muramidase and 2-tyrosine

muramidase has been researched along with 2-tyrosine* in 1 studies

Other Studies

1 other study(ies) available for muramidase and 2-tyrosine

ArticleYear
Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation.
    The Journal of biological chemistry, 1993, Jun-15, Volume: 268, Issue:17

    To evaluate their usefulness as chemical indicators of cumulative oxidative damage to proteins, we studied the kinetics and extent of formation of ortho-tyrosine (o-Tyr), dityrosine (DT), and dityrosine-like fluorescence (Ex = 317 nm, Em = 407 nm) in the model proteins RNase and lysozyme exposed to radiolytic and metal-catalyzed (H2O2/Cu2+) oxidation (MCO). Although there were protein-dependent differences, o-Tyr, DT, and fluorescence increased coordinately during oxidation of the proteins in both oxidation systems. The contribution of DT to total dityrosine-like fluorescence in oxidized proteins varied from 2-100%, depending on the protein, type of oxidation, and extent of oxidative damage. In proteins exposed to MCO, DT typically accounted for > 50% of the fluorescence at DT wavelengths. These studies indicate that o-Tyr and DT should be useful chemical markers of cumulative exposure of proteins to MCO in vitro and in vivo.

    Topics: Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Hydrogen Peroxide; Isomerism; Kinetics; Muramidase; Oxidation-Reduction; Proteins; Ribonucleases; Tyrosine

1993