n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and adenosine

n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine has been researched along with adenosine in 149 studies

Compound Research Comparison

Studies (n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)	Trials (n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)	Recent Studies (post-2010) (n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)	Studies (adenosine)	Trials (adenosine)	Recent Studies (post-2010) (adenosine)
214	5	58	32,536	1,075	8,930

Protein Interaction Comparison

Protein	Taxonomy	adenosine (IC50)
high affinity choline transporter 1 isoform a	Homo sapiens (human)	0.3851
Sodium/nucleoside cotransporter 1	Homo sapiens (human)	5.5
Sodium/nucleoside cotransporter 2	Homo sapiens (human)	5.5
Adenosine receptor A3	Homo sapiens (human)	0.0011
Adenosine receptor A1	Homo sapiens (human)	0.0023
Equilibrative nucleoside transporter 1	Homo sapiens (human)	63
Solute carrier family 28 member 3	Homo sapiens (human)	3.3

Research

Studies (149)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	29 (19.46)	18.2507
2000's	76 (51.01)	29.6817
2010's	41 (27.52)	24.3611
2020's	3 (2.01)	2.80

Authors

Authors	Studies
Cristalli, G; Esker, JL; Jacobson, KA; Ji, XD; Melman, N; Olah, ME; Schneller, SW; Secrist, JA; Siddiqi, SM; Tiwari, KN	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Donegan, RK; Lieberman, RL	1
Carter, MF; Deutsch, SI; Jacobson, KA; Lin, RC; Mastropaolo, J; Meshulam, Y; Von Lubitz, DK	1
Carter, MF; Jacobson, KA; Lin, RC; Popik, P; Von Lubitz, DK	1
Fischer, B; Gallo-Rodriguez, C; Ji, XD; Melman, N; Olah, ME; Orlina, J; Pu, Q; Sanders, LH; Siegman, BD; van Galen, PJ	1
Daly, JW; Gallo-Rodriguez, C; Jacobson, KA; Nikodijević, O; Olah, ME; Shi, D; Stiles, GL	1
Jacobson, KA; Kim, HO; Kohno, Y; Koshiba, M; Sei, Y	1
Haskó, G; Kvetan, V; Németh, ZH; Pastores, SM; Szabó, C; Vizi, ES	1
Buchholz, RA; Hill, RJ; Kennedy, SP; Knight, DR; Magee, W; Masamune, H; Tracey, WR	1
Hourani, SM; Prentice, DJ	2
Abbracchio, MP; Jacobson, KA; Jiang, JL; Kim, YC; Sei, Y; Yao, Y	1
Auchampach, JA; Bolli, R; Maldonado, C; Qiu, Y; Rizvi, A; Tang, XL; Teschner, S	1
Jones, CA; Reeves, JJ; Sheehan, MJ; Vardey, CJ; Whelan, CJ	1
Jacobson, KA; Jiang, JL; Liang, BT; Stambaugh, K	1
Auchampach, JA; Caughey, GH; Jin, X; Linden, J; Wan, TC	1
Carr, CS; Hill, RJ; Kennedy, SP; Knight, DR; Masamune, H; Tracey, WR; Yellon, DM	1
Cappellacci, L; Franchetti, P; Grifantini, M; Lucacchini, A; Marchetti, S; Martini, C; Mazzoni, MR; Trincavelli, L	1
Jacobson, KA; Nawrath, H; Shainberg, A; Shneyvays, V	1
Egnaczyk, G; Haskó, G; Salzman, AL; Scott, GS; Shanley, TP; Szabó, C; Virág, L	1
Liang, BT	1
Haskó, G; Németh, ZH; Salzman, AL; Szabó, C; Vizi, ES	1
Chessell, IP; Eastwood, C; Grundy, D; Humphrey, PP; Kirkup, AJ	1
Bowler, AN; Knutsen, LJ; Mogensen, JP; Roberts, SM; Thomsen, C	1
Carré, DA; Civan, MM; Coca-Prados, M; McGlinn, AM; Mitchell, CH; Peterson-Yantorno, K; Stone, RA	1
Bischofberger, N; Boyd, M; Jacobson, KA; Lin, RC; Von Lubitz, DK	1
Jahania, MS; Kraft, KR; Lasley, RD; Mentzer, RM; Narayan, P; Partin, EL	1
Elliott, GT; Jacobson, KA; Liang, BT; Stambaugh, K	1
Liu, XJ; Reid, A; Sawynok, J	1
Abbracchio, MP; Cattabeni, F	1
Lin, RC; McClellan, J; von Lubitz, DK; Ye, W	1
Abbracchio, MP; Barbieri, D; Brambilla, R; Cattabeni, F; Ceruti, S; Franceschi, C; Jacobson, KA; Kim, YC; Klotz, KN; Lohse, MJ	1
Baraldi, PG; Borea, PA; Cacciari, B; Gessi, S; Klotz, KN; Leung, E; Merighi, S; Romagnoli, R; Spalluto, G; Varani, K	1
Carré, DA; Civan, MM; Coca-Prados, M; Mitchell, CH; Peterson-Yantorno, K	1
Anderson, R; Ker, JA; Ramafi, G; Theron, AJ; Visser, SS	1
Fujita, M; Ito, H; Kohno, Y; Masamune, A; Satoh, A; Satoh, K; Shimosegawa, T; Toyota, T	1
Calacay, J; Cheng, K; Feighner, SD; Griffin, PR; Howard, AD; Leonard, RJ; Leong, D; Liu, K; Pomés, A; Pong, C; Schaeffer, J; Smith, AG; Smith, RG; Van der Ploeg, LH; Xu, Y	1
Day, YJ; Gao, Z; Li, BS; Linden, J	1
Auchampach, JA; Bhattacharya, S; Black, RG; Bolli, R; Kodani, E; Takano, H; Tang, XL; Yang, Z	1
Ghelardoni, S; Ronca, F; Ronca-Testoni, S; Yu, G; Zucchi, R	1
O'Sullivan, RG; Redmond, HP; Street, JT; Wakai, A; Wang, JH; Winter, DC	1
Combes, P; Crumiere, M; Dickenson, JM; Graham, S; Klotz, KN	1
Lin, RC; Simpson, KL; Von Lubitz, DK	1
Antunes, E; Brain, SD; Camargo, EA; Costa, SK; de Nucci, G; Esquisatto, LC; Ribela, MT	1
Kim, KT; Kim, TD; Lee, JU; Seong, JK; Suh, BC	1
de Zeeuw, S; Duncker, DJ; Liem, DA; van den Doel, MA; Verdouw, PD	1
Auchampach, JA; Bolli, R; Kodani, E; Tang, XL	1
Breschi, MC; Calderone, V; Martinotti, E; Nieri, P	1
Baraldi, PG; Borea, PA; Cattabriga, E; Gessi, S; Iannotta, V; Leung, E; Merighi, S; Varani, K	1
Headrick, JP	1
Kondo, M; Nagai, A; Nakata, J; Nishimura, K; Taira, M; Takemura, H; Tamaoki, J	1
Baraldi, PG; Borea, PA; Gessi, S; Klotz, KN; Leung, E; Merighi, S; Varani, K	1
Díaz-Cruz, A; González-Benítez, E; Guinzberg, R; Piña, E	1
Kukreja, RC; Zhao, TC	2
Bar-Yehuda, S; Barer, F; Del Valle, L; Fishman, P; Khalili, K; Madi, L	1
Bril, A; Broadley, KJ; Khandoudi, N; Maddock, HL	1
Avila, MY; Civan, MM; Stone, RA	1
D'Agati, VD; Emala, CW; Jacobson, MA; Lee, HT; Ota-Setlik, A; Xu, H	1
Broadley, KJ; Martin, TJ	1
Corinti, S; Girolomoni, G; Herouy, Y; Idzko, M; la Sala, A; Napp, M; Norgauer, J; Panther, E	1
Ezeamuzie, CI; Philips, E	1
Bober, L; Caux, C; de Bouteiller, O; Deno, G; Du, XK; Fan, X; Fossetta, J; Jackson, J; Lundell, D; Lunn, C; Palmer, RK; Soudé-Bermejo, A	1
Rubaj, A; Sieklucka-Dziuba, M; Zgodziński, W	1
Auchampach, JA; Ge, ZD; Gross, GJ; Moore, J; Wan, TC	1
Haskó, G; Mabley, J; Marton, A; Pacher, P; Salzman, A; Soriano, F; Szabó, C; Wallace, R	1
Blackburn, MR; Jacobson, MA; Molina, JG; Sanborn, BM; Shlykov, SG; Tilley, SL; Zhong, H	1
Ardon, E; Bar-Yehuda, S; Barer, F; Fishman, P; Madi, L; Ochaion, A	1
Bril, A; Broadley, KJ; Gardner, NM; Khandoudi, N; Maddock, HL	1
Lu, J; Pierron, A; Ravid, K	1
Arich, A; Bar-Yehuda, S; Dreznick, Z; Fishman, P; Madi, L; Ohana, G; Rath-Wolfson, L; Silberman, D; Slosman, G	1
Bar-Yehuda, S; Barer, F; Erlanger, A; Fishman, P; Madi, L; Ochaion, A; Ohana, G	1
Fang, G; Linden, J; Scheld, WM; Sullivan, GW	1
Karami-Tehrani, F; Panjehpour, M	1
Chidiac, P; Cook, MA; Gan, XT; Haist, JV; Karmazyn, M; Rajapurohitam, V	1
