mupirocin and hydrocortisone-acetate

mupirocin has been researched along with hydrocortisone-acetate* in 2 studies

Trials

1 trial(s) available for mupirocin and hydrocortisone-acetate

Article	Year
Hydrocortisone acetate alone or combined with mupirocin for atopic dermatitis in infants under two years of age - a randomized double blind pilot trial. European review for medical and pharmacological sciences, 2012, Volume: 16, Issue:14 The skin of patients with atopic dermatitis (AD) is heavily colonized with Staphylococcus (S.) aureus, even at uninvolved sites. Toxins secreted by the majority of S. aureus on the skin behave as superantigens and can directly influence the disease activity, although clinical signs of bacterial superinfection might be absent.. This study was conducted to compare the efficacy of hydrocortisone cream, combined with mupirocin or alone with emmolient ointment for the treatment of mild to moderate AD in infants between six months and two years of age.. A total of 83 patients with mild to moderate AD were randomized to receive hydrocortisone, hydrocortisone+ mupirocin or emmolient ointment twice daily in one week and followed-up for 8 weeks, in a blind study. Efficacy evaluation made by SCORAD and eczema area and severity index (EASI) at baseline, day 7, and weeks 2, 4, and 8. Possible adverse events were recorded to evaluate safety.. At the end of study, 65% (17 of 26) of the patients were treated successfully with hydrocortisone ointment based on SCORAD and EASI scores. Also there was a significant improvement in patients combined with mupirocin ointment [74% (20 of 27)]. The percent improvement from baseline in EASI scores was also significantly greater in hydrocortisone and combined group compared with emmolient-treated patients (36%) (p = 0.0187, p = 0.012 respectively).. Monotherapy with hydrocortisone ointment is the main treatment in infants with mild to moderate AD and combination with mupirocin is safe and effective often needed because of possible Staphylococcus carriage. Topics: Administration, Cutaneous; Anti-Bacterial Agents; Anti-Inflammatory Agents; Dermatitis, Atopic; Double-Blind Method; Drug Therapy, Combination; Emollients; Humans; Hydrocortisone; Infant; Mupirocin; Ointments; Pilot Projects; Severity of Illness Index; Skin; Staphylococcal Skin Infections; Staphylococcus aureus; Time Factors; Treatment Outcome; Turkey	2012

Article

Year

Hydrocortisone acetate alone or combined with mupirocin for atopic dermatitis in infants under two years of age - a randomized double blind pilot trial.

European review for medical and pharmacological sciences, 2012, Volume: 16, Issue:14

The skin of patients with atopic dermatitis (AD) is heavily colonized with Staphylococcus (S.) aureus, even at uninvolved sites. Toxins secreted by the majority of S. aureus on the skin behave as superantigens and can directly influence the disease activity, although clinical signs of bacterial superinfection might be absent.. This study was conducted to compare the efficacy of hydrocortisone cream, combined with mupirocin or alone with emmolient ointment for the treatment of mild to moderate AD in infants between six months and two years of age.. A total of 83 patients with mild to moderate AD were randomized to receive hydrocortisone, hydrocortisone+ mupirocin or emmolient ointment twice daily in one week and followed-up for 8 weeks, in a blind study. Efficacy evaluation made by SCORAD and eczema area and severity index (EASI) at baseline, day 7, and weeks 2, 4, and 8. Possible adverse events were recorded to evaluate safety.. At the end of study, 65% (17 of 26) of the patients were treated successfully with hydrocortisone ointment based on SCORAD and EASI scores. Also there was a significant improvement in patients combined with mupirocin ointment [74% (20 of 27)]. The percent improvement from baseline in EASI scores was also significantly greater in hydrocortisone and combined group compared with emmolient-treated patients (36%) (p = 0.0187, p = 0.012 respectively).. Monotherapy with hydrocortisone ointment is the main treatment in infants with mild to moderate AD and combination with mupirocin is safe and effective often needed because of possible Staphylococcus carriage.

Topics: Administration, Cutaneous; Anti-Bacterial Agents; Anti-Inflammatory Agents; Dermatitis, Atopic; Double-Blind Method; Drug Therapy, Combination; Emollients; Humans; Hydrocortisone; Infant; Mupirocin; Ointments; Pilot Projects; Severity of Illness Index; Skin; Staphylococcal Skin Infections; Staphylococcus aureus; Time Factors; Treatment Outcome; Turkey

2012

Other Studies

1 other study(ies) available for mupirocin and hydrocortisone-acetate

Article	Year
Papulopustular eruptions in a 32-year-old woman after lung cancer treatment. Archives of dermatology, 2011, Volume: 147, Issue:6 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Antineoplastic Agents; Dermatologic Agents; Drug Eruptions; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Hydrocortisone; Lung Neoplasms; Metronidazole; Mupirocin; Quinazolines	2011