Compounds > n(6)-(n-threonylcarbonyl)adenosine
Page last updated: 2024-09-04

n(6)-(n-threonylcarbonyl)adenosine and adenosine

n(6)-(n-threonylcarbonyl)adenosine has been researched along with adenosine in 47 studies

Compound Research Comparison

Studies
(n(6)-(n-threonylcarbonyl)adenosine)		Trials
(n(6)-(n-threonylcarbonyl)adenosine)		Recent Studies (post-2010)
(n(6)-(n-threonylcarbonyl)adenosine)		Studies
(adenosine)		Trials
(adenosine)		Recent Studies (post-2010) (adenosine)
4703232,5361,0758,930

Protein Interaction Comparison

ProteinTaxonomyn(6)-(n-threonylcarbonyl)adenosine (IC50)adenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)0.3851
Sodium/nucleoside cotransporter 1Homo sapiens (human)5.5
Sodium/nucleoside cotransporter 2Homo sapiens (human)5.5
Adenosine receptor A3Homo sapiens (human)0.0011
Adenosine receptor A1Homo sapiens (human)0.0023
Equilibrative nucleoside transporter 1Homo sapiens (human)63
Solute carrier family 28 member 3Homo sapiens (human)3.3

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-19907 (14.89)18.7374
1990's3 (6.38)18.2507
2000's5 (10.64)29.6817
2010's27 (57.45)24.3611
2020's5 (10.64)2.80