Hofer, M; Pipalová, I; Pospísil, M; Vacek, A; Znojil, V	1
Galun, E; Matot, I; Rivo, J; Zeira, E	2
Bar-Yehuda, S; Carey, WD; Clark, EV; Cohn, I; Fishman, P; Fong, KL; Kerns, WD; Silverman, MH; van Troostenburg, AR; Warrington, SJ	1
Antunes, E; De Nucci, G; Priviero, F; Zanesco, A	1
Bar-Yehuda, S; Fishman, P; Gery, S; Madi, L; Shkapenuk, M; Silberman, D	1
Baharav, E; Bar-Yehuda, S; Fishman, P; Halpren, M; Madi, L; Ochaion, A; Rath-Wolfson, L; Silberman, D; Weinberger, A	1
Cowen, DS; Desai, BD; Duann, P; Ho, TY; Kapoian, T; Lianos, EA	1
Cervello, M; D'Alessandro, N; Labbozzetta, M; Lo Cicero, S; Meli, M; Notarbartolo, M; Poma, P	1
Gadina, M; Kelsall, BL; la Sala, A	1
Baharav, E; Bar-Yehuda, S; Cohen, S; Fishman, P; Madi, L; Ochaion, A; Rath-Wolfson, L	1
Broadley, KJ; Clark, JH; James, S; Kidd, EJ; Martin, TJ; Yates, L	1
Carnicelli, V; Frascarelli, S; Ghelardoni, S; Ronca-Testoni, S; Zucchi, R	1
Jang, Y; Mueller, RA; Park, SS; Xu, Z; Zhao, H	1
Hofer, M; Holá, J; Pospísil, M; Streitová, D; Vacek, A; Weiterová, L; Znojil, V	1
Auer, H; Bozarov, A; Cardounel, AJ; Christofi, FL; Cooke, H; Grants, I; Guzman, J; Hassanain, HH; Javed, A; Javed, N; Palatini, J; Suntres, Z; Wunderlich, JE; Yu, JG	1
Grden, M; Kocbuch, K; Pawelczyk, T; Podgorska, M; Szutowicz, A	1
Amital, H; Bar-Yehuda, S; Barer, F; Cohn, S; Del Valle, L; Farbstein, M; Fishman, P; Fishman-Furman, S; Langevitz, P; Levi, Y; Mader, R; Madi, L; Molad, Y; Ochaion, A; Perez-Liz, G; Reitblat, A; Reitblat, T; Tishler, M; Zabutti, A	1
Bar-Yehuda, S; Barer, F; Cohen, S; Fishman, P; Madi, L; Ochayin, A	1
Hofer, M; Holá, J; Pospísil, M; Streitová, D; Vacek, A; Znojil, V	3
Blakely, RD; Daws, LC; Hewlett, WA; Munn, JL; Steiner, JA; Zhu, CB	1
Bar-Yehuda, S; Cohen, S; Fishman, P; Kerns, WD; Ochaion, A; Silverman, MH	1
Adawi, M; Caspi, D; Cohen, S; Cohn, I; Farbstein, M; Fishman, P; Fishman-Furman, S; Friedman, J; Green, L; Kerns, WD; Langevitz, P; Mader, R; Markovits, D; Molad, Y; Nahir, M; Ochaion, A; Reitblat, T; Rosner, I; Rozenbaum, M; Rubinow, A; Silverman, MH; Strand, V; Tanay, A; Tishler, M; Yehuda, SB	1
Brand, F; Fredholm, BB; Jacobson, KA; Klutz, AM; Schulte, G	1
Bai, GY; Kim, SH; Kim, SZ; Park, WH; Yuan, K	1
Church, JE; Coupar, IM; Pouton, CW; Rose'Meyer, RB; Urmaliya, VB; White, PJ	1
Atar, E; Bar-Yehuda, S; Barer, F; Castel, D; Cohen, S; Del Valle, L; Fishman, P; Ochaion, A; Patoka, R; Perez-Liz, G; Piña-Oviedo, S; Rath-Wolfson, L; Zozulya, G	1
Alhaj, M; Bozarov, A; Christofi, FL; Cooke, HJ; Grants, I; Hassanain, HH; Ren, T; Wang, YZ; Wunderlich, J; Yu, JG	1
Jajoo, S; Mukherjea, D; Ramkumar, V; Watabe, K	1
Dolezel, P; Mlejnek, P	1
Avni, I; Bakshi, E; Barequet, IS; Bristol, DR; Chetrit, N; Cohn, I; Farbstein, M; Fishman, P; Fishman, S; Garzozi, HJ; Harpaz, Z; Jacobson, KA; Kerns, WD; Litvin, G; Sartani, G; Segev, F; Silverman, MH; Tomkins, O; Varssano, D; Yehuda, SB; Zadok, D	1
Balasubramanian, R; Jacobson, KA; Keene, AM; Lloyd, J; Shainberg, A	1
Bottle, SE; Devine, SM; Figler, H; Gregg, A; Linden, J; McIntosh, K; Pouton, CW; Scammells, PJ; Urmaliya, V; White, PJ	1
Gazoni, LM; Kron, IL; Laubach, VE; Linden, J; Unger, EB; Walters, DM	1
Dusek, L; Hofer, M; Hoferová, Z; Holá, J; Pospísil, M; Sefc, L; Streitová, D; Vacek, A	1
Borea, PA; Govoni, M; Padovan, M; Trotta, F; Varani, K; Vincenzi, F	1
Akerman, L; David, M; Fishman, P; Gospodinov, D; Kadurina, M; Kouzeva, V; Pavlotsky, F; Ramon, M; Silverman, MH; Yankova, R; Ziv, M	1
Ashar, JN; Mathur, A; Sangwan, V	1
Dušek, L; Hofer, M; Hoferová, Z; Pospíšil, M; Weiterová, L	1
Aghaei, M; Karami-Tehrani, F; Panjehpour, M; Salami, S	1
Bar-Yehuda, S; Caspi, RR; Cohen, S; de Morales, JM; Fishman, P; Luger, D; Ochaion, A; Patokaa, R; Silver, PB; Zozulya, G	1
Kim, TH; Kim, YK; Woo, JS	1
Korenstein, R; Madi, L; Nyska, A; Rosenberg-Haggen, B	1
Dušek, L; Hofer, M; Hoferová, Z; Komůrková, D; Pospíšil, M	2
Dolezel, P; Frydrych, I; Mlejnek, P	1
Grden, M; Kitowska, A; Maciejewska, I; Pawelczyk, T; Sakowicz-Burkiewicz, M; Szutowicz, A	1
Bar-Yehuda, S; Cohen, S; Fishman, P	1
Celinski, K; Czechowska, G; Korolczuk, A; Madro, A; Prozorow-Krol, B; Slomka, M	1
Arellano, RO; González-Fernández, E; Matute, C; Pérez-Samartín, A; Sánchez-Gómez, MV	1
Abedi, H; Aghaei, M; Hajiahmadi, S; Panjehpour, M	1
Diebold, Y; Gasull, X; Guzman-Aranguez, A; Pintor, J	1
Cuzzocrea, S; Doyle, T; Esposito, E; Jacobson, KA; Janes, K; Salvemini, D; Tosh, DK	1
Batista, Ede J; Benzecry, R; Gemaque, J; Herculano, AM; Lima, MG; Maximino, C; Oliveira, KR; Picanço-Diniz, DW	1
French, BA; Linden, J; Marshall, M; Tian, Y; Yang, Z	1
Castonguay, A; Chen, Z; Cottet, M; De Koninck, Y; Doyle, T; Egan, TM; Ford, A; Jacobson, KA; Little, JW; Salvemini, D; Symons-Liguori, AM; Tosh, DK; Vanderah, TW	1
Ambrósio, AF; Cordeiro, MF; Elvas, F; Galvao, J; Martins, T; Santiago, AR	1
Al Haleem, EN; El-Bakly, WM; El-Demerdash, E; Galal, A	1
Warren, RB; Yiu, ZZ	1
Baltos, JA; Christopoulos, A; Gregory, KJ; Jacobson, KA; May, LT; Nguyen, AT; Paoletta, S; Tosh, DK	1
Feng, C; Yan, H; Zhang, E; Zhao, X	1
Benea, V; Bristol, DR; Cohen, S; Cosgarea, MR; Cristodor, P; David, M; Demerdjieva, ZV; Farbstein, M; Fishman, P; Gheorghe, N; Giurcaneanu, C; Gospodinov, DK; Harpaz, Z; Hitova, MC; Horia, B; Hristakieva, E; Kadurina, MI; Mateev, GS; Michael, Z; Morariu, HS; Nica, C; Patel, RV; Purcaru, AI; Ramon, M; Rotaru, M; Rusinova, MV; Silverman, MH; Simionescu, O; Solovastru, LG; Tsingov, II; Yankova, RK	1
Bao, Y; Chen, Y; Hefti, MM; Junger, WG; Ledderose, C; Li, L; Seier, T; Woehrle, T; Zhang, J	1
Briggs, J; Castrop, H; Eisner, C; Grill, A; Hoerl, M; Kim, S; Qin, Y; Schnermann, J; Thiel, M	1
Ahn, S; Cheong, JH; Jacobson, KA; Jeong, LS; Jin, SH; Kim, G; Kim, HJ; Kim, J; Lee, E; Lee, M; Noh, M; Yu, J	1
Cooper, S; Hussain, A; Maddock, H; Mee, C; Sandhu, H	1
Caso, F; Chimenti, MS; Conigliaro, P; Costa, L; De Martino, E; Fonti, GL; Perricone, C; Perricone, R; Sunzini, F; Triggianese, P	1
Barkan, K; Kolocouris, A; Ladds, G; Lagarias, P; Stamatis, D; Vrontaki, E	1
Assumpção, JAF; Caumo, W; Cioato, SG; de Souza, A; Lopes, BC; Medeiros, HR; Medeiros, LF; Roesler, R; Torres, ILS	1
Bai, H; Gao, L; Jiao, G; Li, T; Liu, L; Ma, T; Song, X; Wang, X; Zhang, Z	1
Cheng, P; Chu, Z; Lin, H; Liu, W; Wu, Y; Zhang, J; Zhu, J	1

