myricitrin and 3-hydroxyflavone

We here report on flavonols (myricetin (MCE) and its glycoside myricitrin (MCI)) - 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) membrane interactions focusing on the effects of flavonol clustering on the membrane thermotropic and nanomechanical properties. Atomic force microscopy (AFM), force spectroscopy (FS) and differential scanning calorimetry (DSC) together with molecular dynamics (MD) simulations provided a consistent picture of flavonol - DMPC membrane interactions. DMPC membrane as a supported lipid bilayer preserved its integrity even at higher flavonol molar fraction x. When present at x = 0.1 - 0.3, MCE and MCI both slightly improve DMPC bilayer fluidity which is evidenced by the decrease in the main phase transition temperature T

Topics: Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Flavonoids; Microscopy, Atomic Force; Molecular Dynamics Simulation; Molecular Structure; Single Molecule Imaging