muscimol has been researched along with pregnanolone in 61 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.92) | 18.7374 |
| 1990's | 32 (52.46) | 18.2507 |
| 2000's | 19 (31.15) | 29.6817 |
| 2010's | 5 (8.20) | 24.3611 |
| 2020's | 2 (3.28) | 2.80 |
| Authors | Studies |
|---|---|
| Hiemke, C; Jüptner, M; Jussofie, A | 1 |
| Blinn, JR; Morrow, AL; Paul, SM; Purdy, RH | 1 |
| Falkay, G; Ford-Rice, F; Majewska, MD | 1 |
| Baulieu, EE; Falkay, G; Majewska, MD | 1 |
| Kirkness, EF; Turner, AJ | 1 |
| Akhondzadeh, S; Stone, TW | 3 |
| Akwa, Y; Baulieu, EE; el-Etr, M; Fiddes, RJ; Robel, P | 1 |
| Jussofie, A; Kalff, R; Reinhardt, V | 1 |
| Li, SY; Pelletier, G; Vincens, M | 1 |
| Jussofie, A | 4 |
| Calvo, P; Casanova, E; Chinchetru, MA; Fernández-López, A; Negro, M | 1 |
| Hauser, CA; Holsboer, F; Rupprecht, R; Wetzel, CH | 1 |
| Bennett, PJ; Simmonds, MA | 1 |
| Simmonds, MA; Zhong, Y | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| de las Heras, MA; Perez, LJ; Valcarcel, A | 1 |
| Gillies, GE; Murray, HE | 1 |
| Borodinsky, LN; Fiszman, ML; Pesce, G; Pomata, P | 1 |
| Barros, HM; Manitiu, A; Miczek, KA; Vivian, JA | 1 |
| Ford, E; Hagan, RM; Marshall, FH; Mullings, J; Oakley, NR; Stratton, SC; Worton, SP | 1 |
| Belluzzi, J; Gee, KW; Hawkinson, JE; Hogenkamp, D; Lan, NC; Stein, L; Upasani, R; Wieland, S; Wood, PL | 1 |
| Brozowski, S; Chuang, L; Hadingham, K; Harris, RA; Valenzuela, CF; Whiting, PJ | 1 |
| Akwa, Y; Baulieu, EE; El-Etr, M; Robel, P | 1 |
| Mehta, AK; Ticku, MK | 1 |
| Biggio, G; Concas, A; Floris, S; Follesa, P; Mostallino, MC; Tuligi, G | 1 |
| Acosta-Burruel, M; Carter, RB; Chen, JS; Drewe, JA; Hawkinson, JE; Hogenkamp, DJ; Lan, NC; Upasani, RB; Whittemore, ER; Woodward, RM; Yang, KC | 1 |
| Barbaccia, ML; Biggio, G; Concas, A; Follesa, P; Grisenti, P; Mostallino, MC; Porcu, P; Purdy, RH; Trabucchi, M | 1 |
| Bailey, CD; Brien, JF; Reynolds, JN | 1 |
| Chistina Grobin, A; Devaud, LL; Inglefield, JR; Morrow, AL; Schwartz-Bloom, RD | 1 |
| Bidziński, A; Członkowska, AI; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H | 1 |
| Bargas, J; Brailowsky, S; Calixto, E; Casasola, C; López-Colomé, AM; Montiel, T | 1 |
| Costa, E; Guidotti, A; Matsumoto, K; Mienville, JM; Pinna, G; Puia, G; Uzunova, V | 1 |
| Bäckström, T; Landgren, S; Wang, MD | 1 |
| Fujii, E; Mellon, SH | 1 |
| Adkins, CE; Bonnert, TP; Gonzalez, JE; Haldon, C; Kerby, J; McKernan, RM; Oades, K; Pillai, GV; Simpson, PB; Whiting, PJ | 1 |
| Grobin, AC; Morrow, AL | 1 |
| Chigr, F; M'hamed, SB; Najimi, M | 1 |
| Akk, G; Bracamontes, JR; Covey, DF; Darbandi-Tonkabon, R; Evers, AS; Hastings, WR; Manion, BD; Mennerick, SJ; Steinbach, JH; Zeng, CM | 1 |
| Ferguson, C; Grobin, AC; Homanics, GE; Kralic, JE; Morrow, AL; O'Buckley, TK; Renzi, K; Wheeler, M | 1 |
| Janak, PH; Michael Gill, T | 1 |
| Boyd, SK; Goetz, FW; Hollis, DM; Roberts, SB | 1 |
| Chopde, CT; Hirani, K; Jain, NS | 1 |
| Gizerian, S; Grobin, AC; Lieberman, JA; Morrow, AL | 1 |
| Ahboucha, S; Butterworth, RF; Mamer, O; Pomier-Layrargues, G | 1 |
