Compounds > n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine
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n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and n(6)-cyclopentyladenosine

n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine has been researched along with n(6)-cyclopentyladenosine in 20 studies

Compound Research Comparison

Studies
(n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)		Trials
(n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)		Recent Studies (post-2010)
(n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)		Studies
(n(6)-cyclopentyladenosine)		Trials
(n(6)-cyclopentyladenosine)		Recent Studies (post-2010) (n(6)-cyclopentyladenosine)
214558605062

Protein Interaction Comparison

ProteinTaxonomyn(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine (IC50)n(6)-cyclopentyladenosine (IC50)
Adenosine receptor A1Rattus norvegicus (Norway rat)0.2256
Adenosine receptor A2bRattus norvegicus (Norway rat)1.16
Adenosine receptor A1Homo sapiens (human)0.0027
Adenosine receptor A2aRattus norvegicus (Norway rat)1.16

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (20.00)18.2507
2000's12 (60.00)29.6817
2010's4 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jacobson, KA; Ji, XD; Kim, HO; Olah, ME; Siddiqi, SM; Stiles, GL1
Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C1
Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Marchetti, S; Martini, C; Mazzoni, MR; Trincavelli, L1
Figler, H; Jin, X; Linden, J; Robeva, AS; Thai, T1
Barak, D; Biadatti, T; Chen, W; Gao, ZG; Jacobson, KA; Johnson, CR; Kim, SG; Kim, SK; Lee, K1
Gao, ZG; Jacobson, KA1
Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L1
Donegan, RK; Lieberman, RL1
Amin, EA; Dosa, PI1
Anderson, R; Ker, JA; Ramafi, G; Theron, AJ; Visser, SS1
Antunes, E; Brain, SD; Camargo, EA; Costa, SK; de Nucci, G; Esquisatto, LC; Ribela, MT1
Díaz-Cruz, A; González-Benítez, E; Guinzberg, R; Piña, E1
Bril, A; Broadley, KJ; Khandoudi, N; Maddock, HL1
Chidiac, P; Cook, MA; Gan, XT; Haist, JV; Karmazyn, M; Rajapurohitam, V1
Hofer, M; Pipalová, I; Pospísil, M; Vacek, A; Znojil, V1
Antunes, E; De Nucci, G; Priviero, F; Zanesco, A1
Broadley, KJ; Clark, JH; James, S; Kidd, EJ; Martin, TJ; Yates, L1
Hofer, M; Holá, J; Pospísil, M; Streitová, D; Vacek, A; Znojil, V1
Church, JE; Coupar, IM; Pouton, CW; Rose'Meyer, RB; Urmaliya, VB; White, PJ1
Gazoni, LM; Kron, IL; Laubach, VE; Linden, J; Unger, EB; Walters, DM1

Reviews

4 review(s) available for n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and n(6)-cyclopentyladenosine

ArticleYear
Adenosine receptors as therapeutic targets.
    Nature reviews. Drug discovery, 2006, Volume: 5, Issue:3

    Topics: Animals; Disease; Drug Therapy; Humans; Ligands; Molecular Structure; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Signal Transduction; Structure-Activity Relationship

2006
Fluorescent ligands for adenosine receptors.
    Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1

    Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1

2013
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.
    Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3

    Topics: Adrenergic Agonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; Animals; Drug Discovery; Glaucoma; Humans; Ligands; Protein Kinase Inhibitors; rho-Associated Kinases; Sympathomimetics

2016
Tactical Approaches to Interconverting GPCR Agonists and Antagonists.
    Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3

    Topics: Animals; Humans; Ligands; Models, Molecular; Molecular Structure; Receptors, G-Protein-Coupled; Structure-Activity Relationship

2016

Other Studies

16 other study(ies) available for n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and n(6)-cyclopentyladenosine

ArticleYear
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.
    Journal of medicinal chemistry, 1994, Oct-14, Volume: 37, Issue:21

    Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Cell Membrane; CHO Cells; Cricetinae; Molecular Structure; Rats; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship

1994
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines

1998
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.
    Journal of medicinal chemistry, 1998, May-07, Volume: 41, Issue:10

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Brain; Cattle; Enzyme Inhibitors; In Vitro Techniques; Male; Membranes; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Testis

