Compounds > n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine
Page last updated: 2024-09-03

n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and 1,3-dipropyl-8-cyclopentylxanthine

n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine has been researched along with 1,3-dipropyl-8-cyclopentylxanthine in 17 studies

Compound Research Comparison

Studies
(n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)		Trials
(n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)		Recent Studies (post-2010)
(n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine)		Studies
(1,3-dipropyl-8-cyclopentylxanthine)		Trials
(1,3-dipropyl-8-cyclopentylxanthine)		Recent Studies (post-2010) (1,3-dipropyl-8-cyclopentylxanthine)
2145581,3011165

Protein Interaction Comparison

ProteinTaxonomyn(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine (IC50)1,3-dipropyl-8-cyclopentylxanthine (IC50)
Adenosine receptor A1Rattus norvegicus (Norway rat)0.0051
Adenosine receptor A3Rattus norvegicus (Norway rat)0.0038
Adenosine receptor A2aHomo sapiens (human)0.2033
Adenosine receptor A2bHomo sapiens (human)0.0234
Adenosine receptor A1Homo sapiens (human)0.0083

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (29.41)18.2507
2000's8 (47.06)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Glashofer, M; Jacobson, KA; Jiang, Q; Lee, BX; van Rhee, AM1
Fredholm, BB; Hegler, J; Hessling, J; Klotz, KN; Kull, B; Lohse, MJ; Owman, C1
Baraldi, PG; Borea, PA; Cacciari, B; Gessi, S; Klotz, KN; Leung, E; Merighi, S; Romagnoli, R; Spalluto, G; Varani, K1
Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO1
Cohen, FE; Legname, G; May, BC; Prusiner, SB; Sherrill, J; Wallace, AC; Witkop, J; Zorn, JA1
Axe, FU; Bembenek, SD; Butler, CR; Coles, F; Dunford, PJ; Edwards, JP; Fourie, AM; Grice, CA; Karlsson, L; Lundeen, K; Riley, JP; Savall, BM; Tays, KL; Wei, J; Williams, KN; Xue, X1
Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG1
Federico, S; Jacobson, KA; Jayasekara, PS; Kozma, E; Moro, S; Paoletta, S; Spalluto, G; Squarcialupi, L1
Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S1
Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E1
Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E1
Daly, JW; Gallo-Rodriguez, C; Jacobson, KA; Nikodijević, O; Olah, ME; Shi, D; Stiles, GL1
Jacobson, KA; Jiang, JL; Liang, BT; Stambaugh, K1
Carr, CS; Hill, RJ; Kennedy, SP; Knight, DR; Masamune, H; Tracey, WR; Yellon, DM1
Breschi, MC; Calderone, V; Martinotti, E; Nieri, P1
Headrick, JP1
Church, JE; Coupar, IM; Pouton, CW; Rose'Meyer, RB; Urmaliya, VB; White, PJ1

Reviews

1 review(s) available for n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and 1,3-dipropyl-8-cyclopentylxanthine

ArticleYear
Fluorescent ligands for adenosine receptors.
    Bioorganic & medicinal chemistry letters, 2013, Jan-01, Volume: 23, Issue:1

    Topics: Boron Compounds; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1

2013

Other Studies

16 other study(ies) available for n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine and 1,3-dipropyl-8-cyclopentylxanthine

ArticleYear
Mutagenesis reveals structure-activity parallels between human A2A adenosine receptors and biogenic amine G protein-coupled receptors.
    Journal of medicinal chemistry, 1997, Aug-01, Volume: 40, Issue:16

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; COS Cells; Enzyme-Linked Immunosorbent Assay; GTP-Binding Proteins; Humans; Hydrogen-Ion Concentration; Iodobenzenes; Ligands; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Phenethylamines; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A2A; Receptors, Biogenic Amine; Receptors, Purinergic P1; Structure-Activity Relationship; Xanthines

1997
Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Base Composition; Binding, Competitive; CHO Cells; Cricetinae; Guanylate Cyclase; Humans; Phenethylamines; Phenylisopropyladenosine; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship; Transfection; Xanthines

1998
[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.
    Molecular pharmacology, 2000, Volume: 57, Issue:5

    Topics: Adenosine; Adenylyl Cyclase Inhibitors; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Phenylurea Compounds; Purinergic P1 Receptor Antagonists; Radioligand Assay; Rats; Receptor, Adenosine A3; Receptors, Purinergic P1; Triazoles; Tritium

2000
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
    Journal of medicinal chemistry, 2005, Nov-03, Volume: 48, Issue:22

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles

2005
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.
    Journal of medicinal chemistry, 2007, Jan-11, Volume: 50, Issue:1

    Topics: Aminopyridines; Animals; Cell Line, Tumor; Combinatorial Chemistry Techniques; Membranes, Artificial; Mice; Models, Molecular; Nitriles; Permeability; PrPSc Proteins; Solubility; Structure-Activity Relationship

2007
Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Catalysis; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Magnetic Resonance Spectroscopy; Mice; Structure-Activity Relationship

2008
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship

2008
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

2013
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine

2016
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
    Bioorganic & medicinal chemistry, 2017, 01-15, Volume: 25, Issue:2

    Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship

2017
A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.
    FEBS letters, 1993, Dec-20, Volume: 336, Issue:1

    Topics: Adenosine; Animals; Brain; Locomotion; Male; Mice; Molecular Structure; Phenethylamines; Radioligand Assay; Rats; Receptors, Purinergic P1; Xanthines

1993
A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia.
    The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 2

    Topics: Adenosine; Animals; Cardiotonic Agents; Cell Hypoxia; Cells, Cultured; Chick Embryo; Dihydropyridines; Heart; Heart Ventricles; Myocardial Ischemia; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines

1997
Evidence for a role for both the adenosine A1 and A3 receptors in protection of isolated human atrial muscle against simulated ischaemia.
    Cardiovascular research, 1997, Volume: 36, Issue:1

    Topics: Adenosine; Dinucleoside Phosphates; Heart Atria; Humans; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Models, Biological; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines

1997
Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO.
    British journal of pharmacology, 2001, Volume: 134, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Pressure; Diphenhydramine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Heart Rate; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Triazines; Triazoles; Vasodilator Agents; Xanthines

2001
Apparent activation of cardiovascular A1 adenosine receptors by A3 agonists.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:2

    Topics: Adenosine; Animals; Myocardium; Purinergic P1 Receptor Agonists; Receptor, Adenosine A3; Receptors, Purinergic P1; Xanthines

2002
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.
    Journal of cardiovascular pharmacology, 2009, Volume: 53, Issue:5

    Topics: Acetamides; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Aminopyridines; Animals; Apoptosis; Cardiotonic Agents; Cell Line; Cell Survival; Dihydropyridines; Imidazoles; Myocardial Ischemia; Phenethylamines; Purines; Rats; Triazines; Triazoles; Xanthines

2009