muscimol has been researched along with flunitrazepam in 268 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 106 (39.55) | 18.7374 |
| 1990's | 123 (45.90) | 18.2507 |
| 2000's | 36 (13.43) | 29.6817 |
| 2010's | 3 (1.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kuhar, MJ; Niehoff, DL; Palacios, JM | 1 |
| Chang, RS; Gavish, M; Snyder, SH | 1 |
| Karobath, M; Lippitsch, M | 1 |
| Duggan, MJ; Pollard, S; Stephenson, FA | 1 |
| Lin, ZS; Yang, CY; Yazulla, S | 1 |
| Kukulka, KM; Mans, AM; McAvoy, KJ; Rokosz, NC | 1 |
| Ho, IK; Yu, S | 1 |
| Koenig, JA; Martin, IL | 1 |
| Hales, TG; Kim, H; Longoni, B; Olsen, RW; Tobin, AJ | 1 |
| Cawley, G; Coutcher, JB; Wecker, L | 1 |
| Foucaud, B; Gombos, G; Viennot, F | 1 |
| Bacon, E; de Barry, J; Girard, C; Gombos, G | 2 |
| Kuriyama, K; Ueha, T | 2 |
| Hirouchi, M; Kuriyama, K; Ohkuma, S | 1 |
| Kokka, N; Olsen, RW; Sapp, DW; Witte, U | 1 |
| Frostholm, A; Janapati, V; Luntz-Leybman, V; Rotter, A; Zdilar, D | 1 |
| Bao, J; Lee, YH; Tang, XW; Tsai, WH; Wu, E; Wu, JY; Yarom, M | 1 |
| Karasawa, T; Mimaki, T; Suzuki, Y; Tagawa, T; Yabuuchi, H | 1 |
| Banerjee, PK; Depaulis, A; Hechler, V; Snead, OC; Vergnes, M | 1 |
| Allan, AM; Draski, LJ; Mayes, GG | 1 |
| de Blas, AL; Park, D | 2 |
| Bureau, MH; Olsen, RW | 2 |
| Bolger, MB; Chen, JS; Gee, KW; Lan, NC | 1 |
| Buck, KJ; Harris, RA; McQuilkin, SJ | 1 |
| Cameron, L; Cynader, M; Hendrickson, A; March, D; Shaw, C; Zielinski, B | 1 |
| Demirgören, S; London, ED; Majewska, MD; Spivak, CE | 1 |
| Bureau, MH; Endo, S; Olsen, RW; Smith, G | 1 |
| Harris, RA; Leidenheimer, NJ | 1 |
| Oien, TT; Sethy, VH | 1 |
| Scarth, BA; Shaw, C | 1 |
| Airaksinen, MM; MacDonald, E; Rägo, L; Saano, V | 1 |
| Chesley, S; Greenblatt, DJ; Lopez, F; Miller, LG; Schatzki, A; Shader, RI; Thompson, ML | 1 |
| Deng, L; Nielsen, M; Olsen, RW | 1 |
| Cano, J; Machado, A; Ruano, D; Vitorica, J | 1 |
| Burt, DR; Huganir, RL; Kofuji, P; Mei, L; Moss, SJ; Ravindran, A; Wang, JB | 1 |
| Biggio, G; Concas, A; Sanna, E; Santoro, G; Serra, M | 1 |
| Albers, HE; Liou, SY; Shibata, S; Ueki, S | 1 |
| Farb, DH; Farrant, M; Roca, DJ; Rozenberg, I | 1 |
| Fares, F; Gavish, M; Pick, CG; Weizman, A; Yanai, J | 2 |
| Basile, AS; Gammal, SH; Jones, EA; Ostrowski, NL; Skolnick, P | 1 |
| Bureau, M; Olsen, RW | 2 |
| Andermanis, A; Harro, J; Kiivet, RA; Klusa, V; Liepa, I; Muceniece, R; Rägo, L; Svirskis, S | 1 |
| Fogarty, JD; Hughes, B; Ilinsky, IA; Kultas-Ilinsky, K | 2 |
| Kuriyama, K; Taguchi, J | 2 |
| Hashimoto, T; Kuriyama, K; Zhang, MY | 1 |
| Beales, M; Lorden, JF; Oltmans, GA; Walz, E | 1 |
| deBlas, AL; Fuchs, J; Hendry, SH; Jones, EG | 1 |
| Covey, DF; Ferrendelli, JA; Holland, KD; McKeon, AC | 1 |
| Quinn, MR | 1 |
| Barnard, EA; Casalotti, SO; Mamalaki, C; Stephenson, FA | 1 |
| Cole, RJ; Eldefrawi, AT; Eldefrawi, ME; Gant, DB; Valdes, JJ | 1 |
| Greenblatt, DJ; Miller, LG; Roy, RB; Shader, RI; Summer, WR | 1 |
| Allan, AM; Gallaher, EJ; Gionet, SE; Harris, RA | 1 |
| Allan, AM; Harris, RA | 2 |
| Besson, MJ; Caboche, J; Le Saux, F; Maurin, Y; Mitrovic, N; Sauter, A | 1 |
| Czajkowski, C; Farb, DH; Gibbs, TT | 1 |
| Biggio, G; Cau, A; Corda, MG; Laudani, U; Longoni, B; Paci, S; Salvadori, S | 1 |
| Ho, IK; Ito, Y; Lim, DK; Nabeshima, T | 1 |
| Neale, JH; Sato, TN | 1 |
| Moffett, JR; Namboodiri, A; Neale, JH | 1 |
| Fuchs, K; Sieghart, W | 1 |
| Blakeman, DP; Davis, JP; Im, WB; Tai, MM | 1 |
| Harro, J; Kiivet, RA; Pŏld, M; Rägo, L | 2 |
| Bowen, DM; Cross, AJ; Francis, PT; Green, AR; Robinson, TN; Stirling, JM | 1 |
| Kontro, P; Malminen, O | 1 |
| Lopez, F; Miller, LG; Roy, RB; Weill, CL | 1 |
| Hamon, M; Ruiz, G; Vergé, D | 1 |
| Mehta, AK; Ticku, MK | 5 |
| Cox, DH; Guidotti, A; Santi, MR | 1 |
| Collins, RC; Santori, EM | 1 |
| Ho, IK; Hoskins, B; Ito, Y; Lim, DK | 1 |
| Fujiwara, M; Kameyama, M; Ninomiya, H; Taniguchi, T | 1 |
| Gallager, D; Goldman-Rakic, PS; Rakic, P | 1 |
| Kirkness, EF; Turner, AJ | 2 |
| Fujiwara, M; Ninomiya, H; Taniguchi, T | 1 |
| Basile, AS; Gammal, SH; Jones, EA; Mullen, KD; Skolnick, P | 1 |
| Abalis, IM; Eldefrawi, AT; Eldefrawi, ME | 1 |
| Chweh, AY; Swinyard, EA; Wolf, HH | 1 |
| D'Amato, CJ; Greenamyre, JT; Penney, JB; Young, AB | 1 |
| Kishi, M; Kuriyama, K; Mukainaka, T; Ohkuma, S; Tomono, S | 1 |
| Hashimoto, T; Kuriyama, K; Ohkuma, S; Taguchi, J | 1 |
| Chiu, TH; Ito, M; Yu, O | 1 |
| Chweh, AY; Kupferberg, HJ; Swinyard, EA; Wolf, HH | 1 |
| Kempner, ES; Paul, SM; Schwartz, RD; Skolnick, P; Thomas, JW | 1 |
| Biscoe, TJ; Fry, JP; Rickets, C | 1 |
| Pan, HS; Penney, JB; Young, AB | 1 |
| McNamara, JO; Pedersen, HB; Shin, C | 1 |
| Lee, RJ; Lomax, P; McCabe, RT; Olsen, RW; Wamsley, JK | 1 |
| Allikmets, LH; Harro, JE; Kiivet, RA; Rägo, LK | 1 |
| Barnes, EM; Tehrani, MH | 1 |
| Hattori, H; Ito, M; Mikawa, H | 1 |
| Haefely, W; Möhler, H; Richards, JG; Schoch, P | 1 |
| Stephenson, FA | 2 |
| Sweetnam, PM; Tallman, JF | 1 |
| Chiu, TH; Ito, M; Rosenberg, HC | 1 |
| Hrelia, S; Lucacchini, A; Martini, C; Rossi, CA | 1 |
| Häring, P; Mohler, H; Richards, JG; Schoch, P; Takacs, B | 1 |
| Deng, L; Olsen, RW; Ransom, RW | 1 |
| Chang, LR; Lee, HK; Tao, PL | 1 |
| Barnard, EA; Casalotti, SO; Stephenson, FA | 1 |
| McCabe, RT; Wamsley, JK | 1 |
| Kogure, K; Onodera, H; Sato, G | 1 |
| Alho, H; Guidotti, A; Santi, MR; Vaccarino, FM | 1 |
| Crofton, KM; Mailman, RB; Reiter, LW | 1 |
| Barker, JL; Harrington, JW; Harrison, NL; Majewska, MD | 1 |
| Olsen, RW; Yang, JS | 1 |
| Dilber, AI; Olsen, RW; Ransom, RW; Stauber, GB | 1 |
| Braunwalder, A; Cheney, DL; Loo, P; Wood, PL; Yokoyama, N | 1 |
| Braestrup, C; Tacke, U | 1 |
| Belonogoff, OB; Lideman, RR | 1 |
| Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH | 1 |
| Hösli, E; Hösli, L; Möhler, H; Richards, JG | 1 |
| Karobath, M; Supavilai, P | 2 |
| Arbilla, S; Bartholini, G; Beaumont, K; Briley, M; De Montis, G; Langer, SZ; Lloyd, KG; Scatton, B | 1 |
| Collins, JF; Karobath, M; Mannonen, A; Supavilai, P | 1 |
| Borea, PA; Karobath, M; Supavilai, P | 1 |
| Collins, RJ; Daniels, EG; Sethy, VH | 1 |
| Karobath, M; Placheta, P; Sieghart, W; Supavilai, P | 1 |
| Agnati, LF; Andersson, K; Eneroth, P; Fuxe, K; Karobath, M; Köhler, C; Krogsgaard-Larsen, P; Ogren, SO; Pérez de la Mora, M | 1 |
| Asano, T; Ogasawara, N | 1 |
| Kuhar, MJ; Palacios, JM | 1 |
| Olsen, RW; Stephenson, FA; Watkins, AE | 1 |
| Gardner, CR; Piper, DC | 1 |
| Barnard, EA; Mamalaki, C; Sigel, E | 1 |
| Barnard, EA; Chang, LR | 1 |
| Penney, JB; Young, AB | 1 |
| Asano, T; Ogasawara, N; Yamada, Y | 1 |
| Asano, T; Ogasawara, N; Sakakibara, J | 1 |
| Barnard, EA; Mamalaki, C; Sigel, E; Stephenson, FA | 1 |
| Burch, TP; Thyagarajan, R; Ticku, MK | 1 |
| Lucacchini, A; Martini, C; Rigacci, T | 1 |
| Mitchell, R; Wilson, LE | 1 |
| Hösli, E; Hösli, L | 1 |
| Olsen, RW; Stephenson, FA | 1 |
| Mishra, RK; Racine, RJ; Tuff, LP | 1 |
| Cesselin, F; Euvrard, C; Goetz, C; Hamon, M; Kerdelhue, B; Le Dafniet, M; Pasqualini, C; Peillon, F | 1 |
| Quinn, MR; Somerville, RA | 1 |
| Abbracchio, MP; Balduini, W; Cagiano, R; Cattabeni, F; Coen, E; Cuomo, V; Lombardelli, G; Peruzzi, G; Ragusa, MC | 1 |
| Cooper, EC; Diamond, I; Gordon, A; Greenberg, DA | 1 |
| Kato, R; Muraki, T; Yamazoe, Y | 1 |
| Barnard, EA; Sigel, E | 1 |
| Gähwiler, BH; Maurer, R; Wüthrich, HJ | 1 |
| Haddox, VG; Menon, MK; Vivonia, CA | 1 |
| Kamphuis, W; Lopes da Silva, FH; Titulaer, MN | 1 |
| Hadingham, KL; Harkness, PC; Harris, RA; Klein, RL; Mascia, MP; Whiting, PJ | 1 |
| Keränen, A; Komulainen, H; Saano, V | 2 |
| De Blas, AL; Frostholm, A; Rotter, A; Wu, CH | 1 |
| Camón, L; Martínez, E; Pazos, A; Rodríguez-Farré, E; Solà, C | 1 |
| Boksa, P; Chaudieu, I; Quirion, R; St-Pierre, JA | 1 |
| Bigl, V; Rossner, S; Schliebs, R | 1 |
| Burnham, WM; Lôscher, W; Nobrega, JN; Richter, A | 1 |
| Akwa, Y; Baulieu, EE; el-Etr, M; Fiddes, RJ; Robel, P | 1 |
| Clark, M; Massenburg, GS; Post, RM; Weiss, SR | 1 |
| Hasegawa, T; Hayashi, T; Ishihara, S; Kameyama, T; Kaneyuki, T; Morimasa, T; Nabeshima, T; Shohmori, T; Yamada, K | 1 |
| Allan, AM; Harris, RA; McQuilkin, SJ; Mihic, SJ; Whatley, VJ | 1 |
| Fuchs, K; Mossier, B; Sieghart, W; Tögel, M | 1 |
| Lin, ZS; Yazulla, S | 1 |
| De Blas, AL; Gutiérrez, A; Khan, ZU | 1 |
| Hu, XJ; Ticku, MK | 1 |
| Belelli, D; Chen, R; Lambert, JJ; Lan, NC; Peters, JA; Reyes, A | 1 |
| Ho, IK; Kim, HS; Kimura, T; Oh, KW; Rheu, HM; Saunders, PA | 1 |
| Fuchs, JL; Li, J; Schwark, HD | 1 |
| Item, C; Sieghart, W | 1 |
| Machado, A; Ruano, D; Vitorica, J | 1 |
| Crawley, JN; Drugan, RC; Paul, SM | 1 |
| Nielsen, M; Witt, MR | 1 |
| Airaksinen, MM; Nieminen, SA; Railoma, O; Titievsky, AV | 1 |
| Motohashi, N; Okamoto, Y; Osada, M; Yamawaki, S | 1 |
| Kikuchi de Beltrán, K; Kobayashi, M; Koshikawa, N; Miwa, Y; Stephenson, JD | 1 |
| Amiri, Z; Bar-Ami, S; Fares, F; Gavish, M; Weizman, A | 1 |
| Dunn, SM; Thuynsma, RP | 1 |
| Korpi, ER; Taira, T; Uusi-Oukari, M | 1 |
| Liu, CC; Snead, OC | 1 |
| Carter, DB; Im, WB; Pregenzer, JF; Thomsen, DR | 1 |
| Ho, IK; Miyaoka, T; Tseng, YT | 1 |
| Canonaco, M; Franzoni, MF; Tavolaro, R | 1 |
| Duncalfe, LL; Dunn, SM | 1 |
| Pericić, D; Tvrdeić, A | 1 |
