n(1), n(12)-diethylspermine has been researched along with spermine in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.16) | 18.7374 |
| 1990's | 28 (73.68) | 18.2507 |
| 2000's | 5 (13.16) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bergeron, RJ; Gao, F; Luchetta, GR; McManis, JS; Ortiz-Ocasio, J; Porter, C; Schreier, KM; Vinson, JR; Weimar, WR; Wu, Q | 1 |
| Austin, JK; Bergeron, RJ; McManis, JS; Weimar, WR; Wu, Q | 1 |
| Bergeron, RJ; Feng, Y; McManis, JS; Weimar, WR; Wu, Q | 1 |
| Adams, DM; Barth, RF; Cai, J; Hariharan, JR; Radcliffe, K; Soloway, AH; Wyzlic, IM | 1 |
| Bergeron, RJ; Casero, RA; Celano, P; Mank, AR; Smith, J; Xiao, L | 1 |
| Fukuchi, J; Igarashi, K; Kashiwagi, K; Kusama-Eguchi, K; Shirahata, A; Terao, K | 1 |
| Bergeron, RJ; Bernacki, RJ; Porter, CW | 1 |
| Beerman, TA; Bergeron, RJ; Kelly, EJ; Porter, CW; Vertino, PM | 1 |
| Bergeron, RJ; Ganis, B; Libby, PR; Porter, CW | 1 |
| Casero, RA; Celano, P; Ervin, SJ; Pegg, AE; Wiest, L | 1 |
| Fukuchi, J; Igarashi, K; Isobe, Y; Kashiwagi, K; Otomo, S; Shirahata, A | 1 |
| Bergeron, RJ; Ganis, B; Madhabala, R; Pegg, AE; Porter, CW | 1 |
| Baylin, SB; Bergeron, RJ; Casero, RA; Celano, P; Ervin, SJ | 1 |
| Beck, DE; Bergeron, RJ; Hawthorne, TR; Ingeno, MJ; Vinson, JR | 1 |
| Bergeron, RJ; Pakala, R; Pegg, AE; Wechter, R | 1 |
| Bergeron, RJ; Chang, BK; Libby, PR; Porter, CW | 1 |
| Bergeron, RJ; Casero, RA; McManis, J; Porter, CW | 1 |
| Coleman, CS; Huang, H; Pegg, AE | 1 |
| Balaña Fouce, R; Parry, L; Pegg, AE | 1 |
| Lopez-Ballester, J; Parry, L; Pegg, AE; Wiest, L | 1 |
| Casero, RA; Gabrielson, EW; Pegg, AE | 1 |
| Albanese, L; Bergeron, RJ; Pegg, AE | 1 |
| Bergeron, RJ; Casero, RA; Davidson, NE; Mank, AR; Prestigiacomo, LJ | 1 |
| Bergeron, RJ; Khomutov, A; Khomutov, R; Kramer, DL; Miller, JT; Porter, CW | 1 |
| Pegg, AE; Poulin, R | 1 |
| Clément, S; Delcros, JG; Feuerstein, BG | 1 |
| Casero, RA; Xiao, L | 1 |
| Hu, RH; Pegg, AE; Shantz, LM | 1 |
| Coleman, CS; Pegg, AE | 1 |
| Berchtold, CM; Casero, RA; Kensler, TW; Tamez, P | 1 |
| Barr, LF; Campbell, SE; Casero, RA; Tamez, P | 1 |
| Berkey, KA; Casero, RA; Kern, S; Mank-Seymour, AR; Murray, TR; Xiao, L | 1 |
| Antony, T; Shirahata, A; Thomas, T; Thomas, TJ | 1 |
| Harris, SP; Marton, LJ; Moss, RL; Patel, JR | 1 |
| Astancolle, S; Bettuzzi, S; Marverti, G; Monti, MG; Moruzzi, MS; Pinna, C | 1 |
| Hegardt, C; Johannsson, OT; Oredsson, SM | 1 |
| Bettuzzi, S; Caporali, A; D'Arca, D; Giuseppina Monti, M; Ligabue, A; Marverti, G; McCloskey, DE; Moruzzi, MS; Pegg, AE | 1 |
| Niiranen, K; Wallace, HM | 1 |
1 review(s) available for n(1), n(12)-diethylspermine and spermine
| Article | Year |
|---|---|
Polyamine analogues - an update.
