Compounds > n(1),n(11)-diethylnorspermine

n(1),n(11)-diethylnorspermine and spermine

n(1),n(11)-diethylnorspermine has been researched along with spermine in 113 studies

Research

Studies (113)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.88)18.7374
1990's46 (40.71)18.2507
2000's44 (38.94)29.6817
2010's21 (18.58)24.3611
2020's1 (0.88)2.80

Authors

AuthorsStudies
Bergeron, RJ; Feng, Y; McManis, JS; Weimar, WR; Wu, Q1
Bergeron, RJ; Bernacki, RJ; Porter, CW1
Bergeron, RJ; Chang, BK; Liang, Y; Porter, CW1
Bergeron, RJ; Chang, BK; Liang, Y; Libby, PR; Porter, CW; Vinson, JR1
Bergeron, RJ; Pakala, R; Pegg, AE1
Beck, DE; Bergeron, RJ; Hawthorne, TR; Ingeno, MJ; Vinson, JR1
Bullard, GA; Kanter, PM; King, JM1
Bergeron, RJ; Ganis, B; Kramer, DL; Porter, CW; Rustum, Y; Wrzosek, C1
Casero, RA; Gabrielson, EW; Pegg, AE2
Bergeron, RJ; Fogel-Petrovic, M; Porter, CW; Shappell, NW1
Bergeron, RJ; Chang, BK; Liang, Y; Miller, DW; Porter, CW; Wang, G1
Bergeron, RJ; Bernacki, RJ; Miller, J; Porter, CW1
Casero, RA; Ha, HC; Shao, D; Xiao, L1
Bergeron, RJ; Katovich, MJ; Sninsky, CA; Wiegand, J1
Austin, JK; Hawthorne, TR1
Bergeron, RJ; Dimova, H; Luchetta, G; Perrin, J; Porter, C; Schreier, KM; Streiff, RR; Weimar, WR; Wiegand, J; Yao, GW1
Fogel-Petrovic, M; Miller, J; Porter, CW; Vujcic, S1
Casero, RA; Huang, H; Pegg, AE; Saab, NH; Wiest, L; Woster, PM; Wu, R1
Basu, HS; Jackson, V; Peng, HF; Smirnov, IV; Tiffany, K1
Basu, H; Church, D; Jeffers, L; Marton, L; Wilding, G1
Keithly, JS; Martinez, MP; Upton, SJ; Woods, KM; Yarlett, N; Zhu, G1
Berghorn, E; Creaven, PJ; Levine, E; Loewen, G; Meropol, NJ; Pendyala, L; Perez, R; Raghavan, D1
de Hoog, E; Dorhout, B; Kingma, AW; Muskiet, FA1
Felschow, DM; Frei, J; Mi, Z; Porter, CW; Stanek, J1
Bergeron, RJ; Bernacki, RJ; Cooley, JM; Diegelman, P; Fogel-Petrovic, M; Kramer, DL; McManis, JS; Porter, CW1
Bergeron, RJ; Bernacki, R; Kramer, DL; Mi, Z; Miller, JT; Porter, CW1
Alhonen, L; Halmekytö, M; Hines, R; Jänne, J; Karppinen, A; Korhonen, VP; Kramer, DL; Porter, CW; Uusi-Oukari, M; Vujcic, S1
Casero, RA; Ha, HC; Woster, PA; Yager, JD1
Dolan, ME; Fleig, MJ; Marton, LJ; Rinker-Schaeffer, CW; Shrivastav, M; Zagaja, GP1
Beyaert, R; Denecker, T; Penning, LC; Schipper, RG; Vandenabeele, P; Vercammen, D; Verhofstad, AA1
Barbieri, D; Ghiaroni, S; Marverti, G; Moruzzi, MS; Piccinini, G; Quaglino, D1
Bergeron, RJ; Black, JD; Kramer, DL; Mett, H; Porter, CW1
Bergeron, RJ; McCosar, BH; Müller, R; Smith, RE; Weimar, WR; Yao, H; Zimmerman, CO1
Bernacki, RJ; Glaves, D; Porter, CW; Raghavan, D; Sharma, A1
Atwood, A; Bergeron, RJ; Bernacki, RJ; Oberman, EJ; Porter, CW; Seweryniak, KE1
Casero, RA; Davidson, NE; McCloskey, DE; Woster, PM; Yang, J1
Alhonen, L; Halmekytö, M; Jänne, J; Korhonen, VP; Parkkinen, JJ; Pietilä, M; Porter, CW; Suppola, S1
Black, JD; Diegelman, P; Kramer, DL; Porter, CW; Vujcic, S; White, C1
Basu, HS; Chanbusarakum, L; Dreckschmidt, N; Tu, L1
Alderfer, J; Bergeron, RJ; Black, JD; Diegelman, P; Kramer, DL; Miller, JT; Porter, CW; Vujcic, S1
Alhonen, L; Halmekytö, M; Jänne, J; Kramer, DL; Pietilä, M; Porter, CW1
Barbieri, D; Franceschi, C; Ghiaroni, S; Giuseppina Monti, M; Marverti, G; Moruzzi, MS1
Rojiani, AM; Valenstein, EJ; Williams, LS1
Antony, T; Shirahata, A; Thomas, T; Thomas, TJ1
Casero, RA; Davidson, NE; McCloskey, DE; Woster, PM1
Amenta, P; Antony, T; Haddad, S; Shah, N; Shirahata, A; Thomas, T; Thomas, TJ1
Casero, RA; Davidson, NE; Hahm, HA; McCloskey, DE; Woster, PM1
Alm, K; Berntsson, PS; Kramer, DL; Oredsson, SM; Porter, CW1
Alhonen, L; Herzig, KH; Jänne, J; Keinanen, T; Parkkinen, JJ; Sinervirta, R1
McCloskey, DE; Pegg, AE2
Deli, G; Deloyer, P; Lange, WP; Schalken, JA; Schipper, RG; Verhofstad, AA1
Bender, J; Bergeron, RJ; Merriman, RL; Olson, SG; Streiff, RR; Weimar, WR; Wiegand, J1
Alhonen, L; Diegelman, P; Eloranta, T; Halmekytö, M; Jänne, J; Korhonen, VP; Niiranen, K; Parkkinen, JJ; Pietilä, M; Porter, CW1
Bender, JF; Streiff, RR1
Alhonen, L; Heikkinen, S; Jänne, J; Keinänen, T; Korhonen, VP; Parkkinen, JJ; Suppola, S; Uusi-Oukari, M1
Chen, Y; Diegelman, P; Kramer, DL; Porter, CW; Vujcic, S1
Bowling, K; Casero, RA; Chen, TL; Ettinger, DS; Hahm, HA; Hoker, B; Zabelina, Y1
Alm, K; Chen, Y; Diegelman, P; Kee, K; Kramer, DL; Porter, CW; Vujcic, S1
Chen, Y; Kramer, DL; Li, F; Porter, CW1