| González, MP; Oset-Gasque, MJ; Parramón, M | 1 |
| Harris, RA; Klein, RL; Mascia, MP; Whiting, PJ | 1 |
| Biggio, G; Ghiani, CA; Maciocco, E; Sanna, E; Serra, M; Tuligi, G | 1 |
| Brozowski, SJ; Hadingham, KL; Harris, RA; Whatley, VJ; Whiting, PJ | 1 |
| Sieghart, W; Slany, A; Zezula, J | 1 |
| Basile, AS; Ha, JH | 1 |
| Albin, RL; Caspary, DM; Milbrandt, JC; Turgeon, SM | 1 |
| Karle, J; Nielsen, M; Witt, MR | 1 |
| Crane, DI; Dodd, PR; McCloskey, A; Smith, ID; Thomas, GJ | 1 |
| Bennett, PJ; Simmonds, MA | 1 |
| al-Dahan, MI; Thalmann, RH | 1 |
| Braun, D; Chmielewski, PA; Kane, JM; Miller, JA | 1 |
| Araujo, F; Bentareha, R; Ruano, D; Vitorica, J | 1 |
| Dodd, PR; Harper, CG; Johnston, GA; Kril, JJ; Thomas, GJ; Watson, WE | 1 |
| Kivastik, T; Liljequist, S; Pokk, P; Sobol, D; Zharkovsky, A | 1 |
| Dodd, PR | 1 |
| Simmonds, MA; Zhong, Y | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Cardinali, DP; Golombek, DA; Kanterewicz, BI; Rosenstein, RE; Yannielli, PC | 1 |
| Brozowski, S; Hadingham, K; Harris, RA; Mihic, SJ; Whiting, PJ | 1 |
| Ford, E; Hagan, RM; Marshall, FH; Mullings, J; Oakley, NR; Stratton, SC; Worton, SP | 1 |
| Belluzzi, J; Gee, KW; Hawkinson, JE; Hogenkamp, D; Lan, NC; Stein, L; Upasani, R; Wieland, S; Wood, PL | 1 |
| Brozowski, S; Chuang, L; Hadingham, K; Harris, RA; Valenzuela, CF; Whiting, PJ | 1 |
| Harris, BD; Moody, EJ; Skolnick, P | 1 |
| Davies, M; Dunn, SM; Thuynsma, RP | 1 |
| Hartmann, J; Kettenmann, H; Labrakakis, C; Patt, S | 1 |
| Acosta-Burruel, M; Carter, RB; Chen, JS; Drewe, JA; Hawkinson, JE; Hogenkamp, DJ; Lan, NC; Upasani, RB; Whittemore, ER; Woodward, RM; Yang, KC | 1 |
| Chiu, TH; Li, M; Rosenberg, HC; Zhao, TJ | 1 |
| Bailey, CD; Brien, JF; Reynolds, JN | 1 |
| Hatanaka, T; Katayama, K; Koizumi, T; Srivastava, K | 1 |
| Chistina Grobin, A; Devaud, LL; Inglefield, JR; Morrow, AL; Schwartz-Bloom, RD | 1 |
| Chiu, TH; Li, M; Rosenberg, HC; Walsh, LA; Zhao, TJ | 1 |
| Giompres, P; Kouvelas, ED; Mitsacos, A; Stasi, K; Triarhou, LC | 1 |
| Ai, J; Kahnberg, P; Nielsen, M; Saederup, E; Squires, RF; Sterner, O; Witt, MR | 1 |
| Ho, IK; Jang, CG; Ma, T; Oh, S | 1 |
| Bargas, J; Brailowsky, S; Calixto, E; Casasola, C; López-Colomé, AM; Montiel, T | 1 |
| Cleton, A; Danhof, M; Ghijsen, W; Odman, J; Van der Graaf, PH; Voskuyl, R | 1 |
| Burton, G; Dodd, RH; Furtmüller, R; Ghini, AA; Nicoletti, D; Sieghart, W | 1 |
| Choi, HS; Kim, HS; Lee, SY; Oh, S | 1 |
| Buckley, ST; Dodd, PR; Eckert, AL | 1 |
| Hwang, SL; Kim, HS; Nah, SY; Oh, S | 1 |
| Ai, J; Nielsen, M; Wang, X | 1 |
| Baufreton, J; Bioulac, B; Dovero, S; Dufy, B; Garret, M; Taupignon, A | 1 |
| Grobin, AC; Morrow, AL | 1 |
| Kitazumi, K; Mori, M; Noguchi, H; Shiba, T | 1 |
| Araki, T; Fujihara, K; Imai, Y; Itoyama, Y; Kato, H; Matsubara, M | 1 |
| Bauman, ML; Blatt, GJ; Booker, AB; Fitzgerald, CM; Guptill, JT; Kemper, TL | 1 |
| Gillardin, J; Pansart, Y; Verleye, M | 1 |
| Hodge, CW; Homanics, GE; Khisti, RT; Kralic, JE; Morrow, AL; O'Buckley, TK | 1 |
| Jang, SY; Kim, Y; Oh, S | 1 |
| Ambardekar, AV; Ilinsky, IA; Kultas-Ilinsky, K; Parts, K; Surin, A | 1 |
| Ahboucha, S; Butterworth, RF; Chatauret, N; Desjardins, P; Pomier-Layrargues, G | 1 |
| Jang, S; Kim, EY; Oh, S; Shin, KM | 1 |
| Dubiela, FP; Hipólide, DC; Moreira, KM; Nobrega, JN; Oliveira, MG; Tufik, S | 1 |
| Ahboucha, S; Araqi, F; Butterworth, RF; Layrargues, GP | 1 |
| Abuhamdah, S; Chazot, PL; Fürstner, A; Lees, G | 1 |
| Bujons, J; García, DA; Suñol, C; Vale, C | 1 |
| Feria, A; González-Ramírez, M; Orozco, S; Rocha, L; Salgado, H | 1 |
| Ahboucha, S; Butterworth, RF; Mamer, O; Pomier-Layrargues, G | 1 |
| Feria Velasco, A; González Ramírez, M; Orozco Suárez, S; Rocha, L; Salgado Ceballos, H | 1 |
| Hinton, T; Johnston, GA; O'Reilly, JN; Skilbeck, KJ | 2 |
| Jembrek, MJ; Pericić, D; Strac, DS; Vlainić, J | 1 |
| Bavro, VN; Chan, SL; Chau, PL; Dunn, SM; Martin, IL; Mizuguchi, K; Mokrab, Y; Todorov, NP | 1 |
| Fan, LW; Ho, IK; Loh, HH; Ma, T; Tien, LT | 1 |
| Balon, N; Drolet, G; Genest, SE; Kinkead, R; Laforest, S | 1 |
| Jazvinsćak Jembrek, M; Pericić, D; Svob Strac, D; Vlainić, J | 2 |
| Blatt, GJ; Gibbs, TT; Oblak, A | 1 |
| Lonstein, JS; Miller, SM | 1 |
| Ha, RR; Hong, SI; Jang, CG; Jung, YH; Kim, SY; Kwon, SH; Lee, KH; Lee, SY | 1 |
| Burton, G; Coirini, H; Ghini, AA; Kruse, MS; Rey, M; Veleiro, AS | 1 |
4 review(s) available for muscimol and flunitrazepam
| Article | Year |
|---|---|
Benzodiazepine receptors resolved.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Clonazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Histocytochemistry; Humans; Immunologic Techniques; Ionophores; Muscimol; Neurons; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Spinal Cord; Synapses; Tissue Distribution | 1986 |
GABA receptor associated drug receptors.
Topics: Animals; Brain; Etazolate; Flunitrazepam; Kinetics; Muscimol; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1981 |
GABA and benzodiazepine receptors. Studies on their localization in the hippocampus and their interaction with central dopamine neurons in the rat brain.
Topics: Animals; Brain; Dopamine; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Muscimol; Neural Pathways; Neurons; Neurons, Afferent; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1981 |
Biochemical pharmacology of the GABA receptor-ionophore protein complex.
Topics: Animals; Brain; Chlorides; Flunitrazepam; Humans; Ion Channels; Ionophores; Kinetics; Muscimol; Nerve Tissue Proteins; Picrotoxin; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Neurotransmitter; Sesterterpenes | 1983 |
264 other study(ies) available for muscimol and flunitrazepam
| Article | Year |
|---|---|
Ontogeny of GABA and benzodiazepine receptors: effects of Triton X-100, bromide and muscimol.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Bromides; Cerebellum; Female; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Oxazoles; Polyethylene Glycols; Pregnancy; Rats; Receptors, Drug | 1979 |
Solubilization of histamine H-1, GABA and benzodiazepine receptors.
Topics: Animals; Binding, Competitive; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Pyrilamine; Rats; Receptors, Drug; Receptors, Histamine; Receptors, Histamine H1 | 1979 |
THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Drug | 1979 |
Quantitative immunoprecipitation studies with anti-gamma-aminobutyric acidA receptor gamma 2 1-15 Cys antibodies.
Topics: Amino Acid Sequence; Animals; Antibodies; Binding Sites; Brain; Cattle; Flunitrazepam; Molecular Sequence Data; Muscimol; Peptide Fragments; Precipitin Tests; Receptors, GABA-A; Tissue Distribution | 1992 |
Localization of GABAA receptor subtypes in the tiger salamander retina.
Topics: Ambystoma; Animals; Antibodies, Monoclonal; Autoradiography; Binding Sites; Dark Adaptation; Flunitrazepam; Goldfish; Immunoenzyme Techniques; Muscimol; Receptors, GABA-A; Retina | 1992 |
Regional distribution and kinetics of three sites on the GABAA receptor: lack of effect of portacaval shunting.
Topics: Animals; Autoradiography; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Flumazenil; Flunitrazepam; Image Processing, Computer-Assisted; Kinetics; Male; Muscimol; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tissue Distribution | 1992 |
Effects of acute pentobarbital administration on GABAA receptor-regulated chloride uptake in rat brain synaptoneurosomes.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chlorides; Flunitrazepam; Male; Muscimol; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1992 |
Effect of free fatty acids on GABAA receptor ligand binding.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Nonesterified; Flunitrazepam; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1992 |
Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors.
Topics: Anesthetics; Animals; Barbiturates; Base Sequence; Bicuculline; Cell Line, Transformed; Cell Membrane; Chloride Channels; Diazepam; Electrophysiology; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hypothalamus; Membrane Proteins; Mice; Molecular Sequence Data; Muscimol; Neurons; Peptides; Polymerase Chain Reaction; Receptors, GABA-A; RNA, Messenger; Sensitivity and Specificity; Steroids; Tritium; Tumor Cells, Cultured; Zinc | 1992 |
Dietary choline supplementation increases the density of nicotine binding sites in rat brain.
Topics: Administration, Oral; Animals; Binding Sites; Brain; Choline; Dose-Response Relationship, Drug; Flunitrazepam; Male; Muscimol; Nicotine; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1992 |
Muscimol and flunitrazepam binding sites in a subcellular fraction enriched in rat cerebellar glomeruli.
Topics: Animals; Binding Sites; Cerebellum; Flunitrazepam; Muscimol; Rats; Receptors, GABA-A; Synapses | 1992 |
[3H]muscimol and [3H]flunitrazepam binding sites in the developing cerebellum of mice treated with methylazoxymethanol at different postnatal ages.
Topics: Animals; Binding Sites; Cerebellum; Flunitrazepam; Glutamate Decarboxylase; Methylazoxymethanol Acetate; Mice; Mitosis; Muscimol; Receptors, GABA-A; Synapses | 1992 |
Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles.
