muramidase has been researched along with entacapone* in 1 studies
1 other study(ies) available for muramidase and entacapone
| Article | Year |
|---|---|
Investigating the inhibitory effects of entacapone on amyloid fibril formation of human lysozyme.
The misfolding of soluble protein to amyloid fibers or oligomers leads to cell membrane rupture, cell death, and a variety of amyloid-related diseases. Hence, inhibition of protein fibrillation is an important and promising method to prevent and treat these diseases. In this study, we have investigated the inhibitory effect of entacapone (Ent) on human lysozyme (HL) amyloid fibrillation using a combination of biophysical techniques; Rayleigh scattering (RLS) data indicated that Ent can reduce the aggregation of HL amyloid fibrillation with the inhibition constant (Λ) of (3.0 ± 0.5) × 10 Topics: Amyloid; Catechols; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Models, Chemical; Models, Molecular; Molecular Conformation; Muramidase; Nitriles; Protein Aggregates; Protein Aggregation, Pathological; Spectrum Analysis; Structure-Activity Relationship | 2020 |