n(2)-n(2)-dimethylguanosine and 16-hydroxypalmitic-acid

Causes of CKD differ in prognosis and treatment. Metabolomic indicators of CKD cause may provide clues regarding the different physiologic processes underlying CKD development and progression.. Overall in MDRD, average participant age was 51 years and 61% were men. In the discovery study (Study B), 29% of participants had polycystic kidney disease, 28% had glomerular disease, and 43% had CKD of another cause; in the replication study (Study A), the percentages were 28%, 24%, and 48%, respectively. In the discovery analysis, adjusted for demographics, randomization group, body mass index, hypertensive medications, measured GFR, log-transformed proteinuria, and estimated protein intake, seven metabolites (16-hydroxypalmitate, kynurenate, homovanillate sulfate, N2,N2-dimethylguanosine, hippurate, homocitrulline, and 1,5-anhydroglucitol) were associated with CKD cause after correction for multiple comparisons (. Metabolomic profiling identified several metabolites strongly associated with cause of CKD.

Topics: Adult; Citrulline; Deoxyglucose; Female; Glomerulonephritis; Guanosine; Hippurates; Homovanillic Acid; Humans; Kynurenic Acid; Male; Metabolome; Middle Aged; Palmitic Acids; Polycystic Kidney Diseases; Randomized Controlled Trials as Topic; Renal Insufficiency, Chronic