muromonab-cd3 and morusinol

Chromatographic separation of root extracts of Morus alba and M. nigra led to the identification of the 2-arylbenzofurans moracin C (1), mulberrofuran Y (2), and mulberrofuran H (3), and the prenylated flavonoids kuwanon E (4), kuwanon C (5), sanggenon H (6), cudraflavone B (7), and morusinol (8), and the Diels-Alder adducts soroceal (9), and sanggenon E (10). The cytotoxicity and their antiphlogistic activity, determined as the attenuation of the secretion of TNF-α and IL-1β and the inhibition of NF-κB nuclear translocation in LPS-stimulated macrophages, were evaluated for compounds 1-10.

Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Benzopyrans; Flavonoids; Humans; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Morus; NF-kappa B; Plant Bark; Plant Roots; Prenylation; Tumor Necrosis Factor-alpha