muramidase and beta-lysine

Topics: Child; Child, Preschool; Complement System Proteins; Female; Humans; Hydrogen-Ion Concentration; Lysine; Male; Muramidase; Saliva; Salivation

Susceptibility of 350 strains of staphylococci, isolated from pregnant women, puerperal and newborns and of 170 strains, isolated from obstetrical hospital environment at the region with high risk of radiation after accident was determined. The tested bacterial strains were the following: 56--Staphylococcus aureus, 152--S. epidermidis, 142--S. saprophyticus, isolated from women and newborns; strains isolated from hospital environment included 120 strains of S. saprophyticus and 50 strains E. coli. The tested antimicrobial factors were the following: 22 antibiotics, 2 bioantibiotics of the breast milk and blood (lysozyme, betalysin) not separated from the substrate and tested on test-cultures of M. luteus and B. subtilis, and 5 desinfectants. Analysis was performed by common disk-diffusion method and by contact method elaborated before. High resistance of staphylococci to many antibiotics, bioantibiotics and disinfectants was demonstrated. The resistance is considered to be due to high radiation background because it is much higher than resistance frequency of the similar strains isolated at the safe areas. The resistance to antimicrobial factors was higher among the opportunistic and saprophyte staphylococci along with appearance of pathogenic factors and activation of persistence properties.

Topics: Anti-Bacterial Agents; Disinfectants; Female; Humans; Lysine; Muramidase; Power Plants; Pregnancy; Radioactive Hazard Release; Staphylococcus

Topics: Acetonitriles; Animals; Antibody Formation; Antigen-Presenting Cells; Cell Survival; Corticosterone; Hypersensitivity, Delayed; Immunity, Cellular; Immunity, Innate; Lethal Dose 50; Lysine; Macrophages, Peritoneal; Muramidase; Neutrophils; Poisoning; Rats; Rats, Wistar; Spleen

Efficacy of the combined therapy of experimental salmonellosis was studied on albino rats with using ampicillin, gentamicin, tetracycline and immunomodulators such as levamisole and quadevite. The influence of the combined chemoimmunotherapy on the indices of the nonspecific resistance of the animals i.e. the titers of lysozyme and beta-lysines, the complement activity and the blood serum bactericidal index was investigated. An increase in the survival of the animals exposed to the combinations of tetracycline with levamisole and quadevite by comparison with the animal survival after the monotherapy was revealed. The combinations of gentamicin with quadevite and tetracycline with the immunomodulators significantly increased the blood serum bactericidal index.

Topics: Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Blood Bactericidal Activity; Drug Therapy, Combination; Lysine; Muramidase; Rats; Salmonella Infections, Animal; Salmonella typhimurium

Topics: Adult; Bacteria; Blood Donors; Genetic Markers; HLA Antigens; Humans; Immunity, Innate; Immunoglobulins; Lysine; Middle Aged; Muramidase

Seventy-four patients with alcoholic delirium were studied for the parameters of the T- and B-system of immunity and natural resistance. The patients versus normal donors presented a statistically significant decrease in the number and proliferative activity of T-lymphocytes, an increase in IgA, as well as a reduction in levels of lysozyme, complement and bactericidal activity of the serum. The presence of immunological shifts after the completion of detoxifying therapy suggests that treatment should be continued even after the disappearance of psychic disturbances.

Topics: Adult; Alcohol Withdrawal Delirium; B-Lymphocytes; Blood Bactericidal Activity; Complement System Proteins; Humans; Immunoglobulins; Leukocyte Count; Lymphocyte Activation; Lysine; Male; Muramidase; Psychoses, Alcoholic; T-Lymphocytes

The effect of benzylpenicillin and tetracycline on the activity, intensity and completion of phagocytosis with the leucocytes of the peritoneal exudate, on the activity of lysozyme and beta-lysins of the blood serum, on the content of nucleic acids, the activity of succinate dehydrogenase and total and acid phosphatase in the liver and kidney cells was studied experimentally on noninfected albino mice. The study showed that administration of benzylpenicillin and tetracycline to the animals for 5 days induced a decrease in the activity of the cell and humoral defence and the activity of the above enzymes in the liver and kidney cells. The content of the nucleic acids did not change under the effect of the antibiotics.

Topics: Animals; DNA; Immunity; Kidney; Liver; Lysine; Mice; Muramidase; Penicillin G; Phagocytosis; Phosphoric Monoester Hydrolases; RNA; Tetracycline

Sixty-four patients were examined clinically and immunologically at a long-term period following craniocerebral trauma. In patients with a history of head trauma impaired adaptation mechanisms were shown to underlie the neurologic disorders, which was reflected in changes in the natural immunity system. The severity and duration of natural resistance impairments were correlated with the gravity of clinical manifestations. The study of the time-course of natural resistance parameters allows the objective evaluation of the degree of central nervous system recovery following closed craniocerebral trauma.

Topics: Acute Disease; Blood Bactericidal Activity; Brain Injuries; Complement System Proteins; Diencephalon; Extrapyramidal Tracts; Humans; Lysine; Mesencephalon; Muramidase

67 patients with mammary carcinoma were submitted to an immunological control examination. This control comprised 14 tests which determined the efficacy of the immune systems, among others: activity of complement, properdin, lysozyme, and beta-lysin, the rate of immunoglobulins, and the behavior of leucergy, rosette tests, NBT, BLT, and tuberculin test. The thoroughly executed examinations did not show any significant difference between patients with active neoplasms and patients in remission stage. The analysis of the results achieved for patients in an advanced stage (TNM) only showed a significant increase (p less than 0.05) of IgG in stage III/IV. The patients were treated with CVF, levamisole (Decaris), and BCG. The observation period was twelve months. The results achieved were discussed in detail.

Topics: Adult; BCG Vaccine; Breast Neoplasms; Complement System Proteins; Cyclophosphamide; Female; Fluorouracil; Humans; Immunization; Immunoglobulins; Levamisole; Lysine; Middle Aged; Muramidase; Properdin; Vincristine

Natural immunity parameters (the complement, beta-lysine, lysozyme) were examined in 179 patients with the non-radicular and radicular stages of lumbar osteochondrosis with regard to the disease stage, the patients' age and sex, the efficacy of treatment, and the latter's late results. It was found that the degree of the shifts of the parameters examined depended primarily on the disease stage and the efficacy of the treatment, and to lesser extent on the patients' age and sex. The parameters examined may serve to a certain measure as a objective criterion of the body's general physiological state, and can be used for predicting the disease outcome.

Topics: Complement System Proteins; Female; Humans; Lysine; Male; Muramidase; Osteochondritis; Prognosis; Radiculopathy; Spinal Diseases

Topics: Antibodies, Heterophile; Female; Heart Failure; Humans; Isomerism; Lysine; Male; Muramidase

Topics: Adolescent; Child; Child, Preschool; Complement System Proteins; Eczema; Hemagglutination Tests; Humans; Immunity, Innate; Infant; Isomerism; Lysine; Muramidase; Neurodermatitis; Neutrophils