Compounds > mozavaptan
Page last updated: 2024-09-03

mozavaptan and furosemide

mozavaptan has been researched along with furosemide in 8 studies

Compound Research Comparison

Studies
(mozavaptan)		Trials
(mozavaptan)		Recent Studies (post-2010)
(mozavaptan)		Studies
(furosemide)		Trials
(furosemide)		Recent Studies (post-2010) (furosemide)
16582413,6311,3582,486

Protein Interaction Comparison

ProteinTaxonomymozavaptan (IC50)furosemide (IC50)
Corticosteroid 11-beta-dehydrogenase isozyme 1Homo sapiens (human)3.76
Corticosteroid 11-beta-dehydrogenase isozyme 1Mus musculus (house mouse)3.76
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)3.2

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (50.00)18.2507
2000's4 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fujihara, H; Inoue, T; Ohnishi, A; Okahara, R; Orita, Y; Tanaka, T; Yabuuchi, Y; Yamamura, Y1
Bankir, L; Barberis, C; Brossard, G; Chicot, D; Foulon, L; Galindo, G; Garcia, C; Garcia, G; Guillon, G; Jard, S; Lacour, C; Le Fur, G; Maffrand, JP; Marty, E; Nisato, D; Pouzet, B; Raufaste, D; Serradeil-Le Gal, C; Valette, G; Vilain, P1
Christensen, S; Jonassen, TE; Nielsen, S; Petersen, JS1
Christensen, BM; Frokiaer, J; Knepper, MA; Marples, D; Nielsen, S1
Ezure, Y; Fukaya, AY; Hasegaw, H; Koike, K; Kurasawa, T; Matsukawa, H; Naito, A; Naito, K; Oguma, T; Ohtake, Y; Shigenobu, K; Tanaka, H; Tsuriya, Y1
Shimizu, K1
Arata, T; Ejima, Y; Hatano, R; Kazama, I; Matsubara, M; Michimata, M; Miyama, N; Sasaki, S; Sato, A; Satomi, S; Suzuki, K; Suzuki, M1
Arata, T; Ejima, Y; Hatano, R; Kazama, I; Matsubara, M; Michimata, M; Miyama, N; Sanada, S; Sasaki, S; Sato, A; Satomi, S; Suzuki, M1

Trials

1 trial(s) available for mozavaptan and furosemide

ArticleYear
Combined effects of vasopressin V2 receptor antagonist and loop diuretic in humans.
    Clinical nephrology, 2003, Volume: 59, Issue:3

    Topics: Adult; Benzazepines; Cross-Over Studies; Diuretics; Drug Therapy, Combination; Edema; Electrolytes; Furosemide; Hemodynamics; Humans; Hyponatremia; Male; Osmolar Concentration; Potassium; Regression Analysis; Renin; Sodium; Urination; Water

2003

Other Studies

7 other study(ies) available for mozavaptan and furosemide

ArticleYear
Potent aquaretic agent. A novel nonpeptide selective vasopressin 2 antagonist (OPC-31260) in men.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:6

    Topics: Adult; Aldosterone; Analysis of Variance; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzazepines; Blood Pressure; Chlorides; Diuresis; Diuretics; Dose-Response Relationship, Drug; Furosemide; Heart Rate; Humans; Male; Osmolar Concentration; Potassium; Renin; Sodium; Time Factors; Urine

1993
Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist.
    The Journal of clinical investigation, 1996, Dec-15, Volume: 98, Issue:12

    Topics: Adenylyl Cyclases; Administration, Oral; Adrenal Glands; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Autoradiography; Benzazepines; Binding, Competitive; Furosemide; Hydrochlorothiazide; Kidney; Molecular Structure; Morpholines; Potassium; Rats; Sodium; Spiro Compounds; Urine

1996
Decreased vasopressin-mediated renal water reabsorption in rats with compensated liver cirrhosis.
    The American journal of physiology, 1998, Volume: 275, Issue:2

    Topics: Alanine Transaminase; Animals; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Aquaporin 6; Aquaporins; Benzazepines; Bilirubin; Body Water; Carrier Proteins; Citrates; Diuresis; Female; Furosemide; Glomerular Filtration Rate; Hemodynamics; Ion Channels; Kidney; Liver Cirrhosis, Experimental; Natriuresis; Potassium; Rats; Rats, Wistar; Renal Circulation; Sodium; Sodium-Potassium-Chloride Symporters; Vasopressins

1998
Dehydration reverses vasopressin antagonist-induced diuresis and aquaporin-2 downregulation in rats.
    The American journal of physiology, 1998, Volume: 275, Issue:3

    Topics: Animals; Aquaporin 2; Aquaporin 6; Aquaporins; Benzazepines; Dehydration; Diuresis; Diuretics; Furosemide; Gene Expression; Immunohistochemistry; Ion Channels; Kidney Medulla; Male; Microscopy, Immunoelectron; Polyuria; Rats; Rats, Wistar; RNA, Messenger; Vasopressins; Water Deprivation

1998
Pharmacological profile of VP-343, a novel selective vasopressin V2 receptor antagonist, in rats.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:2

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Blood Pressure; Diuretics; Electrolytes; Female; Furosemide; Male; Mice; Mice, Inbred ICR; Pyrroles; Quinoxalines; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptors, Vasopressin; Urodynamics

2000
BSC1 inhibition complements effects of vasopressin V2 receptor antagonist on hyponatremia in SIADH rats.
    Kidney international, 2005, Volume: 67, Issue:5

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Aquaporins; Benzazepines; Deamino Arginine Vasopressin; Diuretics; Furosemide; Hyponatremia; Inappropriate ADH Syndrome; Kidney Medulla; Male; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Sodium; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1; Urea; Water

2005
Lithium effectively complements vasopressin V2 receptor antagonist in the treatment of hyponatraemia of SIADH rats.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:1

    Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Benzazepines; Diabetes Insipidus, Nephrogenic; Disease Models, Animal; Drug Synergism; Furosemide; Hyponatremia; Inappropriate ADH Syndrome; Kidney Tubules, Collecting; Lithium Chloride; Male; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin

2007