moxidectin and decamethrin

The aim of the present study was to carry out comparative therapeutic effect of moxidectin pour on, doramectin and ivermectin on psoroptes infestation in buffalo. A total of 318 buffalo in 77 small scale herds suspected to have mange mites were examined clinically and parasitologically. Fifty-three (16.66%) buffalo in 25 herds were recorded to be infested; 51 (16.35%) with psoroptic mites, and two (0.31%) with chorioptic mites. Buffalo with psoroptic mites were randomly allocated into three groups (17 buffalo each). First group was treated with moxidectin pour on at a dose rate of 0.5 mg kg(-1). The second group received doramectin (200 microg kg(-1) twice subcutaneously, 14 days apart). The third group received ivermectin (200 microg kg(-1) twice subcutaneously, 14 days apart). Adjunct to each drug, deltamethrin was applied to the surrounding environment twice at a two week interval. Treatment outcomes of 51 buffalo with psoroptic mites showed that moxidectin pour on and doramectin had a significant higher effect on mite count reduction (MANOVA, P < 0.01; Walks' Lambda, P < 0.01) and clinical sum scores (MANOVA, P < 0.05; Walks' Lambda, P < 0.05) compared with injectible ivermectin. On clinical level, the number of clinically recovered buffalo in moxidectin and doramectin treated groups was significantly (P < 0.05) higher than that of ivermectin treated group. The result of the present study indicated that psoroptic mites are the main cause of mange in buffalo in Lower Egypt. This is the first report that describes the effect of moxidectin in buffalo. Moxidectin is a good alternative and easily applied drug for treatment of psoroptes infestation in buffalo.

Topics: Analysis of Variance; Animals; Antiparasitic Agents; Buffaloes; Egypt; Ivermectin; Macrolides; Mite Infestations; Nitriles; Psoroptidae; Pyrethrins

Four trials, three in the United States and one in South Africa, were conducted to evaluate the potential value of a novel self-medicating applicator in the passive control of gastrointestinal nematodes in cattle and deer, and of files and ticks on cattle using oil-based treatments. The results of the trials demonstrated that this applicator is an effective and practical device for the passive treatment of both deer and cattle for trichostrongyle infections using the endectocide, moxidectin (Cydectin. Fort Dodge Animal Health, USA), of cattle for hom fly (Haemotobia irritans) infestations using the insecticide, cyfluthrin (CyLence, Bayer AG, Germany) and of cattle for tick infestations (in particular Amblyomma hebraeum and Rhipicephalus appendiculatus) using the acaricides deltamethrin and amitraz (Delete All, Intervet, South Africa).

Topics: Administration, Topical; Animals; Animals, Domestic; Animals, Wild; Anthelmintics; Cattle; Deer; Drug Combinations; Ectoparasitic Infestations; Female; Insecticides; Intestinal Diseases, Parasitic; Macrolides; Male; Nematode Infections; Nitriles; Pesticide Synergists; Piperonyl Butoxide; Pyrethrins; Random Allocation; Tick Control; Tick Infestations; Toluidines