| Gartside, SE; Ingram, CD; Judge, SJ; Kaura, V; Young, AH | 1 |
| Greer, JJ; Ren, J | 1 |
| Aptel, H; Bancel, F; Dayanithi, G; Méchaly, I; Puech, S; Valmier, J; Viéro, C | 1 |
| Chopde, CT; Hirani, K; Kokare, DM; Sharma, AN; Subhedar, NK; Ugale, RR | 1 |
| Kumar, A; Singh, A | 1 |
| Asiedu, MN; Kaila, K; Malan, TP; Mejia, G; Ossipov, MK; Price, TJ | 1 |
| Akaike, N; Fukuda, A; Iwata, S; Shin, MC; Wakita, M | 1 |
| Ishida, A; Ishihara, Y; Kawami, T; Yamazaki, T | 1 |
| Yamaguchi, K | 1 |
| Burton, G; Coirini, H; Ghini, AA; Kruse, MS; Rey, M; Veleiro, AS | 1 |
| Akk, G; Evers, AS; Germann, AL; Pierce, SR; Steinbach, JH; Sugasawa, Y | 1 |
| Bakalar, D; Clarkson-Paredes, C; Ellegood, J; Gallo, V; Hashimoto-Torii, K; Imamura, Y; Kratimenos, P; Lacaille, H; Lerch, JP; Liere, P; O'Reilly, JJ; Penn, AA; Popratiloff, A; Salzbank, J; Sasaki, T; Sathyanesan, A; Schumacher, M; Sebaoui, S; Vacher, CM | 1 |
1 review(s) available for muscimol and pregnanolone
| Article | Year |
|---|---|
Modulation of allopregnanolone on excitatory transmitters release from single glutamatergic terminal.
Topics: Animals; Animals, Newborn; Bicuculline; Biophysics; CA1 Region, Hippocampal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutamic Acid; Muscimol; Patch-Clamp Techniques; Potassium Channel Blockers; Pregnanolone; Presynaptic Terminals; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Tetraethylammonium; Valine | 2013 |
60 other study(ies) available for muscimol and pregnanolone
| Article | Year |
|---|---|
Evidence that 3 alpha-hydroxy-5 alpha-pregnan-20-one is a physiologically relevant modulator of GABA-ergic neurotransmission.
Topics: Animals; Cell Membrane; Cerebellum; Dose-Response Relationship, Drug; Female; Muscimol; Ovariectomy; Pregnanolone; Rats; Receptors, GABA-A; Synaptic Transmission; Tritium | 1991 |
Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes.
Topics: Acetates; Animals; Cerebral Cortex; Chlorides; Desoxycorticosterone; Drug Synergism; Isomerism; Male; Molecular Conformation; Muscimol; Pregnanes; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship; Synaptosomes | 1990 |
Pregnancy-induced alterations of GABAA receptor sensitivity in maternal brain: an antecedent of post-partum 'blues'?
Topics: Animals; Female; Frontal Lobe; Gestational Age; Muscimol; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Modulation of uterine GABAA receptors during gestation and by tetrahydroprogesterone.
Topics: Animals; Female; Kinetics; Muscimol; Pregnancy; Pregnancy, Animal; Pregnanes; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Uterus | 1989 |
The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively.
Topics: Animals; Anthelmintics; Cerebral Cortex; In Vitro Techniques; Ivermectin; Muscimol; Phenobarbital; Picrotoxin; Pregnanes; Pregnanolone; Radioligand Assay; Receptors, GABA-A; Secobarbital; Sesterterpenes; Swine; Synaptic Membranes | 1988 |
Potentiation by neurosteroids of muscimol/adenosine interactions in rat hippocampus.