Armstrong, DK; Bender, JF; Carducci, MK; Casero, RA; Davidson, NE; Fetting, JH; Riley, CD; Wolff, AC1
Casero, RA; Davidson, NE; Gabrielson, E; Hacker, A; Pegg, AE; Tully, E1
Chen, Y; Clark, K; Diegelman, P; Hector, S; Kisiel, N; Kramer, DL; Pendyala, L; Porter, CW; Prey, J1
Carew, J; Choi, W; Dupart, J; Gerner, EW; Hamilton, SR; Huang, P; Proctor, L; Ramdas, L; Zhang, W1
Balabhadrapathruni, S; Gallo, MA; Santhakumaran, LM; Shirahata, A; Thomas, T; Thomas, TJ1
Holst, CM; Oredsson, SM1
Mesak, FM; Ng, CE; Proulx, D; Qutob, SS1
Fitzpatrick, PF; Royo, M1
Arulpragasam, A; Fogel-Petrovic, M; Knight, S; Minchin, RF1
Casero, RA; Davidson, NE; Hacker, A; Huang, Y; Pledgie, A; Woster, PM; Zhang, Z1
Emanuele, E; Martinelli, V; Politi, P1
Chiao, PJ; Choi, W; Feng, Y; Gerner, EW; Hamilton, SR; Proctor, L; Xia, Q; Zhang, W1
Chou, TC; Gallo, MA; Nair, SK; Shirahata, A; Thomas, T; Thomas, TJ; Verma, A1
Allen, WL; Boyer, J; Casero, RA; Coyle, V; Johnston, PG; Longley, DB; McCulla, A; McLean, EG; Wilson, PM1
Alm, K; Dahlberg, E; Holst, CM; Johansson, VM; Myhre, L; Oredsson, SM; Söderstjerna, E1
Casero, RA; Choi, W; Gerner, EW; Hamilton, SR; Hess, K; Jiang, R; Khan, A; Yung, WK; Zhang, W1
Broadhurst, GM; Butcher, NJ; Minchin, RF1
Beauchemin, R; Carpentier, R; N'soukpoé-Kossi, CN; Tajmir-Riahi, HA; Thomas, T; Thomas, TJ1
Carlemalm, E; Holst, CM; Johansson, F; Nevsten, P; Oredsson, SM1
Alm, K; Holst, CM; Johansson, VM; Oredsson, SM1
Choi, W; Gerner, EW; Hamilton, SR; Hu, L; Jiang, R; Zhang, W1
Clark, K; Diegelman, P; Fakih, M; Hector, S; Kisiel, ND; Kramer, DL; Pendyala, L; Porter, CW; Tummala, R; Vujcic, S1
Borzì, RM; Caldarera, CM; Cetrullo, S; Facchini, A; Flamigni, F; Guarnieri, C; Stanic, I; Stefanelli, C; Tantini, B1
Alm, K; Hegardt, C; Jönsson, G; Larsson, S; Myhre, L; Oredsson, SM; Staaf, J1
Alm, K; Johansson, VM; Oredsson, SM1
Hegardt, C; Holst, CM; Jönsson, G; Oredsson, SM; Staaf, J1
Alm, K; Berntsson, PS; Hegardt, C; Johansson, VM; Jönsson, G; Miniotis, MF; Oredsson, SM; Staaf, J1
Borzì, RM; Facchini, A; Flamigni, F; Stanic', I; Stefanelli, C1
Alm, K; Johansson, M; Myhre, L; Oredsson, SM1
Alhonen, L; Jänne, J; Karppinen, A; Keinänen, TA; Uimari, A; Uimari, P; Woster, P1
Billam, M; Casero, RA; Davidson, NE; Hacker, A; Pledgie-Tracy, A; Sobolewski, MD; Woster, PM; Zhang, Z1
Costi, MP; Farina, D; Frassineti, C; Guerrieri, D; Ligabue, A; Marverti, G; Monti, MG; Moruzzi, MS; Paglietti, G; Piras, S1
Clark, K; Diegelman, P; Fetterly, G; Hector, S; Kramer, DL; Pendyala, L; Porter, CW; Tummala, R; Zagst, P1
Dong, Y; Li, J; Oupický, D; Wu, C1
Alm, K; Holst, CM; Oredsson, SM; Söderstjerna, E1
Amendola, R; Barba, M; Bellavia, G; Casero, RA; Cervelli, M; Federico, R; Fratini, E; Grillo, R; Gucciardo, G; Mariottini, P; Polticelli, F; Signore, F; Woster, PM1
Borzì, RM; Cetrullo, S; Facchini, A; Filardo, G; Flamigni, F; Stanic, I1
Guerra, B; Issinger, OG; Kreutzer, JN; Lech, K; Olsen, BB1
Casero, RA; Fraser, AV; Goodwin, AC; Hacker-Prietz, A; Sugar, E; Woster, PM1
Alhonen, L; Merentie, M; Peräniemi, S; Pirnes-Karhu, S; Sironen, R; Uimari, A1
Jiang, R; Tian, Y; Wang, B; Wang, S; Zhang, J; Zhang, W1
Abou-Gharbia, M; Childers, WE; Gordon, J; Merali, S; Perez-Leal, O1
Berg, CL; Berlin, J; Blaszkowsky, LS; Carpenter, A; Chan, E; Clark, JW; Cotler, S; Goyal, L; Heuman, DM; Hezel, AF; Hilderbrand, SL; Ryan, DP; Senzer, NN; Stuart, KE; Supko, JG; Zhu, AX1
Bavaria, MN; Bhattacharya, S; Johnson, LR; Ray, RM; Viar, MJ1
Arisan, ED; Çoker-Gürkan, A; Obakan, P; Palavan-Unsal, N1
Chanphai, P; Tajmir-Riahi, HA1
Albert, ML; Barba-Spaeth, G; Cesaro, T; Delpeyroux, F; Denison, MR; Flamand, M; Frenkiel, MP; Hooikaas, PJ; Khou, C; Lafon, M; Moratorio, G; Mounce, BC; Pardigon, N; Poirier, EZ; Prot, M; Sakuntabhai, A; Simon-Loriere, E; Smith, EC; Tamietti, C; Vignuzzi, M; Vitry, S; Volle, R; Werneke, SW; Yakovleva, A1
Akyol, Z; Arisan, ED; Çoker-Gürkan, A; Obakan-Yerlikaya, P; Palavan-Ünsal, N1
Casero, RA; Li, J; Marton, LJ; Murray-Stewart, T; Oupický, D; Wang, Y; Xie, Y; Yu, F1
Arisan, ED; Gurkan, AC; Ilhan, H; Unsal, NP; Yerlikaya, PO1
Casero, RA; Dunworth, M; Giardiello, FM; Lui, Y; Murray-Stewart, T; Woster, PM1
Affronti, HC; Attwood, K; Azabdaftari, G; Bianchi-Smiraglia, A; Boerlin, CS; Casero, RA; Foster, BA; Gillard, BM; Jacobi, JJ; Karasik, E; Long, MD; Moser, M; Nikiforov, MA; Pellerite, AJ; Phillips, JG; Pili, R; Rosario, SR; Rowsam, AM; Smiraglia, DJ; Wilton, JH1

Reviews

2 review(s) available for n(1),n(11)-diethylnorspermine and spermine

ArticleYear
Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway.
    Biochemical Society transactions, 1998, Volume: 26, Issue:4

    Topics: Acetyltransferases; Apoptosis; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Induction; Humans; Melanoma; Retinoblastoma Protein; Spermine; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1998
Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment.
    Endocrine-related cancer, 1999, Volume: 6, Issue:1

    Topics: Acetyltransferases; Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Division; Clinical Trials, Phase I as Topic; Dose-Response Relationship, Drug; Estrogens; Female; Humans; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Polyamines; Spermine; Tumor Cells, Cultured

1999

Trials

5 trial(s) available for n(1),n(11)-diethylnorspermine and spermine

ArticleYear
Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.
    Investigational new drugs, 1997, Volume: 15, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Area Under Curve; Biological Availability; Central Nervous System Diseases; Colonic Neoplasms; Female; Half-Life; Humans; Lung Neoplasms; Male; Melanoma; Metabolic Clearance Rate; Middle Aged; Neoplasms; Spermine

1997
Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies.
    Investigational new drugs, 2001, Volume: 19, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Biological Availability; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Spermine

2001
Phase I study of N(1),N(11)-diethylnorspermine in patients with non-small cell lung cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fever; Humans; Infusions, Intravenous; Lung Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Nausea; Safety; Spermine; Vomiting

2002
A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Dec-01, Volume: 9, Issue:16 Pt 1

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Drug Administration Schedule; Female; Humans; Maximum Tolerated Dose; Middle Aged; Prognosis; Spermine; Survival Rate

2003
Phase 1 study of N(1),N(11)‑diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma.
    Cancer chemotherapy and pharmacology, 2013, Volume: 72, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Humans; Infusions, Intravenous; Karnofsky Performance Status; Liver Function Tests; Liver Neoplasms; Male; Maximum Tolerated Dose; Middle Aged; Severity of Illness Index; Spermine; Treatment Outcome

2013

Other Studies

106 other study(ies) available for n(1),n(11)-diethylnorspermine and spermine

ArticleYear
Polyamine analogue regulation of NMDA MK-801 binding: a structure-activity study.
    Journal of medicinal chemistry, 1996, Dec-20, Volume: 39, Issue:26

    Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Structure-Activity Relationship

1996
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.
    Cancer research, 1992, May-01, Volume: 52, Issue:9

    Topics: Acetyltransferases; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Humans; Melanoma; Mice; Mice, Nude; Spermine; Transplantation, Heterologous; Tumor Cells, Cultured

1992
Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models.
    Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Spermine; Tumor Cells, Cultured

1992
Regulatory and antiproliferative effects of N-alkylated polyamine analogues in human and hamster pancreatic adenocarcinoma cell lines.
    Cancer chemotherapy and pharmacology, 1992, Volume: 30, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cricetinae; Humans; Mesocricetus; Pancreatic Neoplasms; Spermine; Tumor Cells, Cultured

1992
Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermine (corrected) and related compounds.
    The Biochemical journal, 1990, Apr-15, Volume: 267, Issue:2

    Topics: Acetyltransferases; Animals; Cell Line; Cycloheximide; Dactinomycin; Enzyme Induction; Gene Expression; Kinetics; Liver; Polyamines; Protein Biosynthesis; Rats; RNA, Messenger; Spermine; Structure-Activity Relationship; Time Factors

1990
Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells.
    Cancer research, 1989, Jun-01, Volume: 49, Issue:11

    Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cell Division; Cell Survival; DNA, Neoplasm; Leukemia L1210; Mice; Spermine; Structure-Activity Relationship; Tumor Cells, Cultured

1989
Preclinical toxicologic evaluation of DENSPM (N1,N11-diethylnorspermine) in rats and dogs.
    Anti-cancer drugs, 1994, Volume: 5, Issue:4

    Topics: Animals; Antineoplastic Agents; Blood Pressure; Body Weight; Dogs; Drug Evaluation, Preclinical; Erythrocytes; Female; Hypotension; Male; Necrosis; Organ Specificity; Rats; Spermine

1994
Collateral sensitivity of human melanoma multidrug-resistant variants to the polyamine analogue, N1,N11-diethylnorspermine.
    Cancer research, 1994, Nov-15, Volume: 54, Issue:22

    Topics: Adenosylmethionine Decarboxylase; Amidines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Multiple; Eflornithine; Humans; Indans; Melanoma; Ornithine Decarboxylase; Rhodamine 123; Rhodamines; Spermine; Tumor Cells, Cultured

1994
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.
    Cancer research, 1994, Aug-01, Volume: 54, Issue:15

    Topics: Acetyltransferases; Adenocarcinoma; Animals; Antibodies; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Humans; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Spermine; Tumor Cells, Cultured

1994
Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells.
    The Journal of biological chemistry, 1993, Sep-05, Volume: 268, Issue:25

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Base Sequence; Blotting, Northern; Dactinomycin; Half-Life; Humans; Melanoma; Molecular Sequence Data; Ornithine Decarboxylase Inhibitors; Polyamines; RNA, Messenger; Spermine; Transcription, Genetic; Tumor Cells, Cultured

1993
Effects of diethyl spermine analogues in human bladder cancer cell lines in culture.
    The Journal of urology, 1993, Volume: 150, Issue:4

    Topics: Carcinoma, Transitional Cell; Drug Screening Assays, Antitumor; Eflornithine; Humans; In Vitro Techniques; Spermine; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1993
Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action.
    Cancer research, 1993, Feb-01, Volume: 53, Issue:3

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Ornithine Decarboxylase Inhibitors; Polyamines; Spermine; Transplantation, Heterologous

1993
Isolation of a polyamine transport deficient cell line from the human non-small cell lung carcinoma line NCI H157.
    Journal of cellular physiology, 1996, Volume: 166, Issue:1

