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n(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid and s-adenosylhomocysteine

n(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid has been researched along with s-adenosylhomocysteine in 5 studies

Compound Research Comparison

Studies
(n(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid)
Trials
(n(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid)
Recent Studies (post-2010)
(n(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid)
Studies
(s-adenosylhomocysteine)
Trials
(s-adenosylhomocysteine)
Recent Studies (post-2010) (s-adenosylhomocysteine)
7041,41220380

Protein Interaction Comparison

ProteinTaxonomyn(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid (IC50)s-adenosylhomocysteine (IC50)
Protein arginine N-methyltransferase 5Homo sapiens (human)0.4533
Histone-lysine N-methyltransferase SUV39H1Homo sapiens (human)1.2
Protein arginine N-methyltransferase 3Homo sapiens (human)0.9567
DNA (cytosine-5)-methyltransferase 1Homo sapiens (human)1.4212
WD repeat-containing protein 5Homo sapiens (human)0.724
Histone-lysine N-methyltransferase 2AHomo sapiens (human)1.512
Histone-lysine N-methyltransferase SETDB1Homo sapiens (human)2.2
Retinoblastoma-binding protein 5Homo sapiens (human)0.724
Histone-lysine N-methyltransferase EZH2Homo sapiens (human)1.9
N6-adenosine-methyltransferase catalytic subunitHomo sapiens (human)0.59
Histone-lysine N-methyltransferase KMT5CHomo sapiens (human)10
Histone-lysine N-methyltransferase, H3 lysine-79 specificHomo sapiens (human)0.39
Histone-lysine N-methyltransferase EZH1Homo sapiens (human)6.4
Histone-lysine N-methyltransferase EHMT2Homo sapiens (human)2.64
Protein arginine N-methyltransferase 1Homo sapiens (human)0.43
Methylosome protein 50Homo sapiens (human)0.58
Protein dpy-30 homologHomo sapiens (human)0.724
Histone-lysine N-methyltransferase EHMT1Homo sapiens (human)0.23
N-lysine methyltransferase SMYD2Homo sapiens (human)0.18
Protein arginine N-methyltransferase 7Homo sapiens (human)0.11
DNA (cytosine-5)-methyltransferase 3BHomo sapiens (human)0.3625
Set1/Ash2 histone methyltransferase complex subunit ASH2Homo sapiens (human)0.724
Non-structural protein 1 Dengue virus0.49

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Blackburn, GM; Couture, JF; Hauk, G; Thompson, MJ; Trievel, RC1
Harmer, JE; Hobley, G; Howe, J; McKelvie, JC; Oyston, PC; Roach, PL1
Bingham, P; Diehl, W; Gajiwala, K; Huang, B; Krivacic, C; Kung, PP; Maegley, KA; Tatlock, J; Yu, X; Zehnder, L1
Fischer, TR; Helm, M; Hoba, SN; Jung, N; Kersten, C; Koch, J; Lyko, F; Meidner, JL; Schirmeister, T; Schwickert, M; Stark, MM; Weber, M; Windbergs, M; Zimmermann, RA1
Hardy, LW; Santi, DV1

Other Studies

5 other study(ies) available for n(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid and s-adenosylhomocysteine

ArticleYear
Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases.
    The Journal of biological chemistry, 2006, Jul-14, Volume: 281, Issue:28

    Topics: Arabidopsis; Binding Sites; Carbon; Catalysis; Cloning, Molecular; Histone-Lysine N-Methyltransferase; Hydrogen Bonding; Kinetics; Lysine; Oxygen; Protein Structure, Tertiary

2006
Development of rationally designed DNA N6 adenine methyltransferase inhibitors.
    Bioorganic & medicinal chemistry letters, 2012, May-01, Volume: 22, Issue:9

    Topics: Binding Sites; Drug Design; Enzyme Inhibitors; Humans; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Structure-Activity Relationship; Substrate Specificity

2012
SAH derived potent and selective EZH2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7

    Topics: Dose-Response Relationship, Drug; Drug Design; Enhancer of Zeste Homolog 2 Protein; Humans; Models, Molecular; Molecular Structure; Polycomb Repressive Complex 2; S-Adenosylhomocysteine; Structure-Activity Relationship

2015
Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment.
    Journal of medicinal chemistry, 2022, 07-28, Volume: 65, Issue:14

    Topics: Archaeal Proteins; Caco-2 Cells; DNA; Humans; Methyltransferases; Neoplasms; S-Adenosylhomocysteine; S-Adenosylmethionine

2022
Catalytic mechanism and inhibition of tRNA (uracil-5-)methyltransferase: evidence for covalent catalysis.
    Biochemistry, 1987, Dec-29, Volume: 26, Issue:26

    Topics: Aminobutyrates; Escherichia coli; Fluorouracil; Kinetics; Methylation; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine; Tritium; tRNA Methyltransferases

1987