Authors

AuthorsStudies
Adamiak, RW; Jezowska-Bojczuk, M; Kozlowski, H; Sóvágó, I; Swiatek, J; Várnagy, K1
Dymarek-Babs, T; Gornicki, P; Podkowinski, J1
Coombes, RC; Kraus, LE; Rimer, VG; Vold, BS1
Chheda, GB; Harmon, GA; Hong, CI; Piskorz, CF1
Keith, DE; Longmire, ME; Vold, BS1
Grosjean, H; Weissenbach, J1
Chheda, GB; Hamill, WD; Reddy, PR; Schweizer, MP1
Keith, DE; Slavik, M; Vold, BS1
Duden, R; Schöch, G; Topp, H1
Bolt, H; Dörrenhaus, A; Föllmann, W; Schöch, G; Topp, H1
Agris, PF; Guenther, R; Malkiewicz, A; Marszalek, M; Miskiewicz, A; Sochacka, E; Yarian, C1
Agris, PF; Gdaniec, Z; Guenther, R; Malkiewicz, A; Marszalek, M; Sochacka, E; Stuart, JW1
Bajji, AC; Davis, DR; Myszka, DG; Sundaram, M1
Fusch, C; Manz, F; Rudloff, S; Schöch, G; Topp, H; Unverzagt, S1
Bajji, AC; Davis, DR; Durant, PC; Kumar, RK; Sundaram, M1
Karzai, AW; Koonin, EV; Mehta, P; Prugar, E; Srinivasan, M; Sternglanz, R; Yu, Y1
de Crécy-Lagard, V; Deutsch, C; El Yacoubi, B; Hatin, I; Iwata-Reuyl, D; Kahveci, T; Murzin, AG; Rousset, JP1
Allers, T; Altman-Price, N; Cohen-Or, I; de Crécy-Lagard, V; Gophna, U; Naor, A; Thiaville, PC1
Ji, Y; Lei, T; Markowski, T; Witthuhn, BA; Yang, J; Zheng, L1
Kimura, S; Miyauchi, K; Suzuki, T1
Bareille, J; Basta, T; Collinet, B; Crozat, E; Forterre, P; Hecker, A; Perrochia, L; van Tilbeurgh, H; Zhang, W1
Caudy, AA; Chiovitti, D; Durocher, D; Kurinov, I; Lissina, E; Mao, DY; Neculai, D; Nislow, C; Poda, G; Sicheri, F; Strecker, J; Szilard, RK; Thevakumaran, N; Wan, LC; Yuan, F1
Basta, T; Forterre, P; Guetta, D; Hecker, A; Perrochia, L1
Basta, T; de Crécy-Lagard, V; El Yacoubi, B; Forterre, P; Hecker, A; Namy, O; Perrochia, L; Prigent, M; Thiaville, JJ; Thiaville, PC1
Crécy-Lagard, Vd; Ikeuchi, Y; Kimura, S; Miyauchi, K; Suzuki, T; Thiaville, PC1
Kim, KY; Kim, S; Kim, YG; Lee, BI; Park, JK; Park, S1
de Crécy-Lagard, V; Iwata-Reuyl, D; Thiaville, PC1
Kim, S; Lee, H; Park, S1
Sambhare, SB; Sonawane, KD1
Armengaud, J; Bacusmo, JM; Bessho, Y; Cao, X; de Crécy-Lagard, V; Deutsch, C; El Yacoubi, B; Iwata-Reuyl, D; Köhrer, C; Limbach, PA; RajBhandary, UL; Thiaville, JJ; Thiaville, PC; Wetzel, C1
Benton, MA; Dedon, PC; Govind, S; Hu, JF; Kellner, SM; Lai, EC; Lin, CJ; Ramroop, J; Smibert, P; Sternglanz, R; Zhao, X1
Chakrabartty, A; Durocher, D; Guarné, A; Kurinov, I; Pillon, MC; Sicheri, F; Sun, Y; Thevakumaran, N; Wan, LC1
Gdaniec, Z; Matuszewski, M; Miyauchi, K; Sochacka, E; Suzuki, T; Wojciechowski, J; Wolf, WM1
Eggers, C; Glavic, A; Rojas-Benítez, D1
Debiec, K; Matuszewski, M; Sochacka, E1
Fernández, FJ; Gómez, S; López-Estepa, M; Navas-Yuste, S; Vega, MC1
Bacusmo, JM; Crécy-Lagard, V; Dedon, PC; DeMott, M; Deutsch, C; Elfarash, A; Hu, J; Iwata-Reuyl, D; Limbach, PA; Meineke, B; Orsini, SS; Paulines, MJ; Rice, KC; Rojas-Benítez, D; Shuman, S; Thiaville, PC1
Bayooz, S; Iwata-Reuyl, D; Luthra, A; Phan, P; Stec, B; Swairjo, MA; Swinehart, W1
Collinet, B; Dammak, R; Durand, D; Li de la Sierra-Gallay, I; Liger, D; Missoury, S; Plancqueel, S; van Tilbeurgh, H; Zhang, W1
He, MH; Liu, JC; Liu, YY; Lu, YS; Peng, J; Zhou, JQ1
Bayooz, S; Iwata-Reuyl, D; Luthra, A; Paranagama, N; Phan, P; Quach, V; Schiffer, JM; Stec, B; Swairjo, MA; Swinehart, W1
Antignac, C; Arrondel, C; Bacchetta, J; Boddaert, N; Boschat, AC; Boyer, O; Braun, DA; Buscara, L; Charbit, M; Collardeau-Frachon, S; Collinet, B; Decramer, S; Durand, D; Gribouval, O; Guerrera, IC; Hildebrandt, F; Laurent, A; Lescop, E; Liger, D; Macher, MA; Machuca, E; Magen, D; Martin, G; Masson, C; Menara, G; Missoury, S; Mollet, G; Nevo, F; Novo, R; Parisot, M; Patat, J; Ranchin, B; Revy, P; Sanquer, S; Snoek, R; van Eerde, AM; van Tilbeurgh, H1
Agris, PF; Bacusmo, JM; de Crécy-Lagard, V; Deutsch, C; Iwata-Reuyl, D; Luthra, A; Sarachan, KL; Swairjo, MA; Swinehart, W1
Cirio, C; Collinet, B; Fulton, MG; Kopina, BJ; Lauhon, CT; Missoury, S; van Tilbeurgh, H1
Beenstock, J; Sicheri, F1
Adachi, M; Chujo, T; Kakizoe, Y; Kaneko, H; Kunisawa, A; Kuratsu, JI; Matsuoka, M; Mizobe, T; Mukoyama, M; Nagata, H; Nagayoshi, Y; Nakamori, Y; Nakata, H; Nishiguchi, K; Oshiumi, H; Sakakida, K; Shimada, S; Tomizawa, K; Wei, FY; Yamamoto, K; Yamamura, R1
Chen, W; Jin, M; Lei, D; Wang, X; Yu, Z; Zhang, W; Zhang, Z1

