mr 2034 has been researched along with naloxone in 16 studies
| Studies (mr 2034) | Trials (mr 2034) | Recent Studies (post-2010) (mr 2034) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 48 | 0 | 0 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | mr 2034 (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (93.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chahl, LA | 1 |
| Herz, A; Nikolarakis, K; Pfeiffer, A; Stalla, GK | 1 |
| Brenner, AS; Geppert, M; Illes, P; Jackisch, R | 1 |
| Ensinger, HA | 2 |
| Herz, A; Loriaux, DL; Pfeiffer, A; Pfeiffer, DG | 1 |
| Brantl, V; Emrich, HM; Herz, A; Pfeiffer, A | 1 |
| Abbott, FV; Franklin, KB; Libman, RB | 1 |
| Brantl, V; Braun, S; Knepel, W; Lohmann, H; Meyer, HD; Pfeiffer, A | 1 |
| Brantl, V; Braun, S; Mann, K; Meyer, HD; Pfeiffer, A | 1 |
| Havemann, U; Kuschinsky, K | 1 |
| Fitzjarrell, AT; Heath, RG; Walker, CF | 1 |
| Rourke, JD; Shaw, JS | 1 |
| Ensinger, HA; Gaida, W; Jennewein, HM; Merz, H; Stockhaus, K | 1 |
| Johnson, N; Pasternak, GW | 1 |
| Antić, J; Djergović, D; Janković, BD; Miljević, C; Radulović, J; von Hörsten, S; Vujić, V | 1 |
16 other study(ies) available for mr 2034 and naloxone
| Article | Year |
|---|---|
Withdrawal responses of guinea-pig isolated ileum following brief exposure to opiates and opioid peptides.
Topics: Animals; Benzomorphans; Buprenorphine; Cyclazocine; Endorphins; Ethylketocyclazocine; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Naloxone; Narcotics; Substance P; Substance Withdrawal Syndrome | 1986 |
The role of CRF in the release of ACTH by opiate agonists and antagonists in rats.
Topics: Adrenocorticotropic Hormone; Animals; Benzomorphans; Corticotropin-Releasing Hormone; Immune Sera; Male; Morphinans; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1987 |
Presynaptic opioid receptors modulating acetylcholine release in the hippocampus of the rabbit.
Topics: Acetylcholine; Animals; Benzomorphans; Choline; Cyclazocine; Dose-Response Relationship, Drug; Dynorphins; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hippocampus; Naloxone; Peptide Fragments; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Synapses | 1986 |
Differentiating aspects of opioid receptor binding by [3H](-) (1R,5R,9R,2''S)-5,9-dimethyl-2-tetrahydrofurfuryl-2'-hydroxy-6,7- benzomorphan hydrochloride ([3H]Mr 2034), a drug preferentially acting on kappa-receptors.
Topics: Animals; Benzomorphans; Binding, Competitive; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Male; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1985 |
Central kappa- and mu-opiate receptors mediate ACTH-release in rats.
Topics: Adrenocorticotropic Hormone; Animals; Benzomorphans; Brain; Female; Male; Morphine; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1985 |
Psychotomimesis mediated by kappa opiate receptors.
Topics: Adult; Anxiety; Benzomorphans; Humans; Male; Middle Aged; Morphinans; Naloxone; Personality Tests; Phencyclidine; Receptors, Opioid; Receptors, Opioid, kappa | 1986 |
A dose-ratio comparison of mu and kappa agonists in formalin and thermal pain.
Topics: Analgesia; Animals; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazocine; Fentanyl; Formaldehyde; Hot Temperature; Male; Naloxone; Pain; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil | 1986 |
Effects of a kappa-opioid agonist on adrenocorticotropic and diuretic function in man.
Topics: Adrenocorticotropic Hormone; Adult; Benzomorphans; Diuresis; Humans; Hydrocortisone; Male; Morphinans; Naloxone; Pituitary Hormones; Receptors, Opioid; Receptors, Opioid, kappa; Stereoisomerism; Vasopressins | 1986 |
Anterior pituitary hormone responses to a kappa-opioid agonist in man.
Topics: Adult; Benzomorphans; Follicle Stimulating Hormone; Growth Hormone; Humans; Kinetics; Luteinizing Hormone; Male; Morphinans; Naloxone; Pituitary Hormones, Anterior; Prolactin; Reference Values; Thyrotropin | 1986 |
Locomotor activity of rats after injection of various opioids into the nucleus accumbens and the septum mediale.
Topics: Animals; Benzomorphans; Drug Synergism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Injections; Male; Morphine; Motor Activity; Naloxone; Narcotics; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Septum Pellucidum | 1985 |
Kappa opiate receptor agonists: effects on behavior and on brain function and structure in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Behavior, Animal; Benzomorphans; Brain; Computers; Cyclazocine; Dose-Response Relationship, Drug; Electroencephalography; Ethylketocyclazocine; Evoked Potentials; Macaca mulatta; Naloxone; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa | 1984 |
Failure to demonstrate mu-isoreceptors.
Topics: Animals; Benzomorphans; Female; Mice; Naloxone; Nociceptors; Receptors, Opioid; Receptors, Opioid, mu; Respiration | 1984 |
Mr 2033 CL--a novel non-morphine-like opioid analgesic.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Humans; Mice; Morphinans; Morphine; Naloxone; Rabbits; Rats; Reaction Time; Receptors, Opioid; Receptors, Opioid, kappa; Stereotyped Behavior | 1983 |
[3H]Mr 2034 labels a high affinity opioid kappa-receptor not accessible to naloxazone.
Topics: Animals; Benzomorphans; Binding, Competitive; Brain; Cyclazocine; Ethylketocyclazocine; In Vitro Techniques; Kinetics; Morphinans; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, kappa | 1983 |
The binding to rat brain homogenates of Mr2034, a universal opiate.
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Dihydromorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Male; Morphinans; Naloxone; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Opioid receptor-mediated suppression of humoral immune response in vivo and in vitro: involvement of kappa opioid receptors.
Topics: Animals; Antibody Formation; Benzomorphans; Immune Tolerance; Immunosuppressive Agents; Male; Naloxone; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sheep | 1995 |