    Topics: Acetyltransferases; Antineoplastic Agents; Biological Transport; Carcinoma, Non-Small-Cell Lung; Cell Division; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Eflornithine; Gene Expression; Humans; Lung Neoplasms; Mitoguazone; Polyamines; Spermine; Tumor Cells, Cultured

1996
The impact of polyamine analogues on the blood pressure of normotensive and hypertensive rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1995, Volume: 17, Issue:8

    Topics: Amines; Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Spermine

1995
Synergism of the polyamine analogue, N1,N11-bisethylnorspermine with cis-diaminedichloroplatinum (II) against murine neoplastic cell lines in vitro and in vivo.
    Cancer letters, 1996, Jan-19, Volume: 99, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cisplatin; Disease Susceptibility; Drug Screening Assays, Antitumor; Drug Synergism; Female; Leukemia L1210; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Spermine; Tumor Cells, Cultured

1996
Metabolism and pharmacokinetics of N1,N11-diethylnorspermine.
    Drug metabolism and disposition: the biological fate of chemicals, 1995, Volume: 23, Issue:10

    Topics: Animals; Dogs; Female; Male; Mice; Spermine

1995
Differential post-transcriptional control of ornithine decarboxylase and spermidine-spermine N1-acetyltransferase by polyamines.
    FEBS letters, 1996, Aug-05, Volume: 391, Issue:1-2

    Topics: Acetyltransferases; Blotting, Northern; Cell Line; Cycloheximide; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Melanoma; Ornithine Decarboxylase; Protein Biosynthesis; RNA, Messenger; Spermidine; Spermine; Transcription, Genetic; Tumor Cells, Cultured

1996
Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase.
    Bioorganic & medicinal chemistry, 1996, Volume: 4, Issue:6

    Topics: Acetyltransferases; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Polyamines; Recombinant Proteins; Spectrophotometry, Infrared; Spermine; Tumor Cells, Cultured

1996
Effects of spermine and its cytotoxic analogs on nucleosome formation on topologically stressed DNA in vitro.
    European journal of biochemistry, 1997, Jan-15, Volume: 243, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Cell-Free System; Chickens; DNA Topoisomerases, Type I; DNA, Superhelical; Histones; Nucleosomes; Peptides; Propylamines; Spermine

1997
Effects of the polyamine analogues BE-4-4-4-4, BE-3-7-3, and BE-3-3-3 on the proliferation of three prostate cancer cell lines.
    Cancer chemotherapy and pharmacology, 1997, Volume: 40, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Division; Growth Inhibitors; Male; Mice; Mice, Nude; Polyamines; Propylamines; Prostatic Neoplasms; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured

1997
Polyamine biosynthesis in Cryptosporidium parvum and its implications for chemotherapy.
    Molecular and biochemical parasitology, 1997, Volume: 88, Issue:1-2

    Topics: Acetyltransferases; AIDS-Related Opportunistic Infections; Animals; Carboxy-Lyases; Coccidiostats; Cryptosporidiosis; Cryptosporidium parvum; Eflornithine; Enzyme Inhibitors; Humans; Polyamines; Spermine

1997
Simultaneous determination of polyamines, N-acetylated polyamines and the polyamine analogues BE-3-3-3 and BE-4-4-4-4 by capillary gas chromatography with nitrogen-phosphorus detection.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Oct-24, Volume: 700, Issue:1-2

    Topics: Acetylation; Animals; Chromatography, Gas; Leukemia L1210; Polyamines; Propylamines; Sensitivity and Specificity; Spermine; Tumor Cells, Cultured

1997
Selective labelling of cell-surface polyamine-binding proteins on leukaemic and solid-tumour cell types using a new polyamine photoprobe.
    The Biochemical journal, 1997, Dec-15, Volume: 328 ( Pt 3)

    Topics: Animals; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Membrane; Cross-Linking Reagents; Humans; Intracellular Signaling Peptides and Proteins; Iodine Radioisotopes; Kinetics; Leukemia L1210; Lung Neoplasms; Membrane Proteins; Mice; Mitoguazone; Photoaffinity Labels; Polyamines; Spermidine; Spermine; Tumor Cells, Cultured

1997
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells.
    Cancer research, 1997, Dec-15, Volume: 57, Issue:24

    Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Cell Cycle; Cell Division; Enzyme Induction; Humans; Melanoma; Spermine; Structure-Activity Relationship; Tumor Cells, Cultured

1997
Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitors.
    The Prostate, 1998, Jan-01, Volume: 34, Issue:1

    Topics: Adenosylmethionine Decarboxylase; Amidines; Biological Transport; Growth Inhibitors; Humans; Indans; Male; Molecular Structure; Polyamines; Prostatic Neoplasms; Spermidine; Spermine; Tumor Cells, Cultured

1998
Correlation of polyamine and growth responses to N1,N11-diethylnorspermine in primary fetal fibroblasts derived from transgenic mice overexpressing spermidine/spermine N1-acetyltransferase.
    The Journal of biological chemistry, 1998, Jan-23, Volume: 273, Issue:4

    Topics: Acetyltransferases; Animals; Blotting, Western; Fibroblasts; Mice; Mice, Transgenic; RNA, Messenger; Spermine; Time Factors

1998
Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species.
    Biochemical and biophysical research communications, 1998, Mar-06, Volume: 244, Issue:1

    Topics: Antineoplastic Agents; Antioxidants; Bacteriophage phi X 174; Biogenic Polyamines; Copper; DNA Damage; Hydrogen Peroxide; Polyamines; Putrescine; Reactive Oxygen Species; Spermidine; Spermine; Structure-Activity Relationship

1998
Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo.
    Cancer chemotherapy and pharmacology, 1998, Volume: 41, Issue:6

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Kidney; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms; Rats; Spermine; Tumor Cells, Cultured

1998
Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines.
    Cytokine, 1998, Volume: 10, Issue:6

    Topics: Amidines; Animals; Antineoplastic Agents; Apoptosis; Eflornithine; Enzyme Inhibitors; Fas Ligand Protein; Granulocyte-Macrophage Colony-Stimulating Factor; HeLa Cells; Humans; Indans; Membrane Glycoproteins; Mice; Mitoguazone; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; T-Lymphocytes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1998
N1,N12-bis(ethyl)spermine effect on growth of cis-diamminedichloroplatinum(II)-sensitive and -resistant human ovarian-carcinoma cell lines.
    International journal of cancer, 1998, Sep-25, Volume: 78, Issue:1

    Topics: Acetyltransferases; Antineoplastic Agents; Cisplatin; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Induction; Female; Humans; Mitochondria; Ovarian Neoplasms; Spermine; Tumor Cells, Cultured

