Compounds > n(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine
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n(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine and adenosine

n(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine has been researched along with adenosine in 6 studies

Compound Research Comparison

Studies
(n(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine)		Trials
(n(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine)		Recent Studies (post-2010)
(n(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine)		Studies
(adenosine)		Trials
(adenosine)		Recent Studies (post-2010) (adenosine)
60032,5361,0758,930

Protein Interaction Comparison

ProteinTaxonomyn(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine (IC50)adenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)0.3851
Sodium/nucleoside cotransporter 1Homo sapiens (human)5.5
Sodium/nucleoside cotransporter 2Homo sapiens (human)5.5
Adenosine receptor A3Homo sapiens (human)0.0011
Adenosine receptor A1Homo sapiens (human)0.0023
Equilibrative nucleoside transporter 1Homo sapiens (human)63
Solute carrier family 28 member 3Homo sapiens (human)3.3

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dunwiddie, TV; Fredholm, BB; Jonzon, B; Sandberg, G1
Paul, SM; Skolnick, P1
Williams, M1
Irmscher, K; Jones, R; Lock, KL; Marangos, PJ; Paul, SM; Skolnick, P1
Borbe, HO; Fehske, KJ; Müller, WE; Wollert, U; Zube, I1
Lock, KL; Marangos, P; Paugh, B; Paul, S; Skolnick, P; Windsor, R1

Reviews

2 review(s) available for n(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine and adenosine

ArticleYear
The mechanism(s) of action of the benzodiazepines.
    Medicinal research reviews, 1981,Spring, Volume: 1, Issue:1

    Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Carbolines; Cats; Cattle; Diazepam; gamma-Aminobutyric Acid; Humans; Molecular Weight; Muscle Relaxation; Neurotransmitter Agents; Niacinamide; Purines; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Seizures; Sleep Wake Disorders

1981
Anxioselective anxiolytics.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:5

    Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety; Azabicyclo Compounds; Benzodiazepines; Brain Chemistry; Drug Interactions; Etazolate; gamma-Aminobutyric Acid; Humans; Molecular Weight; Piperazines; Pyrazoles; Pyridazines; Quinolines; Receptors, Cell Surface; Receptors, GABA-A; Structure-Activity Relationship

1983

Other Studies

4 other study(ies) available for n(6)-(2-(4-chlorophenyl)bicyclo(2.2.2.)-octyl)(3)-adenosine and adenosine

ArticleYear
The adenosine receptor activity of EMD 28422, a purine derivative with reported actions on benzodiazepine receptors.
    British journal of pharmacology, 1985, Volume: 84, Issue:3

    Topics: Adenosine; Adipose Tissue; Animals; Body Temperature; Cats; Chromatography, High Pressure Liquid; Cyclic AMP; Electric Stimulation; Electrophysiology; Guinea Pigs; Hippocampus; In Vitro Techniques; Lipolysis; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Purinergic; T-Lymphocytes; Time Factors

1985
Increased benzodiazepine receptor number elicited in vitro by a novel purine, EMD 28422.
    European journal of pharmacology, 1980, Oct-17, Volume: 67, Issue:2-3

    Topics: Adenosine; Animals; Binding Sites; Brain; Diazepam; In Vitro Techniques; Male; Muscimol; Purines; Radioligand Assay; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Tritium

1980
Beta-carboline binding indicates the presence of benzodiazepine receptor subclasses in the bovine central nervous system.
    Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 319, Issue:2

    Topics: Adenosine; Animals; Binding Sites; Brain Chemistry; Carbolines; Cattle; gamma-Aminobutyric Acid; Indoles; Receptors, Drug; Receptors, GABA-A; Substrate Specificity

1982
Pharmacologic and behavioral effects of EMD 28422: a novel purine which enhances (3H) diazepam binding to brain benzodiazepine receptors.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:5

    Topics: Adenosine; Animals; Anticonvulsants; Benzodiazepines; Binding Sites; Brain; Conflict, Psychological; Diazepam; Male; Mice; Mice, Inbred C3H; Motor Activity; Rats; Receptors, Drug

1980