muramidase and 1-(5-isoquinolinesulfonyl)piperazine

muramidase has been researched along with 1-(5-isoquinolinesulfonyl)piperazine* in 1 studies

Other Studies

1 other study(ies) available for muramidase and 1-(5-isoquinolinesulfonyl)piperazine

Article	Year
Effect of an inhibitor of protein kinase C on human polymorphonuclear leukocyte degranulation. Biochemical and biophysical research communications, 1987, Oct-29, Volume: 148, Issue:2 The protein kinase C inhibitor C-I reduced superoxide production by human neutrophils in response to phorbol myristate acetate by greater than 50%. In contrast to its effects in oxidative metabolism, 100 microM C-I caused minimal inhibition (5-18%) of lysozyme release in response to phorbol myristate acetate. Enzyme release produced by the formylated oligopeptide FMLP was enhanced by 23-54% in neutrophils pretreated with 100 microM C-I. These findings suggest that protein kinase C activation is not required for phorbol myristate acetate induced enzyme release. Enhancement of FMLP stimulated degranulation by C-I suggests that protein kinase C activation may have inhibitory effects on the release of granule enzymes by human neutrophils. Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate	1987

Article

Year

Effect of an inhibitor of protein kinase C on human polymorphonuclear leukocyte degranulation.

Biochemical and biophysical research communications, 1987, Oct-29, Volume: 148, Issue:2

The protein kinase C inhibitor C-I reduced superoxide production by human neutrophils in response to phorbol myristate acetate by greater than 50%. In contrast to its effects in oxidative metabolism, 100 microM C-I caused minimal inhibition (5-18%) of lysozyme release in response to phorbol myristate acetate. Enzyme release produced by the formylated oligopeptide FMLP was enhanced by 23-54% in neutrophils pretreated with 100 microM C-I. These findings suggest that protein kinase C activation is not required for phorbol myristate acetate induced enzyme release. Enhancement of FMLP stimulated degranulation by C-I suggests that protein kinase C activation may have inhibitory effects on the release of granule enzymes by human neutrophils.

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Humans; In Vitro Techniques; Isoquinolines; Kinetics; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate

1987