Reviews

8 review(s) available for n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and adenosine

Article	Year
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3 Topics: Adrenergic Agonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; Animals; Drug Discovery; Glaucoma; Humans; Ligands; Protein Kinase Inhibitors; rho-Associated Kinases; Sympathomimetics	2016
Stimulation of adenosine A3 receptors in cerebral ischemia. Neuronal death, recovery, or both? Annals of the New York Academy of Sciences, 1999, Volume: 890 Topics: Adenosine; Animals; Brain Ischemia; Mice; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Receptors, Purinergic P1	1999
The anti-inflammatory effect of A3 adenosine receptor agonists: a novel targeted therapy for rheumatoid arthritis. Expert opinion on investigational drugs, 2007, Volume: 16, Issue:10 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Leukocytes, Mononuclear; Membrane Proteins	2007
The role of adenosine receptors in rheumatoid arthritis. Autoimmunity reviews, 2010, Volume: 10, Issue:2 Topics: Adenosine; Animals; Arthritis, Rheumatoid; Humans; Inflammation; Purinergic Agonists; Receptors, Purinergic P1	2010
Targeting the A3 adenosine receptor for glaucoma treatment (review). Molecular medicine reports, 2013, Volume: 7, Issue:6 Topics: Adenosine; Adenosine A3 Receptor Agonists; Anti-Inflammatory Agents; Apoptosis; Dry Eye Syndromes; Glaucoma; Humans; Intraocular Pressure; Receptor, Adenosine A3; Retinal Ganglion Cells	2013
Purinergic receptors in ocular inflammation. Mediators of inflammation, 2014, Volume: 2014 Topics: Adenosine; Animals; Dinucleoside Phosphates; Eye; Humans; Inflammation; Receptors, Purinergic	2014
Novel Oral Therapies for Psoriasis and Psoriatic Arthritis. American journal of clinical dermatology, 2016, Volume: 17, Issue:3 Topics: Adamantane; Adenosine; Adenosine A3 Receptor Antagonists; Administration, Oral; Arthritis, Psoriatic; Azetidines; Biological Factors; Biological Therapy; Clinical Trials as Topic; Humans; Isonicotinic Acids; Janus Kinases; Niacinamide; Phosphodiesterase 4 Inhibitors; Piperidines; Protein Kinase Inhibitors; Psoriasis; Purines; Pyrazoles; Pyrimidines; Pyrroles; Receptors, Lysosphingolipid; rho-Associated Kinases; Sulfonamides; Thalidomide; Thiazoles	2016
An update on pathogenesis of psoriatic arthritis and potential therapeutic targets. Expert review of clinical immunology, 2019, Volume: 15, Issue:8 Topics: Abatacept; Adenosine; Alleles; Arthritis, Psoriatic; Genetic Predisposition to Disease; HLA Antigens; Humans; Immunoglobulins; Immunosuppressive Agents; Treatment Outcome	2019

Trials

5 trial(s) available for n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and adenosine

Article	Year
Tolerability, pharmacokinetics and concentration-dependent hemodynamic effects of oral CF101, an A3 adenosine receptor agonist, in healthy young men. International journal of clinical pharmacology and therapeutics, 2004, Volume: 42, Issue:10 Topics: Adenosine; Adenosine A3 Receptor Agonists; Administration, Oral; Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Half-Life; Heart Rate; Humans; Leukocyte Count; Male; Neutrophils	2004
Clinical evidence for utilization of the A3 adenosine receptor as a target to treat rheumatoid arthritis: data from a phase II clinical trial. The Journal of rheumatology, 2008, Volume: 35, Issue:1 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Receptor, Adenosine A3; Severity of Illness Index; Treatment Outcome	2008
Treatment of dry eye syndrome with orally administered CF101: data from a phase 2 clinical trial. Ophthalmology, 2010, Volume: 117, Issue:7 Topics: Adenosine; Adenosine A3 Receptor Agonists; Administration, Oral; Cornea; Double-Blind Method; Dry Eye Syndromes; Electrocardiography; Female; Fluorophotometry; Humans; Intraocular Pressure; Male; Middle Aged; Tears; Treatment Outcome	2010
Treatment of plaque-type psoriasis with oral CF101: data from an exploratory randomized phase 2 clinical trial. Journal of the European Academy of Dermatology and Venereology : JEADV, 2012, Volume: 26, Issue:3 Topics: Adenosine; Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Placebos; Psoriasis; Treatment Outcome	2012
Treatment of Plaque-Type Psoriasis With Oral CF101: Data from a Phase II/III Multicenter, Randomized, Controlled Trial. Journal of drugs in dermatology : JDD, 2016, 08-01, Volume: 15, Issue:8 Topics: Adenosine; Administration, Oral; Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Psoriasis; Statistics as Topic; Treatment Outcome; Young Adult	2016

Other Studies

136 other study(ies) available for n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and adenosine

