mycalamide-b has been researched along with pederin* in 2 studies
1 review(s) available for mycalamide-b and pederin
| Article | Year |
|---|---|
Mycalamides, pederin and psymberin as natural carbohydrates and potential antitumor agents: past and future perspectives.
The mycalamide class of potent antiviral and antitumor natural compounds originally isolated from marine sponges in 1988 is a new interdisciplinary approach to molecular recognition. We review new synthetic approaches to this new family of natural products with remarkable biological activity. Some biological evaluation data are compiled and compared to other structurally similar molecular targets. Topics: Animals; Antineoplastic Agents; Biological Products; Chemistry Techniques, Synthetic; Coleoptera; Coumarins; Humans; Neoplasms; Porifera; Pyrans | 2012 |
1 other study(ies) available for mycalamide-b and pederin
| Article | Year |
|---|---|
Synthesis of psymberin analogues: probing a functional correlation with the pederin/mycalamide family of natural products.
In this letter we describe an efficient synthesis of "psympederin", a hybrid between the novel antitumor natural product psymberin and the blister beetle toxin pederin. Evaluation of antiproliferative activity reveals that the dihydroisocoumarin fragment is important for psymberin toxicity and the cyclic pederate fragment is important for pederin/mycalamide toxicity. On the basis of preliminary results described herein, we speculate that, despite their structural resemblance, psymberin and pederin/mycalamide induce toxicity through different mechanisms. [reaction: see text]. Topics: Cell Line, Tumor; Cell Proliferation; Coumarins; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Pyrans; Pyrones; Sensitivity and Specificity; Structure-Activity Relationship | 2007 |