moxidectin and squalestatin-1

Follow-up of natural products isolation refers to re-isolation of compound(s) of interest in larger amounts for further pharmacological testing, conclusive structure elucidation, structure modifications to synthesize analogs for structure-activity relationships (SAR) studies, preformulation and formulation studies or clinical trials. In addition to conventional synthetic chemistry approaches, several other methodologies can be applied for following-up natural products isolation. This chapter outlines, with specific examples, various strategies and methods involved in follow-up of natural products isolation.

Topics: Alkaloids; Anthracyclines; Anti-Bacterial Agents; Bacteria; Biocatalysis; Biological Products; Biosynthetic Pathways; Biotransformation; Bridged Bicyclo Compounds, Heterocyclic; Chemical Fractionation; Combinatorial Chemistry Techniques; Fungi; Gene Expression; Halogens; Macrolides; Steroids; Terpenes; Tricarboxylic Acids