n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine

n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine has been researched along with 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine in 28 studies

Compound Research Comparison

Studies (n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)	Trials (n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)	Recent Studies (post-2010) (n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)	Studies (2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine)	Trials (2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine)	Recent Studies (post-2010) (2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine)
214	5	58	952	2	169

Protein Interaction Comparison

Protein	Taxonomy	n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine (IC50)	2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine (IC50)
Adenosine receptor A2a	Homo sapiens (human)		0.019

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (35.71)	18.2507
2000's	15 (53.57)	29.6817
2010's	3 (10.71)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Jacobson, KA; Kim, J; Schöneberg, T; van Rhee, AM; Wess, J	1
Jacobson, KA; Ji, XD; Kim, HO; Olah, ME; Siddiqi, SM; Stiles, GL	1
Glashofer, M; Jacobson, KA; Jiang, Q; Lee, BX; van Rhee, AM	1
Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C	1
de Zwart, M; IJzerman, AP; Kooijman, H; Kourounakis, A; Link, R; Spek, AL; von Frijtag Drabbe Künzel, JK	1
Figler, H; Jin, X; Linden, J; Robeva, AS; Thai, T	1
Baraldi, PG; Borea, PA; Cacciari, B; Gessi, S; Klotz, KN; Leung, E; Merighi, S; Romagnoli, R; Spalluto, G; Varani, K	1
Gao, ZG; Jacobson, KA	1
Donegan, RK; Lieberman, RL	1
Ahn, S; Cheong, JH; Jacobson, KA; Jeong, LS; Jin, SH; Kim, G; Kim, HJ; Kim, J; Lee, E; Lee, M; Noh, M; Yu, J	1
Haskó, G; Kvetan, V; Németh, ZH; Pastores, SM; Szabó, C; Vizi, ES	1
Hourani, SM; Prentice, DJ	2
Chessell, IP; Eastwood, C; Grundy, D; Humphrey, PP; Kirkup, AJ	1
Liu, XJ; Reid, A; Sawynok, J	1
Anderson, R; Ker, JA; Ramafi, G; Theron, AJ; Visser, SS	1
Fujita, M; Ito, H; Kohno, Y; Masamune, A; Satoh, A; Satoh, K; Shimosegawa, T; Toyota, T	1
Auchampach, JA; Bhattacharya, S; Black, RG; Bolli, R; Kodani, E; Takano, H; Tang, XL; Yang, Z	1
O'Sullivan, RG; Redmond, HP; Street, JT; Wakai, A; Wang, JH; Winter, DC	1
Breschi, MC; Calderone, V; Martinotti, E; Nieri, P	1
Díaz-Cruz, A; González-Benítez, E; Guinzberg, R; Piña, E	1
Bril, A; Broadley, KJ; Khandoudi, N; Maddock, HL	1
Ezeamuzie, CI; Philips, E	1
Chidiac, P; Cook, MA; Gan, XT; Haist, JV; Karmazyn, M; Rajapurohitam, V	1
Hofer, M; Pipalová, I; Pospísil, M; Vacek, A; Znojil, V	1
Grden, M; Kocbuch, K; Pawelczyk, T; Podgorska, M; Szutowicz, A	1
Church, JE; Coupar, IM; Pouton, CW; Rose'Meyer, RB; Urmaliya, VB; White, PJ	1
Briggs, J; Castrop, H; Eisner, C; Grill, A; Hoerl, M; Kim, S; Qin, Y; Schnermann, J; Thiel, M	1

Reviews

2 review(s) available for n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine

Article	Year
Adenosine receptors as therapeutic targets. Nature reviews. Drug discovery, 2006, Volume: 5, Issue:3 Topics: Animals; Disease; Drug Therapy; Humans; Ligands; Molecular Structure; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Signal Transduction; Structure-Activity Relationship	2006
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3 Topics: Adrenergic Agonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; Animals; Drug Discovery; Glaucoma; Humans; Ligands; Protein Kinase Inhibitors; rho-Associated Kinases; Sympathomimetics	2016