Topics: Administration, Inhalation; Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Muscimol; Neurons; Radioligand Assay; Receptors, GABA-A; Synaptic Membranes; Synaptic Vesicles | 1992 |
Muscimol-induced reduction of GABAA receptor alpha 1-subunit mRNA in primary cultured cerebral cortical neurons.
Topics: Animals; Bicuculline; Blotting, Northern; Cells, Cultured; Cerebral Cortex; Flunitrazepam; Mice; Muscimol; Neurons; Peptide Fragments; Receptors, GABA-A; Ribonucleases; RNA, Messenger | 1992 |
Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding.
Topics: Anesthetics; Animals; Anticonvulsants; Autoradiography; Benzodiazepinones; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam; Electroshock; Ethanol; Female; Flunitrazepam; Male; Muscimol; Orchiectomy; Ovariectomy; Pentylenetetrazole; Pregnanediones; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Sex Characteristics | 1992 |
Ontogeny of GABAA/benzodiazepine receptor subunit mRNAs in the murine inferior olive: transient appearance of beta 3 subunit mRNA and [3H]muscimol binding sites.
Topics: Animals; Autoradiography; Base Sequence; Flunitrazepam; In Situ Hybridization; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Muscimol; Olivary Nucleus; Peptide Fragments; Radioligand Assay; Receptors, Cell Surface; Receptors, GABA-A; RNA Probes; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 1992 |
Isolation and characterization of endogenous modulators for GABA system.
Topics: Animals; Brain Chemistry; Cations, Divalent; Cell Membrane; Drug Stability; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Molecular Weight; Muscimol; Pyrrolidonecarboxylic Acid; Swine | 1992 |
Interaction of zonisamide with benzodiazepine and GABA receptors in rat brain.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Flunitrazepam; Isoxazoles; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Synaptic Membranes; Zonisamide | 1990 |
The GABAA receptor complex in experimental absence seizures in rat: an autoradiographic study.
Topics: Animals; Autoradiography; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; Convulsants; Epilepsy, Absence; Flunitrazepam; GABA-A Receptor Antagonists; Ion Channels; Ionophores; Male; Membrane Proteins; Muscimol; Organ Specificity; Pyramidal Tracts; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Sulfur Radioisotopes; Tritium | 1992 |
gamma-Aminobutyric acid-activated chloride channels in rats selectively bred for differential acute sensitivity to alcohol.
Topics: Alcohol Drinking; Animals; Chloride Channels; Diazepam; Female; Flunitrazepam; gamma-Aminobutyric Acid; Membrane Proteins; Muscimol; Pentobarbital; Phenobarbital; Phenotype; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Selection, Genetic | 1991 |
Ethanol-induced alterations in the function of cerebral GABAA receptor complex: effect on GABA-dependent 36Cl- influx into cerebral membrane vesicles.
Topics: Animals; Brain; Chloride Channels; Chlorides; Culture Techniques; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Isoquinolines; Membrane Proteins; Mice; Muscimol; Radioligand Assay; Receptors, GABA-A; Synaptic Membranes; Synaptic Vesicles | 1991 |
Peptide heterogeneity of GABAA/benzodiazepine receptors in bovine cerebral cortex and cerebellum.
Topics: Animals; Cattle; Cell Membrane; Cerebellum; Cerebral Cortex; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Molecular Weight; Muscimol; Organ Specificity; Peptide Mapping; Receptors, GABA-A | 1991 |
Taurine acts on a subclass of GABAA receptors in mammalian brain in vitro.
Topics: Affinity Labels; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Flunitrazepam; In Vitro Techniques; Muscimol; Photochemistry; Rats; Receptors, GABA-A; Taurine | 1991 |
Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Brain; Cell Line; Flunitrazepam; Humans; Kinetics; Macromolecular Substances; Muscimol; Pregnanediones; Pregnanes; Progesterone; Rats; Receptors, GABA-A; Recombinant Proteins; Spinal Cord; Transfection | 1991 |
Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.
Topics: Animals; Benzodiazepines; Carbolines; Chloride Channels; Chlorides; Convulsants; Ethanol; Flunitrazepam; Genetic Predisposition to Disease; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Muscimol; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome | 1991 |
Pre- and postnatal development of GABA receptors in Macaca monkey visual cortex.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Binding Sites; Corpus Striatum; Embryonic and Fetal Development; Flunitrazepam; Macaca nemestrina; Muscimol; Receptors, GABA-A; Visual Cortex | 1991 |
Receptor binding and electrophysiological effects of dehydroepiandrosterone sulfate, an antagonist of the GABAA receptor.
Topics: Animals; Barbiturates; Binding, Competitive; Brain; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Depression, Chemical; Flunitrazepam; GABA-A Receptor Antagonists; Male; Membrane Lipids; Membrane Proteins; Muscimol; Protein Binding; Rats; Rats, Inbred F344; Receptors, GABA-A; Steroids | 1991 |
The GABAA receptor family in the mammalian brain.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Blotting, Western; Brain Chemistry; Cattle; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Humans; Molecular Sequence Data; Molecular Weight; Muscimol; Peptide Fragments; Photochemistry; Rats; Receptors, GABA-A; Serine Endopeptidases | 1991 |
Effects of methylazoxymethanol treatment on the GABAergic synaptosomes in the P2 fraction from developing mouse cerebellum.
Topics: Animals; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Methylazoxymethanol Acetate; Mice; Muscimol; Receptors, GABA-A; Synaptosomes | 1991 |
A transient osmotic permeabilization method for the introduction of impermeant molecules into functional brain membrane vesicles.
Topics: Alkaline Phosphatase; Animals; Capsules; Carbon Radioisotopes; Cell Membrane; Cell Membrane Permeability; Chloride Channels; Chlorides; Chlorine; Concanavalin A; Flunitrazepam; Hypotonic Solutions; Membrane Proteins; Mice; Mice, Inbred ICR; Muscimol; Pyridazines; Radioisotope Dilution Technique; Radioisotopes; Receptors, Concanavalin A; Receptors, GABA-A; Sucrose; Tritium | 1991 |
Role of cGMP in the mechanism of anxiolytic activity of U-78875.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain Chemistry; Carbolines; Cerebellum; Convulsants; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Electroshock; Flunitrazepam; Male; Mice; Muscimol; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Strains; Stress, Psychological | 1991 |
Characterization and differential regulation of GABAA and benzodiazepine receptors in rat neocortex.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Clonazepam; Down-Regulation; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Muscimol; Pyridazines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium; Veratridine | 1991 |
The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Brain; Cerebral Cortex; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Imidazoles; Kidney; Male; Medetomidine; Muscimol; Myocardium; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Stimulation, Chemical; Stress, Physiological; Tritium | 1991 |
Chronic morphine administration augments benzodiazepine binding and GABAA receptor function.
Topics: Animals; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Chlorine; Flunitrazepam; In Vitro Techniques; Ion Channels; Male; Mice; Morphine; Muscimol; Naltrexone; Radioisotopes; Receptors, GABA-A; Sulfur Radioisotopes | 1990 |
Pharmacological and biochemical properties of the gamma-aminobutyric acid-benzodiazepine receptor protein from codfish brain.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Fishes; Flunitrazepam; gamma-Aminobutyric Acid; Ivermectin; Kinetics; Muscimol; Receptors, GABA-A; Tritium | 1991 |
Pharmacologic characterization of GABAA/benzodiazepine receptor in rat hippocampus during aging.
Topics: Aging; Animals; Binding Sites; Cerebellum; Cerebral Cortex; Culture Techniques; Drug Interactions; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Muscimol; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Peptide subunits of gamma-aminobutyric acidA/benzodiazepine receptors from bovine cerebral cortex.
Topics: Affinity Labels; Animals; Cattle; Cerebral Cortex; Flunitrazepam; Glycosylation; Muscimol; Neuropeptides; Peptide Fragments; Peptide Mapping; Precipitin Tests; Receptors, GABA-A | 1991 |
Characterization of recombinant GABAA receptors produced in transfected cells from murine alpha 1, beta 1, and gamma 2 subunit cDNAs.
Topics: Animals; Binding Sites; Cell Line; DNA; Electrophysiology; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ligands; Mice; Muscimol; Receptors, GABA-A; Recombinant Proteins; Transfection | 1991 |
Neurochemical action of the general anaesthetic propofol on the chloride ion channel coupled with GABAA receptors.
Topics: Anesthetics; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; Flunitrazepam; Male; Membrane Proteins; Muscimol; Propofol; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Effects of GABA and anxiolytics on the single unit discharge of suprachiasmatic neurons in rat hypothalamic slices.
Topics: Animals; Anti-Anxiety Agents; Azabicyclo Compounds; Baclofen; Bicuculline; Diazepam; Flunitrazepam; gamma-Aminobutyric Acid; Hypothalamus; In Vitro Techniques; Muscimol; Neurons; Piperazines; Rats; Receptors, GABA-A; Suprachiasmatic Nucleus | 1990 |
Chronic agonist exposure induces down-regulation and allosteric uncoupling of the gamma-aminobutyric acid/benzodiazepine receptor complex.
Topics: Allosteric Regulation; Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chick Embryo; Down-Regulation; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Muscimol; Pyridazines; Receptors, GABA-A | 1990 |
Effect of prenatal and neonatal chronic exposure to phenobarbital on central and peripheral benzodiazepine receptors.
Topics: Aging; Animals; Brain; Female; Flunitrazepam; Male; Mice; Muscimol; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, GABA-A | 1990 |
The GABAA receptor complex in hepatic encephalopathy. Autoradiographic evidence for the presence of elevated levels of a benzodiazepine receptor ligand.
Topics: Animals; Autoradiography; Brain; Flunitrazepam; Galactosamine; Hepatic Encephalopathy; Muscimol; Organ Specificity; Rabbits; Receptors, GABA-A; Reference Values; Sodium Chloride; Tritium; Up-Regulation | 1990 |
Multiple distinct subunits of the gamma-aminobutyric acid-A receptor protein show different ligand-binding affinities.
Topics: Affinity Labels; Animals; Binding, Competitive; Brain; Cattle; Electrophoresis; Flunitrazepam; Humans; Ligands; Muscimol; Peptides; Rats; Receptors, GABA-A; Species Specificity | 1990 |
Thymopentin antagonizes stress-induced changes of GABA/benzodiazepine receptor complex.
Topics: Animals; Behavior, Animal; Corticosterone; Exploratory Behavior; Flunitrazepam; Hippocampus; Male; Muscimol; Peptide Fragments; Physical Exertion; Rats; Receptors, GABA-A; Stress, Physiological; Swimming; Thymopentin; Thymopoietins; Thymus Hormones | 1990 |
GABA and benzodiazepine receptors in the cat motor thalamus after lesioning of nigro- and pallidothalamic pathways.
Topics: Animals; Cats; Flunitrazepam; Globus Pallidus; Kainic Acid; Muscimol; Neural Pathways; Receptors, GABA-A; Substantia Nigra; Thalamus | 1990 |
Functional modulation of cerebral gamma-aminobutyric acidA receptor/benzodiazepine receptor/chloride ion channel complex with ethyl beta-carboline-3-carboxylate: presence of independent binding site for ethyl beta-carboline-3-carboxylate.
Topics: Animals; Baclofen; Binding Sites; Brain; Carbolines; Cells, Cultured; Chloride Channels; Chlorides; Drug Interactions; Flunitrazepam; Male; Membrane Proteins; Mice; Muscimol; Receptors, GABA-A; Tritium | 1990 |
Stress induced alterations in striatal GABAA receptor complex.
Topics: Animals; Cold Temperature; Corpus Striatum; Flunitrazepam; Kinetics; Male; Muscimol; Postural Balance; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reflex; Restraint, Physical; Secobarbital; Stress, Psychological | 1990 |
Quantitative autoradiography reveals selective changes in cerebellar GABA receptors of the rat mutant dystonic.
Topics: Animals; Autoradiography; Cerebellar Nuclei; Dystonia; Flunitrazepam; Muscimol; Rats; Rats, Mutant Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Serotonin | 1990 |
Distribution and plasticity of immunocytochemically localized GABAA receptors in adult monkey visual cortex.
Topics: Animals; Autoradiography; Flunitrazepam; Immunoenzyme Techniques; Macaca fascicularis; Macaca mulatta; Muscimol; Neurons; Receptors, GABA-A; Tritium; Visual Cortex | 1990 |
Binding interactions of convulsant and anticonvulsant gamma-butyrolactones and gamma-thiobutyrolactones with the picrotoxin receptor.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Convulsants; Female; Flunitrazepam; Furans; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds; Tritium | 1990 |
Taurine allosterically modulates binding sites of the GABAA receptor.
Topics: Allosteric Regulation; Animals; Bicuculline; Flunitrazepam; In Vitro Techniques; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Taurine; Temperature | 1990 |
Antibodies recognising the GABAA/benzodiazepine receptor including its regulatory sites.
Topics: Allosteric Regulation; Animals; Antibodies; Antibody Specificity; Antigens; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cattle; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Epitopes; Flunitrazepam; Immunologic Techniques; Immunosorbent Techniques; Muscimol; Receptors, GABA-A | 1986 |
Action of tremorgenic mycotoxins on GABAA receptor.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Electric Organ; Flunitrazepam; In Vitro Techniques; Ion Channels; Male; Muscimol; Mycotoxins; Rats; Rats, Inbred Strains; Receptors, GABA-A; Torpedo; Tremor | 1987 |
Chronic benzodiazepine administration. II. Discontinuation syndrome is associated with upregulation of gamma-aminobutyric acidA receptor complex binding and function.
Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Drug Tolerance; Flumazenil; Flunitrazepam; Ion Channels; Lorazepam; Male; Mice; Motor Activity; Muscimol; Receptors, GABA-A; Time Factors | 1988 |
Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex.
Topics: Animals; Ataxia; Chlorides; Diazepam; Ethanol; Flunitrazepam; Ion Channels; Isoxazoles; Mice; Muscimol; Phenobarbital; Receptors, GABA-A; Time Factors | 1988 |
Sensitivity to ethanol hypnosis and modulation of chloride channels does not cosegregate with pentobarbital sensitivity in HS mice.
Topics: Animals; Arousal; Brain; Chloride Channels; Chlorides; Dose-Response Relationship, Drug; Drug Tolerance; Ethanol; Flunitrazepam; Ion Channels; Male; Membrane Proteins; Mice; Muscimol; Pentobarbital; Receptors, GABA-A; Sleep Stages | 1989 |
Genetic differences in coupling of benzodiazepine receptors to chloride channels.
Topics: Animals; Cerebral Cortex; Chloride Channels; Chlorides; Ethanol; Flunitrazepam; Ion Channels; Male; Membrane Proteins; Mice; Muscimol; Receptors, GABA-A; Sleep | 1989 |
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mice, Quaking; Muscimol; Receptors, GABA-A; Telencephalon | 1989 |
Transmembrane topology of the gamma-aminobutyric acidA/benzodiazepine receptor: subcellular distribution and allosteric coupling determined in situ.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Cell Membrane; Cells, Cultured; Chick Embryo; Flunitrazepam; Muscimol; Neurons; Receptors, GABA-A; Trypsin | 1989 |
Distribution and pharmacological properties of the GABAA/benzodiazepine/chloride ionophore receptor complex in the brain of the fish Anguilla anguilla.
Topics: Anguilla; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; Ionophores; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, GABA-A; Tissue Distribution | 1989 |
Effects of picrotoxin treatment on GABAA receptor supramolecular complexes in rat brain.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Flunitrazepam; Male; Muscimol; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution | 1989 |
Type I and type II gamma-aminobutyric acid/benzodiazepine receptors: purification and analysis of novel receptor complex from neonatal cortex.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Muscimol; Osmolar Concentration; Peptide Mapping; Rats; Receptors, GABA-A; Spinal Cord; Tritium | 1989 |
Two forms of the GABAA receptor distinguished by anion-exchange chromatography.
Topics: Animals; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Flunitrazepam; Muscimol; Octoxynol; Polyethylene Glycols; Potassium Chloride; Pyridazines; Rats; Receptors, GABA-A; Solubility | 1989 |
Evidence for the existence of several different alpha- and beta-subunits of the GABA/benzodiazepine receptor complex from rat brain.
Topics: Affinity Labels; Animals; Blotting, Western; Brain; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Immunoenzyme Techniques; Muscimol; Rats; Receptors, GABA-A | 1989 |
Immobilized GABAA receptors and their ligand binding characteristics.
Topics: Animals; Cerebral Cortex; Concanavalin A; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Muscimol; Polylysine; Rats; Receptors, GABA-A; Solubility | 1989 |
Central- and peripheral-type benzodiazepine receptors: similar regulation by stress and GABA receptor agonists.
Topics: Animals; Anxiety; Baclofen; Behavior, Animal; Benzodiazepinones; Binding Sites; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Kidney; Male; Mice; Muscimol; Myocardium; Rats; Receptors, GABA-A; Stress, Physiological | 1989 |
The modulation by chlormethiazole of the GABAA-receptor complex in rat brain.
Topics: Animals; Baclofen; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlormethiazole; CLC-2 Chloride Channels; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Picrotoxin; Rats; Receptors, GABA-A | 1989 |
Chronic phenobarbital administration affects GABA and benzodiazepine receptors in the brain and periphery.
Topics: Animals; Brain Chemistry; Flunitrazepam; Hippocampus; In Vitro Techniques; Isoquinolines; Kidney; Male; Membranes; Mice; Muscimol; Myocardium; Olfactory Bulb; Peripheral Nerves; Phenobarbital; Receptors, GABA-A | 1989 |
Gamma-aminobutyric acid and benzodiazepine receptors in cultured cerebellar granule cells: effects of taurine and its lipophilic derivatives.
Topics: Animals; Cells, Cultured; Cerebellum; Chemical Phenomena; Chemistry, Physical; Flunitrazepam; Lipids; Muscimol; Phenytoin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Taurine | 1989 |
Persistent alterations in GABAA receptor binding and function after prenatal lorazepam administration in the chick.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; Chickens; Chlorides; Female; Flunitrazepam; Lorazepam; Muscimol; Pregnancy; Prenatal Exposure Delayed Effects; Radioligand Assay; Receptors, GABA-A | 1989 |
Chronic phenytoin treatment decreases GABAA but not beta-adrenoceptors in the cerebellum of young rats.
Topics: Adrenergic beta-Antagonists; Animals; Autoradiography; Cerebellum; Female; Flunitrazepam; Kinetics; Muscimol; Phenytoin; Pindolol; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, GABA-A; Tritium | 1989 |
Characteristics of flunitrazepam binding to intact primary cultured spinal cord neurons and its modulation by GABAergic drugs.
Topics: Animals; Benzodiazepines; Binding, Competitive; Carbolines; Cells, Cultured; Embryo, Mammalian; Etazolate; Etomidate; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred C57BL; Muscimol; Neurons; Pentobarbital; Receptors, GABA-A; Spinal Cord | 1987 |
Heterogeneity of gamma-aminobutyric acid/benzodiazepine/beta-carboline receptor complex in rat spinal cord.
Topics: Animals; Bicuculline; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Rats; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1988 |
Effects of chronic cortical seizures on GABA and benzodiazepine receptors within seizure pathways.
Topics: Animals; Brain; Cerebral Cortex; Electric Stimulation; Flunitrazepam; Male; Models, Neurological; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1988 |
Bicuculline up-regulation of GABAA receptors in rat brain.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Corpus Striatum; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Male; Muscimol; Octoxynol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra; Synaptic Membranes | 1988 |
gamma-Aminobutyric acid/benzodiazepine receptor protein carries binding sites for both ligands on both two major peptide subunits.
Topics: Affinity Labels; Animals; Binding Sites; Cattle; Flunitrazepam; Humans; Ligands; Macromolecular Substances; Molecular Weight; Muscimol; Photochemistry; Rats; Receptors, GABA-A | 1988 |
Increased binding of [3H]muscimol and [3H]flunitrazepam in the rat brain under hypoxia.
Topics: Animals; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Corpus Striatum; Flunitrazepam; Glutamate Decarboxylase; Hippocampus; Hypoxia, Brain; Kinetics; Male; Muscimol; Octoxynol; Polyethylene Glycols; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Distribution and binding parameters of GABA and benzodiazepine receptors in the cat motor thalamus and adjacent nuclear groups.
Topics: Animals; Autoradiography; Baclofen; Cats; Female; Flunitrazepam; Image Processing, Computer-Assisted; Kinetics; Male; Muscimol; Receptors, GABA-A; Thalamic Nuclei; Thalamus | 1988 |
Quantitative autoradiography of major neurotransmitter receptors in the monkey striate and extrastriate cortex.
Topics: Animals; Autoradiography; Cerebral Cortex; Clonidine; Female; Flunitrazepam; Ketanserin; Macaca mulatta; Male; Muscimol; Pindolol; Prazosin; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Neurotransmitter; Serotonin; Spiperone; Visual Cortex | 1988 |
Behavioral differences in an elevated plus-maze: correlation between anxiety and decreased number of GABA and benzodiazepine receptors in mouse cerebral cortex.
Topics: Animals; Anxiety; Brain; Carbolines; Cerebral Cortex; Diazepam; Exploratory Behavior; Flunitrazepam; Male; Mice; Muscimol; Receptors, GABA-A | 1988 |
Antibodies directed against a nonapeptide sequence of the gamma-aminobutyrate (GABA)/benzodiazepine receptor alpha-subunit. Detection of a distinct alpha-like subunit in pig cerebral cortex but not cerebellum.
Topics: Affinity Labels; Animals; Brain Chemistry; Cerebellum; Cerebral Cortex; Chemical Precipitation; Flunitrazepam; Immunoblotting; Muscimol; Peptides; Receptors, GABA-A; Swine | 1988 |
Effects of hypoxia on muscarinic cholinergic and benzodiazepine/gamma-aminobutyric acid receptors in the rat brain.
Topics: Animals; Brain; Choline O-Acetyltransferase; Flunitrazepam; Glutamate Decarboxylase; Hypoxia; Kinetics; Male; Muscimol; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Muscarinic; Reference Values | 1988 |
Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy.
Topics: Animals; Benzodiazepines; Flumazenil; Flunitrazepam; GABA Antagonists; Galactosamine; Hepatic Encephalopathy; Ligands; Male; Muscimol; Purkinje Cells; Rabbits; Receptors, GABA-A | 1988 |
Actions of avermectin B1a on the gamma-aminobutyric acidA receptor and chloride channels in rat brain.
Topics: Animals; Bicuculline; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Chlorides; Dose-Response Relationship, Drug; Flunitrazepam; Ivermectin; Kinetics; Male; Membrane Proteins; Muscimol; Rats; Receptors, GABA-A | 1986 |
gamma-Aminobutyric acid: temperature dependence in benzodiazepine receptor binding.
Topics: Animals; Anti-Anxiety Agents; Cell Membrane; Diencephalon; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Muscimol; Receptors, GABA-A; Telencephalon; Temperature | 1985 |
Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.
Topics: Alzheimer Disease; Aspartic Acid; Autoradiography; Flunitrazepam; Glutamates; Glutamic Acid; Hippocampus; Histocytochemistry; Humans; Muscimol; N-Methylaspartate; Receptors, GABA-A; Receptors, Muscarinic; Tissue Distribution | 1987 |
Development of gamma-aminobutyric acid (GABA)ergic neurons in cerebral cortical neurons in primary culture.
Topics: 4-Aminobutyrate Transaminase; Animals; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Histocytochemistry; Immunoenzyme Techniques; Mice; Microscopy, Electron, Scanning; Muscimol; Receptors, GABA-A; Time Factors | 1987 |
Alcohol, acetaldehyde and salsolinol-induced alterations in functions of cerebral GABA/benzodiazepine receptor complex.
Topics: 4-Aminobutyrate Transaminase; Acetaldehyde; Acetylcholinesterase; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Ethanol; Flunitrazepam; Glutamate Decarboxylase; Glutamates; Glutamic Acid; In Vitro Techniques; Isoquinolines; Mice; Muscimol; Receptors, GABA-A | 1987 |
Functional coupling of gamma-aminobutyric acid (GABA)A and benzodiazepine type II receptors: analysis using purified GABA/benzodiazepine receptor complex from bovine cerebral cortex.
Topics: Animals; Antipsychotic Agents; Bicuculline; Cattle; Cerebral Cortex; Flumazenil; Flunitrazepam; In Vitro Techniques; Kinetics; Muscimol; Pyridazines; Receptors, GABA-A | 1987 |
Interactions of ACTH4-10 and ACTH1-24 with L-[3H]glutamate binding sites and GABA/benzodiazepine/picrotoxin receptor complexes in vitro.
Topics: Adrenocorticotropic Hormone; Animals; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flunitrazepam; Glutamates; Glutamic Acid; Male; Muscimol; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
Effect of GABA agonists on the neurotoxicity and anticonvulsant activity of benzodiazepines.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Synergism; Electroshock; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Nervous System; Receptors, GABA-A | 1985 |
Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex.
Topics: Animals; Barbiturates; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Carbolines; Cell Membrane; Chlorides; Diazepam; Flumazenil; Flunitrazepam; Ionophores; Male; Molecular Weight; Muscimol; Picrotoxin; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
On the location of gamma-aminobutyrate and benzodiazepine receptors in the cerebellum of the normal C3H and Lurcher mutant mouse.
Topics: Animals; Autoradiography; Brain Stem; Cerebellum; Flunitrazepam; Male; Mice; Mice, Inbred C3H; Mice, Neurologic Mutants; Muscimol; Receptors, GABA-A | 1985 |
Gamma-aminobutyric acid and benzodiazepine receptor changes induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundle.
Topics: Animals; Autoradiography; Benzodiazepines; Brain; Dopamine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Flunitrazepam; Hydroxydopamines; Kinetics; Muscimol; Naloxone; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spiperone; Tritium | 1985 |
gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study.
Topics: Animals; Binding Sites; Epilepsy; Flunitrazepam; Histocytochemistry; Kindling, Neurologic; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tissue Distribution; Tritium | 1985 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; Muscimol; Pentobarbital; Receptors, GABA-A; Seizures | 1985 |
Benzodiazepine binding sites in mice forebrain and kidneys: evidence for similar regulation by GABA agonists.