Topics: Acetyltransferases; Animals; Antimetabolites; Antineoplastic Agents; Humans; Ornithine Decarboxylase Inhibitors; Polyamines; Spermine | 2007 |
37 other study(ies) available for n(1), n(12)-diethylspermine and spermine
| Article | Year |
|---|---|
The role of charge in polyamine analogue recognition.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Electrochemistry; Kinetics; Mice; Ornithine Decarboxylase Inhibitors; Polyamines; Tumor Cells, Cultured | 1995 |
Impact of polyamine analogues on the NMDA receptor.
Topics: Animals; Binding Sites; Cerebral Cortex; Dizocilpine Maleate; Male; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Polyamine analogue regulation of NMDA MK-801 binding: a structure-activity study.
Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Magnetic Resonance Spectroscopy; Male; Protons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spermine; Structure-Activity Relationship | 1996 |
Boron-containing polyamines as DNA targeting agents for neutron capture therapy of brain tumors: synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Boron Compounds; Boron Neutron Capture Therapy; Brain Neoplasms; DNA; Female; Glioma; Pregnancy; Rats; Rats, Inbred F344; Spermidine; Spermine; Structure-Activity Relationship; Tumor Cells, Cultured | 1997 |
Steady-state messenger RNA and activity correlates with sensitivity to N1,N12-bis(ethyl)spermine in human cell lines representing the major forms of lung cancer.
Topics: Acetyltransferases; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Survival; Enzyme Induction; Humans; Lung Neoplasms; Phenotype; Polyamines; RNA, Messenger; Sensitivity and Specificity; Spermine; Tumor Cells, Cultured | 1992 |
Mechanism of the inhibition of cell growth by N1,N12-bis(ethyl)spermine.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Division; Cell Nucleus; Kinetics; Leucine; Liver; Magnesium; Mammary Neoplasms, Experimental; Mice; Microscopy, Electron; Mitochondria; Nucleic Acid Conformation; Polyamines; Polydeoxyribonucleotides; Rats; RNA, Transfer, Ile; Spermine; Thymidine; Tumor Cells, Cultured | 1992 |
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.
Topics: Acetyltransferases; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Humans; Melanoma; Mice; Mice, Nude; Spermine; Transplantation, Heterologous; Tumor Cells, Cultured | 1992 |
Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function.
Topics: Animals; Antineoplastic Agents; Blotting, Southern; Cell Division; Cell Line, Transformed; DNA; DNA Damage; DNA, Mitochondrial; DNA, Neoplasm; DNA, Superhelical; Electrophoresis, Agar Gel; Fibroblasts; Leukemia L1210; Mice; Polyamines; Spermidine; Spermine; Structure-Activity Relationship; Time Factors | 1991 |
Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines.
Topics: Acetyltransferases; Antineoplastic Agents; Biogenic Polyamines; Cell Division; Enzyme Induction; Humans; Melanoma; Spermine; Tumor Cells, Cultured | 1991 |
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.
Topics: Acetyltransferases; Amino Acid Sequence; Amino Acids; Blotting, Western; Carcinoma; Enzyme Induction; Humans; Kinetics; Liver; Lung Neoplasms; Molecular Sequence Data; Peptide Mapping; Precipitin Tests; Spermine; Tumor Cells, Cultured | 1990 |
Spermine-like functions of N1, N12-bis(ethyl)spermine: stimulation of protein synthesis and cell growth and inhibition of gastric ulceration.
Topics: Animals; Anti-Ulcer Agents; Cattle; Cell Division; Cells, Cultured; Gastric Juice; Globins; Lymphocytes; Mice; Ornithine Decarboxylase; Protein Biosynthesis; Rabbits; Rats; Reticulocytes; Spermine; Stomach Ulcer; Stress, Psychological | 1990 |
Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Kinetics; Leukemia L1210; Mice; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Biosynthesis; RNA, Messenger; Spermine; Transcription, Genetic; Tumor Cells, Cultured | 1990 |
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.