Topics: Adenosine; Anesthetics; Animals; Anti-Anxiety Agents; Barium; Bicuculline; Chloride Channel Agonists; Drug Synergism; GABA-A Receptor Agonists; Hippocampus; Male; Muscimol; Neural Inhibition; Pregnanediones; Pregnanolone; Rats; Rats, Wistar | 1995 |
Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors.
Topics: Action Potentials; Adenosine; Alanine; Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Corpus Striatum; Culture Techniques; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; Hippocampus; Male; Muscimol; Neuronal Plasticity; Pregnanediones; Pregnanolone; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA; Receptors, Metabotropic Glutamate; Valine | 1995 |
A progesterone metabolite stimulates the release of gonadotropin-releasing hormone from GT1-1 hypothalamic neurons via the gamma-aminobutyric acid type A receptor.
Topics: Animals; Anti-Anxiety Agents; Brain; Cell Line; Dose-Response Relationship, Drug; Flunitrazepam; Gene Expression; Gonadotropin-Releasing Hormone; Hypothalamus; Kinetics; Muscimol; Neurons; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; RNA, Messenger | 1995 |
GABA binding sites: their density, their affinity to muscimol and their behaviour against neuroactive steroids in human gliomas of different degrees of malignancy.
Topics: Anti-Anxiety Agents; Brain Neoplasms; Desoxycorticosterone; Glioma; Humans; In Vitro Techniques; Membranes; Muscimol; Pregnanolone; Receptors, GABA; Steroids | 1994 |
Inhibitory effect of 5 beta-pregnan-3 alpha-o1-20-one on gonadotropin-releasing hormone gene expression in the male rat.
Topics: Animals; Autoradiography; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Hypothalamus; In Situ Hybridization; Injections, Intraperitoneal; Male; Muscimol; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA; RNA, Messenger | 1994 |
Brain region-specific effects of neuroactive steroids on the affinity and density of the GABA-binding site.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Brain; Cerebellum; Desoxycorticosterone; Female; Hippocampus; Hypothalamus; Medulla Oblongata; Muscimol; Pregnanediones; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Differential effect of chronic ethanol treatment on barbiturate and steroid modulation of muscimol-binding to rat brain cortex.
Topics: Animals; Barbiturates; Cerebral Cortex; Ethanol; In Vitro Techniques; Kinetics; Male; Muscimol; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Thiopental | 1993 |
Brain area specific differences in the effects of neuroactive steroids on the GABAA receptor complexes following acute treatment with anaesthetically active steroids.
Topics: Anesthetics; Animals; Binding Sites; Brain; Cerebellum; Cerebral Cortex; Female; Hippocampus; Hypothalamus; Medulla Oblongata; Muscimol; Ovariectomy; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Time Factors | 1993 |
A new highly sensitive procedure--a prerequisite to evaluate the density of GABAA receptors and to study their allosteric properties in distinct areas of rat brain.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain; Cerebellum; Desoxycorticosterone; Female; Frontal Lobe; Humans; Hydrogen-Ion Concentration; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Progesterone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Allopregnanolone acts as an inhibitory modulator on alpha1- and alpha6-containing GABA-A receptors.
Topics: Animals; Anti-Anxiety Agents; Cell Line; Cell Membrane; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypothalamus; Kinetics; Membrane Potentials; Molecular Sequence Data; Muscimol; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection | 1996 |
The influence of membrane cholesterol on the GABAA receptor.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cholesterol; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; GABA Agents; Liposomes; Male; Muscimol; Pregnanolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1996 |
Steroid modulation of central nervous GABAA receptor binding in three female rat brain areas during postnatal development.
Topics: Animals; Brain; Brain Chemistry; Cerebellum; Desoxycorticosterone; Female; Frontal Lobe; GABA Agonists; Medulla Oblongata; Membranes; Muscimol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Regression Analysis; Steroids | 1995 |
Pharmacological characterisation of multiple components in the enhancement by pregnanolone and propofol of [3H]flunitrazepam binding to GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Flunitrazepam; GABA Agonists; GABA Modulators; In Vitro Techniques; Male; Muscimol; Pregnanolone; Progesterone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Membranes | 1996 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
In vitro capacitating effect of gamma-aminobutyric acid in ram spermatozoa.
