myxothiazol and 2-nitrosofluorene

myxothiazol has been researched along with 2-nitrosofluorene* in 1 studies

Other Studies

1 other study(ies) available for myxothiazol and 2-nitrosofluorene

ArticleYear
2-Nitrosofluorene and N-hydroxy-2-aminofluorene react with the ubiquinone-reduction center (center N) of the mitochondrial cytochrome bc1 complex.
    FEBS letters, 1996, Jul-08, Volume: 389, Issue:3

    We determined the sites of artificial electron transfer onto 2-nitrosofluorene (NOF), a metabolite of carcinogenic 2- acetylaminofluorene in mitochondria and isolated cytochrome bc1 complex. NOF-induced O2 consumption in mitochondria was sensitive to antimycin A, but insensitive to myxothiazol. In the isolated cytochrome bc1 complex, NOF induced rapid MOA-stilbene-insensitive reoxidation of cytochrome b, whereas in the presence of antimycin A, reoxidation was very slow. The corresponding hydroxylamine, N-hydroxy-2-aminofluorene (N-OH-AF), reduced cytochrome b specifically through center N of the cytochrome bc1 complex. We conclude that NOF and N-OH-AF bind to center N of the cytochrome bc1 complex and act as electron acceptor and donor, respectively. The N-OH-AF/NOF interconversion is considered to be involved in the cytotoxicity of 2-acetylaminofluorene in vivo.

    Topics: Animals; Antimycin A; Cytochrome b Group; Dithionite; Electron Transport Complex III; Fluorenes; Male; Methacrylates; Mitochondria, Liver; Nitroso Compounds; Oxidation-Reduction; Oxygen Consumption; Potassium Cyanide; Rats; Rats, Wistar; Stilbenes; Tetramethylphenylenediamine; Thiazoles; Ubiquinone; Uncoupling Agents

1996
chemdatabank.com