Article	Year
Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors. Journal of medicinal chemistry, 1995, Mar-31, Volume: 38, Issue:7 Topics: Adenosine; Animals; Cell Membrane; CHO Cells; Corpus Striatum; Cricetinae; In Vitro Techniques; Magnetic Resonance Spectroscopy; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Rats; Recombinant Proteins; Ribose; Structure-Activity Relationship	1995
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
The effects of adenosine A3 receptor stimulation on seizures in mice. European journal of pharmacology, 1995, Feb-24, Volume: 275, Issue:1 Topics: Adenosine; Animals; Clonidine; Drug Interactions; Electroshock; Injections, Intraperitoneal; Male; Mice; N-Methylaspartate; p-Methoxy-N-methylphenethylamine; Pentylenetetrazole; Purinergic P1 Receptor Agonists; Seizures	1995
Adenosine A3 receptor stimulation and cerebral ischemia. European journal of pharmacology, 1994, Sep-22, Volume: 263, Issue:1-2 Topics: Adenosine; Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Drug Administration Schedule; Female; Gerbillinae; Neurons; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Xanthines	1994
Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists. Journal of medicinal chemistry, 1994, Mar-04, Volume: 37, Issue:5 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain; Cell Membrane; Cerebral Cortex; CHO Cells; Cricetinae; Molecular Structure; Rats; Receptors, Purinergic P1; Structure-Activity Relationship	1994
A role for central A3-adenosine receptors. Mediation of behavioral depressant effects. FEBS letters, 1993, Dec-20, Volume: 336, Issue:1 Topics: Adenosine; Animals; Brain; Locomotion; Male; Mice; Molecular Structure; Phenethylamines; Radioligand Assay; Rats; Receptors, Purinergic P1; Xanthines	1993
Induction of apoptosis in HL-60 human promyelocytic leukemia cells by adenosine A(3) receptor agonists. Biochemical and biophysical research communications, 1996, Feb-27, Volume: 219, Issue:3 Topics: Adenosine; Apoptosis; Base Sequence; Calcium; Cytosol; DNA Primers; DNA, Neoplasm; Electrophoresis, Agar Gel; HL-60 Cells; Humans; Kinetics; Molecular Sequence Data; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; RNA, Messenger; Structure-Activity Relationship	1996
Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. Journal of immunology (Baltimore, Md. : 1950), 1996, Nov-15, Volume: 157, Issue:10 Topics: Adenosine; Animals; Endotoxemia; Interleukin-10; Macrophages; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha	1996
Selective adenosine A3 receptor stimulation reduces ischemic myocardial injury in the rabbit heart. Cardiovascular research, 1997, Volume: 33, Issue:2 Topics: Adenosine; Animals; Disease Models, Animal; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Phenylisopropyladenosine; Rabbits; Receptors, Purinergic; Stimulation, Chemical	1997
Adenosine analogues relax guinea-pig taenia caeci via an adenosine A2B receptor and a xanthine-resistant site. European journal of pharmacology, 1997, Mar-26, Volume: 323, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cecum; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines	1997
Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists. Biochemical and biophysical research communications, 1997, Mar-17, Volume: 232, Issue:2 Topics: Adenosine; Apoptosis; Dihydropyridines; DNA Fragmentation; Dose-Response Relationship, Drug; HL-60 Cells; Humans; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazoles; Quinazolines; Triazoles	1997
Selective activation of A3 adenosine receptors with N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits. Circulation research, 1997, Volume: 80, Issue:6 Topics: Adenosine; Animals; Heart; Hemodynamics; Histamine; Male; Myocardial Infarction; Myocardial Stunning; Rabbits; Rats; Receptors, Purinergic P1	1997
Adenosine A3 receptors promote degranulation of rat mast cells both in vitro and in vivo. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46, Issue:5 Topics: Adenosine; Administration, Cutaneous; Animals; Blood Proteins; Cell Degranulation; Cyproheptadine; Dinitrophenols; Female; Humans; In Vitro Techniques; Injections, Intravenous; Male; Mast Cells; Mice; p-Methoxy-N-methylphenethylamine; Pleura; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Rats; Rats, Wistar; Receptors, Purinergic P1; Serotonin; Serotonin Antagonists; Serum Albumin; Skin; Theophylline; Triazoles; Xanthines	1997
A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia. The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2 Topics: Adenosine; Animals; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Chick Embryo; Dihydropyridines; Heart; Heart Ventricles; Myocardial Ischemia; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines	1997
Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. Molecular pharmacology, 1997, Volume: 52, Issue:5 Topics: Adenine; Adenosine; Amino Acid Sequence; Animals; Base Sequence; beta-N-Acetylhexosaminidases; Calcium; Chlorocebus aethiops; COS Cells; Dinucleoside Phosphates; DNA, Complementary; Dogs; Mast Cells; Mast-Cell Sarcoma; Molecular Sequence Data; Neoplasm Proteins; Norbornanes; Receptor, Adenosine A3; Receptors, Purinergic P1; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Xanthines	1997
Evidence for a role for both the adenosine A1 and A3 receptors in protection of isolated human atrial muscle against simulated ischaemia. Cardiovascular research, 1997, Volume: 36, Issue:1 Topics: Adenosine; Dinucleoside Phosphates; Heart Atria; Humans; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Models, Biological; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines	1997
2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. Journal of medicinal chemistry, 1998, May-07, Volume: 41, Issue:10 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Brain; Cattle; Enzyme Inhibitors; In Vitro Techniques; Male; Membranes; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Testis	1998
Induction of apoptosis in cardiac myocytes by an A3 adenosine receptor agonist. Experimental cell research, 1998, Sep-15, Volume: 243, Issue:2 Topics: Adenosine; Animals; Apoptosis; Calcium; Cells, Cultured; DNA Fragmentation; Heart; Myocardium; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A3	1998
Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists. British journal of pharmacology, 1998, Volume: 125, Issue:2 Topics: Adenosine; Animals; Arthritis; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Collagen; Cytokines; Disease Models, Animal; Gene Expression; Macrophage Activation; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred DBA; Purinergic P1 Receptor Agonists; RNA, Messenger	1998
Protein kinase C-dependent activation of KATP channel enhances adenosine-induced cardioprotection. The Biochemical journal, 1998, Dec-01, Volume: 336 ( Pt 2) Topics: Adenosine; Animals; Cells, Cultured; Chick Embryo; Enzyme Activation; Glyburide; Ischemic Preconditioning, Myocardial; Myocardial Ischemia; Myocardium; Pinacidil; Potassium Channels; Protein Kinase C; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Tetradecanoylphorbol Acetate	1998
An agonist of adenosine A3 receptors decreases interleukin-12 and interferon-gamma production and prevents lethality in endotoxemic mice. European journal of pharmacology, 1998, Oct-09, Volume: 358, Issue:3 Topics: Adenosine; Animals; Corticosterone; Endotoxemia; Endotoxins; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-12; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitrates; Nitrites; Polysaccharides, Bacterial; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Species Specificity; Survival Analysis	1998
Characterization of adenosine receptors evoking excitation of mesenteric afferents in the rat. British journal of pharmacology, 1998, Volume: 125, Issue:6 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Bethanechol; Female; Jejunum; Male; Muscarinic Agonists; Neurons, Afferent; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1	1998
The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles. Bioorganic & medicinal chemistry letters, 1998, Jul-07, Volume: 8, Issue:13 Topics: Adenosine; Animals; Cell Line; Humans; Isoxazoles; Ligands; Rats; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship	1998
A3 adenosine receptors regulate Cl- channels of nonpigmented ciliary epithelial cells. The American journal of physiology, 1999, Volume: 276, Issue:3 Topics: Adenosine; Adult; Animals; Chloride Channels; Ciliary Body; Electric Conductivity; Epithelial Cells; Humans; Iris; Male; Purinergic P1 Receptor Agonists; Rabbits; Receptors, Purinergic P1; RNA, Messenger	1999
Chronic administration of adenosine A3 receptor agonist and cerebral ischemia: neuronal and glial effects. European journal of pharmacology, 1999, Feb-19, Volume: 367, Issue:2-3 Topics: Adenosine; Animals; Brain Chemistry; Carotid Arteries; Coloring Agents; Female; Gerbillinae; Glial Fibrillary Acidic Protein; Immunohistochemistry; Ischemia; Microtubule-Associated Proteins; Nitric Oxide Synthase; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Time Factors	1999
Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA. The American journal of physiology, 1999, Volume: 276, Issue:6 Topics: Adenosine; Animals; Coronary Circulation; Coronary Vessels; Dihydropyridines; Female; Hemodynamics; In Vitro Techniques; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Swine; Triazoles; Vasodilation	1999
Additive effects of late preconditioning produced by monophosphoryl lipid A and the early preconditioning mediated by adenosine receptors and KATP channel. Circulation, 1999, Jun-29, Volume: 99, Issue:25 Topics: Adenosine; Animals; Cells, Cultured; Chick Embryo; Ischemic Preconditioning, Myocardial; Lipid A; Myocardium; omega-N-Methylarginine; Pinacidil; Potassium Channels; Purinergic P1 Receptor Agonists; Vasodilator Agents	1999
Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists. European journal of pharmacology, 1999, Dec-15, Volume: 386, Issue:2-3 Topics: Acute Disease; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Drug Interactions; Edema; Enzyme Inhibitors; Histamine H1 Antagonists; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3	1999
Brain adenosine receptors as targets for therapeutic intervention in neurodegenerative diseases. Annals of the New York Academy of Sciences, 1999, Volume: 890 Topics: Adenosine; Animals; Astrocytes; Brain Infarction; Brain Ischemia; Cell Death; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles	1999
Activation of the A3 adenosine receptor affects cell cycle progression and cell growth. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Analysis of Variance; Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Membrane; Cell Survival; CHO Cells; Cricetinae; Dihydropyridines; Flow Cytometry; Humans; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A3; Receptors, Purinergic P1; Transfection; Triazoles	2000
