n(1),n(14)-bis(ethyl)homospermine and spermine

n(1),n(14)-bis(ethyl)homospermine has been researched along with spermine in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (8.33)	18.7374
1990's	19 (79.17)	18.2507
2000's	3 (12.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Austin, JK; Bergeron, RJ; McManis, JS; Weimar, WR; Wu, Q	1
Bergeron, RJ; Feng, Y; McManis, JS; Weimar, WR; Wu, Q	1
Basu, HS; Coffino, P; Ghoda, L; Marton, LJ; Porter, CW	1
Basu, HS; Csokan, PP; Delcros, JG; Feuerstein, BG; Marton, LJ; Sturkenboom, MC; Szollosi, J	1
Bergeron, RJ; Bernacki, RJ; Porter, CW	1
Bergeron, RJ; Chang, BK; Liang, Y; Porter, CW	1
Bergeron, RJ; Chang, BK; Liang, Y; Libby, PR; Porter, CW; Vinson, JR	1
Basu, HS; Deen, DF; Feuerstein, BG; Marton, LJ; Pellarin, M	1
Basu, HS; Bergeron, RJ; Deen, DF; Feuerstein, BG; Marton, LJ; Pellarin, M	1
Baylin, SB; Bergeron, RJ; Casero, RA; Celano, P; Ervin, SJ	1
Beck, DE; Bergeron, RJ; Hawthorne, TR; Ingeno, MJ; Vinson, JR	1
Fernández, CO; Frydman, B; Samejima, K	1
Basu, HS; Bergeron, CJ; Deen, DF; Feuerstein, BG; Marton, LJ; Pellarin, M	1
Bergeron, RJ; Chen, CZ; Deen, DF; Hu, LJ; Marton, LJ	1
Bergeron, RJ; Chang, BK; Liang, Y; Miller, DW; Porter, CW; Wang, G	1
Basu, HS; Deen, DF; Marton, LJ; Roti-Roti, J; Wright, WD	1
Bergeron, RJ; Katovich, MJ; Sninsky, CA; Wiegand, J	1
Bergeron, RJ; Feng, Y; Gao, F; Raisler, B; Sninsky, CA; Weimar, WR; Wu, Q; Yao, GW; Yao, H	1
Bergeron, RJ; Luchetta, G; Sninsky, CA; Weimar, WR; Wiegand, J	1
Bergeron, RJ; McCosar, BH; Müller, R; Smith, RE; Weimar, WR; Yao, H; Zimmerman, CO	1
Basu, HS; Frydman, B; Marton, LJ; Reddy, VK; Sarkar, A; Valasinas, A	1
Bergeron, RJ; Fannin, TL; Wiegand, J	1
Alberti, D; Arzoomanian, R; Feierabend, C; King, D; Pomplun, M; Tutsch, K; Wilding, G	1

Trials

1 trial(s) available for n(1),n(14)-bis(ethyl)homospermine and spermine

Article	Year
Phase I trial of the polyamine analog N1,N14-diethylhomospermine (DEHSPM) in patients with advanced solid tumors. Investigational new drugs, 2004, Volume: 22, Issue:2 Topics: Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Neoplasms; Polyamines; Spermine	2004