Topics: Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Kidney; Male; Mice; Muscimol; Receptors, GABA-A | 1986 |
Ontogeny of the GABA receptor complex in chick brain: studies in vivo and in vitro.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chick Embryo; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Receptors, GABA-A | 1986 |
gamma-Aminobutyric acid, benzodiazepine binding sites and gamma-aminobutyric acid concentrations in epileptic E1 mouse brain.
Topics: Animals; Binding Sites; Brain; Epilepsy; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains; Muscimol; Receptors, GABA-A | 1985 |
Isolation of the gamma-aminobutyric acid/benzodiazepine receptor.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Chromatography, Affinity; Flunitrazepam; Isoelectric Point; Molecular Weight; Muscimol; Radioimmunoassay; Rats; Receptors, GABA-A | 1985 |
Regional difference in brain benzodiazepine receptor carbohydrates.
Topics: Acetylglucosaminidase; Animals; Asparagine; Benzodiazepinones; Brain Chemistry; Carbohydrates; Electrophoresis, Polyacrylamide Gel; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Molecular Weight; Muscimol; Neuraminidase; Pentobarbital; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sialic Acids; Tritium | 1986 |
The gamma-aminobutyrate/benzodiazepine receptor from pig brain. Purification and characterization of the receptor complex from cerebral cortex and cerebellum.
Topics: Animals; Brain Chemistry; Cerebellum; Cerebral Cortex; Cholic Acids; Detergents; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Ligands; Muscimol; Octoxynol; Peptide Fragments; Polyethylene Glycols; Receptors, GABA-A; Swine | 1986 |
Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Tissue Distribution | 1986 |
Central- and peripheral-type benzodiazepine receptors.
Topics: Animals; Benzodiazepinones; Binding, Competitive; Brain; Clonazepam; Convulsants; Flunitrazepam; Kidney; Kinetics; Membranes; Muscimol; Rats; Receptors, GABA-A; Subcellular Fractions; Tissue Distribution | 1986 |
Structural analysis and localization of GABA/benzodiazepine/TBPS-receptor complex using monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Convulsants; Flunitrazepam; Humans; Immunoenzyme Techniques; Mice; Muscimol; Rats; Receptors, GABA-A; Sulfur Radioisotopes; Tritium | 1986 |
[3H]muscimol photolabels the gamma-aminobutyric acid receptor binding site on a peptide subunit distinct from that labeled with benzodiazepines.
Topics: Affinity Labels; Animals; Benzodiazepines; Binding Sites; Cattle; Cerebral Cortex; Flunitrazepam; In Vitro Techniques; Muscimol; Photochemistry; Receptors, GABA-A; Time Factors; Ultraviolet Rays | 1986 |
Heterogeneity of [3H]ethyl beta-carboline-3-carboxylate binding sites and [3H]gamma-aminobutyric acid binding sites.
Topics: Animals; Binding, Competitive; Carbolines; Cattle; Cerebral Cortex; Detergents; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Molecular Weight; Muscimol; Photolysis; Radioligand Assay; Receptors, GABA-A; Receptors, Neurotransmitter; Synaptosomes | 1986 |
Separate subunits for agonist and benzodiazepine binding in the gamma-aminobutyric acidA receptor oligomer.
Topics: Animals; Binding Sites; Brain; Cattle; Cell Membrane; Cerebral Cortex; Flunitrazepam; Kinetics; Molecular Weight; Muscimol; Receptors, GABA-A | 1986 |
Autoradiographic localization of subcomponents of the macromolecular GABA receptor complex.
Topics: Animals; Autoradiography; Baclofen; Bicuculline; Binding, Competitive; Brain Chemistry; Flunitrazepam; Macromolecular Substances; Muscimol; Rats; Receptors, GABA-A; Tissue Distribution; Tritium | 1986 |
GABA and benzodiazepine receptors in the gerbil brain after transient ischemia: demonstration by quantitative receptor autoradiography.
Topics: Animals; Autoradiography; Brain Chemistry; Flunitrazepam; Gerbillinae; Hippocampus; Ischemic Attack, Transient; Muscimol; Receptors, GABA-A; Tritium | 1987 |
Coexistence of GABA receptors and GABA-modulin in primary cultures of rat cerebellar granule cells.
Topics: Animals; Carrier Proteins; Cells, Cultured; Cerebellum; Flunitrazepam; Fluorescent Antibody Technique; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Histocytochemistry; Membrane Proteins; Membrane Transport Proteins; Muscimol; Nerve Tissue Proteins; Organic Anion Transporters; Radioimmunoassay; Rats; Receptors, GABA-A; Synaptosomes | 1987 |
Pyrethroid insecticides and radioligand displacement from the GABA receptor chloride ionophore complex.
Topics: Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; Male; Muscimol; Nitriles; Permethrin; Pyrethrins; Rats; Receptors, GABA-A | 1987 |
Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Desoxycorticosterone; Electric Conductivity; Ethanol; Evoked Potentials; Flunitrazepam; Muscimol; Pregnanes; Progesterone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Steroids; Structure-Activity Relationship | 1987 |
gamma-Aminobutyric acid receptor-regulated 36Cl- flux in mouse cortical slices.
Topics: Androstanes; Animals; Azasteroids; Barbiturates; Cerebral Cortex; Chlorides; Dose-Response Relationship, Drug; Electrophysiology; Flunitrazepam; Male; Mathematics; Mice; Muscimol; Receptors, GABA-A | 1987 |
The gamma-aminobutyric-acid/benzodiazepine-receptor protein from rat brain. Large-scale purification and preparation of antibodies.
Topics: Animals; Antibodies, Monoclonal; Brain Chemistry; Chromatography, Affinity; Flunitrazepam; Muscimol; Rabbits; Rats; Receptors, GABA-A; Solubility | 1987 |
Progress towards the understanding of the GABAA receptor structure.
Topics: Allosteric Site; Animals; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Cholic Acids; Deoxycholic Acid; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Protein Binding; Receptors, GABA-A | 1987 |
In vitro characterization of benzodiazepine receptor agonists, antagonists, inverse agonists and agonist/antagonists.
Topics: Animals; Brain; Chlorides; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Channels; Muscimol; Rats; Receptors, GABA-A | 1984 |
A study on benzodiazepine receptor binding in audiogenic seizure-susceptible rats.
Topics: Acoustic Stimulation; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Convulsants; Diazepam; Female; Flunitrazepam; In Vitro Techniques; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1984 |
Single class of muscimol binding sites in the solubilized gamma-aminobutyrate-benzodiazepine receptor complex.
Topics: Animals; Brain; Brain Chemistry; Cattle; Cerebral Cortex; Chromatography, Gel; Flunitrazepam; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Pentylenetetrazole; Picrotoxin; Rats; Seizures; Stress, Physiological; Thiosemicarbazones | 1980 |
Autoradiographic localization of binding sites for [3H]gamma-aminobutyrate, [3H]muscimol,(+)[3H]bicuculline methiodide and [3H] flunitrazepam in cultures of rat cerebellum and spinal cord.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Autoradiography; Bicuculline; Binding Sites; Cells, Cultured; Cerebellum; Female; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Oxazoles; Pregnancy; Rats; Receptors, Drug; Spinal Cord; Tritium | 1980 |
Action of pyrazolopyridines as modulators of [3H]flunitrazepam binding to the gaba/benzodiazepine receptor complex of the cerebellum.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Binding Sites; Cerebellum; Chlorides; Etazolate; Flunitrazepam; Isoxazoles; Male; Muscimol; Nicotinic Acids; Pyrazoles; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Tritium | 1981 |
gamma-Aminobutyric acid (GABA) receptor stimulation. II. Specificity of progabide (SL 76002) and SL 75102 for the GABA receptor.
Topics: Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Muscimol; Neurotransmitter Agents; Rabbits; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Anion-dependent modulation of [3H]muscimol binding and of GABA-stimulated [3H]flunitrazepam binding by picrotoxin and related CNS convulsants.
Topics: Animals; Anions; Anti-Anxiety Agents; Cerebral Cortex; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Oxazoles; Picrotoxin; Rats; Receptors, Drug; Receptors, GABA-A; Strychnine; Tubocurarine | 1982 |
Differential modulation of etazolate or pentobarbital enhanced [3H] muscimol binding by benzodiazepine agonists and inverse agonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cell Membrane; Cerebral Cortex; Convulsants; Etazolate; Flumazenil; Flunitrazepam; Kinetics; Muscimol; Nicotinic Acids; Oxazoles; Pentobarbital; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Determination of biological activity of adinazolam and its metabolites.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Bicuculline; Brain; Cell Membrane; Flunitrazepam; In Vitro Techniques; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1984 |
Soluble gamma-aminobutyric acid and benzodiazepine receptors from rat cerebral cortex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Mitochondria; Muscimol; Rats; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Solubility; Synaptosomes | 1981 |
Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study.
Topics: Aging; Animals; Autoradiography; Cerebellum; Clonazepam; Female; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A | 1981 |
Physicochemical characterization of detergent-solubilized gamma-aminobutyric acid and benzodiazepine receptor proteins from bovine brain.
Topics: Animals; Cattle; Centrifugation, Density Gradient; Cerebral Cortex; Chemical Phenomena; Chemistry, Physical; Chromatography, Gel; Deoxycholic Acid; Flunitrazepam; gamma-Aminobutyric Acid; Molecular Weight; Muscimol; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Solubility | 1982 |
Effects of agents which enhance GABA-mediated neurotransmission on licking conflict in rats and exploration in mice.
Topics: Animals; Conflict, Psychological; Diazepam; Exploratory Behavior; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nitrazepam; Rats; Rats, Inbred Strains; Synaptic Transmission; Urethane; Valproic Acid | 1982 |
Isolation of a GABA receptor from bovine brain using a benzodiazepine affinity column.
Topics: Animals; Cattle; Cell Membrane; Cerebral Cortex; Chromatography, Affinity; Clorazepate Dipotassium; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
The benzodiazepine/GABA receptor complex: molecular size in brain synaptic membranes and in solution.
Topics: Animals; Brain Chemistry; Cattle; Cerebral Cortex; Chromatography, Gel; Flunitrazepam; Male; Molecular Weight; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Drug; Receptors, GABA-A; Subcellular Fractions; Synaptic Membranes | 1982 |
Quantitative autoradiography of neurotransmitter receptors in Huntington disease.
Topics: Adult; Autoradiography; Brain; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Huntington Disease; Muscimol; Receptors, Amino Acid; Receptors, Drug; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Neurotransmitter | 1982 |
Characterization of the solubilized GABA and benzodiazepine receptors from various regions of bovine brain.
Topics: Animals; Benzodiazepines; Brain; Brain Chemistry; Cattle; Cerebellum; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Molecular Weight; Muscimol; Organ Specificity; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Molecular sizes of photolabeled GABA and benzodiazepine receptor proteins are identical.
Topics: Animals; Benzodiazepines; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Muscimol; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptosomes | 1983 |
A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex.
Topics: Animals; Benzodiazepines; Cattle; Cerebral Cortex; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Macromolecular Substances; Molecular Weight; Muscimol; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Group-selective reagent modification of the benzodiazepine-gamma-aminobutyric acid receptor-ionophore complex reveals that low-affinity gamma-aminobutyric acid receptors stimulate benzodiazepine binding.
Topics: Animals; Benzodiazepines; Cell Membrane; Cerebellum; Cerebral Cortex; Diazepam; Diazonium Compounds; Diethyl Pyrocarbonate; Flunitrazepam; Hippocampus; Male; Muscimol; Pentobarbital; Rats; Receptors, Cell Surface; Receptors, GABA-A; Sulfanilic Acids | 1983 |
[3H]muscimol binding site on purified benzodiazepine receptor.
Topics: Animals; Binding Sites; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Molecular Weight; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Effects of GABA receptor agonists on [3H] flunitrazepam binding to rat cerebellar and hippocampal membranes.
Topics: Animals; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Imidazoles; Male; Membranes; Muscimol; Piperidines; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Autoradiographic localization of binding sites for inhibitory amino acids and their antagonists in cultured rat CNS.
Topics: Amino Acids; Animals; Animals, Newborn; Autoradiography; Bicuculline; Brain Stem; Cells, Cultured; Cerebellum; Female; Fetus; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Neuroglia; Neurons; Pregnancy; Rats; Receptors, Cell Surface; Spinal Cord; Tritium | 1983 |
The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. II. Receptor binding.
Topics: Amygdala; Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Muscimol; Neural Inhibition; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Biochemical and functional alterations of central GABA receptors during chronic estradiol treatment.
Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Corpus Striatum; Estradiol; Female; Flunitrazepam; Hippocampus; Interneurons; Muscimol; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Transmission | 1983 |
Decreased high-affinity binding of [3H]muscimol to cerebral synaptic membranes of scrapie-infected mice.
Topics: Animals; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Muscimol; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A; Scrapie; Sheep; Synaptic Membranes | 1984 |
Early postnatal chlordiazepoxide administration: permanent behavioural effects in the mature rat and possible involvement of the GABA-benzodiazepine system.
Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Brain Chemistry; Chlordiazepoxide; Female; Flunitrazepam; Kinetics; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Ethanol and the gamma-aminobutyric acid-benzodiazepine receptor complex.
Topics: Animals; Benzodiazepinones; Brain; Carbolines; Ethanol; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Membranes; Muscimol; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Temperature | 1984 |
Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens.
