mycobactin has been researched along with acinetoferrin* in 1 studies
1 other study(ies) available for mycobactin and acinetoferrin
Article | Year |
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Synthesis and biological evaluation of new acinetoferrin homologues for use as iron transport probes in mycobacteria.
Four new acinetoferrin homologues were synthesized using a modular synthetic approach. Two linear and two cyclic imide derivatives were generated and evaluated for growth stimulating behavior in Mycobacterium avium subsp paratuberculosis. The yield for the tandem coupling of a functionalized aminohydroxamic acid motif (2 equiv) to a tert-butyl citrate derivative was significantly improved using DCC and N-hydroxysuccinimide. (1)H NMR spectroscopy (CD(3)OD) provided a convenient method for monitoring the final imidization step in TFA using the doublet patterns between 2.5 and 3.06 ppm. New protocols demonstrated that only a 20% growth enhancement was observed with M. avium subsp. paratuberculosis using the imide of acinetoferrin. Last, a siderophore from Streptomyces pilosus, deferrioxamine B, was shown to cross-feed M. avium subsp. paratuberculosis with the same efficiency as the more costly, native chelator, mycobactin J. Topics: Biochemistry; Biological Transport; Cell Division; Citrates; Deferoxamine; Drug Evaluation, Preclinical; Hydroxamic Acids; Iron; Iron Chelating Agents; Magnetic Resonance Spectroscopy; Mycobacterium; Mycobacterium avium; Mycobacterium avium subsp. paratuberculosis; Oxazoles | 2004 |