Compounds > moxifloxacin
Page last updated: 2024-09-04

moxifloxacin and trimethoprim

moxifloxacin has been researched along with trimethoprim in 21 studies

Compound Research Comparison

Studies
(moxifloxacin)		Trials
(moxifloxacin)		Recent Studies (post-2010)
(moxifloxacin)		Studies
(trimethoprim)		Trials
(trimethoprim)		Recent Studies (post-2010) (trimethoprim)
3,1575521,6906,989845894

Protein Interaction Comparison

ProteinTaxonomymoxifloxacin (IC50)trimethoprim (IC50)
Chain A, Dihydrofolate reductaseBacillus anthracis77200
Chain A, dihydrofolate reductase (DHFR)Bacillus anthracis77200
Dihydrofolate reductase Mycobacterium avium0.2588
Dihydrofolate reductaseHomo sapiens (human)1.8206
Dihydrofolate reductaseLacticaseibacillus casei0.3493
Dihydrofolate reductase type 1Escherichia coli0.25
Dihydrofolate reductaseNeisseria gonorrhoeae0.45
Thymidylate synthaseHomo sapiens (human)3.405
Dihydrofolate reductaseStaphylococcus aureus0.0875
Thymidylate synthaseEscherichia coli K-123.405
Dihydrofolate reductaseEscherichia coli K-120.6064
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum K10.01
Dihydrofolate reductase type 1 from Tn4003Staphylococcus aureus0.023
Dipeptidyl peptidase 4Rattus norvegicus (Norway rat)2.7
Dihydrofolate reductasePneumocystis carinii0.7061
Dihydrofolate reductaseCandida albicans0.1361
Dipeptidyl peptidase 4Homo sapiens (human)2.7
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.45
Metabotropic glutamate receptor 5Rattus norvegicus (Norway rat)2.73
Mu-type opioid receptorCavia porcellus (domestic guinea pig)2.8
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii3.2206
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium berghei ANKA0.12
Dihydrofolate reductaseStreptococcus pneumoniae TIGR40.0297
Dihydrofolate reductaseLactococcus lactis subsp. lactis Il14030.45
Dihydrofolate reductase Bacillus anthracis4.77
Dihydrofolate reductaseRattus norvegicus (Norway rat)1.244
Dihydrofolate reductase Pneumocystis jirovecii0.092

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's10 (47.62)29.6817
2010's10 (47.62)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Keserü, GM1
Frank, KL; Patel, R; Piper, KE; Reichert, EJ1
Cho, SH; Franzblau, SG; Hwang, CH; Pauli, GF; Wan, B; Warit, S1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
Jia, L; Sun, H1
Cattoir, V; Nordmann, P; Poirel, L1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Bowker, KE; Caspers, P; Gaucher, B; MacGowan, AP1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Sen, S; Sinha, N1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Domalaon, R; Gorityala, BK; Goswami, S; Idowu, T; Lyu, Y; Schweizer, F; Shan, A; Yang, X; Zhanel, GG1
Dahan, K; Delahousse, M; El Kabbaj, D; Pastural, M; Venditto, M1
Garg, S; Milder, E; Shah, C; Vander, J1
Cook, S; Gigliotti, F; Hardy, D; Laverty, S; Malhotra, Y; Murante, B; Topa, D; Wang, H; Williams, L1
Chojnacki, M; Dunman, PM; Philbrick, A; Reed, JN; Tomaras, A; Wozniak, RAF; Wucher, B1
Sowka, J; Vollmer, L1
Bhamare, P; Dunman, PM; Johnson, W; Kinn, B; Laskey, E; Mei, JA; Nolin, L; Stalker, C; Wozniak, RAF1

Reviews

1 review(s) available for moxifloxacin and trimethoprim

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for moxifloxacin and trimethoprim

ArticleYear
A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children.
    The Journal of pediatrics, 2013, Volume: 162, Issue:4

    Topics: Adolescent; Anti-Bacterial Agents; Aza Compounds; Child; Child, Preschool; Conjunctiva; Conjunctivitis, Bacterial; Drug Therapy, Combination; Female; Fluoroquinolones; Haemophilus influenzae; Humans; Infant; Male; Moraxella catarrhalis; Moxifloxacin; Ophthalmic Solutions; Polymyxin B; Quinolines; Single-Blind Method; Streptococcus pneumoniae; Trimethoprim

