet; Eating; Female; Kidney; Lysine; Lysinoalanine; Maillard Reaction; Pilot Projects

2016

Other Studies

23 other study(ies) available for n(6)-carboxymethyllysine and fructosyl-lysine

ArticleYear
Effect of diabetes and aging on carboxymethyllysine levels in human urine.
    Diabetes, 1991, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Aged; Aging; Diabetes Mellitus, Type 1; Humans; Lysine; Middle Aged; Oxidation-Reduction

1991
Decrease in skin collagen glycation with improved glycemic control in patients with insulin-dependent diabetes mellitus.
    The Journal of clinical investigation, 1991, Volume: 87, Issue:6

    Topics: Arginine; Blood Glucose; Collagen; Diabetes Mellitus, Type 1; Humans; Hyperglycemia; Lysine; Maillard Reaction; Skin

1991
Role of glycation in modification of lens crystallins in diabetic and nondiabetic senile cataracts.
    Diabetes, 1991, Volume: 40, Issue:8

    Topics: Aged; Arginine; Cataract; Cataract Extraction; Crystallins; Diabetic Retinopathy; Female; Glycosylation; Humans; Lysine; Male

1991
Oxidation of glycated proteins: age-dependent accumulation of N epsilon-(carboxymethyl)lysine in lens proteins.
    Biochemistry, 1989, Nov-28, Volume: 28, Issue:24

    Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Chromatography, Ion Exchange; Crystallins; Humans; Infant; Lysine; Middle Aged; Oxidation-Reduction

1989
Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein.
    The Journal of biological chemistry, 1986, Apr-15, Volume: 261, Issue:11

    Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Crystallins; Free Radicals; Gas Chromatography-Mass Spectrometry; Glycoproteins; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine; Middle Aged; Mucoproteins; Oxidation-Reduction; Phosphates

1986
Pathways of formation of glycoxidation products during glycation of collagen.
    Biochemistry, 1995, Nov-21, Volume: 34, Issue:46

    Topics: Animals; Arginine; Carbon Isotopes; Collagen; Glucose; Glycosylation; Lysine; Oxidation-Reduction; Phosphates; Rats

1995
Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arginine; Collagen; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Retinopathy; Female; Humans; Lysine; Maillard Reaction; Male; Microcirculation; Middle Aged; Skin

1993
Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes.
    The Journal of clinical investigation, 1997, Aug-15, Volume: 100, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arginine; Child; Child, Preschool; Collagen; Diabetes Mellitus; Glucose; Humans; Infant; Infant, Newborn; Lysine; Methionine; Middle Aged; Oxidative Stress; Skin; Time Factors; Tyrosine

1997
Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins.
    Free radical biology & medicine, 1999, Volume: 27, Issue:7-8

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Deoxyguanosine; DNA Damage; Endopeptidases; Fatty Acids; Gas Chromatography-Mass Spectrometry; Glycation End Products, Advanced; Glycosylation; Hyperthyroidism; Hypothyroidism; Lipid Peroxidation; Liver; Lysine; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Thyroid Hormones

1999
Mechanisms for the formation of glycoxidation products in end-stage renal disease.
    Kidney international, 2000, Volume: 57, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Arginine; Enzyme Inhibitors; Female; Glucose; Glycation End Products, Advanced; Guanidines; Humans; Kidney Failure, Chronic; Lysine; Maillard Reaction; Male; Middle Aged; Oxidation-Reduction; Peritoneal Dialysis; Renal Dialysis

2000
Age-related accumulation of Maillard reaction products in human articular cartilage collagen.
    The Biochemical journal, 2000, Sep-01, Volume: 350 Pt 2

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Arginine; Cartilage, Articular; Child; Child, Preschool; Collagen; Collagenases; Cross-Linking Reagents; Female; Femur; Glycation End Products, Advanced; Humans; Lysine; Maillard Reaction; Male; Middle Aged; Skin; Spectrometry, Fluorescence

2000
Effect of heat-treated proteins on selected parameters of the biotransformation system in the rat.
    Annals of nutrition & metabolism, 2002, Volume: 46, Issue:1

    Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Dietary Proteins; Enzyme Activation; Glutathione; Glutathione Transferase; Hot Temperature; Intestinal Mucosa; Kidney; Liver; Lysine; Lysinoalanine; Maillard Reaction; Male; Rats; Rats, Wistar