Topics: Adenosylmethionine Decarboxylase; Carcinoma; Carcinoma, Small Cell; Cells, Cultured; Humans; Lung Neoplasms; Ornithine Decarboxylase Inhibitors; Spermine | 1989 |
Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells.
Topics: Animals; Antineoplastic Agents; Binding, Competitive; Cell Division; Cell Survival; DNA, Neoplasm; Leukemia L1210; Mice; Spermine; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells.
Topics: Acetylation; Acetyltransferases; Colonic Neoplasms; Humans; Polyamines; Radiometry; Spermine; Tumor Cells, Cultured | 1989 |
Modulation of polyamine biosynthesis and transport by oncogene transfection.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cell Transformation, Neoplastic; Eflornithine; Genes, ras; Oncogenes; Polyamines; Rats; Spermine; Transfection | 1988 |
Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Cell Division; Leukemia L1210; Mice; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Structure-Activity Relationship | 1987 |
Role of the carboxyl terminal MATEE sequence of spermidine/spermine N1-acetyltransferase in the activity and stabilization by the polyamine analog N1,N12-bis(ethyl)spermine.
Topics: Acetyltransferases; Amino Acid Sequence; Animals; Antineoplastic Agents; Binding Sites; Cloning, Molecular; Escherichia coli; Humans; Kinetics; Mammals; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Recombinant Proteins; Spermine | 1995 |
Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine.
Topics: Acetyltransferases; Animals; Base Sequence; CHO Cells; Cricetinae; Enzyme Induction; Gene Expression Regulation, Enzymologic; Half-Life; Molecular Sequence Data; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; RNA Processing, Post-Transcriptional; RNA, Messenger; Spermine; Transfection | 1995 |
Effect of expression of human spermidine/spermine N1-acetyltransferase in Escherichia coli.
Topics: Acetyltransferases; Amino Acid Sequence; Cell Division; Escherichia coli; Gene Expression; Genetic Vectors; Humans; In Vitro Techniques; Kinetics; Molecular Sequence Data; Plasmids; Polyamines; Recombinant Proteins; Spermine; Substrate Specificity | 1995 |
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.
Topics: Acetyltransferases; Adenocarcinoma; Animals; Antibodies; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Humans; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Spermine; Tumor Cells, Cultured | 1994 |
Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine.
Topics: Animals; Cell Division; Cell Line; DNA, Mitochondrial; Humans; Leukemia L1210; Mitoguazone; Oxygen Consumption; Polyamines; Spermine; Tumor Cells, Cultured | 1993 |
Growth inhibition of hormone-responsive and -resistant human breast cancer cells in culture by N1, N12-bis(ethyl)spermine.
Topics: Acetyltransferases; Breast Neoplasms; Carcinoma; Cell Division; Drug Resistance; Enzyme Induction; Female; Gene Expression; Growth Inhibitors; Humans; In Vitro Techniques; Polyamines; Receptors, Estrogen; RNA, Messenger; Spermine; Tumor Cells, Cultured | 1993 |
Regulation of polyamine transport by polyamines and polyamine analogs.
Topics: Animals; Biological Transport; Cycloheximide; Deoxyadenosines; Dose-Response Relationship, Drug; Eflornithine; Polyamines; Spermine; Time Factors; Tumor Cells, Cultured | 1993 |
Stable intracellular acidification upon polyamine depletion induced by alpha-difluoromethylornithine or N1,N12-bis(ethyl)spermine in L1210 leukaemia cells.
Topics: Animals; Antineoplastic Agents; Bicarbonates; Eflornithine; Hydrogen-Ion Concentration; Leukemia L1210; Mice; Nigericin; Polyamines; Putrescine; Sodium-Hydrogen Exchangers; Spermidine; Spermine | 1995 |
Spermine uptake is necessary to induce haemoglobin synthesis in murine erythroleukaemia cells.
Topics: Animals; Antineoplastic Agents; Biological Transport; Carrier Proteins; Drug Resistance; Eflornithine; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice; Mutagenesis; Putrescine; Spermine; Transfection; Tumor Cells, Cultured | 1995 |
Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells.