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Molecular pharmacology, 2000, Volume: 57, Issue:5 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Phenylurea Compounds; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Tritium	2000
Similarity of A(3)-adenosine and swelling-activated Cl(-) channels in nonpigmented ciliary epithelial cells. American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:2 Topics: Adenosine; Cells, Cultured; Chloride Channels; Cilia; Epithelial Cells; Humans; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Receptors, Purinergic P1	2000
Apparent involvement of the A(2A) subtype adenosine receptor in the anti-inflammatory interactions of CGS 21680, cyclopentyladenosine, and IB-MECA with human neutrophils. Biochemical pharmacology, 2000, Oct-01, Volume: 60, Issue:7 Topics: Adenosine; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Cyclic AMP; Fura-2; Humans; In Vitro Techniques; Neutrophils; Pancreatic Elastase; Phenethylamines; Reactive Oxygen Species; Receptor, Adenosine A2A; Receptors, Purinergic P1	2000
Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats. Gastroenterology, 2000, Volume: 119, Issue:3 Topics: Acute Disease; Adenosine; Amylases; Animals; Ceruletide; Edema; Leukocytes; Male; Pancreas; Pancreatic Diseases; Pancreatitis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, Purinergic P1; Taurocholic Acid	2000
Adenosine: A partial agonist of the growth hormone secretagogue receptor. Biochemical and biophysical research communications, 2000, Oct-05, Volume: 276, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aequorin; Animals; Binding Sites; Cell Extracts; Cell Line; Chromatography, High Pressure Liquid; Dopamine; Humans; Hypothalamus; Indoles; Ligands; Luminescent Measurements; Mass Spectrometry; Models, Biological; Mutagenesis, Site-Directed; Neurons; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Spiro Compounds; Swine; Theophylline	2000
Characterisation of adenosine receptors mediating relaxation in hamster isolated aorta. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:4-5 Topics: 2-Chloroadenosine; Adenosine; Animals; Aorta; Cricetinae; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mesocricetus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenethylamines; Receptors, Purinergic P1; Theophylline; Thioinosine; Vasodilation	2000
A3 adenosine receptor activation triggers phosphorylation of protein kinase B and protects rat basophilic leukemia 2H3 mast cells from apoptosis. Molecular pharmacology, 2001, Volume: 59, Issue:1 Topics: Adenosine; Animals; Apoptosis; Leukemia, Basophilic, Acute; Mast Cells; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Signal Transduction; Tumor Cells, Cultured; Ultraviolet Rays	2001
A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms. Circulation research, 2001, Mar-16, Volume: 88, Issue:5 Topics: Adenine; Adenosine; Animals; Binding, Competitive; Cell Line; Consciousness; Decanoic Acids; Humans; Hydroxy Acids; Iodine Radioisotopes; Ischemic Preconditioning, Myocardial; Membranes; Myocardial Infarction; Nitroarginine; Norbornanes; Phenethylamines; Rabbits; Radioligand Assay; Receptor, Adenosine A3; Receptors, Purinergic P1	2001
A3 adenosine receptor stimulation modulates sarcoplasmic reticulum Ca(2+) release in rat heart. Cardiovascular research, 2001, Volume: 50, Issue:1 Topics: Adenosine; Animals; Calcium; Dantrolene; Hemodynamics; Male; Muscle Relaxants, Central; Myocardial Reperfusion Injury; Myocardium; Organ Culture Techniques; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Ryanodine; Sarcoplasmic Reticulum; Vasodilator Agents	2001
Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation. Shock (Augusta, Ga.), 2001, Volume: 15, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); CD18 Antigens; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Depression, Chemical; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Lymphokines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Theobromine; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Regulation of p42/p44 mitogen-activated protein kinase by the human adenosine A3 receptor in transfected CHO cells. European journal of pharmacology, 2001, May-18, Volume: 420, Issue:1 Topics: Adenosine; Androstadienes; Animals; CHO Cells; Chromones; Colforsin; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Luciferases; Mitogen-Activated Protein Kinase 1; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Receptor, Adenosine A3; Receptors, Purinergic P1; Recombinant Fusion Proteins; Wortmannin	2001
Right thing at a wrong time? Adenosine A3 receptors and cerebroprotection in stroke. Annals of the New York Academy of Sciences, 2001, Volume: 939 Topics: Adenosine; Animals; Brain; Brain Ischemia; Male; Mice; Neurons; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Stroke	2001
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells. British journal of pharmacology, 2001, Volume: 134, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Proteins; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Isotonic Solutions; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Skin; Substance P; Theobromine	2001
Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells. British journal of pharmacology, 2001, Volume: 134, Issue:1 Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Calcium; Colforsin; Cyclic AMP; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Activation; Estrenes; Gene Expression Regulation, Neoplastic; GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Isoproterenol; Mice; Mice, Inbred CBA; Pertussis Toxin; Phospholipases; Pinealoma; Pyrrolidinones; Receptor, Adenosine A2B; Receptor, Adenosine A3; Receptors, Purinergic P1; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella	2001
Role of adenosine in ischemic preconditioning in rats depends critically on the duration of the stimulus and involves both A(1) and A(3) receptors. Cardiovascular research, 2001, Volume: 51, Issue:4 Topics: Acetamides; Adenosine; Analysis of Variance; Animals; Cryoprotective Agents; Dihydropyridines; Histamine H1 Antagonists; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Purinergic Antagonists; Purinergic P1 Receptor Antagonists; Pyrilamine; Rats; Rats, Wistar; Receptors, Purinergic; Receptors, Purinergic P1; Theophylline; Time Factors	2001
Protection of IB-MECA against myocardial stunning in conscious rabbits is not mediated by the A1 adenosine receptor. Basic research in cardiology, 2001, Volume: 96, Issue:5 Topics: Adenosine; Animals; Cardiotonic Agents; Consciousness; Heart Rate; Male; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Rabbits; Receptors, Purinergic P1	2001
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. British journal of pharmacology, 2001, Volume: 134, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines	2001
A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study. Molecular pharmacology, 2002, Volume: 61, Issue:2 Topics: Adenosine; Binding, Competitive; Biological Transport; Calcium; Cyclic AMP; Gene Expression; Granulocytes; HL-60 Cells; Humans; Neutrophils; Phenylurea Compounds; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Superoxides; Triazoles	2002
Apparent activation of cardiovascular A1 adenosine receptors by A3 agonists. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:2 Topics: Adenosine; Animals; Myocardium; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines	2002
Adenosine A(3) receptor-mediated potentiation of mucociliary transport and epithelial ciliary motility. American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:3 Topics: Adenosine; Animals; Calcium; Cilia; Dose-Response Relationship, Drug; Epithelium; Intracellular Membranes; Mucociliary Clearance; Osmolar Concentration; Purinergic P1 Receptor Agonists; Rabbits; Receptor, Adenosine A3; Receptors, Purinergic P1; Respiratory Mucosa; Trachea	2002
Binding thermodynamics at the human A(3) adenosine receptor. Biochemical pharmacology, 2002, Jan-15, Volume: 63, Issue:2 Topics: Adenosine; Animals; Cells, Cultured; CHO Cells; Cricetinae; Humans; Kinetics; Phenylurea Compounds; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Thermodynamics; Transfection; Triazoles	2002
Regulation of glycogen metabolism in hepatocytes through adenosine receptors. Role of Ca2+ and cAMP. European journal of pharmacology, 2002, Feb-22, Volume: 437, Issue:3 Topics: Adenosine; Animals; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Gluconeogenesis; Glycogen; Glycolysis; Hepatocytes; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1	2002
Late preconditioning elicited by activation of adenosine A(3) receptor in heart: role of NF- kappa B, iNOS and mitochondrial K(ATP) channel. Journal of molecular and cellular cardiology, 2002, Volume: 34, Issue:3 Topics: Adenosine; Animals; Electrophoretic Mobility Shift Assay; Heart; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Inbred ICR; Mitochondria, Heart; Myocardium; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Potassium Channels; Receptor, Adenosine A3; Receptors, Purinergic P1; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2002
Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells. Oncogene, 2002, Jun-06, Volume: 21, Issue:25 Topics: Adenosine; beta Catenin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclins; Cytoskeletal Proteins; Down-Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Melanoma; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Signal Transduction; Trans-Activators; Tumor Cells, Cultured; Ubiquitin; Wnt Proteins; Zebrafish Proteins	2002
Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:6 Topics: Adenosine; Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; Guinea Pigs; Heart; Hemodynamics; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Prostaglandins; Purinergic P1 Receptor Agonists; Triazines; Triazoles	2002
Knockout of A3 adenosine receptors reduces mouse intraocular pressure. Investigative ophthalmology & visual science, 2002, Volume: 43, Issue:9 Topics: Adenosine; Administration, Topical; Animals; Dihydropyridines; Intraocular Pressure; Mice; Mice, Inbred C57BL; Mice, Knockout; Ophthalmic Solutions; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1	2002
A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure. American journal of physiology. Renal physiology, 2003, Volume: 284, Issue:2 Topics: Acute Kidney Injury; Adenosine; Animals; Genotype; Histamine; Ischemia; Kidney; Mice; Mice, Inbred C57BL; Mice, Knockout; Myoglobinuria; p-Methoxy-N-methylphenethylamine; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Reference Values; Renal Circulation; Reperfusion Injury	2003
