moxidectin and nemadectin

moxidectin has been researched along with nemadectin* in 2 studies

Other Studies

2 other study(ies) available for moxidectin and nemadectin

ArticleYear
New biotransformation products of nemadectins.
    The Journal of antibiotics, 2001, Volume: 54, Issue:10

    Selected nemadectins (formerly LL-F28249 series) have been fed to a panel of microorganisms with the aim of generating new derivatives. In addition to products resulting from the oxidation of the terminal methyl group (C-29), a unique phosphorylated nemadectin was isolated. The phosphate group was determined to be at C-23 by HMBC between phosphorus and H-23. Milbemycin or nemadectin derivatives with natural substituents involving the 23-hydroxyl group were hitherto unknown.

    Topics: Animals; Anti-Bacterial Agents; Antinematodal Agents; Biotransformation; Caenorhabditis elegans; Chromatography, High Pressure Liquid; Cyclotrons; Fourier Analysis; Macrolides; Mass Spectrometry; Mucor; Oxidation-Reduction; Phosphorylation; Streptomyces griseus

2001
Efficacy of moxidectin, nemadectin and ivermectin against an ivermectin-resistant strain of Haemonchus contortus in sheep.
    The Veterinary record, 1992, Mar-21, Volume: 130, Issue:12

    The efficacies of ivermectin, nemadectin and moxidectin were evaluated when administered orally to lambs infected with either a susceptible laboratory strain of Haemonchus contortus or a strain reported to be resistant to ivermectin. Groups of 24 Dorset cross Cheviot cross Suffolk lambs were infected with either the susceptible or resistant strain of H contortus and allocated to treatment groups according to their faecal egg counts 27 days after infection. One day later the lambs were dosed orally with one of the three anthelmintics at 0.2 mg/kg bodyweight, and they were killed and surviving worms were recovered 13 or 14 days after treatment. Against the ivermectin resistant strain, ivermectin did not significantly reduce the egg count or the numbers of adult H contortus; however, both nemadectin and moxidectin reduced the nematode egg counts and the numbers of H contortus by 99 and 100 per cent, respectively. Against the susceptible strain, all the anthelmintics reduced the egg counts by 100 per cent as early as four days after treatment and reduced the numbers of susceptible H contortus by 100 per cent. No adverse reactions to any of the drugs were observed.

    Topics: Animals; Anti-Bacterial Agents; Antinematodal Agents; Drug Resistance; Feces; Haemonchiasis; Haemonchus; Ivermectin; Macrolides; Parasite Egg Count; Sheep; Sheep Diseases

1992