2002
Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions.
    The Journal of biological chemistry, 2003, Nov-21, Volume: 278, Issue:47

    Topics: Animals; Carbon Isotopes; Diabetes Mellitus; Glucose; Glycation End Products, Advanced; Humans; Lysine; Metals; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Protein Processing, Post-Translational; Proteins; Pyridoxamine

2003
Metal complexation by the peptide-bound maillard reaction products N(epsilon)-fructoselysine and N(epsilon)-carboxymethyllysine.
    Journal of agricultural and food chemistry, 2004, Apr-21, Volume: 52, Issue:8

    Topics: Copper; Lysine; Maillard Reaction; Metals; Peptides; Zinc

2004
Dose-dependent utilisation of casein-linked lysinoalanine, N(epsilon)-fructoselysine and N(epsilon)-carboxymethyllysine in rats.
    Molecular nutrition & food research, 2006, Volume: 50, Issue:9

    Topics: Animals; Caseins; Diet; Dose-Response Relationship, Drug; Feces; Hot Temperature; Kidney; Liver; Lysine; Lysinoalanine; Maillard Reaction; Male; Rats; Rats, Wistar

2006
Evidence against nitric oxide-quenching effects of chemically defined Maillard reaction products.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2008, Volume: 40, Issue:4

    Topics: Amino Acids; Edetic Acid; Glycation End Products, Advanced; Lysine; Maillard Reaction; Nitric Oxide; Nitric Oxide Donors; Protein Binding; S-Nitroso-N-Acetylpenicillamine; Serum Albumin, Bovine; Solutions

2008
Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration.
    Molecular & cellular proteomics : MCP, 2009, Volume: 8, Issue:8

    Topics: Aged; Aged, 80 and over; Arginine; Autoantibodies; Biomarkers; Blood Proteins; Case-Control Studies; Chromatography, Liquid; Female; Fluorometry; Humans; Logistic Models; Lysine; Macular Degeneration; Male; Mass Spectrometry; Middle Aged; Pyrroles

2009
N-ε-fructosyllysine and N-ε-carboxymethyllysine, but not lysinoalanine, are available for absorption after simulated gastrointestinal digestion.
    Amino acids, 2014, Volume: 46, Issue:2

    Topics: Caseins; Chromatography, Gel; Digestion; Glycoproteins; Hydrogen-Ion Concentration; Intestinal Absorption; Lysine; Lysinoalanine; Models, Biological; Proteolysis

2014
Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 60

    Topics: Chromatography, High Pressure Liquid; Diet; Food Handling; Glyoxal; Hydroxyl Radical; Linoleic Acid; Lipid Metabolism; Lysine; Maillard Reaction; Models, Biological; Oleic Acid; Triolein

2013
Stability of Individual Maillard Reaction Products in the Presence of the Human Colonic Microbiota.
    Journal of agricultural and food chemistry, 2015, Aug-05, Volume: 63, Issue:30

    Topics: Adult; Bacteria; Colon; Female; Gastrointestinal Microbiome; Humans; Lysine; Maillard Reaction; Male; Middle Aged; Norleucine; Pyridones; Pyrroles

2015
Formation of N
    Food research international (Ottawa, Ont.), 2019, Volume: 121

    Topics: Camellia sinensis; Catechin; Food Analysis; Food Handling; Gallic Acid; Glyoxal; Lysine; Plant Leaves; Polyphenols; Pyruvaldehyde; Tea

2019
Inter- and Intraindividual Differences in the Capacity of the Human Intestinal Microbiome in Fecal Slurries to Metabolize Fructoselysine and Carboxymethyllysine.
    Journal of agricultural and food chemistry, 2022, Sep-21, Volume: 70, Issue:37

    Topics: Feces; Gastrointestinal Microbiome; Glycation End Products, Advanced; Humans; Lysine; RNA, Ribosomal, 16S

2022
The Effect of Free and Protein-Bound Maillard Reaction Products N-ε-Carboxymethyllysine, N-ε-Fructosyllysine, and Pyrraline on Nrf2 and NFκB in HCT 116 Cells.
    Molecular nutrition & food research, 2023, Volume: 67, Issue:18

    Topics: Caseins; Chromatography, Liquid; Glycation End Products, Advanced; HCT116 Cells; Humans; Lysine; Maillard Reaction; NF-E2-Related Factor 2; Receptor for Advanced Glycation End Products; Tandem Mass Spectrometry

2023