1998
Lysosomal sequestration of polyamine analogues in Chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664.
    Cancer research, 1998, Sep-01, Volume: 58, Issue:17

    Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Drug Resistance, Neoplasm; Indans; Lysosomes; RNA, Messenger; Spermine; Vacuoles

1998
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
    Journal of medicinal chemistry, 1998, Sep-24, Volume: 41, Issue:20

    Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Division; Chromatography, High Pressure Liquid; Dansyl Compounds; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia L1210; Lysine; Ornithine Decarboxylase Inhibitors; Spermidine; Spermine; Tumor Cells, Cultured

1998
Antitumor efficacy of N1,N11-diethylnorspermine on a human bladder tumor xenograft in nude athymic mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1997, Volume: 3, Issue:8

    Topics: Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Cell Division; Cell Survival; Humans; Mice; Mice, Nude; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured; Urinary Bladder Neoplasms

1997
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:8

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Melanoma; Mice; Mice, Nude; Ovarian Neoplasms; Spermine; Transplantation, Heterologous; Tumor Cells, Cultured

1995
Polyamine analogue induction of programmed cell death in human lung tumor cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1996, Volume: 2, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; DNA Fragmentation; Humans; Lung Neoplasms; Polyamines; Spermine; Tumor Cells, Cultured

1996
Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue.
    The Biochemical journal, 1999, Mar-01, Volume: 338 ( Pt 2)

    Topics: Acetyltransferases; Animals; Biogenic Polyamines; Gene Expression Regulation, Enzymologic; Liver; Metallothionein; Mice; Mice, Transgenic; Microscopy, Electron; RNA Processing, Post-Transcriptional; Spermine; Transgenes; Zinc Sulfate

1999
Polyamine analog bis(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) enhances simian virus 40 late gene expression.
    Cancer chemotherapy and pharmacology, 1999, Volume: 43, Issue:4

    Topics: Animals; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation, Viral; Genes, Reporter; Humans; Kinetics; Luciferases; Nucleosomes; Propylamines; Recombinant Proteins; Simian virus 40; Spermine; Transfection; Tumor Cells, Cultured

1999
Polyamine analogue induction of the p53-p21WAF1/CIP1-Rb pathway and G1 arrest in human melanoma cells.
    Cancer research, 1999, Mar-15, Volume: 59, Issue:6

    Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; G1 Phase; Humans; Kinetics; Melanoma; Phosphorylation; Retinoblastoma Protein; RNA, Messenger; Spermine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N1-acetyltransferase show enhanced sensitivity to the polyamine analog, N1, N11-diethylnorspermine.
    Molecular pharmacology, 1999, Volume: 55, Issue:4

    Topics: Acetyltransferases; Animals; Enzyme Activation; Mice; Mice, Transgenic; Polyamines; Spermidine; Spermine

1999
2-deoxy-d-ribose-induced apoptosis in HL-60 cells is associated with the cell cycle progression by spermidine.
    Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Cell Cycle; Deoxyribose; Eflornithine; Flow Cytometry; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Onium Compounds; Organophosphorus Compounds; Ornithine Decarboxylase Inhibitors; Oxidative Stress; Putrescine; Spermidine; Spermine

1999
The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:7

    Topics: Acetyltransferases; Antineoplastic Agents; Biomarkers; Carcinoma, Small Cell; Clinical Trials, Phase II as Topic; Enzyme Induction; Female; Humans; In Vitro Techniques; Lung Neoplasms; Male; Outcome Assessment, Health Care; Phenotype; Polyamines; Spermine

1999
Chemotherapy for pancreatic cancer: a neuroimaging clinicopathologic correlation.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 1999, Volume: 9, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Brain; Brain Neoplasms; Demyelinating Diseases; Diagnosis, Differential; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Pancreatic Neoplasms; Spermine; Tomography, X-Ray Computed

1999
Selectivity of polyamines on the stability of RNA-DNA hybrids containing phosphodiester and phosphorothioate oligodeoxyribonucleotides.
    Biochemistry, 1999, Aug-17, Volume: 38, Issue:33

    Topics: Binding, Competitive; DNA; Magnesium; Nucleic Acid Heteroduplexes; Oligodeoxyribonucleotides; Organophosphates; Polyamines; Propylamines; RNA; Sodium; Spermidine; Spermine; Thionucleotides

1999
Effects of the polyamine analogues N1-ethyl-N11-((cyclopropyl)methyl)-4,8-diazaundecane and N1-ethylN-11-((cycloheptyl)methyl)-4,8-diazaundecane in human prostate cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Cell Division; DNA Fragmentation; Humans; Kinetics; Male; Polyamines; Propylamines; Prostatic Neoplasms; Putrescine; Spermidine; Spermine; Tumor Cells, Cultured

2000
Antitumor effects of bis(ethyl)polyamine analogs on mammary tumor development in FVB/NTgN (MMTVneu) transgenic mice.
    Cancer letters, 1999, Nov-01, Volume: 146, Issue:1

    Topics: Acetyltransferases; Animals; Antineoplastic Agents; Biogenic Polyamines; Female; Genes, erbB-2; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Polyamines; Spermine

1999
Treatment of cells with the polyamine analog N, N11-diethylnorspermine retards S phase progression within one cell cycle.
    European journal of biochemistry, 2000, Volume: 267, Issue:13

    Topics: Amidines; Animals; Antineoplastic Agents; Biogenic Polyamines; Bromodeoxyuridine; CHO Cells; Cricetinae; DNA; G1 Phase; Indans; S Phase; Spermine

2000
Activation of polyamine catabolism in transgenic rats induces acute pancreatitis.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Jul-18, Volume: 97, Issue:15

    Topics: Acetyltransferases; Acute Disease; Animals; Animals, Genetically Modified; Disease Models, Animal; Enzyme Induction; Female; Male; Mice; Oxidoreductases Acting on CH-NH Group Donors; Pancreas; Pancreatitis; Polyamine Oxidase; Polyamines; Putrescine; Rats; Rats, Wistar; Spermine; Zinc

2000
Altered spermidine/spermine N1-acetyltransferase activity as a mechanism of cellular resistance to bis(ethyl)polyamine analogues.
    The Journal of biological chemistry, 2000, Sep-15, Volume: 275, Issue:37

    Topics: Acetyltransferases; Amino Acid Sequence; Animals; Antineoplastic Agents; Biogenic Polyamines; CHO Cells; Cricetinae; DNA, Complementary; Drug Resistance, Neoplasm; Molecular Sequence Data; Propylamines; Spermine

2000
Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells.
    The Prostate, 2000, Sep-01, Volume: 44, Issue:4