Topics: Animals; Binding, Competitive; Carbolines; Chlorides; Diazepam; Flunitrazepam; Harmine; Indoles; Ion Channels; Kinetics; Male; Mice; Mice, Inbred Strains; Muscimol; Mutagens; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures | 1984 |
A gamma-aminobutyric acid/benzodiazepine receptor complex from bovine cerebral cortex. Improved purification with preservation of regulatory sites and their interactions.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cerebral Cortex; Cholic Acids; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Methods; Muscimol; Pentobarbital; Receptors, Cell Surface; Receptors, GABA-A; Solubility | 1984 |
Pitrazepin, a novel GABAA antagonist.
Topics: Animals; Baclofen; Bicuculline; Binding, Competitive; Culture Techniques; Dibenzazepines; Flunitrazepam; GABA Antagonists; Hippocampus; Hypothalamus; Membrane Potentials; Muscimol; Neurons; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Muscarinic | 1984 |
A new method for the evaluation of benzodiazepines based on their ability to block muscimol-induced myoclonic jerks in mice.
Topics: Animals; Benzodiazepines; Diazepam; Drug Evaluation; Flunitrazepam; Male; Mice; Muscimol; Myoclonus; Oxazoles; Spinal Cord | 1981 |
Interaction of SQ 20009 and GABA-like drugs as modulators of benzodiazepine receptor binding.
Topics: Animals; Benzodiazepines; Cerebellum; Drug Interactions; Etazolate; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Membranes; Muscimol; Nicotinic Acids; Rats; Receptors, Drug | 1980 |
Long-term and regional specific changes in [3H]flunitrazepam binding in kindled rat hippocampus.
Topics: Animals; Autoradiography; Electrodes, Implanted; Flunitrazepam; GABA Modulators; Hippocampus; Image Processing, Computer-Assisted; In Vitro Techniques; Kindling, Neurologic; Kinetics; Male; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A; Seizures | 1995 |
Regulation of allosteric coupling and function of stably expressed gamma-aminobutyric acid (GABA)A receptors by chronic treatment with GABAA and benzodiazepine agonists.
Topics: Allosteric Regulation; Animals; Cattle; Cell Line; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; Mice; Muscimol; Protein Binding; Receptors, GABA-A; RNA, Messenger; Transfection | 1995 |
Methylmercury modulates GABAA receptor complex differentially in rat cortical and cerebellar membranes in vitro.
Topics: Animals; Cell Membrane; Cerebellum; Cerebral Cortex; Flunitrazepam; Kinetics; Male; Methylmercury Compounds; Muscimol; Neurons; Organ Specificity; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Triethyllead decreases central benzodiazepine receptor binding in rat cerebellum ex vivo.
Topics: Animals; Binding, Competitive; Cerebellum; Cerebral Cortex; Flunitrazepam; GABA-A Receptor Antagonists; In Vitro Techniques; Male; Muscimol; Nerve Tissue Proteins; Organometallic Compounds; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Differential expression of GABAA/benzodiazepine receptor subunit mRNAs and ligand binding sites in mouse cerebellar neurons following in vivo ethanol administration: an autoradiographic analysis.
Topics: Animals; Autoradiography; Base Sequence; Binding Sites; Cerebellum; Ethanol; Female; Flunitrazepam; Gene Expression; In Situ Hybridization; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Muscimol; Neurons; Receptors, GABA-A; RNA, Messenger; Tritium | 1995 |
Lindane administration to the rat induces modifications in the regional cerebral binding of [3H]Muscimol, [3H]-flunitrazepam, and t-[35S]butylbicyclophosphorothionate: an autoradiographic study.
Topics: Animals; Autoradiography; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Flunitrazepam; Hexachlorocyclohexane; Male; Muscimol; Rats; Rats, Wistar; Reference Values; Sulfur Radioisotopes; Tissue Distribution; Tritium | 1993 |
GABAA receptor-mediated inhibition of N-methyl-D-aspartate-evoked [3H]dopamine release from mesencephalic cell cultures.
Topics: Animals; Baclofen; Cells, Cultured; Dopamine; Flunitrazepam; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Kainic Acid; Mesencephalon; Muscimol; N-Methylaspartate; Picrotoxin; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA; Ventral Tegmental Area | 1994 |
Ibotenic acid lesion of nucleus basalis magnocellularis differentially affects cholinergic, glutamatergic and GABAergic markers in cortical rat brain regions.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Biomarkers; Cerebral Cortex; Flunitrazepam; Glutamic Acid; Hemicholinium 3; Ibotenic Acid; In Situ Hybridization; Male; Muscimol; Rats; Rats, Wistar; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Substantia Innominata | 1994 |
Alterations in the brain GABAA/benzodiazepine receptor-chloride ionophore complex in a genetic model of paroxysmal dystonia: a quantitative autoradiographic analysis.
Topics: Animals; Autoradiography; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Cricetinae; Dystonia; Flunitrazepam; Ionophores; Male; Models, Genetic; Muscimol; Radiography; Receptors, GABA-A | 1995 |
A progesterone metabolite stimulates the release of gonadotropin-releasing hormone from GT1-1 hypothalamic neurons via the gamma-aminobutyric acid type A receptor.
Topics: Animals; Anti-Anxiety Agents; Brain; Cell Line; Dose-Response Relationship, Drug; Flunitrazepam; Gene Expression; Gonadotropin-Releasing Hormone; Hypothalamus; Kinetics; Muscimol; Neurons; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; RNA, Messenger | 1995 |
Analysis of the hippocampal GABAA receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine.
Topics: Affinity Labels; Amygdala; Animals; Autoradiography; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbamazepine; Convulsants; Drug Tolerance; Electric Stimulation; Electroencephalography; Flunitrazepam; Functional Laterality; Gene Expression; Hippocampus; In Situ Hybridization; Kindling, Neurologic; Macromolecular Substances; Muscimol; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Seizures; Tritium | 1994 |
Effects of Kamikihito, a traditional Chinese medicine, on neurotransmitter receptor binding in the aged rat brain determined by in vitro autoradiography (2): changes in GABAA and benzodiazepine receptor binding.
Topics: Aging; Animals; Autoradiography; Brain Chemistry; Drugs, Chinese Herbal; Flunitrazepam; Image Processing, Computer-Assisted; Male; Muscimol; Rats; Receptors, GABA-A; Receptors, Neurotransmitter | 1994 |
Gamma-aminobutyric acidA receptor function is inhibited by microtubule depolymerization.
Topics: Animals; Biological Transport; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Chlorides; Colchicine; Convulsants; Dose-Response Relationship, Drug; Flunitrazepam; Histones; Humans; Lumicolchicines; Membranes; Mice; Microtubules; Muscimol; Nocodazole; Paclitaxel; Phosphorylation; Receptors, GABA-A; Vinblastine; Xenopus | 1994 |
Immunoaffinity purification of gamma-aminobutyric acidA (GABAA) receptors containing gamma 1-subunits. Evidence for the presence of a single type of gamma-subunit in GABAA receptors.
Topics: Animals; Antibody Specificity; Base Sequence; Blotting, Western; Brain Chemistry; Chromatography, Affinity; Clonazepam; Enzyme-Linked Immunosorbent Assay; Flumazenil; Flunitrazepam; Immunologic Techniques; Molecular Sequence Data; Molecular Weight; Muscimol; Peptide Fragments; Protein Conformation; Rats; Receptors, GABA-A; Recombinant Fusion Proteins | 1994 |
Heterogeneity of GABAA receptor in goldfish retina.
Topics: Affinity Labels; Animals; Antibodies, Monoclonal; Autoradiography; Cattle; Flunitrazepam; gamma-Aminobutyric Acid; Goldfish; Immunoblotting; Immunohistochemistry; Indicators and Reagents; Molecular Weight; Muscimol; Receptors, GABA-A; Retina; Synaptic Membranes; Synaptic Transmission | 1994 |
Short and long form gamma 2 subunits of the GABAA/benzodiazepine receptors.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Brain; Cattle; Cell Membrane; Cerebellum; Cerebral Cortex; Chromatography, Affinity; Flunitrazepam; Hippocampus; Immunoblotting; Macromolecular Substances; Muscimol; Rats; Receptors, GABA-A | 1994 |
Development pattern of the GABAA-benzodiazepine receptor ionophore complex in primary cultures of cortical neurons.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; Mice; Mice, Inbred C57BL; Muscimol; Neurons; Receptors, GABA-A | 1994 |
Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cloning, Molecular; Convulsants; DNA Primers; DNA, Complementary; Drosophila melanogaster; Female; Flunitrazepam; gamma-Aminobutyric Acid; Gene Expression; Macromolecular Substances; Molecular Sequence Data; Muscimol; Oocytes; Pentobarbital; Picrotoxin; Polymerase Chain Reaction; Receptors, GABA; Receptors, GABA-A; Transcription, Genetic; Xenopus laevis | 1994 |
Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors.
Topics: Animals; Baclofen; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbohydrate Sequence; Flunitrazepam; Ginsenosides; Herb-Drug Interactions; Ligands; Male; Molecular Sequence Data; Muscimol; Panax; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Saponins; Sulfur Radioisotopes; Tritium | 1994 |
Regional distribution of GABAA receptor binding sites in cat somatosensory and motor cortex.
Topics: Animals; Auditory Cortex; Autoradiography; Binding Sites; Cats; Flunitrazepam; Motor Cortex; Muscimol; Receptors, GABA; Somatosensory Cortex; Tissue Distribution; Visual Cortex | 1994 |
Binding of gamma-aminobutyric acidA receptors to tubulin.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Brain; Chemical Precipitation; Chromatography, Affinity; Cytoskeleton; Flunitrazepam; Microtubules; Muscimol; Rats; Receptors, GABA; Tritium; Tubulin | 1994 |
Absence of modifications of the pharmacological properties of the GABAA receptor complex during aging, as assessed in 3- and 24-month-old rat cerebral cortex.
Topics: Affinity Labels; Aging; Animals; Anti-Anxiety Agents; Binding, Competitive; Cerebral Cortex; Flunitrazepam; Hypnotics and Sedatives; In Vitro Techniques; Male; Membrane Proteins; Muscimol; Photochemistry; Pyridazines; Pyridines; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, GABA-A; Zolpidem | 1993 |
Decreased forebrain [35S]TBPS binding and increased [3H]muscimol binding in rats that do not develop stress-induced behavioral depression.
Topics: Adrenalectomy; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Depression; Desoxycorticosterone; Electroshock; Flunitrazepam; Helplessness, Learned; Male; Muscimol; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stress, Psychological | 1993 |
Characterization of the influence of unsaturated free fatty acids on brain GABA/benzodiazepine receptor binding in vitro.
Topics: Animals; Anura; Birds; Brain; Cell Membrane; Cerebral Cortex; Chloride Channels; Diazepam; Fatty Acids, Nonesterified; Fishes; Flunitrazepam; Male; Muscimol; Oleic Acid; Oleic Acids; Phylogeny; Rats; Rats, Wistar; Receptors, GABA; Tritium | 1994 |
Influence of flumazenil on the learning-enhancing effect of ambocarb in rats.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Discrimination Learning; Discrimination, Psychological; Flumazenil; Flunitrazepam; Harmine; Learning; Ligands; Male; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A | 1994 |
Acute swim stress increases benzodiazepine receptors, but not GABAA or GABAB receptors, in the rat cerebral cortex.
Topics: Animals; Baclofen; Brain; Cerebellum; Cerebral Cortex; Flunitrazepam; Hippocampus; Male; Muscimol; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Stress, Psychological; Swimming | 1993 |
Further evidence for a functional dorsal-ventral division of the rat striatum: GABAergic involvement in oral movements.
Topics: Animals; Apomorphine; Behavior, Animal; Benzamides; Benzazepines; Carbachol; Corpus Striatum; Dopamine; Flunitrazepam; gamma-Aminobutyric Acid; Jaw; Male; Muscimol; N-Methylscopolamine; Picrotoxin; Pilocarpine; Rats; Rats, Sprague-Dawley; Scopolamine Derivatives | 1993 |
Long-term testosterone or diethylstilbestrol treatment affects gamma-aminobutyric acid and central-type benzodiazepine receptors but not peripheral-type benzodiazepine receptors in the female rat brain.
Topics: Animals; Brain; Cerebellum; Diethylstilbestrol; Female; Flunitrazepam; In Vitro Techniques; Isoquinolines; Membranes; Muscimol; Parietal Lobe; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Testosterone | 1993 |
Reconstitution of purified GABAA receptors: ligand binding and chloride transporting properties.
Topics: Animals; Bicuculline; Biological Transport; Brain Chemistry; Cattle; Chlorides; Chromatography, Affinity; Dose-Response Relationship, Drug; Flow Injection Analysis; Flunitrazepam; Ligands; Liposomes; Membrane Proteins; Muscimol; Picrotoxin; Quinolinium Compounds; Receptors, GABA-A | 1994 |
Early postnatal treatment with muscimol transiently alters brain GABAA receptors and open-field behavior in rat.
Topics: Aging; Animals; Animals, Newborn; Azides; Behavior, Animal; Benzodiazepines; Brain Chemistry; Ethanol; Flunitrazepam; Male; Muscimol; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Weight Gain | 1993 |
GABAA receptor function in the gamma-hydroxybutyrate model of generalized absence seizures.