Other Studies

26 other study(ies) available for n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and 2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine

Article	Year
Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. The Journal of biological chemistry, 1995, Jun-09, Volume: 270, Issue:23 Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Histidine; Ligands; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Receptors, Purinergic P1; Structure-Activity Relationship	1995
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors. Journal of medicinal chemistry, 1994, Oct-14, Volume: 37, Issue:21 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Brain; Cell Membrane; CHO Cells; Cricetinae; Molecular Structure; Rats; Receptors, Purinergic P1; Recombinant Proteins; Structure-Activity Relationship	1994
Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors. Journal of medicinal chemistry, 1997, Aug-01, Volume: 40, Issue:16 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; COS Cells; Enzyme-Linked Immunosorbent Assay; GTP-Binding Proteins; Humans; Hydrogen-Ion Concentration; Iodobenzenes; Ligands; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A2A; Receptors, Biogenic Amine; Receptors, Purinergic P1; Structure-Activity Relationship; Xanthines	1997
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines	1998
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. Journal of medicinal chemistry, 1999, Apr-22, Volume: 42, Issue:8 Topics: Adenosine; Animals; Cell Line; Cerebral Cortex; CHO Cells; Corpus Striatum; Cricetinae; Crystallography, X-Ray; Cyclic AMP; Humans; In Vitro Techniques; Molecular Conformation; Purinergic P1 Receptor Agonists; Radioligand Assay; Rats; Receptors, Purinergic P1; Structure-Activity Relationship	1999
Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular pharmacology, 1999, Volume: 56, Issue:4 Topics: Animals; Anti-Asthmatic Agents; Blotting, Western; Calcium; Cell Degranulation; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Humans; Kidney; Mast Cells; Purinergic P1 Receptor Agonists; Radioligand Assay; Receptor, Adenosine A2B; Receptors, Purinergic P1; Theophylline; Type C Phospholipases; Xanthines	1999
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors. Molecular pharmacology, 2000, Volume: 57, Issue:5 Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Phenylurea Compounds; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Tritium	2000
Polypharmacology of N Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals; Cell Line; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin Resistance; Ligands; Male; Mice; Mice, Inbred C57BL; Polypharmacology; PPAR delta; PPAR gamma; Receptor, Adenosine A3	2017
Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. Journal of immunology (Baltimore, Md. : 1950), 1996, Nov-15, Volume: 157, Issue:10 Topics: Adenosine; Animals; Endotoxemia; Interleukin-10; Macrophages; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenethylamines; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Tumor Necrosis Factor-alpha	1996
Adenosine analogues relax guinea-pig taenia caeci via an adenosine A2B receptor and a xanthine-resistant site. European journal of pharmacology, 1997, Mar-26, Volume: 323, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cecum; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines	1997
Characterization of adenosine receptors evoking excitation of mesenteric afferents in the rat. British journal of pharmacology, 1998, Volume: 125, Issue:6 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analgesics; Animals; Bethanechol; Female; Jejunum; Male; Muscarinic Agonists; Neurons, Afferent; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1	1998
Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists. European journal of pharmacology, 1999, Dec-15, Volume: 386, Issue:2-3 Topics: Acute Disease; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Drug Interactions; Edema; Enzyme Inhibitors; Histamine H1 Antagonists; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3	1999
Apparent involvement of the A(2A) subtype adenosine receptor in the anti-inflammatory interactions of CGS 21680, cyclopentyladenosine, and IB-MECA with human neutrophils. Biochemical pharmacology, 2000, Oct-01, Volume: 60, Issue:7 Topics: Adenosine; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Cyclic AMP; Fura-2; Humans; In Vitro Techniques; Neutrophils; Pancreatic Elastase; Phenethylamines; Reactive Oxygen Species; Receptor, Adenosine A2A; Receptors, Purinergic P1	2000
Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats. Gastroenterology, 2000, Volume: 119, Issue:3 Topics: Acute Disease; Adenosine; Amylases; Animals; Ceruletide; Edema; Leukocytes; Male; Pancreas; Pancreatic Diseases; Pancreatitis; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, Purinergic P1; Taurocholic Acid	2000