Topics: Acrosome; Analysis of Variance; Animals; Baclofen; Calcimycin; Chlortetracycline; Dose-Response Relationship, Drug; Exocytosis; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Neuroprotective Agents; Pregnanolone; Prostate-Specific Antigen; Receptors, GABA-A; Receptors, GABA-B; Sheep; Sperm Capacitation; Spermatozoa | 1997 |
Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures.
Topics: Animals; Bicuculline; Cells, Cultured; Dehydroepiandrosterone Sulfate; Dopamine; Drug Synergism; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Muscimol; Pregnanolone; Pregnenolone; Rats; Somatostatin | 1997 |
Neurosteroid modulation of GABAA receptors in the developing rat brain cortex.
Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Embryo, Mammalian; Embryonic and Fetal Development; Muscimol; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Steroids | 1997 |
Ultrasonic vocalizations in rat pups: modulation at the gamma-aminobutyric acidA receptor complex and the neurosteroid recognition site.
Topics: Alprazolam; Animals; Diazepam; Female; Male; Muscimol; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Vocalization, Animal | 1997 |
Development of tolerance in mice to the sedative effects of the neuroactive steroid minaxolone following chronic exposure.
Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Antagonists; Hypnotics and Sedatives; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred Strains; Motor Activity; Muscimol; Pregnanolone; Radioligand Assay; Rats; Temazepam | 1997 |
Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Binding, Competitive; Cerebral Cortex; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Antagonists; In Vitro Techniques; Male; Mice; Muscimol; Phenolsulfonphthalein; Postural Balance; Pregnanolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
Adaptation of gamma-aminobutyric acid type A receptors to alcohol exposure: studies with stably transfected cells.
Topics: Animals; Cells, Cultured; Drug Tolerance; Ethanol; Flunitrazepam; Humans; Mice; Muscimol; Pentobarbital; Pregnanolone; Protein Kinase C; Receptors, GABA-A; Transfection; Zinc | 1998 |
Opposing effects of different steroid sulfates on GABAA receptor-mediated chloride uptake.
Topics: Animals; Biological Transport; Cerebral Cortex; Chlorides; Dehydroepiandrosterone Sulfate; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; In Vitro Techniques; Ionophores; Male; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes | 1998 |
Chronic ethanol administration alters the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one on the binding characteristics of various radioligands of GABAA receptors.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Ethanol; Flunitrazepam; GABA Agonists; GABA Modulators; Hippocampus; Male; Muscimol; Pregnanolone; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Molecular and functional adaptation of the GABA(A) receptor complex during pregnancy and after delivery in the rat brain.
Topics: Allosteric Regulation; Alternative Splicing; Animals; Brain Chemistry; Cerebral Cortex; Chlorides; Diazepam; Female; Hippocampus; Isotopes; Muscimol; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger | 1998 |
Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptors.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; GABA Modulators; Humans; Male; Mice; Muscimol; Pregnanolone; Rats; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 1998 |
Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.
Topics: Animals; Cell Membrane; Cerebral Cortex; Chlorides; Desoxycorticosterone; Estrus; Female; Finasteride; Gene Expression Regulation; Hippocampus; Muscimol; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic | 1998 |
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Time Factors | 1998 |
Neurosteroid modulation of the GABAA receptor in the developing guinea pig cerebral cortex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Guinea Pigs; Hypnotics and Sedatives; Male; Muscimol; Organ Size; Pregnanolone; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Zolpidem | 1999 |
Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties.
Topics: Animals; Central Nervous System Depressants; Chlorides; Diazepam; DNA Primers; Ethanol; Flunitrazepam; Fluorescent Dyes; GABA Agonists; GABA Modulators; Gene Expression; Mice; Muscimol; Neoplastic Stem Cells; Neuroglia; Pentobarbital; Pregnanolone; Quinolinium Compounds; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium | 1999 |
The effects of neurosteroids on rat behavior and 3H-muscimol binding in the brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Brain Chemistry; Conflict, Psychological; Desoxycorticosterone; Dose-Response Relationship, Drug; Drinking Behavior; Fear; GABA Agonists; GABA Modulators; Injections, Intraventricular; Male; Midazolam; Muscimol; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 1999 |
Neocortical hyperexcitability after GABA withdrawal in vitro.