Reviews

2 review(s) available for n(6)-(n-threonylcarbonyl)adenosine and adenosine

ArticleYear
Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNA.
    RNA biology, 2014, Volume: 11, Issue:12

    Topics: Adenosine; Anticodon; Archaeal Proteins; Codon; Escherichia coli; Escherichia coli Proteins; Haloferax volcanii; Humans; Nucleic Acid Conformation; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Transfer; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Telomerase

2014
The structural and functional workings of KEOPS.
    Nucleic acids research, 2021, 11-08, Volume: 49, Issue:19

    Topics: Adenosine; Animals; Anion Exchange Protein 1, Erythrocyte; Archaea; Conserved Sequence; Gene Expression Regulation; Hernia, Hiatal; Humans; Intracellular Signaling Peptides and Proteins; Microcephaly; Models, Molecular; Nephrosis; Nuclear Proteins; Protein Conformation; Protein Serine-Threonine Kinases; RNA, Transfer; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors

2021

Other Studies

45 other study(ies) available for n(6)-(n-threonylcarbonyl)adenosine and adenosine

ArticleYear
Metal binding ability of hypermodified nucleosides of t-RNA. Potentiometric and spectroscopic studies on the metal complexes of N-[(9-beta-D-ribofuranosylpurin-6-yl)-carbamoyl] threonine.
    Journal of inorganic biochemistry, 1990, Volume: 40, Issue:4

    Topics: Adenosine; Ligands; Metals; Potentiometry; RNA, Transfer; Spectrophotometry; Threonine

1990
Modified tRNAs for probing tRNA binding sites on the ribosome.
    Acta biochimica Polonica, 1989, Volume: 36, Issue:3-4

    Topics: Adenosine; Affinity Labels; Binding Sites; Chromatography, High Pressure Liquid; Ribosomes; RNA, Transfer, Met; Uridine

1989
Use of a monoclonal antibody to detect elevated levels of a modified nucleoside, N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine, in the urine of breast cancer patients.
    Cancer research, 1986, Volume: 46, Issue:6

    Topics: Adenosine; Animals; Antibodies, Monoclonal; Antibody Specificity; Breast Neoplasms; Chromatography, High Pressure Liquid; Creatinine; Female; Humans; Hybridomas; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Radioimmunoassay

1986
Biosynthesis of N-(purin-6-ylcarbamoyl)-L-threonine riboside. Incorporation of L-threonine in vivo into modified nucleoside of transfer ribonucleic acid.
    The Biochemical journal, 1972, Volume: 127, Issue:3

    Topics: Adenosine; Animals; Carbamates; Carbon Isotopes; Chromatography, Paper; Cytidine; Escherichia coli; Guanosine; Liver; Purines; Rats; Ribonucleosides; RNA, Bacterial; RNA, Transfer; Threonine; Uridine

1972
Thiolation and 2-methylthio- modification of Bacillus subtilis transfer ribonucleic acids.
    Journal of bacteriology, 1981, Volume: 148, Issue:3

    Topics: Adenosine; Bacillus subtilis; Isopentenyladenosine; Purine Nucleosides; RNA, Bacterial; RNA, Transfer; Sulfides; Thionucleosides; Thiouridine; Threonine

1981
Effect of threonylcarbamoyl modification (t6A) in yeast tRNA Arg III on codon-anticodon and anticodon-anticodon interactions. A thermodynamic and kinetic evaluation.
    European journal of biochemistry, 1981, Volume: 116, Issue:1

    Topics: Adenosine; Anticodon; Base Composition; Codon; Escherichia coli; Kinetics; Purine Nucleosides; Ribosomes; RNA, Messenger; RNA, Transfer; RNA, Transfer, Amino Acyl; Saccharomyces cerevisiae; Thermodynamics; Threonine