Contractile responses to adenosine, R-PIA and ovalbumen in passively sensitized guinea-pig isolated airways. British journal of pharmacology, 2002, Volume: 137, Issue:6 Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Immune Sera; In Vitro Techniques; Isotonic Solutions; Methacholine Chloride; Muscle Contraction; Ovalbumin; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Time Factors; Trachea; Vasodilator Agents	2002
Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells. Blood, 2003, May-15, Volume: 101, Issue:10 Topics: Adenosine; Antigens, CD; Cells, Cultured; Chemokines; Cytokines; Dendritic Cells; Endocytosis; Flow Cytometry; Histocompatibility Antigens Class I; Humans; Interleukin-12; Kinetics; Lipopolysaccharides; Lymphocyte Activation; T-Lymphocytes; Tumor Necrosis Factor-alpha	2003
Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase. Biochemical and biophysical research communications, 2003, Jan-17, Volume: 300, Issue:3 Topics: Adenosine; Adenylyl Cyclases; Adult; Cell Degranulation; Cyclic AMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Eosinophils; Histamine; Humans; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles	2003
Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells. Molecular pharmacology, 2003, Volume: 63, Issue:2 Topics: Adenosine; Binding Sites; Calcium; Cell Membrane; Cells, Cultured; Dendritic Cells; Humans; Iodine Radioisotopes; Monocytes; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1	2003
The influence of adenosine A3 receptor agonist: IB-MECA, on scopolamine- and MK-801-induced memory impairment. Behavioural brain research, 2003, Apr-17, Volume: 141, Issue:1 Topics: Adenosine; Animals; Avoidance Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Maze Learning; Memory; Memory Disorders; Mice; Motor Activity; Muscarinic Antagonists; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Scopolamine; Theophylline	2003
A3 adenosine receptor agonist IB-MECA reduces myocardial ischemia-reperfusion injury in dogs. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:2 Topics: Adenosine; Anesthesia; Animals; Cardiotonic Agents; Coronary Circulation; Disease Models, Animal; Dogs; Iodine Radioisotopes; Myocardial Infarction; Myocardial Reperfusion Injury; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A3; Receptors, Purinergic P1	2003
The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitis. European journal of pharmacology, 2003, Apr-18, Volume: 466, Issue:3 Topics: Adenosine; Animals; Chemokine CCL4; Chemokine CXCL2; Chemokines; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Hemorrhage; Interleukin-1; Interleukin-12; Interleukin-6; Macrophage Inflammatory Proteins; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Mice, Knockout; Peroxidase; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Rectal Diseases; Weight Loss	2003
Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse. American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:1 Topics: Adenosine; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Cell Nucleus; Cytosol; Dihydropyridines; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Heart Diseases; Heart Function Tests; In Vitro Techniques; Isoenzymes; Male; Mice; Myocardial Contraction; Myocardial Infarction; NF-kappa B; Phenanthridines; Protein Kinase C; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1	2003
Activation of murine lung mast cells by the adenosine A3 receptor. Journal of immunology (Baltimore, Md. : 1950), 2003, Jul-01, Volume: 171, Issue:1 Topics: Adenosine; Adenosine Deaminase; Animals; Calcium; Cell Degranulation; Cells, Cultured; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Histamine Antagonists; Histamine Release; Intracellular Fluid; Lung; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nebulizers and Vaporizers; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptor, Adenosine A2B; Receptor, Adenosine A3; Receptors, Purinergic P1; Up-Regulation	2003
A3 adenosine receptor activation in melanoma cells: association between receptor fate and tumor growth inhibition. The Journal of biological chemistry, 2003, Oct-24, Volume: 278, Issue:43 Topics: Adenosine; Animals; Cell Division; Cell Line, Tumor; Cyclin D1; Down-Regulation; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Neoplasms, Experimental; Protein Transport; Proto-Oncogene Proteins c-myc; Receptor, Adenosine A3; Signal Transduction	2003
Protection from myocardial stunning by ischaemia and hypoxia with the adenosine A3 receptor agonist, IB-MECA. European journal of pharmacology, 2003, Sep-23, Volume: 477, Issue:3 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Coronary Circulation; Endothelium, Vascular; Guinea Pigs; Heart Atria; Hypoxia; Male; Myocardial Ischemia; Myocardial Stunning; Oxygen; Papillary Muscles; Perfusion; Receptor, Adenosine A3; Reperfusion Injury; Time Factors; Xanthines	2003
An adenosine analogue, IB-MECA, down-regulates estrogen receptor alpha and suppresses human breast cancer cell proliferation. Cancer research, 2003, Oct-01, Volume: 63, Issue:19 Topics: Adenosine; Adenosine A3 Receptor Agonists; Apoptosis; Breast Neoplasms; Cell Adhesion; Cell Division; Cell Line, Tumor; Down-Regulation; Estrogen Receptor alpha; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Receptors, Estrogen; S Phase; Signal Transduction; Transcription, Genetic	2003
Inhibition of primary colon carcinoma growth and liver metastasis by the A3 adenosine receptor agonist CF101. British journal of cancer, 2003, Oct-20, Volume: 89, Issue:8 Topics: Adenosine; Administration, Oral; Animals; Biological Availability; Carcinoma; Cell Division; Colonic Neoplasms; Disease Models, Animal; Humans; Liver Neoplasms; Mice; Mice, Inbred BALB C; Purinergic P1 Receptor Agonists; Transplantation, Heterologous; Tumor Cells, Cultured	2003
An agonist to the A3 adenosine receptor inhibits colon carcinoma growth in mice via modulation of GSK-3 beta and NF-kappa B. Oncogene, 2004, Apr-01, Volume: 23, Issue:14 Topics: Adenosine; Animals; beta Catenin; Carcinoma; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Cytoskeletal Proteins; Down-Regulation; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Growth Inhibitors; Humans; Indoles; Lithium; Maleimides; Mice; Mice, Nude; NF-kappa B; Proto-Oncogene Proteins c-myc; Purinergic P1 Receptor Agonists; Pyridines; Trans-Activators	2004
A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis. The Journal of infectious diseases, 2004, May-15, Volume: 189, Issue:10 Topics: Adenosine; Adenosine A2 Receptor Agonists; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Endotoxemia; Escherichia coli; Escherichia coli Infections; Female; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Purines; Receptors, Adenosine A2; Sepsis; Survival Analysis	2004
An adenosine analog (IB-MECA) inhibits anchorage-dependent cell growth of various human breast cancer cell lines. The international journal of biochemistry & cell biology, 2004, Volume: 36, Issue:8 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Colforsin; Cyclic AMP; Female; Gene Expression Regulation, Neoplastic; Humans; Receptor, Adenosine A3; Signal Transduction	2004
Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:1 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A3 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Drug Interactions; Hypertrophy; Myocytes, Cardiac; Phenethylamines; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3	2005
Effects of stable adenosine receptor agonists on bone marrow hematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil. Physiological research, 2004, Volume: 53, Issue:5 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Drug Interactions; Fluorouracil; Hematopoiesis; Hematopoietic Stem Cells; Mice; Phenethylamines; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1	2004
Activation of A3 adenosine receptors attenuates lung injury after in vivo reperfusion. Anesthesiology, 2004, Volume: 101, Issue:5 Topics: Adamantane; Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; ATP-Binding Cassette Transporters; Cats; Dihydropyridines; Enzyme Inhibitors; Hemodynamics; Histamine; In Vitro Techniques; KATP Channels; Lung; Morpholines; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pulmonary Artery; Reperfusion Injury	2004
Negative chronotropic response to adenosine receptor stimulation in rat right atria after run training. Clinical and experimental pharmacology & physiology, 2004, Volume: 31, Issue:10 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A3 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; Depression, Chemical; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Physical Conditioning, Animal; Physical Exertion; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Vasodilator Agents	2004
Activation of A3 adenosine receptor provides lung protection against ischemia-reperfusion injury associated with reduction in apoptosis. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2004, Volume: 4, Issue:12 Topics: Adenosine; Animals; Apoptosis; Cats; Disease Models, Animal; In Situ Nick-End Labeling; Lung; Lung Injury; Receptor, Adenosine A3; Reperfusion Injury	2004
CF101, an agonist to the A3 adenosine receptor, enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model. Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:1 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Antimetabolites, Antineoplastic; Cell Proliferation; Colonic Neoplasms; Colony-Forming Units Assay; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Transplantation, Heterologous; Tumor Cells, Cultured	2005
Antiinflammatory effect of A3 adenosine receptor agonists in murine autoimmune arthritis models. The Journal of rheumatology, 2005, Volume: 32, Issue:3 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen; Dose-Response Relationship, Drug; Female; Joints; Lymph Nodes; Male; Mice; Mice, Inbred DBA; Quinazolines; Rats; Receptor, Adenosine A3; Spleen; Triazoles; Tumor Necrosis Factor-alpha	2005
Mesangial cell apoptosis induced by stimulation of the adenosine A3 receptor: signaling and apoptotic events. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2005, Volume: 53, Issue:1 Topics: Adenosine; Animals; Apoptosis; bcl-2-Associated X Protein; Butadienes; Caspase 3; Caspases; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Glomerular Mesangium; Mice; Mitogen-Activated Protein Kinase 1; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Receptor, Adenosine A3; Signal Transduction	2005