Characterisation of adenosine receptors mediating relaxation in hamster isolated aorta. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 362, Issue:4-5 Topics: 2-Chloroadenosine; Adenosine; Animals; Aorta; Cricetinae; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mesocricetus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenethylamines; Receptors, Purinergic P1; Theophylline; Thioinosine; Vasodilation	2000
A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms. Circulation research, 2001, Mar-16, Volume: 88, Issue:5 Topics: Adenine; Adenosine; Animals; Binding, Competitive; Cell Line; Consciousness; Decanoic Acids; Humans; Hydroxy Acids; Iodine Radioisotopes; Ischemic Preconditioning, Myocardial; Membranes; Myocardial Infarction; Nitroarginine; Norbornanes; Phenethylamines; Rabbits; Radioligand Assay; Receptor, Adenosine A3; Receptors, Purinergic P1	2001
Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation. Shock (Augusta, Ga.), 2001, Volume: 15, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); CD18 Antigens; Cell Movement; Cells, Cultured; Chemotaxis, Leukocyte; Depression, Chemical; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Lymphokines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A2B; Receptors, Purinergic P1; Recombinant Proteins; Theobromine; Tumor Necrosis Factor-alpha; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. British journal of pharmacology, 2001, Volume: 134, Issue:4 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines	2001
Regulation of glycogen metabolism in hepatocytes through adenosine receptors. Role of Ca2+ and cAMP. European journal of pharmacology, 2002, Feb-22, Volume: 437, Issue:3 Topics: Adenosine; Animals; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Gluconeogenesis; Glycogen; Glycolysis; Hepatocytes; Male; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P1	2002
Effects of adenosine receptor agonists on guinea-pig isolated working hearts and the role of endothelium and NO. The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:6 Topics: Adenosine; Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; Guinea Pigs; Heart; Hemodynamics; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Prostaglandins; Purinergic P1 Receptor Agonists; Triazines; Triazoles	2002
Positive coupling of atypical adenosine A3 receptors on human eosinophils to adenylyl cyclase. Biochemical and biophysical research communications, 2003, Jan-17, Volume: 300, Issue:3 Topics: Adenosine; Adenylyl Cyclases; Adult; Cell Degranulation; Cyclic AMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Eosinophils; Histamine; Humans; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinazolines; Receptor, Adenosine A2A; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles	2003
Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:1 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A3 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Drug Interactions; Hypertrophy; Myocytes, Cardiac; Phenethylamines; Phenylephrine; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A3	2005
Effects of stable adenosine receptor agonists on bone marrow hematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil. Physiological research, 2004, Volume: 53, Issue:5 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Drug Interactions; Fluorouracil; Hematopoiesis; Hematopoietic Stem Cells; Mice; Phenethylamines; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1	2004
Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level. Archives of biochemistry and biophysics, 2006, Nov-01, Volume: 455, Issue:1 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclases; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Glucose; Heart Ventricles; Insulin; Male; Phenethylamines; Protein Isoforms; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger; Triazines; Triazoles	2006
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine. Journal of cardiovascular pharmacology, 2009, Volume: 53, Issue:5 Topics: Acetamides; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Aminopyridines; Animals; Apoptosis; Cardiotonic Agents; Cell Line; Cell Survival; Dihydropyridines; Imidazoles; Myocardial Ischemia; Phenethylamines; Purines; Rats; Triazines; Triazoles; Xanthines	2009
Profound hypothermia after adenosine kinase inhibition in A1AR-deficient mice suggests a receptor-independent effect of intracellular adenosine. Pflugers Archiv : European journal of physiology, 2017, Volume: 469, Issue:2 Topics: Adenosine; Adenosine Kinase; Animals; Hypothermia; Male; Mice; Mice, Inbred C57BL; Nucleosides; Phenethylamines; Receptor, Adenosine A1	2017