Page last updated: 2024-09-04

moxifloxacin and diclofenac

moxifloxacin has been researched along with diclofenac in 20 studies

Compound Research Comparison

Studies
(moxifloxacin)
Trials
(moxifloxacin)
Recent Studies (post-2010)
(moxifloxacin)
Studies
(diclofenac)
Trials
(diclofenac)
Recent Studies (post-2010) (diclofenac)
3,1575521,6908,8741,8743,616

Protein Interaction Comparison

ProteinTaxonomymoxifloxacin (IC50)diclofenac (IC50)
Aldo-keto reductase family 1 member B10Homo sapiens (human)1.9
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.003
Prostaglandin G/H synthase 1Ovis aries (sheep)1.3376
Interleukin-8Homo sapiens (human)0.008
Prostaglandin G/H synthase 1Homo sapiens (human)0.0415
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.5
C-X-C chemokine receptor type 1Homo sapiens (human)0.012
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.5
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.5
Prostaglandin G/H synthase 2Homo sapiens (human)0.4165
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.5
Prostaglandin G/H synthase 2Ovis aries (sheep)1.6867
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.0502
Solute carrier family 22 member 6Homo sapiens (human)4
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.02

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (15.00)29.6817
2010's16 (80.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Jolivette, LJ; Ward, KW1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Eswaran, S; Narayanan, S; Shivarudraiah, P; Shruthi, TG; Subramanian, S1
Bishai, WR; Duan, G; Gunosewoyo, H; Liu, LL; Lun, S; Tang, J; Xiao, S; Yang, F; Yu, LF; Zhang, W1
Caljon, G; Cappoen, D; Claes, P; Cools, F; Cos, P; De Kimpe, N; de Macedo, MB; Delputte, P; Holvoet, F; Maes, L; Mangelinckx, S; Matheeussen, A; Meiresonne, T; Neyrolles, O; Piller, T; Semina, E; Torfs, E; Van Calster, K1
Bouchard, A; Carr, DB; Hamilton, DA; Lacouture, PG; Lang, E; Madden, D; McDonnell Moorehead, T; Sprenger, CR; Wright, C1
Chen, L; Guo, S; Wu, LX; Xu, M; Zhang, JH1
Ashfaq, M; Faizan Nazar, M; Iqbal, J; Mulla, SI; Mustafa, G; Nawaz Khan, K; Saif Ur Rehman, M; Sun, Q; Yu, CP1
Fernandes, A; Nunes, TG; Oliveira, AS; Saramago, B; Serro, AP; Topete, A1
Gil, MH; Moutinho, GM; Santos, LF; Saramago, B; Serro, AP; Silva, D; Sousa, HC1
Saramago, B; Serro, AP; Topete, A1
Chauhan, A; Colaço, R; Pimenta, AFR; Serro, AP1
Arshad, S; Batool, F; Fu, Q; Shahzad, A; Shahzad, S; Zubair, F1

Reviews

1 review(s) available for moxifloxacin and diclofenac

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for moxifloxacin and diclofenac

ArticleYear
Effects of injectable HPβCD-diclofenac on the human delayed rectifier potassium channel current in vitro and on proarrhythmic QTc in vivo.
    Clinical therapeutics, 2013, Volume: 35, Issue:5

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Aza Compounds; beta-Cyclodextrins; Cross-Over Studies; Diclofenac; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; HEK293 Cells; Humans; Long QT Syndrome; Male; Middle Aged; Moxifloxacin; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Quinolines; Young Adult

2013

Other Studies

18 other study(ies) available for moxifloxacin and diclofenac

ArticleYear
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety.
    Bioorganic & medicinal chemistry letters, 2019, 01-01, Volume: 29, Issue:1

    Topics: Antitubercular Agents; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Microsomes, Liver; Molecular Structure; Mycobacterium tuberculosis; Oxadiazoles; Quinolines; Structure-Activity Relationship

2019
Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.
    Journal of medicinal chemistry, 2019, 04-11, Volume: 62, Issue:7

    Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Coumarins; Crystallography, X-Ray; Drug Resistance, Bacterial; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Molecular Docking Simulation; Mycobacterium tuberculosis; Polyketide Synthases; Structure-Activity Relationship; Vero Cells

2019
The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis.
    European journal of medicinal chemistry, 2019, Nov-01, Volume: 181

    Topics: Animals; Antitubercular Agents; Benzophenanthridines; Cell Line; Dose-Response Relationship, Drug; Humans; Hydrocarbons, Fluorinated; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship

2019
Effect of diclofenac on the pharmacokinetics of moxifloxacin in rats.
    Drug research, 2014, Volume: 64, Issue:7

    Topics: Administration, Oral; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Diclofenac; Drug Interactions; Female; Fluoroquinolones; Male; Moxifloxacin; Rats; Rats, Sprague-Dawley

2014
Ecological risk assessment of pharmaceuticals in the receiving environment of pharmaceutical wastewater in Pakistan.
    Ecotoxicology and environmental safety, 2017, Volume: 136

    Topics: Animals; Diclofenac; Ecology; Environmental Monitoring; Fishes; Fluoroquinolones; Gemifloxacin; Ibuprofen; Moxifloxacin; Naphthyridines; Pakistan; Risk Assessment; Sewage; Wastewater; Water Pollutants, Chemical

2017
Improving sustained drug delivery from ophthalmic lens materials through the control of temperature and time of loading.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, May-30, Volume: 117

    Topics: Administration, Ophthalmic; Anti-Bacterial Agents; Anti-Inflammatory Agents; Contact Lenses, Hydrophilic; Delayed-Action Preparations; Diclofenac; Drug Delivery Systems; Drug Liberation; Fluoroquinolones; Ketorolac; Lenses, Intraocular; Moxifloxacin; Temperature

2018
Antibacterial layer-by-layer coatings to control drug release from soft contact lenses material.
    International journal of pharmaceutics, 2018, Dec-20, Volume: 553, Issue:1-2

    Topics: Administration, Ophthalmic; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Chlorhexidine; Contact Lenses, Hydrophilic; Cross-Linking Reagents; Delayed-Action Preparations; Diclofenac; Drug Liberation; Excipients; Models, Theoretical; Moxifloxacin; Polyelectrolytes; Tears

2018
Dual drug delivery from intraocular lens material for prophylaxis of endophthalmitis in cataract surgery.
    International journal of pharmaceutics, 2019, Mar-10, Volume: 558

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cataract Extraction; Diclofenac; Drug Delivery Systems; Drug Liberation; Endophthalmitis; Humans; Hydrogels; Ketorolac; Lenses, Intraocular; Models, Biological; Moxifloxacin; Staphylococcus aureus; Staphylococcus epidermidis

2019
Optimization of intraocular lens hydrogels for dual drug release: Experimentation and modelling.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2019, Volume: 141

    Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Delivery Systems; Drug Liberation; Hydrogels; Lenses, Intraocular; Methacrylates; Methylmethacrylate; Moxifloxacin

2019
Development and Validation of Facile RP-HPLC Method for Simultaneous Determination of Timolol Maleate, Moxifloxacin Hydrochloride, Diclofenac Sodium and Dexamethasone in Plasma, Aqueous Humor and Pharmaceutical Products.
    Journal of chromatographic science, 2023, Aug-19, Volume: 61, Issue:7

    Topics: Animals; Aqueous Humor; Cattle; Chromatography, High Pressure Liquid; Dexamethasone; Diclofenac; Humans; Moxifloxacin; Pharmaceutical Preparations; Reproducibility of Results; Timolol

2023