Page last updated: 2024-08-16

moxonidine and prazosin

moxonidine has been researched along with prazosin in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.09)18.7374
1990's5 (22.73)18.2507
2000's10 (45.45)29.6817
2010's5 (22.73)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Campillo, NE; Guerra, A; Páez, JA1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Armah, BI1
Plänitz, V1
Penner, SB; Smyth, DD3
Ernsberger, P; Furin, J; Liedtke, CM1
Heintz, B; Kirsten, D; Kirsten, R; Nelson, K1
Lutz, EA; Shannon, HE1
De Luca, LA; dos Santos Moreira, T; Menani, JV; Renzi, A; Takakura, AC1
Edwards, LP; George, OK; Gonzalez, RR1
Gutkowska, J; Menaouar, A; Mukaddam-Daher, S1
Colombari, E; Menani, JV; Moreira, TS; Takakura, AC1
Lu, HG; Ren, LM; Zhang, X; Zhao, D1
Colombari, DS; De Luca, LA; Menani, JV; Moreira, TS; Takakura, AC1
Sun, N; Xiong, Q; Yang, J; Yang, R1
Aston-Jones, G; Smith, RJ1
Hennig, S; Karlsson, MO1

Reviews

1 review(s) available for moxonidine and prazosin

ArticleYear
Clinical pharmacokinetics of vasodilators. Part II.
    Clinical pharmacokinetics, 1998, Volume: 35, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Alprostadil; Amrinone; Carbazoles; Carvedilol; Enoximone; Female; Humans; Iloprost; Imidazoles; Indoramin; Isosorbide Dinitrate; Labetalol; Milrinone; Molsidomine; Nitroglycerin; Nitroprusside; Oxyfedrine; Pentaerythritol Tetranitrate; Phosphodiesterase Inhibitors; Piperazines; Prazosin; Pregnancy; Propanolamines; Pyridones; Theophylline; Trapidil; Vasodilator Agents

1998

Other Studies

21 other study(ies) available for moxonidine and prazosin

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:3

    Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Unique presynaptic alpha 2-receptor selectivity and specificity of the antihypertensive agent moxonidine.
    Arzneimittel-Forschung, 1988, Volume: 38, Issue:10

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Cerebral Cortex; Chemical Phenomena; Chemistry; Clonidine; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart Atria; Heart Rate; Imidazoles; Ligands; Male; Norepinephrine; Papillary Muscles; Phenylephrine; Prazosin; Pulmonary Artery; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Venae Cavae; Yohimbine

1988
Intraindividual comparison of moxonidine and prazosin in hypertensive patients.
    European journal of clinical pharmacology, 1986, Volume: 29, Issue:6

    Topics: Adult; Aged; Blood Pressure; Electrocardiography; Female; Heart Rate; Humans; Hypertension; Imidazoles; Male; Middle Aged; Prazosin

1986
Central and renal I1 imidazoline preferring receptors: two unique sites mediating natriuresis in the rat.
    Cardiovascular drugs and therapy, 1994, Volume: 8 Suppl 1

    Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Dioxanes; Drug Interactions; Idazoxan; Imidazoles; Imidazoline Receptors; Infusions, Intravenous; Injections, Intraventricular; Male; Natriuresis; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Drug

1994
Alpha 2-adrenergic, but not imidazole, agonists activate NaCl cotransport in rabbit tracheal epithelial cells.
    The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 1

    Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Carrier Proteins; Cells, Cultured; Chloride-Bicarbonate Antiporters; Clonidine; Colforsin; Cyclic AMP; Drug Interactions; Epithelial Cells; Epithelium; Guanabenz; Imidazoles; Imidazoline Receptors; Iodine Radioisotopes; Isoproterenol; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Second Messenger Systems; Sodium Chloride Symporters; Symporters; Thromboxane-A Synthase; Trachea

1993
The role of the peripheral sympathetic nervous system in the natriuresis following central administration of an I1 imidazoline agonist, moxonidine.
    British journal of pharmacology, 1995, Volume: 116, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Drug Interactions; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Kidney; Male; Natriuresis; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sympathectomy; Sympathetic Nervous System

1995
Imidazoline receptor mediated natriuresis: central and/or peripheral effect?
    Journal of the autonomic nervous system, 1998, Oct-15, Volume: 72, Issue:2-3