1998
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.
    Molecular pharmacology, 1999, Volume: 56, Issue:4

    Topics: Animals; Anti-Asthmatic Agents; Blotting, Western; Calcium; Cell Degranulation; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Humans; Kidney; Mast Cells; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A2B; Receptors, Purinergic P1; Theophylline; Type C Phospholipases; Xanthines

1999
Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.
    Journal of medicinal chemistry, 2002, Sep-26, Volume: 45, Issue:20

    Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Epoxy Compounds; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Models, Molecular; Mutation; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Ribose; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship

2002
Apparent involvement of the A(2A) subtype adenosine receptor in the anti-inflammatory interactions of CGS 21680, cyclopentyladenosine, and IB-MECA with human neutrophils.
    Biochemical pharmacology, 2000, Oct-01, Volume: 60, Issue:7

    Topics: Adenosine; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Cyclic AMP; Fura-2; Humans; In Vitro Techniques; Neutrophils; Pancreatic Elastase; Phenethylamines; Reactive Oxygen Species; Receptor, Adenosine A2A; Receptors, Purinergic P1

2000
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells.
    British journal of pharmacology, 2001, Volume: 134, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Proteins; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Isotonic Solutions; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Skin; Substance P; Theobromine

2001
Regulation of glycogen metabolism in hepatocytes through adenosine receptors. Role of Ca2+ and cAMP.
    European journal of pharmacology, 2002, Feb-22, Volume: 437, Issue:3

    Topics: Adenosine; Animals; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Gluconeogenesis; Glycogen; Glycolysis; Hepatocytes; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1

2002
Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO.
    The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:6

    Topics: Adenosine; Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; Guinea Pigs; Heart; Hemodynamics; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Prostaglandins; Purinergic P1 Receptor Agonists; Triazines; Triazoles

2002
Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:1

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A3 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Drug Interactions; Hypertrophy; Myocytes, Cardiac; Phenethylamines; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3

2005
Effects of stable adenosine receptor agonists on bone marrow hematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil.
    Physiological research, 2004, Volume: 53, Issue:5

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Drug Interactions; Fluorouracil; Hematopoiesis; Hematopoietic Stem Cells; Mice; Phenethylamines; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1

2004
Negative chronotropic response to adenosine receptor stimulation in rat right atria after run training.
    Clinical and experimental pharmacology & physiology, 2004, Volume: 31, Issue:10

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A3 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Depression, Chemical; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Physical Conditioning, Animal; Physical Exertion; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Vasodilator Agents

2004
Radioligand binding and functional responses of ligands for human recombinant adenosine A(3) receptors.
    Autonomic & autacoid pharmacology, 2006, Volume: 26, Issue:2

    Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Iodine Radioisotopes; Ligands; Magnesium Chloride; Quinazolines; Radioligand Assay; Receptor, Adenosine A3; Recombinant Proteins; Transfection; Triazoles

2006
Homeostatic action of adenosine A3 and A1 receptor agonists on proliferation of hematopoietic precursor cells.
    Experimental biology and medicine (Maywood, N.J.), 2008, Volume: 233, Issue:7

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A3 Receptor Agonists; Animals; Bone Marrow Cells; Cell Proliferation; Dose-Response Relationship, Drug; Erythroid Cells; Granulocytes; Hematopoietic Stem Cells; Homeostasis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Receptor, Adenosine A1; Receptor, Adenosine A3

2008
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.
    Journal of cardiovascular pharmacology, 2009, Volume: 53, Issue:5

    Topics: Acetamides; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Aminopyridines; Animals; Apoptosis; Cardiotonic Agents; Cell Line; Cell Survival; Dihydropyridines; Imidazoles; Myocardial Ischemia; Phenethylamines; Purines; Rats; Triazines; Triazoles; Xanthines

2009
Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury.
    The Journal of thoracic and cardiovascular surgery, 2010, Volume: 140, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Blood Pressure; Disease Models, Animal; In Vitro Techniques; Lung; Lung Compliance; Lung Diseases; Perfusion; Peroxidase; Piperidines; Protective Agents; Pulmonary Artery; Pulmonary Edema; Rabbits; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Reperfusion Injury; Tumor Necrosis Factor-alpha

2010