muramidase and dioxidine

In experiments in vitro dioxidineeee was highly effective as regards all the test cultures of NAG-vibrios. The MTC ranged within 1 to 62 micrograms/ml. Bactericidal action of the drug became manifest at concentrations from 4 to 250 micrograms/ml. The derivatives of di-N-oxide quinoxaline, dioxidin and quinoxidine exerted a chemotherapeutic effect and sterilizing action in experimental NAG-infection. The action of the drugs was potentiated upon combined use with lysozyme. As far as depo-sulfanilamides are concerned, sulfalenee was little active, while sulfamonomethoxine ineffective in experimental NAG-infection.

Topics: Animals; Anti-Infective Agents; Delayed-Action Preparations; Drug Evaluation, Preclinical; Drug Therapy, Combination; Mice; Muramidase; Quinoxalines; Sulfalene; Sulfamonomethoxine; Sulfanilamides; Vibrio Infections