Topics: Animals; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Muscimol; Neocortex; Pregnanolone; Progesterone; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome; Synaptic Transmission | 2000 |
Brain allopregnanolone regulates the potency of the GABA(A) receptor agonist muscimol.
Topics: 5-alpha-Dihydroprogesterone; Animals; Brain; Enzyme Inhibitors; GABA Agonists; Male; Mice; Muscimol; Pregnanediones; Pregnanolone; Pyramidal Cells; Receptors, GABA-A; Synaptic Transmission | 2000 |
The inhibitory effects of allopregnanolone and pregnanolone on the population spike, evoked in the rat hippocampal CA1 stratum pyramidale in vitro, can be blocked selectively by epiallopregnanolone.
Topics: Action Potentials; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electrophysiology; Female; GABA Agonists; Hippocampus; In Vitro Techniques; Muscimol; Pregnanolone; Progesterone; Pyramidal Cells; Rats; Receptors, GABA-A; Stereoisomerism; Steroids | 2000 |
Regulation of uterine gamma-aminobutyric acid(A) receptor subunit expression throughout pregnancy.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; Animals; Female; Gene Expression Regulation, Developmental; Muscimol; Pregnancy; Pregnancy, Animal; Pregnanolone; Protein Subunits; Rats; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Uterus | 2001 |
alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.
Topics: Animals; Benzodiazepines; Cell Line; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mice; Models, Biological; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Protein Binding; Protein Conformation; Receptors, GABA-A; Spectrometry, Fluorescence; Time Factors; Transfection | 2001 |
3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex.
Topics: Allosteric Regulation; Animals; Animals, Newborn; Anti-Anxiety Agents; Biological Transport; Cerebral Cortex; Chlorine; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Labor, Obstetric; Male; Muscimol; Pregnancy; Pregnanolone; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Characteristics | 2001 |
Modulation Of [35S]-tert-butylbicyclophosphorothionate binding by somatostatin in rat hypothalamus.
Topics: Animals; Bicuculline; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Muscimol; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Somatostatin; Sulfur Radioisotopes | 2002 |
Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.
Topics: Affinity Labels; Animals; Aziridines; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Female; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Muscimol; Oocytes; Porins; Pregnanolone; Rats; Recombinant Proteins; Steroids; Telencephalon; Transfection; Voltage-Dependent Anion Channel 1; Voltage-Dependent Anion Channels; Xenopus laevis | 2003 |
Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics.
Topics: Anesthetics; Animals; Anxiety; Behavior, Animal; Bicuculline; Brain; Central Nervous System Depressants; Chlorides; Desoxycorticosterone; Drug Tolerance; Ethanol; Exploratory Behavior; Female; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Knockout; Muscimol; Postural Balance; Pregnanolone; Receptors, GABA-A; Steroids | 2003 |
Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose.
Topics: Alcohol Drinking; Animals; Baclofen; Central Nervous System Depressants; Conditioning, Operant; Dose-Response Relationship, Drug; Ethanol; GABA Agonists; Male; Muscimol; Pregnanolone; Rats; Rats, Long-Evans; Reinforcement, Psychology; Sucrose | 2003 |
Acute neurosteroid modulation and subunit isolation of the gamma-aminobutyric acidA receptor in the bullfrog, Rana catesbeiana.
Topics: Amino Acid Sequence; Anesthetics; Animals; Brain; Cell Membrane; Cloning, Molecular; GABA Agonists; Male; Molecular Sequence Data; Muscimol; Pregnanolone; Pregnenolone; Protein Isoforms; Protein Subunits; Radioligand Assay; Rana catesbeiana; Receptors, GABA-A; Sequence Alignment; Tritium | 2004 |
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.
Topics: Adrenalectomy; Analysis of Variance; Anesthetics; Animals; Anxiety; Bicuculline; Caffeine; Central Nervous System Stimulants; Corticotropin-Releasing Hormone; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Muscimol; Peptide Fragments; Pregnanolone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time | 2005 |
Perinatal allopregnanolone influences prefrontal cortex structure, connectivity and behavior in adult rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Cell Count; Female; Muscimol; Neurons; Prefrontal Cortex; Pregnanolone; Rats; Receptors, GABA-A | 2006 |
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzodiazepines; Brain Chemistry; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; In Vitro Techniques; Liver Cirrhosis; Male; Membranes; Middle Aged; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Standards | 2006 |
The progesterone metabolite allopregnanolone potentiates GABA(A) receptor-mediated inhibition of 5-HT neuronal activity.