Topics: Aminocaproates; Animals; Anticonvulsants; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Chlorine; Convulsants; Electroencephalography; Epilepsy, Absence; Flunitrazepam; In Vitro Techniques; Kinetics; Male; Muscimol; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium Oxybate; Synaptosomes; Vigabatrin | 1993 |
Comparison of interactions of [3H]muscimol, t-butylbicyclophosphoro[35S]thionate, and [3H]flunitrazepam with cloned gamma-aminobutyric acidA receptors of the alpha 1 beta 2 and alpha 1 beta 2 gamma 2 subtypes.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cloning, Molecular; Flunitrazepam; Moths; Muscimol; Radioligand Assay; Receptors, GABA-A; Recombinant Proteins; Zinc | 1993 |
Region-specific changes of GABAA receptors by tolerance to and dependence upon pentobarbital.
Topics: Animals; Body Temperature; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Corpus Striatum; Drug Tolerance; Flunitrazepam; Frontal Lobe; In Vitro Techniques; Injections, Intraventricular; Male; Muscimol; Pentobarbital; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance-Related Disorders; Sulfur Radioisotopes; Synaptic Membranes | 1993 |
A quantitative autoradiographic study of GABAA and benzodiazepine receptors in the brain of the frog, Rana esculenta.
Topics: Animals; Autoradiography; Brain; Brain Mapping; Female; Flunitrazepam; Male; Muscimol; Rana esculenta; Receptors, GABA-A | 1993 |
Benzodiazepine binding to GABAA receptors: differential effects of sulfhydryl modification.
Topics: Animals; Azides; Benzodiazepines; Cattle; Cerebral Cortex; Disulfides; Dithiothreitol; Ethylmaleimide; Flunitrazepam; In Vitro Techniques; Kinetics; Membranes; Muscimol; Radioligand Assay; Receptors, GABA-A; Sulfhydryl Compounds | 1993 |
GABAA receptor subtypes: ligand binding heterogeneity demonstrated by photoaffinity labeling and autoradiography.
Topics: Affinity Labels; Animals; Autoradiography; Brain; Flunitrazepam; gamma-Aminobutyric Acid; Muscimol; Rats; Receptors, GABA-A; Tissue Distribution | 1993 |
Dihydroergosine: anticonflict effect in rats and enhancing effects on [3H]muscimol binding in the human brain post mortem.
Topics: Animals; Behavior, Animal; Brain; Conflict, Psychological; Dose-Response Relationship, Drug; Ergotamines; Female; Flunitrazepam; Humans; In Vitro Techniques; Locomotion; Male; Muscimol; Pain Threshold; Protein Binding; Rats; Rats, Wistar; Tritium | 1993 |
Pharmacological modulation of adrenal medullary GABAA receptor: consistent with its subunit composition.
Topics: Adrenal Glands; Animals; Binding, Competitive; Carbolines; Cattle; Chromaffin System; Dose-Response Relationship, Drug; Flunitrazepam; Muscimol; Receptors, GABA-A | 1995 |
GABAA receptor function and binding in stably transfected cells: chronic ethanol treatment.
Topics: Alcoholism; Animals; Cattle; Cell Line; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Gene Expression; Mice; Muscimol; Rats; Receptors, GABA-A; Transfection | 1995 |
Biochemical evaluations of the effects of loreclezole and propofol on the GABAA receptor in rat brain.
Topics: Anesthetics; Animals; Anticonvulsants; Brain; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanediones; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Triazoles; Tritium | 1996 |
Microtubule depolymerization inhibits ethanol-induced enhancement of GABAA responses in stably transfected cells.
Topics: Animals; Cattle; Cell Line; Chlorides; Colchicine; Ethanol; Flunitrazepam; Humans; Mice; Microtubules; Muscimol; Pentobarbital; Polymers; Receptor Aggregation; Receptors, GABA-A; Transfection | 1996 |
Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits.
Topics: Allosteric Site; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Convulsants; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Antagonists; Humans; Kidney; Membranes; Muscimol; Radioligand Assay; Receptors, GABA-A | 1996 |
Modulation of ligand binding to components of the GABAA receptor complex by ammonia: implications for the pathogenesis of hyperammonemic syndromes.
Topics: Ammonia; Animals; Flunitrazepam; GABA Agonists; GABA Modulators; Hepatic Encephalopathy; Ligands; Male; Muscimol; Quaternary Ammonium Compounds; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tartrates | 1996 |
GABAA receptor binding in the aging rat inferior colliculus.
Topics: Aged; Aging; Animals; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Inferior Colliculi; Ligands; Muscimol; Picrotoxin; Rats; Rats, Inbred F344; Receptors, GABA-A; Tritium | 1996 |
Antisense oligonucleotide to GABAA receptor gamma 2 subunit induces loss of neurones in rat hippocampus.
Topics: Animals; Base Sequence; Behavior, Animal; Benzodiazepines; Bridged Bicyclo Compounds, Heterocyclic; Cell Count; Convulsants; Flunitrazepam; GABA Agonists; GABA Modulators; Hippocampus; Male; Molecular Sequence Data; Muscimol; Neurons; Oligonucleotides, Antisense; Rats; Rats, Wistar; Receptors, GABA-A; Sulfur Radioisotopes; Tritium | 1995 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Goats; In Vitro Techniques; Male; Muscimol; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Synaptosomes; Thiamine Deficiency | 1996 |
The influence of membrane cholesterol on the GABAA receptor.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cholesterol; Dose-Response Relationship, Drug; Drug Interactions; Flunitrazepam; GABA Agents; Liposomes; Male; Muscimol; Pregnanolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Synaptic Membranes | 1996 |
Progesterone regulates gamma-aminobutyric acid B (GABAB) receptors in the neocortex of female rats.
Topics: Adrenalectomy; Analysis of Variance; Animals; Baclofen; Cell Membrane; Cerebral Cortex; Corticosterone; Estrogens; Female; Flunitrazepam; Kinetics; Mifepristone; Muscimol; Ovariectomy; Progesterone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Synaptic Membranes; Time Factors | 1996 |
The enhancement of muscimol-stimulated 36C1 influx by the antispastic 5-aryl-3-(alkylsulfonyl)-4H-1,2,4-triazole (MDL 27,531) in rat brain membrane vesicles.
Topics: Animals; Brain Chemistry; Chloride Channels; Chlorine; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Ion Channel Gating; Male; Membranes; Muscimol; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles | 1995 |
Age-related modifications on the GABAA receptor binding properties from Wistar rat prefrontal cortex.
Topics: Aging; Animals; Benzodiazepines; Binding Sites; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Muscimol; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, GABA-A | 1996 |
Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Diazepam; Female; Fibrosis; Flunitrazepam; Frontal Lobe; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Motor Cortex; Muscimol; Receptors, GABA; Synaptic Transmission; Wernicke Encephalopathy | 1996 |
Is upregulation of benzodiazepine receptors a compensatory reaction to reduced GABAergic tone in the brain of stressed mice?
Topics: Animals; Brain; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Receptors, GABA-A; Stress, Physiological; Thiopental; Up-Regulation | 1996 |
GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics.
Topics: Adult; Aged; Alcoholism; Binding Sites; Case-Control Studies; Cerebral Cortex; Diazepam; Flunitrazepam; Humans; In Vitro Techniques; Kinetics; Liver Cirrhosis, Alcoholic; Middle Aged; Muscimol; Receptors, GABA-A; Wernicke Encephalopathy | 1994 |
Pharmacological characterisation of multiple components in the enhancement by pregnanolone and propofol of [3H]flunitrazepam binding to GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Flunitrazepam; GABA Agonists; GABA Modulators; In Vitro Techniques; Male; Muscimol; Pregnanolone; Progesterone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Membranes | 1996 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Daily variations in GABA receptor function in Syrian hamster cerebral cortex.
Topics: Animals; Cerebral Cortex; Chloride Channels; Circadian Rhythm; Cricetinae; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Kinetics; Male; Mesocricetus; Muscimol; Receptors, GABA-A | 1995 |
Ethanol, flunitrazepam, and pentobarbital modulation of GABAA receptors expressed in mammalian cells and Xenopus oocytes.
Topics: Animals; Cattle; Cell Line, Transformed; Chloride Channels; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Gene Expression; Humans; Mice; Muscimol; Oocytes; Pentobarbital; Protein Processing, Post-Translational; Receptors, GABA-A; Xenopus | 1997 |
Development of tolerance in mice to the sedative effects of the neuroactive steroid minaxolone following chronic exposure.
Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Antagonists; Hypnotics and Sedatives; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred Strains; Motor Activity; Muscimol; Pregnanolone; Radioligand Assay; Rats; Temazepam | 1997 |
Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-0593.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Binding, Competitive; Cerebral Cortex; Flunitrazepam; GABA Agonists; GABA Modulators; GABA-A Receptor Antagonists; In Vitro Techniques; Male; Mice; Muscimol; Phenolsulfonphthalein; Postural Balance; Pregnanolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
Adaptation of gamma-aminobutyric acid type A receptors to alcohol exposure: studies with stably transfected cells.
Topics: Animals; Cells, Cultured; Drug Tolerance; Ethanol; Flunitrazepam; Humans; Mice; Muscimol; Pentobarbital; Pregnanolone; Protein Kinase C; Receptors, GABA-A; Transfection; Zinc | 1998 |
Stereoselective actions of halothane at GABA(A) receptors.
Topics: Anesthetics, Inhalation; Animals; Binding, Competitive; Drug Interactions; Flunitrazepam; GABA Agonists; GABA Modulators; Halothane; Male; Mice; Muscimol; Receptors, GABA-A; Stereoisomerism | 1998 |
Effects of propofol and pentobarbital on ligand binding to GABAA receptors suggest a similar mechanism of action.
Topics: Allosteric Site; Anesthetics, Intravenous; Animals; Azides; Benzodiazepines; Brain; Cattle; Flunitrazepam; GABA Agonists; In Vitro Techniques; Ligands; Membranes; Muscimol; Pentobarbital; Propofol; Receptors, GABA-A | 1998 |
Chronic ethanol administration alters the modulatory effect of 5alpha-pregnan-3alpha-ol-20-one on the binding characteristics of various radioligands of GABAA receptors.
Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Ethanol; Flunitrazepam; GABA Agonists; GABA Modulators; Hippocampus; Male; Muscimol; Pregnanolone; Rats; Rats, Sprague-Dawley; Time Factors | 1998 |
Functional GABA(A) receptors on human glioma cells.
Topics: Anti-Bacterial Agents; Calcium; Calcium Channel Blockers; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Glioblastoma; Gramicidin; Humans; Membrane Potentials; Muscimol; Oligodendroglioma; Patch-Clamp Techniques; Picrotoxin; Potassium; Receptors, GABA-A; Tumor Cells, Cultured; Verapamil | 1998 |
Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptors.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; GABA Modulators; Humans; Male; Mice; Muscimol; Pregnanolone; Rats; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 1998 |
Decreased benzodiazepine binding with little effect on gamma-aminobutyric acid binding in rat brain after treatment with antisense oligodeoxynucleotide to the gamma-aminobutyric acidA receptor gamma-2 subunit.
Topics: Animals; Base Sequence; Benzodiazepines; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Male; Muscimol; Oligonucleotides, Antisense; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium; Xanthines | 1998 |
Neurosteroid modulation of the GABAA receptor in the developing guinea pig cerebral cortex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Guinea Pigs; Hypnotics and Sedatives; Male; Muscimol; Organ Size; Pregnanolone; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Zolpidem | 1999 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous System Depressants; Cerebellum; Cerebral Cortex; Chronic Disease; Ethanol; Flunitrazepam; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Male; Muscimol; Precipitin Tests; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium; Zolpidem | 1999 |
Influence of plasma dialysate from normal and renal dysfunction rats on the electroencephalogram and gamma-aminobutyric acid A receptor complex modulation of thiopental.
Topics: Animals; Dialysis; Drug Evaluation, Preclinical; Electroencephalography; Flunitrazepam; GABA Modulators; Kidney Diseases; Male; Membranes; Muscimol; Plasma; Rats; Rats, Wistar; Receptors, GABA-A; Reference Values; Thiopental | 1999 |
Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties.
Topics: Animals; Central Nervous System Depressants; Chlorides; Diazepam; DNA Primers; Ethanol; Flunitrazepam; Fluorescent Dyes; GABA Agonists; GABA Modulators; Gene Expression; Mice; Muscimol; Neoplastic Stem Cells; Neuroglia; Pentobarbital; Pregnanolone; Quinolinium Compounds; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium | 1999 |
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with No effect on benzodiazepine binding site density.
Topics: Animals; Autoradiography; Brain; Down-Regulation; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Male; Muscimol; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic; Tritium | 1999 |
Partial restoration of striatal GABAA receptor balance by functional mesencephalic dopaminergic grafts in mice with hereditary parkinsonism.
Topics: Animals; Autoradiography; Brain Tissue Transplantation; Corpus Striatum; Fetal Tissue Transplantation; Flunitrazepam; Functional Laterality; Heterozygote; Mesencephalon; Mice; Mice, Inbred Strains; Mice, Neurologic Mutants; Muscimol; Parkinson Disease; Piperazines; Prosencephalon; Receptors, GABA-A; Time Factors; Tritium | 1999 |
Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Binding Sites; Biphenyl Compounds; Cell Membrane; Central Nervous System Depressants; Cerebellum; Diflunisal; Drugs, Chinese Herbal; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Lignans; Muscimol; Picrotoxin; Propofol; Prosencephalon; Rats; Receptors, GABA-A; Tritium | 1999 |
Activation of protein kinase C by phorbol dibutyrate modulates GABAA receptor binding in rat brain slices.