1981
On the function of N-[(9-beta-D-ribofuranosylpurin-6-yl)carbamoyl]threonine in transfer ribonucleic acid. Metal ion binding studies.
    Biochemistry, 1981, Aug-18, Volume: 20, Issue:17

    Topics: Adenosine; Anticodon; Chemical Phenomena; Chemistry; Kinetics; Magnesium; Magnetic Resonance Spectroscopy; Manganese; Mathematics; Nucleic Acid Conformation; Potentiometry; Purine Nucleosides; RNA, Transfer; Threonine

1981
Urine levels of N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine, N6-(delta 2-isopentenyl)adenosine, and 2'-O-methylguanosine as determined by radioimmunoassay for normal subjects and cancer patients.
    Cancer research, 1982, Volume: 42, Issue:12

    Topics: Adenosine; Chromatography, High Pressure Liquid; Guanosine; Humans; Isopentenyladenosine; Neoplasms; Radioimmunoassay; Reference Values

1982
5,6-Dihydrouridine: a marker ribonucleoside for determining whole body degradation rates of transfer RNA in man and rats.
    Clinica chimica acta; international journal of clinical chemistry, 1993, Sep-17, Volume: 218, Issue:1

    Topics: Adenosine; Adult; Animals; Biomarkers; Cytoplasm; Female; Free Radicals; Humans; Infant, Newborn; Male; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Transfer; Species Specificity; Uridine

1993
Determination of degradation rates of transfer and ribosomal ribonucleic acids in cultured rat hepatocytes by measuring N6-threoninocarbonyladenosine, dihydrouridine, and pseudouridine in medium using high-performance liquid chromatography.
    Analytical biochemistry, 1997, Dec-15, Volume: 254, Issue:2

    Topics: Adenosine; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Liver; Male; Pseudouridine; Rats; Rats, Inbred F344; Reactive Oxygen Species; RNA; RNA, Ribosomal; RNA, Transfer; Uridine

1997
Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNALysUUU species.
    Biochemistry, 2000, Nov-07, Volume: 39, Issue:44

    Topics: Adenosine; Anticodon; Binding Sites; Humans; Nucleic Acid Conformation; Protein Binding; Pseudouridine; Ribosomal Proteins; RNA, Ribosomal, 16S; RNA, Transfer, Lys; Structure-Activity Relationship; Thermodynamics; Uridine

2000
Functional anticodon architecture of human tRNALys3 includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t6A.
    Biochemistry, 2000, Nov-07, Volume: 39, Issue:44

    Topics: Adenosine; Amino Acid Substitution; Anticodon; Crystallography, X-Ray; Humans; Hydrogen Bonding; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Protein Binding; Pseudouridine; Ribosomal Proteins; RNA, Transfer, Lys; Thermodynamics; Threonine

2000
An RNA complex of the HIV-1 A-loop and tRNA(Lys,3) is stabilized by nucleoside modifications.
    Journal of the American Chemical Society, 2002, Dec-04, Volume: 124, Issue:48

    Topics: Adenosine; Anticodon; HIV-1; Kinetics; Nucleic Acid Conformation; Nucleosides; Organophosphorus Compounds; RNA, Transfer, Lys; RNA, Viral; Surface Plasmon Resonance; Thiouridine

2002
Diurnal variation in the renal excretion of modified RNA catabolites in humans.
    Clinical science (London, England : 1979), 2003, Volume: 105, Issue:2

    Topics: Adenosine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Circadian Rhythm; Dietary Proteins; Guanosine; Humans; Male; Pseudouridine; RNA, Ribosomal; RNA, Transfer; Specimen Handling

2003
Structural effects of hypermodified nucleosides in the Escherichia coli and human tRNALys anticodon loop: the effect of nucleosides s2U, mcm5U, mcm5s2U, mnm5s2U, t6A, and ms2t6A.
    Biochemistry, 2005, Jun-07, Volume: 44, Issue:22