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antihypertensive Agents; Brain; Idazoxan; Imidazoles; Imidazoline Receptors; Injections; Injections, Intravenous; Injections, Intraventricular; Kidney; Male; Natriuresis; Peripheral Nervous System; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reserpine; Sodium; Sympathectomy

1998
Effects of the I(1) imidazoline/alpha(2)-adrenergic receptor agonist moxonidine in comparison with clonidine in the formalin test in rats.
    Pain, 2000, Volume: 85, Issue:1-2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Benzofurans; Clonidine; Dose-Response Relationship, Drug; Formaldehyde; Imidazoles; Imidazoline Receptors; Injections, Subcutaneous; Male; Pain; Pain Measurement; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Drug; Time Factors; Yohimbine

2000
Central alpha(2) adrenergic receptors and cholinergic-induced salivation in rats.
    Brain research bulletin, 2003, Jan-30, Volume: 59, Issue:5

    Topics: Adrenergic alpha-Antagonists; Animals; Brain; Idazoxan; Imidazoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscarinic Agonists; Pilocarpine; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Salivation; Sympatholytics; Yohimbine

2003
Moxonidine, an antihypertensive agent, is permissive to alpha1-adrenergic receptor pathway in the rat-tail artery.
    Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:2

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Antihypertensive Agents; Drug Interactions; Imidazoles; Male; Muscle, Smooth, Vascular; Piperazines; Prazosin; Rats; Rats, Sprague-Dawley; Vasoconstriction; Yohimbine

2004
Receptors involved in moxonidine-stimulated atrial natriuretic peptide release from isolated normotensive rat hearts.
    European journal of pharmacology, 2006, Jul-10, Volume: 541, Issue:1-2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Bridged Bicyclo Compounds; Brimonidine Tartrate; Clonidine; Coronary Circulation; Drug Synergism; Female; Heart; Heart Rate; Heptanes; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Myocardium; Perfusion; Phenoxybenzamine; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine

2006
Involvement of central alpha1- and alpha2-adrenoceptors on cardiovascular responses to moxonidine.
    European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Brain; Brain Stem; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Injections, Intraventricular; Male; Prazosin; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Renal Circulation; Splanchnic Circulation; Vascular Resistance; Yohimbine

2007
Potentiation by yohimbine of alpha-adrenoceptor-mediated vasoconstriction in response to clonidine in the rabbit ear vein.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Ear; Imidazoles; Male; Norepinephrine; Prazosin; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction; Vasoconstrictor Agents; Veins; Yohimbine

2008
Activation of alpha(2)-adrenoceptors in the lateral hypothalamus reduces pilocarpine-induced salivation in rats.
    Neuroscience letters, 2009, Feb-06, Volume: 450, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Drug Interactions; Hypothalamic Area, Lateral; Idazoxan; Imidazoles; Male; Muscarinic Agonists; Norepinephrine; Pilocarpine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Salivation

2009
Effect of moxonidine on the uveoscleral outflow: role of alpha2-adrenoceptors or i1 imidazoline receptors.
    Current eye research, 2009, Volume: 34, Issue:4

    Topics: Administration, Topical; Adrenergic alpha-Antagonists; Animals; Aqueous Humor; Benzofurans; Bridged Bicyclo Compounds; Drug Synergism; Fluorescein-5-isothiocyanate; Heptanes; Imidazoles; Imidazoline Receptors; Prazosin; Rabbits; Receptors, Adrenergic, alpha-2; Sclera; Serum Albumin, Bovine; Uvea; Yohimbine

2009
α(2) Adrenergic and imidazoline receptor agonists prevent cue-induced cocaine seeking.
    Biological psychiatry, 2011, Oct-15, Volume: 70, Issue:8

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cocaine; Cues; Dose-Response Relationship, Drug; Drug Interactions; Drug-Seeking Behavior; Extinction, Psychological; Guanfacine; Imidazoles; Imidazoline Receptors; Isoquinolines; Male; Motor Activity; Naphthyridines; Prazosin; Propranolol; Pyrimidines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration

2011
Concordance between criteria for covariate model building.
    Journal of pharmacokinetics and pharmacodynamics, 2014, Volume: 41, Issue:2

    Topics: Docetaxel; Humans; Imidazoles; Leukocyte Count; Models, Biological; Neutrophils; Pefloxacin; Pharmacokinetics; Prazosin; Stochastic Processes; Taxoids

2014