    Topics: Acetyltransferases; Animals; Antineoplastic Agents; Biogenic Polyamines; Carcinoma; Cell Division; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Prostatic Neoplasms; Spermine; Transplantation, Heterologous; Tumor Cells, Cultured

2000
Metabolism and pharmacokinetics of N1,N11-diethylnorspermine in a Cebus apella primate model.
    Cancer research, 2000, Aug-15, Volume: 60, Issue:16

    Topics: Animals; Antineoplastic Agents; Cebus; Dogs; Humans; Infusions, Intravenous; Male; Species Specificity; Spermine; Tissue Distribution

2000
Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs.
    Molecular pharmacology, 2001, Volume: 59, Issue:2

    Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biogenic Polyamines; Cell Division; Cells, Cultured; Embryo, Mammalian; Etoposide; Gene Silencing; Mice; Molecular Sequence Data; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Spermine; Spermine Synthase; Stem Cells

2001
Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N(1)-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice.
    The Biochemical journal, 2001, Sep-01, Volume: 358, Issue:Pt 2

    Topics: Acetyltransferases; Animals; Chimera; Liver; Longevity; Mice; Mice, Transgenic; Ornithine Decarboxylase; Polyamines; Proteins; Spermidine; Spermine; Zinc

2001
Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells.
    Cancer research, 2001, Sep-01, Volume: 61, Issue:17

    Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Biogenic Polyamines; Caspase 3; Caspases; Cytochrome c Group; Enzyme Activation; Enzyme Induction; Humans; Hydrogen Peroxide; Intracellular Membranes; Melanoma; Membrane Potentials; Mitochondria; Signal Transduction; Spermine; Tumor Cells, Cultured

2001
Properties of the spermidine/spermine N1-acetyltransferase mutant L156F that decreases cellular sensitivity to the polyamine analogue N1, N11-bis(ethyl)norspermine.
    The Journal of biological chemistry, 2003, Apr-18, Volume: 278, Issue:16

    Topics: Acetyltransferases; Animals; Antihypertensive Agents; Blotting, Western; Cell Division; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Kinetics; Mutation; Plasmids; Polyamines; Propylamines; Spermine; Time Factors; Ubiquitin

2003
The role of mitogen-activated protein kinase activation in determining cellular outcomes in polyamine analogue-treated human melanoma cells.
    Cancer research, 2003, Jul-01, Volume: 63, Issue:13

    Topics: Antineoplastic Agents; Apoptosis; Enzyme Activation; Flavonoids; Humans; Kinetics; Melanoma; Mitogen-Activated Protein Kinases; Oligonucleotide Array Sequence Analysis; Phosphorylation; Polyamines; Spermine; Tumor Cells, Cultured

2003
Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells.
    Oncogene, 2003, Aug-07, Volume: 22, Issue:32

    Topics: Antineoplastic Agents; Apoptosis; Humans; Inhibitor of Apoptosis Proteins; Melanoma; Polyamines; Proteins; Spermine

2003
Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine.
    Cancer chemotherapy and pharmacology, 2004, Volume: 54, Issue:2

    Topics: Acetyltransferases; Antineoplastic Agents; Breast Neoplasms; Enzyme Induction; Female; Humans; Immunohistochemistry; Spermine; Tumor Cells, Cultured

2004
Polyamine catabolism in platinum drug action: Interactions between oxaliplatin and the polyamine analogue N1,N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:7

    Topics: Acetyltransferases; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Interactions; Female; Gene Expression; Humans; Organoplatinum Compounds; Ovarian Neoplasms; Oxaliplatin; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; RNA, Messenger; Spermine

2004
Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.
    The Journal of biological chemistry, 2005, Feb-04, Volume: 280, Issue:5

    Topics: Acetyltransferases; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antioxidants; Apoptosis; Caspase 9; Caspases; Cytochromes c; Drug Synergism; Fluorouracil; Gene Deletion; HCT116 Cells; Humans; Hydrogen Peroxide; Mitochondria; Polyamines; Spermine; Transcription, Genetic; Tumor Suppressor Protein p53

2005
Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells.
    Oncology reports, 2005, Volume: 13, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Caspase 8; Caspases; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Estradiol; Estrogen Antagonists; Fulvestrant; Humans; Polyamines; Proto-Oncogene Proteins c-bcl-2; Spermine

2005
Comparison of three cytotoxicity tests in the evaluation of the cytotoxicity of a spermine analogue on human breast cancer cell lines.
    Toxicology in vitro : an international journal published in association with BIBRA, 2005, Volume: 19, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Formazans; Humans; Spermine; Tetrazolium Salts

2005
Effects of N1, N13-diethylnorspermine (DENSPM) and X-radiation treatment on human colorectal tumor clones with varying X-radiation and drug responses.
    Radiation research, 2005, Volume: 163, Issue:4

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cloning, Molecular; Colorectal Neoplasms; Combined Modality Therapy; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Humans; Radiation Tolerance; Spermine; Treatment Outcome; X-Ray Therapy

2005
Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate.
    Biochemistry, 2005, May-10, Volume: 44, Issue:18

    Topics: Animals; Catalysis; Flavoproteins; Hydrogen-Ion Concentration; Kinetics; Mice; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Phenylalanine; Polyamine Oxidase; Spermine; Substrate Specificity; Tyrosine

2005
Concentration-dependent effects of N1, N11-diethylnorspermine on melanoma cell proliferation.
    International journal of cancer, 2006, Jan-15, Volume: 118, Issue:2

    Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Melanoma; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Skin Neoplasms; Spermine; Tumor Cells, Cultured

2006
Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.
    The Journal of biological chemistry, 2005, Dec-02, Volume: 280, Issue:48

    Topics: Acetyltransferases; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Hydrogen Peroxide; Oxidoreductases Acting on CH-NH Group Donors; Peroxisomes; Polyamine Oxidase; Polyamines; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Interference; RNA, Messenger; RNA, Small Interfering; Spermine; Tetrazolium Salts; Thiazoles; Time Factors; Transfection

2005
Potential usefulness of N1,N11-diethylnorspermine to prevent suicidal behaviour.
    Medical hypotheses, 2006, Volume: 67, Issue:1

    Topics: Acetyltransferases; Antidepressive Agents; Antihypertensive Agents; Genetic Predisposition to Disease; Humans; Oligonucleotide Array Sequence Analysis; Pharmaceutical Preparations; Spermine; Suicide Prevention

2006
Inactivation of IkappaB contributes to transcriptional activation of spermidine/spermine N(1)-acetyltransferase.
    Molecular carcinogenesis, 2006, Volume: 45, Issue:9

