Page last updated: 2024-09-04

moxifloxacin and ritonavir

moxifloxacin has been researched along with ritonavir in 14 studies

Compound Research Comparison

Studies
(moxifloxacin)
Trials
(moxifloxacin)
Recent Studies (post-2010)
(moxifloxacin)
Studies
(ritonavir)
Trials
(ritonavir)
Recent Studies (post-2010) (ritonavir)
3,1575521,6905,4191,2912,772

Protein Interaction Comparison

ProteinTaxonomymoxifloxacin (IC50)ritonavir (IC50)
Solute carrier organic anion transporter family member 2B1 Homo sapiens (human)6.1
Bile salt export pumpHomo sapiens (human)2.085
ATP-dependent translocase ABCB1Homo sapiens (human)2.65
Cytochrome P450 3A4Homo sapiens (human)0.1623
Cytochrome P450 2D6Homo sapiens (human)2.3
Cytochrome P450 2C9 Homo sapiens (human)2.458
Gag-Pol polyproteinHuman immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)0.067
Substance-K receptorHomo sapiens (human)2.622
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)2.35
Thromboxane-A synthase Homo sapiens (human)0.076
Multidrug and toxin extrusion protein 2Homo sapiens (human)4.4
Multidrug and toxin extrusion protein 1Homo sapiens (human)2.1933
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)4.4
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)2
Protease Human immunodeficiency virus 14.9253

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (14.29)29.6817
2010's5 (35.71)24.3611
2020's7 (50.00)2.80

Authors

AuthorsStudies
Jolivette, LJ; Nagilla, R; Ward, KW1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Caceres, M; Devinsky, O; Huddlestone, JR; Kasserra, C; Medlock, M; Morrison, R; O'Mara, E; Soni, P; Wan, Y1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Amantea, MA; Nickens, DJ; Raber, SR; Reynolds, RR; Sarapa, N1
Cristea, L; Farha, R; Jordan, P; Kolis, S; Lee, LS; Salgo, M; Zhang, X1
Cao, Y; Xu, S; Zhou, M; Zhu, F1
Chen, Q; Dai, Y; Gao, G; Han, W; Li, J; Li, L; Li, X; Liu, C; Quan, B; Wang, C; Yang, J; Zhang, G; Zhang, J; Zhang, Z; Zheng, W1
Chen, T; Hu, Y; Li, L; Liu, H; Liu, M; Wang, F; Wang, Y; Xia, H; Zhang, L; Zhao, S1
Cao, J; Fan, L; He, F; Hu, K; Lei, M; Luo, Q; Qin, S; Shao, X; Yang, L; Yu, N1
Luo, S; Tian, M; Wang, L; Xia, W; Zeng, Y; Zha, Y; Zhang, K; Zhang, X1
Chen, Y; Fan, L; Gu, Y; Li, N; Liu, C; Liu, H; Liu, Y1
Tang, L; Zeng, X1

Reviews

2 review(s) available for moxifloxacin and ritonavir

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Successful recovery of recurrence of positive SARS-CoV-2 RNA in COVID-19 patient with systemic lupus erythematosus: a case report and review.
    Clinical rheumatology, 2020, Volume: 39, Issue:9

    Topics: Adult; Anti-Bacterial Agents; Antirheumatic Agents; Antiviral Agents; Betacoronavirus; Clinical Laboratory Techniques; Coronavirus Infections; COVID-19; COVID-19 Testing; Drug Combinations; Female; Glucocorticoids; Humans; Hydroxychloroquine; Immunosuppressive Agents; Lopinavir; Lung; Lupus Erythematosus, Systemic; Moxifloxacin; Mycophenolic Acid; Pandemics; Pneumonia, Viral; Prednisone; Recurrence; Reverse Transcriptase Polymerase Chain Reaction; Ritonavir; RNA, Viral; SARS-CoV-2; Tomography, X-Ray Computed

2020

Trials

3 trial(s) available for moxifloxacin and ritonavir

ArticleYear
Effect of vicriviroc on the QT/corrected QT interval and central nervous system in healthy subjects.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:6

    Topics: Adolescent; Adult; Anti-HIV Agents; Arrhythmias, Cardiac; CCR5 Receptor Antagonists; Central Nervous System; Electrocardiography; Electroencephalography; Female; Heart; HIV Infections; Humans; Male; Middle Aged; Piperazines; Pyrimidines; Ritonavir; Young Adult

2010
Ritonavir 100 mg does not cause QTc prolongation in healthy subjects: a possible role as CYP3A inhibitor in thorough QTc studies.
    Clinical pharmacology and therapeutics, 2008, Volume: 83, Issue:1

    Topics: Adult; Aza Compounds; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electrocardiography; Female; Fluoroquinolones; Heart Rate; HIV Protease Inhibitors; Humans; Imidazoles; Ketoconazole; Liver; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Reference Values; Reproducibility of Results; Research Design; Reverse Transcriptase Inhibitors; Ritonavir; Sulfur Compounds; Treatment Outcome

2008
Thorough QT/QTc study of ritonavir-boosted saquinavir following multiple-dose administration of therapeutic and supratherapeutic doses in healthy participants.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:4

    Topics: Adolescent; Adult; Aza Compounds; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Fluoroquinolones; HIV Protease Inhibitors; Humans; Least-Squares Analysis; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Quinolines; Ritonavir; Saquinavir; Torsades de Pointes; Young Adult

2012

Other Studies

9 other study(ies) available for moxifloxacin and ritonavir

ArticleYear
Comparative evaluation of oral systemic exposure of 56 xenobiotics in rat, dog, monkey and human.
    Xenobiotica; the fate of foreign compounds in biological systems, 2005, Volume: 35, Issue:2

    Topics: Administration, Oral; Animals; Area Under Curve; Dogs; Haplorhini; Humans; Models, Statistical; Rats; Software; Species Specificity; Xenobiotics

2005
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city, China.
    Journal of medical virology, 2020, Volume: 92, Issue:6

    Topics: Anti-HIV Agents; Betacoronavirus; China; Clinical Laboratory Techniques; Coinfection; Coronavirus Infections; COVID-19; COVID-19 Testing; Diabetes Mellitus, Type 2; Drug Combinations; gamma-Globulins; HIV; HIV Infections; Humans; Lopinavir; Male; Methylprednisolone; Middle Aged; Moxifloxacin; Pandemics; Pneumonia, Viral; Ritonavir; SARS-CoV-2; Tomography, X-Ray Computed; Treatment Outcome

2020
A report of clinical diagnosis and treatment of nine cases of coronavirus disease 2019.
    Journal of medical virology, 2020, Volume: 92, Issue:6

    Topics: Adolescent; Adult; Betacoronavirus; China; Clinical Laboratory Techniques; Contact Tracing; Coronavirus Infections; COVID-19; COVID-19 Testing; Female; Humans; Interferon alpha-2; Lopinavir; Male; Methylprednisolone; Middle Aged; Moxifloxacin; Oropharynx; Oxygen; Pandemics; Pneumonia, Viral; Retrospective Studies; Ritonavir; RNA, Viral; SARS-CoV-2; Severity of Illness Index; T-Lymphocytes; Tomography, X-Ray Computed

2020
Positive detection of SARS-CoV-2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non-conjunctivitis COVID-19 patient with obstruction of common lacrimal duct.
    Acta ophthalmologica, 2020, Volume: 98, Issue:8

    Topics: Aged; Anti-Bacterial Agents; Conjunctiva; Conjunctivitis, Viral; COVID-19; COVID-19 Drug Treatment; Drug Therapy, Combination; Eye Infections, Viral; Flow Cytometry; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 6, Human; High-Throughput Nucleotide Sequencing; HIV Protease Inhibitors; Humans; Lacrimal Duct Obstruction; Lopinavir; Male; Medicine, Chinese Traditional; Moxifloxacin; Nasopharynx; Nucleic Acids; Polymerase Chain Reaction; Ritonavir; RNA, Viral; Roseolovirus Infections; SARS-CoV-2; Tears

2020
The combined therapy of a traditional Chinese medicine formula and Western medicine for a critically ill case infected with COVID-19.
    Complementary therapies in medicine, 2020, Volume: 52

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Critical Illness; Drug Combinations; Drugs, Chinese Herbal; Female; Humans; Indoles; Lopinavir; Medicine, Chinese Traditional; Methylprednisolone; Middle Aged; Moxifloxacin; Noninvasive Ventilation; Oxygen Inhalation Therapy; Pandemics; Pneumonia, Viral; Qi; Ritonavir; SARS-CoV-2

2020
Medical treatment of 55 patients with COVID-19 from seven cities in northeast China who fully recovered: A single-center, retrospective, observational study.
    Medicine, 2021, Jan-15, Volume: 100, Issue:2

    Topics: Anti-Bacterial Agents; Antiviral Agents; China; COVID-19 Drug Treatment; Female; Glucocorticoids; Humans; Immunologic Factors; Indoles; Linezolid; Lopinavir; Male; Middle Aged; Moxifloxacin; Retrospective Studies; Ritonavir

2021
One-year Follow-up after Severe SARS-CoV-2 Pneumonia.
    Radiology, 2021, Volume: 300, Issue:1

    Topics: Anti-Bacterial Agents; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Female; Follow-Up Studies; Humans; Lung; Middle Aged; Moxifloxacin; Ritonavir; SARS-CoV-2; Severity of Illness Index; Tomography, X-Ray Computed

2021