    Topics: Adenosine; Anticodon; Base Pairing; Binding Sites; Codon; Escherichia coli; Genetic Engineering; Humans; Magnesium; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Pseudouridine; Ribosomes; RNA, Transfer, Lys; Thermodynamics; Thionucleosides; Thiouridine

2005
The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.
    The EMBO journal, 2011, Mar-02, Volume: 30, Issue:5

    Topics: Adenosine; Amino Acid Sequence; Base Sequence; Metalloendopeptidases; Molecular Sequence Data; Multiprotein Complexes; Nucleic Acid Conformation; Protein Biosynthesis; Protein Serine-Threonine Kinases; RNA, Transfer; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2011
A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification.
    The EMBO journal, 2011, Mar-02, Volume: 30, Issue:5

    Topics: Adenosine; Genetic Complementation Test; Metalloendopeptidases; Mitochondrial Proteins; Multiprotein Complexes; RNA, Transfer; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

2011
A genetic investigation of the KEOPS complex in halophilic Archaea.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Adenosine; Archaeal Proteins; DNA, Archaeal; Gene Fusion; Glycation End Products, Advanced; Haloferax; Mutation; RNA, Archaeal

2012
The essentiality of staphylococcal Gcp is independent of its repression of branched-chain amino acids biosynthesis.
    PloS one, 2012, Volume: 7, Issue:10

    Topics: Adenosine; Amino Acids; Culture Media; Down-Regulation; Operon; Peptide Hydrolases; Proteomics; Staphylococcus aureus; Transcription, Genetic

2012
A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification.
    Nature chemical biology, 2013, Volume: 9, Issue:2

    Topics: Adenosine; Adenosine Triphosphate; Catalysis; Codon; Escherichia coli; Escherichia coli Proteins; Hydrolysis; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Genetic; Nucleic Acid Conformation; Oxazolone; Protein Biosynthesis; Protein Structure, Secondary; Recombinant Proteins; RNA, Transfer; Ubiquitin-Activating Enzymes

2013
In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya.
    Nucleic acids research, 2013, Feb-01, Volume: 41, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Archaeal Proteins; Bacterial Proteins; Biocatalysis; DNA-Binding Proteins; Endopeptidases; Protein Kinases; Pyrococcus abyssi; RNA-Binding Proteins; RNA, Transfer; Saccharomyces cerevisiae Proteins

2013
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
    Nucleic acids research, 2013, Volume: 41, Issue:12

    Topics: Adenosine; Dimerization; DNA-Binding Proteins; Metalloendopeptidases; Mitochondrial Proteins; Models, Molecular; Protein Subunits; RNA, Transfer; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Telomere Homeostasis

2013
Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modification.
    Nucleic acids research, 2013, Volume: 41, Issue:20

    Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphatases; Allosteric Regulation; Archaeal Proteins; Catalytic Domain; Dimerization; Iron; Iron-Binding Proteins; Molecular Docking Simulation; Nucleotides; Protein Serine-Threonine Kinases; Protein Subunits; Pyrococcus abyssi; RNA, Transfer

2013
Cross kingdom functional conservation of the core universally conserved threonylcarbamoyladenosine tRNA synthesis enzymes.
    Eukaryotic cell, 2014, Volume: 13, Issue:9

    Topics: Adenosine; Anticodon; Cytoplasm; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Mitochondria; Mitochondrial Proteins; Nucleic Acid Conformation; RNA, Transfer; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

2014
Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs.
    Nucleic acids research, 2014, Volume: 42, Issue:14

    Topics: Adenosine; Binding Sites; Codon; Escherichia coli Proteins; HeLa Cells; Humans; Methylation; Proteins; RNA, Transfer, Ser; RNA, Transfer, Thr; S-Adenosylmethionine; Substrate Specificity; tRNA Methyltransferases

2014
Overproduction, crystallization and preliminary X-ray crystallographic analysis of Escherichia coli tRNA N6-threonylcarbamoyladenosine dehydratase.
    Acta crystallographica. Section F, Structural biology communications, 2014, Volume: 70, Issue:Pt 11

