muramidase and indolicidin

muramidase has been researched along with indolicidin* in 2 studies

Other Studies

2 other study(ies) available for muramidase and indolicidin

Article	Year
CpG oligonucleotide, host defense peptide and polyphosphazene act synergistically, inducing long-lasting, balanced immune responses in cattle. Vaccine, 2009, Mar-23, Volume: 27, Issue:14 Vaccines consisting of subunit or protein antigens are less immunogenic than traditional vaccines, and therefore require formulation with an adjuvant. Conventional adjuvants, however, often cause undesirable injection site reactions and Th2-biased immune responses. Therefore, novel vaccine adjuvants which can safely enhance and selectively bias the resulting immune response are required. Here the adjuvant combination of CpG ODN, indolicidin and polyphosphazene (CpG+indol+PP) was evaluated for its ability to enhance and modulate the immune response when formulated with the antigen hen egg lysozyme (HEL). Cattle immunized with HEL co-adjuvanted with CpG+indol+PP developed higher antigen-specific humoral responses, and long-lasting cell-mediated immune responses, as evidenced by elevated levels of IFN-gamma secretion by re-stimulated PBMCs, that were superior even to EMULSIGEN((R)), an oil-in-water based adjuvant that was used as positive control. Physical characterization of the vaccines indicated that formulation of HEL with CpG+indol+PP resulted in the formation of antigen-adjuvant complexes, which may have contributed to their enhanced immunogenicity. Furthermore, the addition of polyphosphazene to CpG ODN and indolicidin dose-dependently enhanced the secretion of the cytokines IFN-alpha, TNF-alpha and IFN-gammain vitro, indicating that polyphosphazene can also synergize with CpG ODN and indolicidin to stimulate innate immune responses. Topics: Adjuvants, Immunologic; Animals; Antibody Specificity; Antimicrobial Cationic Peptides; Cattle; Immunity, Cellular; Immunity, Innate; Immunoglobulin G; Injections, Subcutaneous; Interferon-alpha; Interferon-gamma; Leukocytes, Mononuclear; Muramidase; Oligodeoxyribonucleotides; Organophosphorus Compounds; Polymers; Tumor Necrosis Factor-alpha; Vaccination; Vaccines	2009
Synergistic interactions between mammalian antimicrobial defense peptides. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:5 A single animal can express several cationic antimicrobial peptides with different sequences and structures. We demonstrate that mammalian peptides from different structural classes frequently show synergy with each other and selectively show synergy with human lysozyme. Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Drug Synergism; Escherichia coli; Humans; Microbial Sensitivity Tests; Muramidase; Peptides; Peptides, Cyclic; Proteins; Pseudomonas aeruginosa; Staphylococcus aureus	2001

Article

Year

CpG oligonucleotide, host defense peptide and polyphosphazene act synergistically, inducing long-lasting, balanced immune responses in cattle.

Vaccine, 2009, Mar-23, Volume: 27, Issue:14

Vaccines consisting of subunit or protein antigens are less immunogenic than traditional vaccines, and therefore require formulation with an adjuvant. Conventional adjuvants, however, often cause undesirable injection site reactions and Th2-biased immune responses. Therefore, novel vaccine adjuvants which can safely enhance and selectively bias the resulting immune response are required. Here the adjuvant combination of CpG ODN, indolicidin and polyphosphazene (CpG+indol+PP) was evaluated for its ability to enhance and modulate the immune response when formulated with the antigen hen egg lysozyme (HEL). Cattle immunized with HEL co-adjuvanted with CpG+indol+PP developed higher antigen-specific humoral responses, and long-lasting cell-mediated immune responses, as evidenced by elevated levels of IFN-gamma secretion by re-stimulated PBMCs, that were superior even to EMULSIGEN((R)), an oil-in-water based adjuvant that was used as positive control. Physical characterization of the vaccines indicated that formulation of HEL with CpG+indol+PP resulted in the formation of antigen-adjuvant complexes, which may have contributed to their enhanced immunogenicity. Furthermore, the addition of polyphosphazene to CpG ODN and indolicidin dose-dependently enhanced the secretion of the cytokines IFN-alpha, TNF-alpha and IFN-gammain vitro, indicating that polyphosphazene can also synergize with CpG ODN and indolicidin to stimulate innate immune responses.

Topics: Adjuvants, Immunologic; Animals; Antibody Specificity; Antimicrobial Cationic Peptides; Cattle; Immunity, Cellular; Immunity, Innate; Immunoglobulin G; Injections, Subcutaneous; Interferon-alpha; Interferon-gamma; Leukocytes, Mononuclear; Muramidase; Oligodeoxyribonucleotides; Organophosphorus Compounds; Polymers; Tumor Necrosis Factor-alpha; Vaccination; Vaccines

2009

Synergistic interactions between mammalian antimicrobial defense peptides.

Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:5

A single animal can express several cationic antimicrobial peptides with different sequences and structures. We demonstrate that mammalian peptides from different structural classes frequently show synergy with each other and selectively show synergy with human lysozyme.

Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Drug Synergism; Escherichia coli; Humans; Microbial Sensitivity Tests; Muramidase; Peptides; Peptides, Cyclic; Proteins; Pseudomonas aeruginosa; Staphylococcus aureus

2001