2013

Other Studies

19 other study(ies) available for moxifloxacin and trimethoprim

ArticleYear
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:3

    Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Biofilms; DNA, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Nafcillin; Oxazolidinones; Penicillin-Binding Proteins; Penicillins; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcal Infections; Staphylococcus; Tetracycline

2007
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Anti-Bacterial Agents; Antitubercular Agents; DNA, Bacterial; Drug Evaluation, Preclinical; Mycobacterium tuberculosis; Oxygen

2007
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Plasmid-mediated quinolone resistance pump QepA2 in an Escherichia coli isolate from France.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:10

    Topics: Aged; Base Sequence; DNA Primers; DNA, Bacterial; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Female; Fluoroquinolones; France; Genes, Bacterial; Humans; Models, Genetic; Molecular Sequence Data; Plasmids

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
In vitro activities of three new dihydrofolate reductase inhibitors against clinical isolates of gram-positive bacteria.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:11

    Topics: Folic Acid Antagonists; Gram-Positive Bacteria; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Phthalazines; Staphylococcus aureus; Streptococcus

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline.
    Journal of medicinal chemistry, 2017, 05-11, Volume: 60, Issue:9

    Topics: Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Lysine; Microbial Sensitivity Tests; Minocycline; Models, Biological; Rifampin; Tobramycin

2017
Intracranial Nocardia recurrence during fluorinated quinolones therapy.
    Transplant infectious disease : an official journal of the Transplantation Society, 2006, Volume: 8, Issue:3

    Topics: Amikacin; Aza Compounds; Brain Abscess; Drug Combinations; Fluoroquinolones; Humans; Imipenem; Kidney Transplantation; Male; Middle Aged; Moxifloxacin; Nocardia; Nocardia Infections; Quinolines; Sulfamethizole; Trimethoprim

2006
Changes in antibiotic resistance patterns of conjunctival flora due to repeated use of topical antibiotics after intravitreal injection.
    Ophthalmology, 2012, Volume: 119, Issue:7

    Topics: Administration, Topical; Aged; Aged, 80 and over; Anti-Bacterial Agents; Aza Compounds; Bacteria; Case-Control Studies; Conjunctiva; Cross-Sectional Studies; Drug Resistance, Multiple, Bacterial; Eye Infections, Bacterial; Female; Fluoroquinolones; Humans; Intravitreal Injections; Macular Degeneration; Male; Microbial Sensitivity Tests; Middle Aged; Moxifloxacin; Ofloxacin; Ophthalmic Solutions; Polymyxin B; Quinolines; Trimethoprim

2012
Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections.
    Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Cornea; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Eye Infections, Bacterial; Female; Humans; Keratitis; Mice; Mice, Inbred BALB C; Moxifloxacin; Ophthalmic Solutions; Polymyxin B; Pseudomonas aeruginosa; Pseudomonas Infections; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome; Trimethoprim

2019
Case Report: Corneal Ulceration from Bilateral Ectropion Due to Congenital Ichthyosis.
    Optometry and vision science : official publication of the American Academy of Optometry, 2019, Volume: 96, Issue:9

    Topics: Adult; Anti-Bacterial Agents; Corneal Ulcer; Drug Therapy, Combination; Ectropion; Female; Humans; Ichthyosis, Lamellar; Moxifloxacin; Parasympatholytics; Polymyxin B; Slit Lamp Microscopy; Trimethoprim; Tropanes

2019
Antimicrobial Activity of a Triple Antibiotic Combination Toward Ocular Pseudomonas aeruginosa Clinical Isolates.
    Translational vision science & technology, 2022, 05-02, Volume: 11, Issue:5

    Topics: Anti-Bacterial Agents; Bacitracin; Drug Combinations; Erythromycin; Framycetin; Humans; Keratitis; Levofloxacin; Moxifloxacin; Polymyxin B; Pseudomonas aeruginosa; Pseudomonas Infections; Rifampin; Tobramycin; Trimethoprim

2022