Topics: Action Potentials; Analysis of Variance; Anesthetics; Animals; Drug Interactions; Female; GABA Agonists; In Vitro Techniques; Isoxazoles; Muscimol; Neural Inhibition; Neurons; Pregnanolone; Progesterone; Raphe Nuclei; Rats; Receptors, GABA-A; Serotonin; Time Factors | 2007 |
Neurosteroid modulation of respiratory rhythm in rats during the perinatal period.
Topics: Action Potentials; Animals; Animals, Newborn; Central Nervous System; Dehydroepiandrosterone Sulfate; Female; GABA Agonists; Muscimol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Respiratory Mechanics | 2006 |
Rapid inhibition of Ca2+ influx by neurosteroids in murine embryonic sensory neurones.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chelating Agents; Embryo, Mammalian; Fluorescent Dyes; Fura-2; GABA Agonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Membrane Proteins; Mice; Muscimol; Neurons, Afferent; Potassium Channel Blockers; Pregnanolone; Progesterone; Receptors, GABA-A; Receptors, Progesterone; Sodium Channel Blockers | 2006 |
Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats.
Topics: Adrenalectomy; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Male; Maze Learning; Muscimol; Oxazines; Pregnanolone; Rats; Rats, Sprague-Dawley; Reaction Time | 2007 |
Possible GABAergic modulation in the protective effect of allopregnanolone on sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Catalase; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Glutathione; Lipid Peroxidation; Male; Maze Learning; Mice; Motor Activity; Muscimol; Neuroprotective Agents; Nitrites; Oxidative Stress; Picrotoxin; Pregnanolone; Sleep Deprivation | 2008 |
Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
Topics: Analgesia; Analgesics; Animals; Benzodiazepines; Chlorides; GABA-A Receptor Agonists; Isoxazoles; K Cl- Cotransporters; Male; Mice; Mice, Inbred ICR; Muscimol; Neuralgia; Peripheral Nerve Injuries; Pregnanolone; Receptors, GABA-A; Sciatic Nerve; Symporters | 2012 |
Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices.
Topics: 5-alpha Reductase Inhibitors; Anesthetics; Animals; Bicuculline; Cell Death; Cytochrome P-450 Enzyme Inhibitors; Finasteride; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; Hormone Antagonists; Mifepristone; Muscimol; Neurons; Neuroprotective Agents; Organ Culture Techniques; Pregnanolone; Progesterone; Progestins; Rats; Rats, Wistar; Tetrahydronaphthalenes; Trialkyltin Compounds | 2013 |
Evaluation for roles of neurosteroids in modulating forebrain mechanisms controlling vasopressin secretion and related phenomena in conscious rats.
Topics: Aminoglutethimide; Animals; Aromatase Inhibitors; Autonomic Nervous System; Bicuculline; Blood Glucose; Blood Pressure; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Heart Rate; Male; Muscimol; Pregnanolone; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA; Vasopressins | 2015 |
Effect of synthetic steroids on GABAA receptor binding in rat brain.
Topics: Animals; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flunitrazepam; GABA-A Receptor Agonists; Hippocampus; Male; Muscimol; Pregnanolone; Protein Binding; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Tritium | 2015 |
Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA
Topics: Allosteric Regulation; Binding Sites; GABA-A Receptor Agonists; HEK293 Cells; Humans; Multiprotein Complexes; Muscimol; Pregnanolone; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; Steroids; Tritium | 2020 |
Placental endocrine function shapes cerebellar development and social behavior.
Topics: Aldehyde Reductase; Animals; Autism Spectrum Disorder; Cerebellum; Endocrine Glands; Female; GABA Agonists; GABA Modulators; Gene Deletion; Humans; Infant; Infant, Newborn; Male; Mice; Muscimol; Placenta; Pregnancy; Pregnanolone; Receptors, GABA-A; Sex Characteristics; Social Behavior; Trophoblasts; White Matter | 2021 |