Topics: Animals; Autoradiography; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Enzyme Activation; Flunitrazepam; GABA Agonists; GABA Modulators; In Vitro Techniques; Ligands; Muscimol; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Receptors, GABA-A | 1999 |
Neocortical hyperexcitability after GABA withdrawal in vitro.
Topics: Animals; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Muscimol; Neocortex; Pregnanolone; Progesterone; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome; Synaptic Transmission | 2000 |
Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam.
Topics: Adaptation, Physiological; Animals; Biological Transport; Brain Chemistry; Chlorine; Dose-Response Relationship, Drug; Electroencephalography; Flunitrazepam; GABA Agonists; GABA Modulators; Male; Midazolam; Models, Biological; Muscimol; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Tritium | 2000 |
Synthesis and GABA(A) receptor activity of 6-oxa-analogs of neurosteroids.
Topics: Animals; Antipsychotic Agents; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cholestanones; Flunitrazepam; GABA Modulators; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Structure; Muscimol; Rats; Receptors, GABA-A; Steroids; Structure-Activity Relationship | 2000 |
Changes of GABA(A) receptor binding and subunit mRNA level in rat brain by infusion of subtoxic dose of MK-801.
Topics: Animals; Autoradiography; Brain; Caudate Nucleus; Cerebellum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunitrazepam; Frontal Lobe; Gene Expression Regulation; Hippocampus; Infusions, Parenteral; Male; Muscimol; Neurons; Putamen; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Transcription, Genetic; Tritium | 2000 |
Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex.
Topics: Alcoholism; Autoradiography; Blotting, Northern; Cerebral Cortex; Flunitrazepam; GABA Agonists; GABA Modulators; Gene Expression Regulation; Humans; Muscimol; Protein Binding; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium | 2000 |
Unsulfated and sulfated neurosteroids differentially modulate the binding characteristics of various radioligands of GABA(A) receptors following chronic ethanol administration.
Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Central Nervous System Depressants; Cerebellum; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Ethanol; Flunitrazepam; GABA Agonists; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids | 2001 |
Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Flunitrazepam; GABA Agonists; GABA Modulators; Ginsenosides; Injections, Intraventricular; Male; Muscimol; Panax; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Saponins | 2001 |
Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro.
Topics: Animals; Biphenyl Compounds; Cell Line; Cerebellum; Drugs, Chinese Herbal; Flunitrazepam; GABA Agonists; GABA Modulators; Hippocampus; Humans; Insecta; Lignans; Male; Muscimol; Nitric Oxide Synthase; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Recombinant Proteins; Tritium | 2001 |
Activation of GABA(A) receptors in subthalamic neurons in vitro: properties of native receptors and inhibition mechanisms.
Topics: Animals; Bicarbonates; Bicuculline; Chlorides; Diazepam; Electrophysiology; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; Organ Culture Techniques; Pentobarbital; Picrotoxin; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes; Subthalamic Nucleus | 2001 |
3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex.
Topics: Allosteric Regulation; Animals; Animals, Newborn; Anti-Anxiety Agents; Biological Transport; Cerebral Cortex; Chlorine; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Labor, Obstetric; Male; Muscimol; Pregnancy; Pregnanolone; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Characteristics | 2001 |
Binding and neuropharmacological profile of zaleplon, a novel nonbenzodiazepine sedative/hypnotic.
Topics: Acetamides; Animals; Benzodiazepinones; Electroencephalography; Flunitrazepam; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Male; Muscimol; Pyrimidines; Rabbits; Rats; Rats, Sprague-Dawley; Sleep | 2002 |
Gamma-aminobutyric acidA and benzodiazepine receptor alterations in the rat brain after unilateral 6-hydroxydopamine lesions of the medial forebrain bundle.
Topics: Animals; Dopamine; Dopamine Uptake Inhibitors; Down-Regulation; Flunitrazepam; GABA Agonists; GABA Modulators; Male; Mazindol; Muscimol; Neostriatum; Neural Pathways; Oxidopamine; Parkinson Disease; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, GABA-A; Substantia Nigra; Sympatholytics; Tritium; Up-Regulation | 2002 |
Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study.
Topics: Adolescent; Adult; Autistic Disorder; Autoradiography; Binding Sites; Cell Count; Culture Techniques; Flunitrazepam; GABA Modulators; Hippocampus; Humans; Male; Muscimol; Receptors, GABA; Receptors, Neurotransmitter | 2001 |
Effects of etifoxine on ligand binding to GABA(A) receptors in rodents.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Dose-Response Relationship, Drug; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; Male; Mice; Mice, Inbred ICR; Muscimol; Neurons; Oxazines; Rats; Receptors, GABA-A; Seizures; Tritium | 2002 |
GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Chlorides; Diazepam; Exploratory Behavior; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gene Deletion; Hypnotics and Sedatives; Male; Mice; Mice, Knockout; Motor Activity; Muscimol; Postural Balance; Pyridines; Radioligand Assay; Receptors, GABA-A; Seizures; Zolpidem | 2002 |
The bindings of [3H]muscimol and [3H]flunitrazapam are elevated in discrete brain regions of butorphanol-withdrawal rats.
Topics: Animals; Autoradiography; Brain; Butorphanol; Flunitrazepam; Immunohistochemistry; Male; Muscimol; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tritium | 2002 |
Distribution and binding parameters of GABAA receptors in the thalamic nuclei of Macaca mulatta and changes caused by lesioning in the globus pallidus and reticular thalamic nucleus.
Topics: Animals; Autoradiography; Basal Ganglia; Binding, Competitive; Denervation; Excitatory Amino Acid Agonists; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Globus Pallidus; Ibotenic Acid; Kainic Acid; Macaca mulatta; Male; Muscimol; Neural Pathways; Receptors, GABA-A; Thalamic Nuclei; Time Factors; Tritium | 2003 |
Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Brain; Female; Flumazenil; Flunitrazepam; Hepatic Encephalopathy; Humans; Intracranial Aneurysm; Kinetics; Male; Middle Aged; Muscimol; Receptors, GABA-A; Reference Values; Shock, Septic | 2003 |
Effect of chronic administration of ethanol on GABAA receptor assemblies derived from alpha2-, alpha3-, beta2- and gamma2-subunits in the rat cerebral cortex.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Cerebral Cortex; Ethanol; Flunitrazepam; GABA Agonists; GABA Modulators; Male; Muscimol; Protein Subunits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium | 2005 |
Changes of [3H]muscimol, [3H]flunitrazepam and [3H]MK-801 binding in rat brain by prolonged ventricular infusion of 7-nitroindazole.
Topics: Animals; Autoradiography; Brain; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flunitrazepam; GABA Agonists; GABA Modulators; Indazoles; Infusion Pumps, Implantable; Injections, Intraventricular; Male; Muscimol; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2004 |
Learning deficits induced by sleep deprivation and recovery are not associated with altered [(3)H]muscimol and [(3)H]flunitrazepam binding.
Topics: Animals; Autoradiography; Avoidance Learning; Brain; Flunitrazepam; GABA Agonists; GABA Modulators; Learning Disabilities; Male; Muscimol; Rats; Rats, Wistar; Sleep Deprivation | 2005 |
Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain.
Topics: Ammonia; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dose-Response Relationship, Drug; Down-Regulation; Flumazenil; Flunitrazepam; GABA Agonists; GABA Modulators; Hepatic Encephalopathy; Humans; Hyperammonemia; Ligands; Muscimol; Radioligand Assay; Receptors, GABA-A; Subcellular Fractions; Synaptic Transmission; Tartrates | 2005 |
Radioligand binding studies of caloporoside and novel congeners with contrasting effects upon [35S] TBPS binding to the mammalian GABA(A) receptor.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Flunitrazepam; gamma-Aminobutyric Acid; Glucosides; Male; Mannose; Muscimol; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Salicylates; Structure-Activity Relationship; Sulfur Radioisotopes | 2005 |
Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons.
Topics: Anesthetics, Intravenous; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Chloride Channels; Computer Simulation; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; L-Lactate Dehydrogenase; Mice; Models, Molecular; Models, Neurological; Muscimol; Neurons; Neurotoxins; Pregnancy; Propidium; Propofol; Receptors, GABA-A; Thymol | 2006 |
Hyperthermia-induced seizures modify the GABAA and benzodiazepine receptor binding in immature rat brain.
Topics: Animals; Animals, Newborn; Autoradiography; Brain; Child; Female; Fever; Flunitrazepam; GABA Agonists; GABA Modulators; Humans; Male; Muscimol; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Time Factors; Tritium | 2005 |
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzodiazepines; Brain Chemistry; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; In Vitro Techniques; Liver Cirrhosis; Male; Membranes; Middle Aged; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Standards | 2006 |
Hyperthermia-induced seizures modify the GABA(A) and benzodiazepine receptor binding in immature rat brain.
Topics: Age Factors; Animals; Autoradiography; Brain; Female; Fever; Flunitrazepam; GABA Agonists; GABA Modulators; Male; Muscimol; Pregnancy; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures, Febrile; Tritium | 2007 |
The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Binding, Competitive; Flunitrazepam; GABA Agonists; GABA Modulators; Haloperidol; Humans; Long-Term Care; Male; Muscimol; Olanzapine; Prefrontal Cortex; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia | 2007 |
Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Diazepam; Flumazenil; Flunitrazepam; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Muscimol; Picrotoxin; Protein Subunits; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Receptors, GABA-B; Transfection; Up-Regulation | 2007 |
Exploring ligand recognition and ion flow in comparative models of the human GABA type A receptor.
Topics: Amino Acid Sequence; Benzodiazepines; Binding Sites; Computer Simulation; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Ligands; Models, Molecular; Molecular Sequence Data; Muscimol; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, GABA-A; Sequence Homology, Amino Acid | 2007 |
Autoradiographic analysis of GABAA receptors in mu-opioid receptor knockout mice.
Topics: Animals; Autoradiography; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Down-Regulation; Flunitrazepam; Male; Mice; Mice, Knockout; Muscimol; Receptors, GABA-A; Receptors, Opioid, mu; Tritium; Up-Regulation | 2007 |
Neonatal maternal separation and enhancement of the hypoxic ventilatory response in rat: the role of GABAergic modulation within the paraventricular nucleus of the hypothalamus.
Topics: Animals; Animals, Newborn; Anxiety, Separation; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypoxia; Male; Muscimol; Paraventricular Hypothalamic Nucleus; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Respiratory Mechanics; Synaptic Transmission | 2007 |
Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Densitometry; Flunitrazepam; Haloperidol; Hippocampus; Humans; Male; Muscimol; Olanzapine; Prefrontal Cortex; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia; Thalamus; Tissue Distribution; Tritium | 2008 |
The role of transcriptional and translational mechanisms in flumazenil-induced up-regulation of recombinant GABA(A) receptors.
Topics: Analysis of Variance; Cell Line, Transformed; Cell Proliferation; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Interactions; Flumazenil; Flunitrazepam; GABA Modulators; Humans; Muscimol; Protein Biosynthesis; Protein Synthesis Inhibitors; Receptors, GABA-A; RNA, Messenger; Transcription, Genetic; Transcriptional Activation; Transfection; Tritium; Up-Regulation | 2008 |
Differential effects of diazepam treatment and withdrawal on recombinant GABAA receptor expression and functional coupling.
Topics: Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Count; Cell Proliferation; Cell Survival; Cells, Cultured; Diazepam; Flunitrazepam; GABA Agonists; GABA Modulators; Gene Expression; Humans; Muscimol; Protein Binding; Protein Biosynthesis; Receptors, GABA-A; Transcriptional Activation | 2008 |
Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism.
Topics: Adaptor Proteins, Signal Transducing; Adult; Autistic Disorder; Down-Regulation; Female; Flunitrazepam; Gyrus Cinguli; Humans; Male; Middle Aged; Muscimol; Receptors, GABA-A; Reference Values; Young Adult | 2009 |
Autoradiographic analysis of GABAA receptor binding in the neural anxiety network of postpartum and non-postpartum laboratory rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Autoradiography; Brain; Female; Flunitrazepam; GABA-A Receptor Agonists; Humans; Male; Muscimol; Nerve Net; Postpartum Period; Pregnancy; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptors, GABA-A | 2011 |
Anxiolytic effects of Julibroside C1 isolated from Albizzia julibrissin in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Albizzia; Analysis of Variance; Animals; Anti-Anxiety Agents; Autoradiography; Brain; Dose-Response Relationship, Drug; Flunitrazepam; Male; Maze Learning; Mice; Mice, Inbred ICR; Motor Activity; Muscimol; Plant Preparations; Protein Binding; Radionuclide Imaging; Saponins; Triterpenes; Tritium | 2013 |
Effect of synthetic steroids on GABAA receptor binding in rat brain.
Topics: Animals; Autoradiography; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Flunitrazepam; GABA-A Receptor Agonists; Hippocampus; Male; Muscimol; Pregnanolone; Protein Binding; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes; Tritium | 2015 |