muramidase and hypericin

muramidase has been researched along with hypericin* in 1 studies

Other Studies

1 other study(ies) available for muramidase and hypericin

ArticleYear
Photosensitization of aqueous model systems by hypericin.
    Biochimica et biophysica acta, 1992, Jan-23, Volume: 1115, Issue:3

    Absorption and fluorescence measurements of purified hypericin (HY) were made in various media. Photosensitization of two aqueous systems was investigated: resealed red blood cell membranes (ghosts) and hen lysozyme (Lys). Solubilization of HY by ghost membranes was shown by means of diffuse reflectance spectroscopy. Visible light irradiation of the ghosts incorporating HY led to lipid peroxidation with evidence of singlet oxygen involvement. A binding model applicable for insoluble ligands is indicative of strong HY binding to HSA. The HY-HSA complex photosensitized inactivation of Lys. The pseudo-first-order reaction kinetics with protection by azide ion are consistent with a Type II mechanism mediated by singlet oxygen. The results are discussed in the context of the HY photodynamic and antiretroviral activities.

    Topics: Animals; Anthracenes; Cattle; Erythrocyte Membrane; Humans; Kinetics; Light; Lipid Peroxidation; Muramidase; Perylene; Photochemistry; Scattering, Radiation; Serum Albumin; Solubility; Spectrometry, Fluorescence; Spectrophotometry; Water

1992