    Topics: Acetyltransferases; Antineoplastic Agents; Colonic Neoplasms; Cycloheximide; Dactinomycin; Fluorouracil; Humans; I-kappa B Proteins; Membrane Potentials; Mitochondria; Mitochondrial Membranes; NF-kappa B; NF-kappa B p50 Subunit; Promoter Regions, Genetic; Protein Biosynthesis; Protein Synthesis Inhibitors; Response Elements; Spermine; Transcription Factor RelA; Transcriptional Activation; Tumor Cells, Cultured

2006
Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine.
    Cancer letters, 2007, Jun-08, Volume: 250, Issue:2

    Topics: 2-Methoxyestradiol; Apoptosis; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cyclin D1; Drug Synergism; Estradiol; Humans; Microscopy, Confocal; Phosphorylation; Proto-Oncogene Proteins c-akt; Spermine

2007
The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:1

    Topics: Acetyltransferases; Antineoplastic Agents; Cell Death; Cell Survival; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Formazans; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; RNA, Messenger; RNA, Small Interfering; Spermine; Tetrazolium Salts; Tumor Suppressor Protein p53

2007
Inhibition of cell proliferation and induction of apoptosis by N(1),N(11)-diethylnorspermine-induced polyamine pool reduction.
    Biochemical Society transactions, 2007, Volume: 35, Issue:Pt 2

    Topics: Animals; Apoptosis; Cell Cycle; Cell Death; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Humans; Polyamines; Putrescine; Spermine

2007
Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma.
    International journal of oncology, 2007, Volume: 31, Issue:2

    Topics: Animals; Cell Death; Cytochromes c; Glioblastoma; Humans; Hydrogen Peroxide; Male; Membrane Potentials; Mice; Mice, Nude; Mitochondria; Polyamines; RNA, Small Interfering; Spermine

2007
Polyamine-dependent regulation of spermidine-spermine N1-acetyltransferase mRNA translation.
    The Journal of biological chemistry, 2007, Sep-28, Volume: 282, Issue:39

    Topics: Acetyltransferases; Antibiotics, Antineoplastic; Base Sequence; Biogenic Polyamines; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Stability; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Protein Biosynthesis; RNA, Messenger; Sequence Deletion; Spermine

2007
Polyamine analogues bind human serum albumin.
    Biomacromolecules, 2007, Volume: 8, Issue:10

    Topics: Circular Dichroism; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Models, Molecular; Polyamines; Protein Binding; Protein Denaturation; Protein Structure, Secondary; Serum Albumin; Software; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spermine

2007
Subcellular distribution of spermidine/spermine N1-acetyltransferase.
    Cell biology international, 2008, Volume: 32, Issue:1

    Topics: Acetyltransferases; Apoptosis; Cell Fractionation; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Humans; Immunohistochemistry; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitochondria; Spermine

2008
Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death.
    Cell biology international, 2008, Volume: 32, Issue:1

    Topics: Acetyltransferases; Apoptosis; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cytochromes c; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Microtubule-Associated Proteins; Mitochondrial Proteins; Neoplasm Proteins; Polyamines; Proto-Oncogene Proteins c-bcl-2; Spermine; Survivin; Transfection

2008
Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells.
    Cancer biology & therapy, 2007, Volume: 6, Issue:10

    Topics: Antineoplastic Agents; Cell Adhesion Molecules; Cell Line, Tumor; Down-Regulation; Glioblastoma; Humans; Hydrogen Peroxide; Neoplasms; Polyamines; Protein Kinases; Spermine; TOR Serine-Threonine Kinases

2007
Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine.
    Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:3

    Topics: Acetyltransferases; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Fluorouracil; Gene Expression; Humans; Organoplatinum Compounds; Oxaliplatin; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Rectal Neoplasms; Spermine

2008
Effect of the polyamine analogue N1,N11-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes.
    Journal of cellular physiology, 2008, Volume: 216, Issue:1

    Topics: Acetyltransferases; Amidines; Antineoplastic Agents; Apoptosis; Caspases; Cell Line; Cell Survival; Chondrocytes; Cycloheximide; DNA Fragmentation; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Humans; Indans; Ornithine Decarboxylase; Polyamines; Protein Synthesis Inhibitors; Spermine; Tumor Necrosis Factor-alpha

2008
Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines.
    Anti-cancer drugs, 2008, Volume: 19, Issue:4

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Cell Survival; Cyclins; Female; Flow Cytometry; Humans; Microscopy, Fluorescence; Polyamines; Spermine

2008
Polyamine depletion with two different polyamine analogues causes DNA damage in human breast cancer cell lines.
    DNA and cell biology, 2008, Volume: 27, Issue:9

    Topics: Amidines; Cell Cycle; Cell Line; Cell Line, Tumor; Comet Assay; DNA Damage; Histones; Humans; Indans; Polyamines; Spermine

2008
Molecular mechanisms underlying N1, N11-diethylnorspermine-induced apoptosis in a human breast cancer cell line.
    Anti-cancer drugs, 2008, Volume: 19, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Cytochromes c; Humans; Membrane Potential, Mitochondrial; Mitochondria; Spermine

2008
Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.
    Cell biology international, 2008, Volume: 32, Issue:12

    Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Cell Line, Tumor; DNA; DNA Ligase ATP; DNA Ligases; DNA Replication; Drug Resistance, Neoplasm; Flap Endonucleases; Humans; Polyamines; S Phase; Spermine

2008
The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines.
    Journal of cellular physiology, 2009, Volume: 219, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Line; Chondrocytes; Cycloheximide; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Polyamines; Protein Synthesis Inhibitors; Signal Transduction; Spermine

2009
Normal-like breast cells, but not breast cancer cells, recovered from treatment with N',N''-diethylnorspermine.
    Anti-cancer drugs, 2009, Volume: 20, Issue:4

    Topics: Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line; Cell Line, Tumor; Cyclin A; Cyclin A2; Cyclin B; Cyclin B1; Cyclin E; DNA; Epithelial Cells; Female; Flow Cytometry; Humans; Oncogene Proteins; Spermine

2009
Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts.
    The Biochemical journal, 2009, Jul-29, Volume: 422, Issue:1

    Topics: Acetyltransferases; Animals; Fetus; Fibroblasts; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins; Half-Life; Intracellular Space; Mice; Ornithine Decarboxylase; Polyamines; Protein Transport; Recombinant Fusion Proteins; RNA, Messenger; Spermine; Transcription, Genetic; Transfection

2009
The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:6

    Topics: Acetyltransferases; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Paclitaxel; Polyamine Oxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Spermine; Xenograft Model Antitumor Assays

2010
Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines.
    Gynecologic oncology, 2010, Volume: 117, Issue:2

