mupirocin and lauric-acid

Due to increasing mupirocin resistance, alternatives for Staphylococcus aureus nasal decolonization are needed. Lauric acid monoesters combined with lactic, mandelic, malic, or benzoic acid are being evaluated as possible alternatives. We determined the in vitro activity of 13 lauric acid monoester (LAM) formulations and mupirocin against 30 methicillin-susceptible S. aureus (MSSA) isolates and 30 methicillin-resistant S. aureus (MRSA) isolates. We then used a murine model of MRSA nasopharyngeal colonization to compare the in vivo activity of mupirocin with three LAM formulations. MSSA and MRSA MIC(90) values were 0.25 microg/ml for mupirocin and

Topics: Animals; Anti-Bacterial Agents; Carrier State; Disease Models, Animal; Esters; Humans; Lauric Acids; Methicillin; Methicillin Resistance; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Mupirocin; Nasopharynx; Ointments; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome