moxifloxacin has been researched along with sotalol in 15 studies
| Studies (moxifloxacin) | Trials (moxifloxacin) | Recent Studies (post-2010) (moxifloxacin) | Studies (sotalol) | Trials (sotalol) | Recent Studies (post-2010) (sotalol) |
|---|---|---|---|---|---|
| 3,157 | 552 | 1,690 | 2,196 | 346 | 291 |
| Protein | Taxonomy | moxifloxacin (IC50) | sotalol (IC50) |
|---|---|---|---|
| Beta-2 adrenergic receptor | Homo sapiens (human) | 3.8169 | |
| Beta-1 adrenergic receptor | Homo sapiens (human) | 7.1087 | |
| Beta-3 adrenergic receptor | Homo sapiens (human) | 7.2 | |
| Beta-2 adrenergic receptor | Canis lupus familiaris (dog) | 5.0667 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 11 (73.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cox, BF; Gintant, GA; Limberis, JT; McDermott, JS; Wegner, CD | 1 |
| Hughes, NP; Mason, JW; Poonawala, MH; Strachan, IG; Tarassenko, L | 1 |
| Andersen, MP; Graff, C; Kanters, JK; Matz, J; Nielsen, J; Struijk, JJ; Toft, E | 1 |
| Chain, AS; Danhof, M; Della Pasqua, O; Dubois, VF; Sturkenboom, MC | 1 |
| Mainardi, LT; Rivolta, MW; Sassi, R | 1 |
| Cools, F; Danhof, M; Gallacher, DJ; Gotta, V; Morissette, P; Sannajust, F; van Ammel, K; van der Graaf, PH; Visser, SA | 1 |
| Bhuiyan, TA; Graff, C; Kanters, JK; Matz, J; Melgaard, J; Nielsen, J; Struijk, JJ; Toft, E | 1 |
2 review(s) available for moxifloxacin and sotalol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Inter-study variability of preclinical in vivo safety studies and translational exposure-QTc relationships--a PKPD meta-analysis.
Topics: Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluoroquinolones; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Moxifloxacin; Phenethylamines; Potassium Channel Blockers; Reproducibility of Results; Sotalol; Sulfonamides; Telemetry; Translational Research, Biomedical | 2015 |
2 trial(s) available for moxifloxacin and sotalol
| Article | Year |
|---|---|
Covariate analysis of QTc and T-wave morphology: new possibilities in the evaluation of drugs that affect cardiac repolarization.
Topics: Adolescent; Adult; Algorithms; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Aza Compounds; Cardiovascular Agents; Data Interpretation, Statistical; Drug-Related Side Effects and Adverse Reactions; Electrocardiography; Female; Fluoroquinolones; Heart; Humans; Male; Middle Aged; Moxifloxacin; Quinolines; Risk Assessment; Sotalol; Torsades de Pointes; Young Adult | 2010 |
Identifying the translational gap in the evaluation of drug-induced QTc interval prolongation.
Topics: Adolescent; Adult; Animals; Aza Compounds; Bayes Theorem; Cisapride; Cross-Over Studies; Dogs; Double-Blind Method; Drug Evaluation, Preclinical; Female; Fluoroquinolones; Humans; Long QT Syndrome; Male; Middle Aged; Models, Biological; Moxifloxacin; Probability; Quinolines; Single-Blind Method; Sotalol; Species Specificity; Translational Research, Biomedical; Young Adult | 2013 |
11 other study(ies) available for moxifloxacin and sotalol
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis.
Topics: Action Potentials; Animals; Anti-Infective Agents; Arrhythmias, Cardiac; Aza Compounds; Cisapride; Dogs; Erythromycin; Female; Fluoroquinolones; Imidazoles; In Vitro Techniques; Indoles; Long QT Syndrome; Male; Models, Biological; Moxifloxacin; Perfusion; Piperazines; Purkinje Fibers; Quinolines; Sotalol; Swine; Torsades de Pointes | 2001 |
Automated QT analysis that learns from cardiologist annotations.
Topics: Anti-Arrhythmia Agents; Aza Compounds; Electrocardiography, Ambulatory; Fluoroquinolones; Heart Rate; Humans; Markov Chains; Models, Statistical; Moxifloxacin; Quinolines; Signal Processing, Computer-Assisted; Software; Sotalol | 2009 |
Quantification of ventricular repolarization heterogeneity during moxifloxacin or sotalol administration using [Formula: see text]-index.
Topics: Cardiovascular Agents; Electrocardiography; Fluoroquinolones; Heart Rate; Humans; Moxifloxacin; Placebo Effect; Retrospective Studies; Signal Processing, Computer-Assisted; Sotalol; Ventricular Function | 2015 |
The T-peak-T-end interval as a marker of repolarization abnormality: a comparison with the QT interval for five different drugs.
Topics: Adult; Biomarkers; Clinical Trials as Topic; Dihydropyridines; Electrocardiography; Female; Fluoroquinolones; Humans; Imidazoles; Indoles; Male; Moxifloxacin; Naltrexone; Pharmaceutical Preparations; Sotalol | 2015 |