    Topics: Acetyltransferases; Antineoplastic Combined Chemotherapy Protocols; Cell Growth Processes; Cell Line, Tumor; Cisplatin; Cystadenocarcinoma, Serous; Drug Resistance, Neoplasm; Drug Synergism; Female; Folic Acid Antagonists; Humans; Ovarian Neoplasms; Quinoxalines; Reactive Oxygen Species; Spermine

2010
Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:2

    Topics: Acetyltransferases; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Induction; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Organoplatinum Compounds; Ovarian Neoplasms; Oxaliplatin; Polyamines; Putrescine; Spermidine; Spermine

2011
Bisethylnorspermine lipopolyamine as potential delivery vector for combination drug/gene anticancer therapies.
    Pharmaceutical research, 2010, Volume: 27, Issue:9

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; DNA; Drug Carriers; Epithelial Cells; Gene Transfer Techniques; Genetic Therapy; Humans; Lipids; Luciferases; Molecular Structure; Neoplasms; Spermine; Transfection

2010
Apoptosis induced by the potential chemotherapeutic drug N1, N11-Diethylnorspermine in a neuroblastoma cell line.
    Anti-cancer drugs, 2010, Volume: 21, Issue:10

    Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Child; Culture Media; Dose-Response Relationship, Drug; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neuroblastoma; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Spermine; Survivin

2010
Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.
    BMC cancer, 2010, Oct-14, Volume: 10

    Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Breast Neoplasms; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Mice; Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Recombinant Proteins; Spermine

2010
Sulforaphane protects human chondrocytes against cell death induced by various stimuli.
    Journal of cellular physiology, 2011, Volume: 226, Issue:7

    Topics: Apoptosis; Caspases; Cell Proliferation; Cells, Cultured; Chemokine CXCL1; Chondrocytes; Cycloheximide; Cytoprotection; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Isothiocyanates; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Spermine; Sulfoxides; Thiocyanates; Time Factors; Tumor Necrosis Factor-alpha

2011
Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity.
    Molecular and cellular biochemistry, 2011, Volume: 356, Issue:1-2

    Topics: Acetyltransferases; Antineoplastic Agents; Casein Kinase II; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Synergism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Polyamines; RNA, Messenger; Spermine

2011
Knockdown of ornithine decarboxylase antizyme 1 causes loss of uptake regulation leading to increased N1, N11-bis(ethyl)norspermine (BENSpm) accumulation and toxicity in NCI H157 lung cancer cells.
    Amino acids, 2012, Volume: 42, Issue:2-3

    Topics: Base Sequence; Blotting, Northern; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Lung Neoplasms; Molecular Sequence Data; Polyamines; Proteins; RNA, Small Interfering; Spermine

2012
Overexpression of spermidine/spermine N1-acetyltransferase or treatment with N1-N11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in mouse.
    Amino acids, 2012, Volume: 42, Issue:2-3

    Topics: Acetyltransferases; Animals; Immunohistochemistry; Mice; Mice, Transgenic; Pancreatitis; Severity of Illness Index; Spermine; Zinc

2012
Overexpression of SSAT by DENSPM treatment induces cell detachment and apoptosis in glioblastoma.
    Oncology reports, 2012, Volume: 27, Issue:4

    Topics: Acetyltransferases; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Integrin alpha5beta1; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Messenger; Spermine; Time Factors; TOR Serine-Threonine Kinases; Transfection; Up-Regulation

2012
A novel assay platform for the detection of translation modulators of spermidine/spermine acetyltransferase.
    Current pharmaceutical design, 2014, Volume: 20, Issue:2

    Topics: Acetyltransferases; Biosensing Techniques; HEK293 Cells; High-Throughput Screening Assays; Humans; Luciferases; Open Reading Frames; Polyamines; RNA, Messenger; Spermine

2014
Spermidine, a sensor for antizyme 1 expression regulates intracellular polyamine homeostasis.
    Amino acids, 2014, Volume: 46, Issue:8

    Topics: Adenosylmethionine Decarboxylase; Animals; Cell Line; Eflornithine; Homeostasis; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Proteins; Putrescine; Rats; Spermidine; Spermine

2014
Lack of functional p53 renders DENSpm-induced autophagy and apoptosis in time dependent manner in colon cancer cells.
    Amino acids, 2015, Volume: 47, Issue:1

    Topics: Apoptosis; Autophagy; Cell Survival; Colonic Neoplasms; HCT116 Cells; Humans; Male; Spermine; Tumor Suppressor Protein p53

2015
Thermodynamic analysis of biogenic and synthetic polyamines conjugation with PAMAM-G4 nanoparticles.
    Journal of photochemistry and photobiology. B, Biology, 2016, Volume: 155

    Topics: Biogenic Polyamines; Dendrimers; Hydrogen Bonding; Nanoparticles; Nylons; Polyamines; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spermidine; Spermine; Static Electricity; Thermodynamics

2016
Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses.
    Journal of virology, 2016, Nov-01, Volume: 90, Issue:21

    Topics: Acetyltransferases; Animals; Antiviral Agents; Cell Line; Chikungunya Fever; Chikungunya virus; Disease Outbreaks; Ebolavirus; Eflornithine; Hemorrhagic Fever, Ebola; Humans; Mice; Mice, Inbred C57BL; Polyamines; RNA Viruses; Spermine; Virus Replication; Zika Virus; Zika Virus Infection

2016
DENSpm overcame Bcl-2 mediated resistance against Paclitaxel treatment in MCF-7 breast cancer cells via activating polyamine catabolic machinery.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 84

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Female; Humans; MCF-7 Cells; Paclitaxel; Polyamines; Proto-Oncogene Proteins c-bcl-2; Spermine

2016
Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2017, 01-28, Volume: 246

    Topics: Animals; Antineoplastic Agents; Colon; Colorectal Neoplasms; Drug Carriers; Female; HCT116 Cells; Humans; Mice, Nude; MicroRNAs; Nanoparticles; Polyamines; Rectum; Spermine

2017
Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner.
    Cellular oncology (Dordrecht), 2018, Volume: 41, Issue:3

    Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; HCT116 Cells; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Polyamines; RNA, Small Interfering; Spermine; Tumor Suppressor Protein p53

2018
Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.
    PloS one, 2018, Volume: 13, Issue:8

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Antineoplastic Agents; Biosynthetic Pathways; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; Drug Synergism; Eflornithine; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Spermine

2018
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy.
    Nature communications, 2020, 01-07, Volume: 11, Issue:1

    Topics: Acetyltransferases; Adenine; Animals; Apoptosis; Cell Line, Tumor; Drug Therapy, Combination; Humans; Male; Methionine; Mice; Mice, Inbred BALB C; Polyamines; Prostatic Neoplasms; Purine-Nucleoside Phosphorylase; Pyrrolidines; Salvage Therapy; Spermine

2020