Other Studies

23 other study(ies) available for n(1),n(14)-bis(ethyl)homospermine and spermine

Article	Year
Impact of polyamine analogues on the NMDA receptor. Journal of medicinal chemistry, 1995, Feb-03, Volume: 38, Issue:3 Topics: Animals; Binding Sites; Cerebral Cortex; Dizocilpine Maleate; Male; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1995
Polyamine analogue regulation of NMDA MK-801 binding: a structure-activity study. Journal of medicinal chemistry, 1996, Dec-20, Volume: 39, Issue:26 Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Structure-Activity Relationship	1996
Role of ornithine decarboxylase suppression and polyamine depletion in the antiproliferative activity of polyamine analogs. Molecular pharmacology, 1992, Volume: 42, Issue:2 Topics: Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Cell Division; CHO Cells; Cricetinae; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Spermidine; Spermine; Transfection; Trypanosoma	1992
Effect of polyamine depletion on chromatin structure in U-87 MG human brain tumour cells. The Biochemical journal, 1992, Mar-15, Volume: 282 ( Pt 3) Topics: Brain Neoplasms; Cell Nucleus; Chromatin; Culture Media, Serum-Free; Deoxyribonuclease I; Eflornithine; Humans; Intracellular Fluid; Kinetics; Micrococcal Nuclease; Polyamines; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured	1992
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts. Cancer research, 1992, May-01, Volume: 52, Issue:9 Topics: Acetyltransferases; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Humans; Melanoma; Mice; Mice, Nude; Spermine; Transplantation, Heterologous; Tumor Cells, Cultured	1992
Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models. Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:3 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Spermine; Tumor Cells, Cultured	1992
Regulatory and antiproliferative effects of N-alkylated polyamine analogues in human and hamster pancreatic adenocarcinoma cell lines. Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:3 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cricetinae; Humans; Mesocricetus; Pancreatic Neoplasms; Spermine; Tumor Cells, Cultured	1992
Effect on N1,N14-bis-(ethyl)-homospermine (BE-4-4-4) on the growth of U-251 MG and SF-188 human brain tumor cells. International journal of cancer, 1991, Jul-30, Volume: 48, Issue:6 Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line; Cell Survival; Humans; Kinetics; Polyamines; Putrescine; Spermidine; Spermine	1991
Effect of N1,N14-bis(ethyl)homospermine on the growth of U-87 MG and SF-126 human brain tumor cells. Cancer research, 1990, Jun-01, Volume: 50, Issue:11 Topics: Brain Neoplasms; Cell Division; Humans; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured	1990
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture. Cancer research, 1989, Feb-01, Volume: 49, Issue:3 Topics: Adenosylmethionine Decarboxylase; Carcinoma; Carcinoma, Small Cell; Cells, Cultured; Humans; Lung Neoplasms; Ornithine Decarboxylase Inhibitors; Spermine	1989
Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells. Cancer research, 1989, Jun-01, Volume: 49, Issue:11 Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cell Division; Cell Survival; DNA, Neoplasm; Leukemia L1210; Mice; Spermine; Structure-Activity Relationship; Tumor Cells, Cultured	1989
Interactions between polyamine analogs with antiproliferative effects and tRNA: a 15N NMR analysis. Cellular and molecular biology (Noisy-le-Grand, France), 1994, Volume: 40, Issue:7 Topics: Antineoplastic Agents; Binding Sites; Escherichia coli; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Molecular Structure; Polyamines; RNA, Bacterial; RNA, Transfer; Spermine; Thermodynamics	1994
Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines. Cancer chemotherapy and pharmacology, 1995, Volume: 36, Issue:5 Topics: Antineoplastic Agents; Brain Neoplasms; Flow Cytometry; Growth Inhibitors; Humans; Spermine; Tumor Cells, Cultured	1995
Radiopotentiation of human brain tumor cells by the spermine analog N1,N14-bis(ethyl)homospermine. International journal of radiation oncology, biology, physics, 1994, Jul-30, Volume: 29, Issue:5 Topics: Brain Neoplasms; Combined Modality Therapy; Humans; Polyamines; Radiation-Sensitizing Agents; Spermine; Tumor Cells, Cultured	1994
Effects of diethyl spermine analogues in human bladder cancer cell lines in culture. The Journal of urology, 1993, Volume: 150, Issue:4 Topics: Carcinoma, Transitional Cell; Drug Screening Assays, Antitumor; Eflornithine; Humans; In Vitro Techniques; Spermine; Tumor Cells, Cultured; Urinary Bladder Neoplasms	1993
Treatment with a polyamine analog alters DNA-matrix association in HeLa cell nuclei: a nucleoid halo assay. Biochemistry, 1993, Apr-20, Volume: 32, Issue:15 Topics: Cell Division; Cell Nucleus; DNA, Neoplasm; HeLa Cells; Histones; Humans; Kinetics; Nuclear Matrix; Polyamines; Spermine	1993
The impact of polyamine analogues on the blood pressure of normotensive and hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993), 1995, Volume: 17, Issue:8 Topics: Amines; Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Spermine	1995
Metabolically programmed polyamine analogue antidiarrheals. Journal of medicinal chemistry, 1996, Jun-21, Volume: 39, Issue:13 Topics: Animals; Antidiarrheals; Biological Transport; Castor Oil; Cell Division; Computer Simulation; Diarrhea; Drug Design; Female; Kidney; Leukemia L1210; Liver; Male; Mice; Models, Chemical; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Tumor Cells, Cultured	1996
Metabolism and pharmacokinetics of N1,N14-diethylhomospermine. Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:3 Topics: Animals; Antineoplastic Agents; Dogs; Female; Kidney; Liver; Male; Mice; Spermine; Tissue Distribution	1996
Effect of polyamine analogues on hypusine content in JURKAT T-cells. Journal of medicinal chemistry, 1998, Sep-24, Volume: 41, Issue:20 Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Division; Chromatography, High Pressure Liquid; Dansyl Compounds; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia L1210; Lysine; Ornithine Decarboxylase Inhibitors; Spermidine; Spermine; Tumor Cells, Cultured	1998
Lymphoma trials recruiting. AIDS patient care and STDs, 1998, Volume: 12, Issue:4 Topics: Antineoplastic Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Humans; Lymphoma, Non-Hodgkin; Patient Selection; Spermine; Topotecan	1998
Conformationally restricted analogues of 1N,14N-bisethylhomospermine (BE-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cells. Journal of medicinal chemistry, 2001, Feb-01, Volume: 44, Issue:3 Topics: Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Male; Prostatic Neoplasms; Spermine; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured	2001
Control of irritable bowel syndrome with polyamine analogs: a structure-activity study. Digestive diseases and sciences, 2001, Volume: 46, Issue:12 Topics: Animals; Colonic Diseases, Functional; Mice; Mice, Inbred Strains; Polyamines; Rats; Rats, Sprague-Dawley; Spermine; Structure-Activity Relationship	2001