Topics: Acetyltransferases; Base Sequence; Carcinoma, Small Cell; Cloning, Molecular; Deoxyribonuclease I; Humans; Lung Neoplasms; Molecular Sequence Data; Oligodeoxyribonucleotides; RNA, Messenger; Spermine; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Regulation of ornithine decarboxylase in a transformed cell line that overexpresses translation initiation factor eIF-4E.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eukaryotic Initiation Factor-4E; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Mice; Ornithine Decarboxylase; Peptide Initiation Factors; Promoter Regions, Genetic; Recombinant Proteins; Spermine | 1996 |
Proteasomal degradation of spermidine/spermine N1-acetyltransferase requires the carboxyl-terminal glutamic acid residues.
Topics: Acetyltransferases; Amino Acid Sequence; Animals; Cysteine Endopeptidases; Enzyme Inhibitors; Glutamic Acid; Kinetics; Multienzyme Complexes; Mutagenesis, Site-Directed; Ornithine Decarboxylase; Polyamines; Proteasome Endopeptidase Complex; Protein Biosynthesis; Rabbits; Recombinant Proteins; Reticulocytes; Spermine; Substrate Specificity | 1997 |
Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels.
Topics: Antineoplastic Agents; Caco-2 Cells; Cell Division; DNA Topoisomerases, Type I; Enzyme Activation; Genes, myc; Growth Inhibitors; Humans; Ornithine Decarboxylase; Polyamines; Proto-Oncogene Proteins c-myc; Spermine | 1998 |
The growth inhibitory effect of N1,N12-bis(ethyl)spermine in small cell lung cancer cells is maintained in cells expressing the c-myc and Ha-ras oncogenes.
Topics: Acetyltransferases; Antineoplastic Agents; Carcinoma, Small Cell; Cell Division; Genes, myc; Genes, ras; Growth Inhibitors; Humans; Kinetics; Lung Neoplasms; Oncogene Protein p21(ras); Polyamines; Proto-Oncogene Proteins c-myc; Spermine; Time Factors; Tumor Cells, Cultured | 1998 |
Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
Topics: Acetyltransferases; Alleles; Antineoplastic Agents; Biogenic Polyamines; Cell Division; Cell Survival; DNA Methylation; DNA, Neoplasm; Enzyme Induction; Female; Genetic Linkage; Humans; Lung Neoplasms; Male; Phenotype; Sex Factors; Spermine; Tumor Cells, Cultured; X Chromosome | 1998 |
Selectivity of polyamines on the stability of RNA-DNA hybrids containing phosphodiester and phosphorothioate oligodeoxyribonucleotides.
Topics: Binding, Competitive; DNA; Magnesium; Nucleic Acid Heteroduplexes; Oligodeoxyribonucleotides; Organophosphates; Polyamines; Propylamines; RNA; Sodium; Spermidine; Spermine; Thionucleotides | 1999 |
Polyamines decrease Ca(2+) sensitivity of tension and increase rates of activation in skinned cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Magnesium; Myocardial Contraction; Myocardium; Putrescine; Rats; Rats, Sprague-Dawley; Spermidine; Spermine | 2000 |
Differential induction of spermidine/spermine N1-acetyltransferase activity in cisplatin-sensitive and -resistant ovarian cancer cells in response to N1,N12-bis(ethyl)spermine involves transcriptional and post-transcriptional regulation.
Topics: Acetyltransferases; Antineoplastic Agents; Blotting, Northern; Cisplatin; Drug Resistance, Neoplasm; Enzyme Induction; Female; Humans; Ovarian Neoplasms; RNA, Messenger; RNA, Neoplasm; Spermine; Transcription, Genetic; Tumor Cells, Cultured | 2001 |
Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine.
Topics: Antineoplastic Agents; Breast Neoplasms; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Death; Cell Division; Enzyme Activation; Female; Genes, BRCA1; Humans; Polyamines; Spermine; Tumor Cells, Cultured | 2002 |
Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin.
Topics: Acetyltransferases; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Cystadenocarcinoma; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Spermine; Transfection | 2005 |