    Topics: Adenosine; Amino Acid Sequence; Crystallization; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Molecular Sequence Data; RNA, Transfer; Threonine Dehydratase

2014
The Structure of Escherichia coli TcdA (Also Known As CsdL) Reveals a Novel Topology and Provides Insight into the tRNA Binding Surface Required for N(6)-Threonylcarbamoyladenosine Dehydratase Activity.
    Journal of molecular biology, 2015, Sep-25, Volume: 427, Issue:19

    Topics: Adenosine; Adenosine Triphosphate; Amino Acid Sequence; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Hydro-Lyases; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Multimerization; RNA, Transfer; Sequence Alignment; Ubiquitin-Activating Enzymes

2015
The influence of hypermodified nucleosides lysidine and t(6)A to recognize the AUA codon instead of AUG: a molecular dynamics simulation study.
    Integrative biology : quantitative biosciences from nano to macro, 2015, Volume: 7, Issue:11

    Topics: Adenosine; Anticodon; Base Sequence; Codon; Computer Simulation; Hydrogen Bonding; Lysine; Methionine; Molecular Dynamics Simulation; Molecular Sequence Data; Nucleosides; Pyrimidine Nucleosides; Ribosomes; Static Electricity

2015
Essentiality of threonylcarbamoyladenosine (t(6)A), a universal tRNA modification, in bacteria.
    Molecular microbiology, 2015, Volume: 98, Issue:6

    Topics: Adenosine; Amino Acid Sequence; Amino Acyl-tRNA Synthetases; Aminoacylation; Conserved Sequence; Deinococcus; Escherichia coli; Molecular Sequence Data; Prokaryotic Cells; Proteomics; RNA, Bacterial; RNA, Transfer; Saccharomyces cerevisiae

2015
An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis.
    RNA (New York, N.Y.), 2015, Volume: 21, Issue:12

    Topics: Adenosine; Alleles; Amino Acid Sequence; Animals; Biosynthetic Pathways; Conserved Sequence; Drosophila melanogaster; Drosophila Proteins; Female; Genetic Complementation Test; Imaginal Discs; Larva; Male; Mitosis; Molecular Sequence Data; Mutation; Organ Specificity; Saccharomyces cerevisiae

2015
Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.
    Nucleic acids research, 2016, 08-19, Volume: 44, Issue:14

    Topics: Adenosine; Archaeal Proteins; Biophysical Phenomena; Chromatography, Gel; Crystallography, X-Ray; Multiprotein Complexes; Protein Multimerization; Pyrococcus furiosus; Scattering, Radiation; Scattering, Small Angle; Solutions; Structure-Activity Relationship; X-Ray Diffraction

2016
A hydantoin isoform of cyclic N6-threonylcarbamoyladenosine (ct6A) is present in tRNAs.
    Nucleic acids research, 2017, 02-28, Volume: 45, Issue:4

    Topics: Adenosine; Escherichia coli; Hydantoins; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; RNA, Bacterial; RNA, Transfer

2017
Modulation of the Proteostasis Machinery to  Overcome Stress Caused by Diminished Levels of  t6A-Modified tRNAs in Drosophila.
    Biomolecules, 2017, 03-06, Volume: 7, Issue:1

    Topics: Adenosine; Animals; Drosophila melanogaster; Drosophila Proteins; Protein Biosynthesis; RNA Processing, Post-Transcriptional; RNA, Transfer; Unfolded Protein Response

2017
Efficient conversion of N
    Chemical communications (Cambridge, England), 2017, Jul-11, Volume: 53, Issue:56

    Topics: Adenosine; Anticodon; Carbodiimides; Cyclization; Escherichia coli; Hydantoins; Hydrogen-Ion Concentration; Oligoribonucleotides; RNA Stability; RNA, Transfer, Lys; Schizosaccharomyces

2017
Protein-tRNA Agarose Gel Retardation Assays for the Analysis of the N 6-threonylcarbamoyladenosine TcdA Function.
    Journal of visualized experiments : JoVE, 2017, 06-21, Issue:124