Induction of apoptosis by the adenosine derivative IB-MECA in parental or multidrug-resistant HL-60 leukemia cells: possible relationship to the effects on inhibitor of apoptosis protein levels. Chemotherapy, 2005, Volume: 51, Issue:5 Topics: Adenosine; Apoptosis; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; HL-60 Cells; Humans; Inhibitor of Apoptosis Proteins	2005
G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK. Journal of immunology (Baltimore, Md. : 1950), 2005, Sep-01, Volume: 175, Issue:5 Topics: Adenosine; Cells, Cultured; Complement C5a; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Interleukin-12; Interleukin-23; Interleukin-23 Subunit p19; Interleukins; JNK Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction	2005
The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis. Arthritis research & therapy, 2006, Volume: 8, Issue:1 Topics: Adenosine; Adenosine A3 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Female; Intracellular Signaling Peptides and Proteins; Lymph Nodes; Monocytes; NF-kappa B; Phosphatidylinositol 3-Kinases; Rats; Rats, Inbred Lew; Severity of Illness Index; Signal Transduction; Synovial Membrane	2006
Radioligand binding and functional responses of ligands for human recombinant adenosine A(3) receptors. Autonomic & autacoid pharmacology, 2006, Volume: 26, Issue:2 Topics: Adenosine; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Guanosine 5'-O-(3-Thiotriphosphate); Iodine Radioisotopes; Ligands; Magnesium Chloride; Quinazolines; Radioligand Assay; Receptor, Adenosine A3; Recombinant Proteins; Transfection; Triazoles	2006
Modulation of cardiac sarcoplasmic reticulum calcium release by aenosine: a protein kinase C- dependent pathway. Molecular and cellular biochemistry, 2006, Volume: 288, Issue:1-2 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Alkaloids; Animals; Benzophenanthridines; Calcium; Calcium Signaling; Estrenes; Male; Myocardium; Protein Kinase C; Pyrrolidinones; Rats; Rats, Wistar; Receptor, Adenosine A3; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Serine; Type C Phospholipases	2006
N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3 beta. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:1 Topics: Adenosine; Animals; Cardiotonic Agents; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Rats; Rats, Wistar	2006
Effects of adenosine A(3) receptor agonist on bone marrow granulocytic system in 5-fluorouracil-treated mice. European journal of pharmacology, 2006, May-24, Volume: 538, Issue:1-3 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Bone Marrow Cells; Cell Proliferation; Fluorouracil; Granulocytes; Immunosuppressive Agents; Injections, Intraperitoneal; Male; Mice; Time Factors	2006
ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis. Inflammatory bowel diseases, 2006, Volume: 12, Issue:8 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Colitis; Disease Models, Animal; Free Radicals; Gene Expression Regulation; Glutathione Peroxidase; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Trinitrobenzenesulfonic Acid	2006
Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level. Archives of biochemistry and biophysics, 2006, Nov-01, Volume: 455, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Glucose; Heart Ventricles; Insulin; Male; Phenethylamines; Protein Isoforms; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger; Triazines; Triazoles	2006
Methotrexate enhances the anti-inflammatory effect of CF101 via up-regulation of the A3 adenosine receptor expression. Arthritis research & therapy, 2006, Volume: 8, Issue:6 Topics: Adenosine; Animals; Anti-Inflammatory Agents; Arthritis; Blotting, Western; Drug Therapy, Combination; Female; Humans; Immunohistochemistry; Leukocytes, Mononuclear; Methotrexate; Middle Aged; Rats; Rats, Inbred Lew; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation	2006
Overexpression of A3 adenosine receptor in peripheral blood mononuclear cells in rheumatoid arthritis: involvement of nuclear factor-kappaB in mediating receptor level. The Journal of rheumatology, 2007, Volume: 34, Issue:1 Topics: Adenosine; Arthritis, Rheumatoid; Gene Expression Regulation; Humans; Interleukin-2; Leukocytes, Mononuclear; Middle Aged; Mitogens; NF-kappa B; Promoter Regions, Genetic; Receptor, Adenosine A3; Tumor Necrosis Factor-alpha	2007
Adenosine A(3) receptor agonist acts as a homeostatic regulator of bone marrow hematopoiesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2007, Volume: 61, Issue:6 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Bone Marrow; Bone Marrow Cells; Cell Lineage; Cell Proliferation; Erythroid Cells; Granulocytes; Hematopoiesis; Homeostasis; Male; Mice; Mice, Inbred Strains	2007
Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Biological Transport; Cyclic GMP-Dependent Protein Kinases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes	2007
Activation of adenosine A(3) receptors potentiates stimulatory effects of IL-3, SCF, and GM-CSF on mouse granulocyte-macrophage hematopoietic progenitor cells. Physiological research, 2009, Volume: 58, Issue:2 Topics: Adenosine; Animals; Cell Division; Cells, Cultured; Drug Synergism; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cells; Hepatocyte Growth Factor; In Vitro Techniques; Interleukin-3; Macrophages; Male; Mice; Mice, Inbred Strains; Receptor, Adenosine A3	2009
Homeostatic action of adenosine A3 and A1 receptor agonists on proliferation of hematopoietic precursor cells. Experimental biology and medicine (Maywood, N.J.), 2008, Volume: 233, Issue:7 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A3 Receptor Agonists; Animals; Bone Marrow Cells; Cell Proliferation; Dose-Response Relationship, Drug; Erythroid Cells; Granulocytes; Hematopoietic Stem Cells; Homeostasis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Receptor, Adenosine A1; Receptor, Adenosine A3	2008
Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC. European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3 Topics: Adenosine; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarboxamide); Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Fluorescent Dyes; Humans; Radioligand Assay; Receptor, Adenosine A2A	2008
Stimulation of ANP secretion by 2-Cl-IB-MECA through A(3) receptor and CaMKII. Peptides, 2008, Volume: 29, Issue:12 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Atrial Natriuretic Factor; Calcium; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP; Extracellular Fluid; Heart Atria; In Vitro Techniques; Inositol 1,4,5-Trisphosphate Receptors; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3; Ryanodine Receptor Calcium Release Channel; Type C Phospholipases	2008
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine. Journal of cardiovascular pharmacology, 2009, Volume: 53, Issue:5 Topics: Acetamides; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Aminopyridines; Animals; Apoptosis; Cardiotonic Agents; Cell Line; Cell Survival; Dihydropyridines; Imidazoles; Myocardial Ischemia; Phenethylamines; Purines; Rats; Triazines; Triazoles; Xanthines	2009
Induction of an antiinflammatory effect and prevention of cartilage damage in rat knee osteoarthritis by CF101 treatment. Arthritis and rheumatism, 2009, Volume: 60, Issue:10 Topics: Adenosine; Adenosine A3 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Apoptosis; Cartilage, Articular; Disease Models, Animal; Inflammation; Iodoacetates; Male; NF-kappa B; Osteoarthritis; Rats; Rats, Wistar; Signal Transduction	2009
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine. American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:6 Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relationship, Drug; Enteric Nervous System; Gastrointestinal Motility; Guinea Pigs; Histamine; Histamine Agonists; Histamine H2 Antagonists; In Vitro Techniques; Intestinal Secretions; Male; Mecamylamine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neural Inhibition; Neurogenic Bowel; Neurokinin-1 Receptor Antagonists; Nicotinic Antagonists; Piperidines; Propane; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Histamine H2; Receptors, Neurokinin-1; Reflex; Theophylline; Xanthines	2009
Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity. Neoplasia (New York, N.Y.), 2009, Volume: 11, Issue:11 Topics: Adenosine; Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Cyclic AMP-Dependent Protein Kinases; Humans; Immunohistochemistry; Male; Mice; Mice, SCID; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NADPH Oxidases; Neoplasm Invasiveness; Prostatic Neoplasms; Rats; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection; Xenograft Model Antitumor Assays	2009
Induction of apoptosis by A3 adenosine receptor agonist N-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide in human leukaemia cells: a possible involvement of intracellular mechanism. Acta physiologica (Oxford, England), 2010, Volume: 199, Issue:2 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine Triphosphatases; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Drug Resistance, Multiple; HL-60 Cells; Humans; K562 Cells; Signal Transduction; Verapamil	2010
Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochemical pharmacology, 2010, Jul-15, Volume: 80, Issue:2 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Death; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cytoprotection; Dendrimers; Gene Expression Regulation; Humans; Hydrogen Peroxide; Mice; Myocytes, Cardiac; Oxidants; Protein Binding; Receptors, Purinergic P1; Transfection	2010
Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists. Bioorganic & medicinal chemistry, 2010, May-01, Volume: 18, Issue:9 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Binding Sites; Cardiotonic Agents; Cell Line; Combinatorial Chemistry Techniques; Drug Design; Molecular Structure; Myocytes, Cardiac; Rats; Structure-Activity Relationship	2010
Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. The Journal of thoracic and cardiovascular surgery, 2010, Volume: 140, Issue:2 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Blood Pressure; Disease Models, Animal; In Vitro Techniques; Lung; Lung Compliance; Lung Diseases; Perfusion; Peroxidase; Piperidines; Protective Agents; Pulmonary Artery; Pulmonary Edema; Rabbits; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3; Reperfusion Injury; Tumor Necrosis Factor-alpha	2010
Activation of adenosine A(3) receptors supports hematopoiesis-stimulating effects of granulocyte colony-stimulating factor in sublethally irradiated mice. International journal of radiation biology, 2010, Volume: 86, Issue:8 Topics: Adenosine; Animals; Erythroid Precursor Cells; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Male; Mice; Mice, Inbred C57BL; Receptor, Adenosine A3; Whole-Body Irradiation	2010
CF101 for dry eye. Ophthalmology, 2011, Volume: 118, Issue:5 Topics: Adenosine; Adenosine A3 Receptor Agonists; Administration, Oral; Cornea; Dry Eye Syndromes; Humans; Tears; Treatment Outcome	2011
Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A₃ receptor agonist on hematopoiesis in sublethally γ-irradiated mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2011, Volume: 65, Issue:6 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Cell Count; Crosses, Genetic; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Erythroid Precursor Cells; Gamma Rays; Granulocyte Colony-Stimulating Factor; Granulocyte Precursor Cells; Hematinics; Hematopoiesis; Hematopoietic Stem Cells; Male; Meloxicam; Mice; Mice, Inbred CBA; Radiation Injuries, Experimental; Thiazines; Thiazoles; Whole-Body Irradiation	2011
Molecular mechanisms of A3 adenosine receptor-induced G1 cell cycle arrest and apoptosis in androgen-dependent and independent prostate cancer cell lines: involvement of intrinsic pathway. Journal of cancer research and clinical oncology, 2011, Volume: 137, Issue:10 Topics: Adenosine; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; G1 Phase; Humans; Male; Membrane Potential, Mitochondrial; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptor, Adenosine A3; Tumor Suppressor Protein p53	2011
Inhibition of experimental auto-immune uveitis by the A3 adenosine receptor agonist CF101. International journal of molecular medicine, 2011, Volume: 28, Issue:5 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Cell Proliferation; Cells, Cultured; Interleukin-10; Interleukin-2; Lymph Nodes; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Receptor, Adenosine A3; Spleen; STAT1 Transcription Factor; Tumor Necrosis Factor-alpha; Uveitis	2011
The adenosine A3 receptor agonist Cl-IB-MECA induces cell death through Ca²⁺/ROS-dependent down regulation of ERK and Akt in A172 human glioma cells. Neurochemical research, 2012, Volume: 37, Issue:12 Topics: Adenosine; Adenosine A3 Receptor Agonists; Base Sequence; Blotting, Western; Calcium; Cell Death; Cell Line, Tumor; Cell Proliferation; DNA Primers; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Humans; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction	2012
Enhancing pigmentation via activation of A3 adenosine receptors in B16 melanoma cells and in human skin explants. Experimental dermatology, 2013, Volume: 22, Issue:1 Topics: Adenosine; Androstadienes; Cell Line, Tumor; Cyclic AMP; Dihydroxyphenylalanine; Humans; In Vitro Techniques; Keratinocytes; MAP Kinase Signaling System; Melanoma, Experimental; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Phosphatidylinositol 3-Kinases; Phosphorylation; Pigmentation; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor, Adenosine A3; Skin; Skin Neoplasms; Wortmannin	2013
IB-MECA, an adenosine A(3) receptor agonist, does not influence survival of lethally γ-irradiated mice. Physiological research, 2012, Volume: 61, Issue:6 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Gamma Rays; Hematopoiesis; Male; Mice; Mice, Inbred Strains; Radiation Injuries, Experimental; Receptor, Adenosine A3	2012
Effects of synthetic A3 adenosine receptor agonists on cell proliferation and viability are receptor independent at micromolar concentrations. Journal of physiology and biochemistry, 2013, Volume: 69, Issue:3 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; CHO Cells; Cricetulus; Cytotoxins; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Proto-Oncogene Proteins c-akt; Receptor, Adenosine A3; Signal Transduction; Transfection	2013
Differential effect of adenosine receptors on growth of human colon cancer HCT 116 and HT-29 cell lines. Archives of biochemistry and biophysics, 2013, Volume: 533, Issue:1-2 Topics: Adenosine; Cell Proliferation; Cell Survival; Colonic Neoplasms; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Extracellular Space; Fluorouracil; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Protein Phosphatase 2; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Signal Transduction	2013
The effects of the adenosine A3 receptor agonist IB-MECA on sodium taurocholate-induced experimental acute pancreatitis. Archives of pharmacal research, 2013, Volume: 36, Issue:9 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Edema; Injections, Intraperitoneal; Lipase; Male; Necrosis; Pancreas; Pancreatic alpha-Amylases; Pancreatitis, Acute Necrotizing; Rats; Rats, Wistar; Receptor, Adenosine A3; Taurocholic Acid; Time Factors	2013
Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice. Radiation and environmental biophysics, 2014, Volume: 53, Issue:1 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Interactions; Gamma Rays; Male; Meloxicam; Mice; Radiation-Protective Agents; Receptor, Adenosine A3; Survival Rate; Thiazines; Thiazoles; Time Factors; Whole-Body Irradiation	2014
A3 Adenosine receptors mediate oligodendrocyte death and ischemic damage to optic nerve. Glia, 2014, Volume: 62, Issue:2 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Apoptosis; Caspase 3; Cells, Cultured; Oligodendroglia; Optic Nerve; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3	2014
Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:11 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Apoptosis; Biomarkers, Tumor; Blotting, Western; Caspases; Cell Proliferation; Cyclic AMP; Female; Flow Cytometry; Gene Expression Profiling; Humans; Membrane Potential, Mitochondrial; Mitochondria; Ovarian Neoplasms; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured	2014
A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways. Pain, 2014, Volume: 155, Issue:12 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Hyperalgesia; Male; NADP; Neuralgia; Neuroglia; NF-kappa B; Oxidation-Reduction; Paclitaxel; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Tumor Necrosis Factor-alpha	2014
Role of nitric oxide in the behavioral and neurochemical effects of IB-MECA in zebrafish. Psychopharmacology, 2015, Volume: 232, Issue:10 Topics: Adenosine; Animals; Anxiety; Dose-Response Relationship, Drug; Male; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Serotonin; Serotonin Plasma Membrane Transport Proteins; Signal Transduction; Zebrafish	2015
The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A 2A receptors. Basic research in cardiology, 2015, Volume: 110, Issue:2 Topics: Adenosine; Animals; Disease Models, Animal; Hemodynamics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Myocardial Reperfusion Injury; Receptor, Adenosine A2A; Receptor, Adenosine A3	2015
Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 04-15, Volume: 35, Issue:15 Topics: Adenosine; Adenosine A3 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hyperalgesia; K Cl- Cotransporters; Male; Mice; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sciatica; Signal Transduction; Spinal Nerve Roots; Symporters; Thiazoles; Thioglycolates	2015
Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration. Experimental eye research, 2015, Volume: 140 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Animals; Animals, Newborn; Apoptosis; Cell Survival; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Intravitreal Injections; Male; N-Methylaspartate; Neuroprotection; Optic Nerve Injuries; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Adenosine A3; Retina; Retinal Degeneration; Retinal Neurons	2015
Selective A3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity. Cancer chemotherapy and pharmacology, 2016, Volume: 77, Issue:2 Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Cardiotonic Agents; Cardiotoxicity; Doxorubicin; Hemodynamics; Immunohistochemistry; Male; Myocardium; Oxidative Stress; Rats; Rats, Wistar; Receptor, Adenosine A3	2016
Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor. Molecular pharmacology, 2016, Volume: 90, Issue:1 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Ligands; Molecular Docking Simulation; Receptor, Adenosine A3; Signal Transduction; Structure-Activity Relationship	2016
Role of A3 adenosine receptor in diabetic neuropathy. Journal of neuroscience research, 2016, Volume: 94, Issue:10 Topics: Action Potentials; Adenosine; Animals; Blood Glucose; Body Weight; Diabetic Neuropathies; Disease Models, Animal; Eating; Hyperalgesia; Male; Mice; Muscle, Skeletal; Neural Conduction; NF-kappa B; Pain Threshold; Receptor, Adenosine A3; Sciatic Nerve; Spinal Cord; Streptozocin	2016
Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic signalling, 2016, Volume: 12, Issue:4 Topics: Adenosine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Female; Humans; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Signal Transduction	2016
Profound hypothermia after adenosine kinase inhibition in A1AR-deficient mice suggests a receptor-independent effect of intracellular adenosine. Pflugers Archiv : European journal of physiology, 2017, Volume: 469, Issue:2 Topics: Adenosine; Adenosine Kinase; Animals; Hypothermia; Male; Mice; Mice, Inbred C57BL; Nucleosides; Phenethylamines; Receptor, Adenosine A1	2017
Polypharmacology of N Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals; Cell Line; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Male; Mice; Mice, Inbred C57BL; Polypharmacology; PPAR delta; PPAR gamma; Receptor, Adenosine A3	2017
Attenuation of Sunitinib-induced cardiotoxicity through the A3 adenosine receptor activation. European journal of pharmacology, 2017, Nov-05, Volume: 814 Topics: Adenosine; Adenosine A3 Receptor Agonists; Cell Survival; Heart; Heart Rate; Hemodynamics; HL-60 Cells; Humans; Indoles; MicroRNAs; Protein Kinase C-alpha; Pyrroles; Receptor, Adenosine A3; Signal Transduction; Sunitinib; Ventricular Function, Left	2017
Structural Characterization of Agonist Binding to an A Journal of medicinal chemistry, 2019, 10-10, Volume: 62, Issue:19 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Receptor, Adenosine A3; Signal Transduction; Thermodynamics	2019
Antinociceptive and neurochemical effects of a single dose of IB-MECA in chronic pain rat models. Purinergic signalling, 2020, Volume: 16, Issue:4 Topics: Adenosine; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Inflammation; Male; Neuralgia; Rats; Rats, Wistar	2020
CF101 alleviates OA progression and inhibits the inflammatory process via the AMP/ATP/AMPK/mTOR axis. Bone, 2022, Volume: 155 Topics: Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Cartilage, Articular; Chondrocytes; Collagen Type II; Disease Models, Animal; Inflammation; Osteoarthritis; Rats; TOR Serine-Threonine Kinases	2022
A3 adenosine receptor agonist IB-MECA reverses chronic cerebral ischemia-induced inhibitory avoidance memory deficit. European journal of pharmacology, 2022, Apr-15, Volume: 921 Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Brain Ischemia; Memory Disorders; Mice	2022