    Topics: Adenosine; Electrophoresis, Agar Gel; Models, Molecular; Nucleic Acid Conformation; Protein Binding; RNA, Transfer

2017
The t
    RNA biology, 2018, Volume: 15, Issue:4-5

    Topics: Adenosine; Anticodon; Bacterial Proteins; Bacterial Toxins; Endoribonucleases; Escherichia coli; Nucleic Acid Conformation; Protein Biosynthesis; RNA Processing, Post-Transcriptional; RNA, Transfer, Lys; Streptococcus mutans

2018
Structure and mechanism of a bacterial t6A biosynthesis system.
    Nucleic acids research, 2018, 02-16, Volume: 46, Issue:3

    Topics: Adenosine; Adenosine Triphosphatases; Adenosine Triphosphate; Bacterial Proteins; Binding Sites; Cloning, Molecular; Codon; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Isoenzymes; Kinetics; Ligases; Models, Molecular; Nucleic Acid Conformation; Protein Binding; Protein Biosynthesis; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins; RNA, Transfer; Substrate Specificity; Thermotoga maritima

2018
The structure of the TsaB/TsaD/TsaE complex reveals an unexpected mechanism for the bacterial t6A tRNA-modification.
    Nucleic acids research, 2018, 06-20, Volume: 46, Issue:11

    Topics: Adenosine; Adenosine Triphosphate; Archaeal Proteins; Bacterial Proteins; Binding Sites; Catalytic Domain; Enzymes; Models, Molecular; Protein Conformation; Protein Structure, Quaternary; RNA, Transfer; Thermotoga maritima

2018
Yeast KEOPS complex regulates telomere length independently of its t
    Journal of genetics and genomics = Yi chuan xue bao, 2018, 05-20, Volume: 45, Issue:5

    Topics: Adenosine; DNA-Binding Proteins; DNA, Single-Stranded; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Telomere

2018
Conformational communication mediates the reset step in t6A biosynthesis.
    Nucleic acids research, 2019, 07-09, Volume: 47, Issue:12

    Topics: Adenosine; Adenosine Triphosphatases; Amino Acid Motifs; Bacterial Proteins; Models, Molecular; Mutagenesis; Protein Conformation; RNA, Transfer; Thermotoga maritima

2019
Defects in t
    Nature communications, 2019, 09-03, Volume: 10, Issue:1

    Topics: Adenosine; Child; Female; GTP-Binding Proteins; Hernia, Hiatal; Humans; Intrinsically Disordered Proteins; Male; Microcephaly; Multiprotein Complexes; Mutation; Nephrosis; Nuclear Proteins; RNA-Binding Proteins; RNA, Transfer

2019
Specificity in the biosynthesis of the universal tRNA nucleoside
    RNA (New York, N.Y.), 2020, Volume: 26, Issue:9

    Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Amino Acids; Biosynthetic Pathways; Catalytic Domain; Escherichia coli; Nucleosides; Protein Conformation; RNA, Transfer; Substrate Specificity; Thermotoga maritima; Threonine

2020
Structure of a reaction intermediate mimic in t6A biosynthesis bound in the active site of the TsaBD heterodimer from Escherichia coli.
    Nucleic acids research, 2021, 02-26, Volume: 49, Issue:4

    Topics: Adenosine; Catalytic Domain; Escherichia coli; Escherichia coli Proteins; Models, Molecular; Mutagenesis, Site-Directed; Organophosphonates; Protein Multimerization; RNA, Transfer

2021
t
    Biomolecules, 2022, 09-03, Volume: 12, Issue:9

    Topics: Adenosine; Biomarkers; COVID-19; Humans; Nucleosides; RNA; SARS-CoV-2; Threonine

2022
Structure-function analysis of an ancient TsaD-TsaC-SUA5-TcdA modular enzyme reveals a prototype of tRNA t6A and ct6A synthetases.
    Nucleic acids research, 2023, 09-08, Volume: 51, Issue:16

    Topics: Adenosine; Escherichia coli; Ligases; Models, Molecular; Nucleosides; RNA, Transfer

2023