Page last updated: 2024-08-23

moxalactam and 1-n-methyl-5-thiotetrazole

moxalactam has been researched along with 1-n-methyl-5-thiotetrazole in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199020 (95.24)18.7374
1990's1 (4.76)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Freimer, EH; Ingalls, CS1
Adam, D; Naber, K; Schäfer, H1
Hejmanowski, LG; Rigan, D; Schentag, JJ; Walawander, C; Welage, LS; Williams, JS; Wilton, JH1
Gallego, MO; Kerremans, AL; Lipsky, JJ; Van Loon, J; Weinshilboum, RM1
Hirai, E; Kawamoto, K; Matsubara, T; Ogawa, A; Okamoto, J; Otsubo, S; Sugeno, K; Tochino, Y; Yoshida, T1
Adelman, MH; Grasela, TH; Rigan, D; Schentag, JJ; Welage, LS; Williams, JS; Wilton, JH1
Adelman, MH; Grasela, TH; Schentag, JJ; Welage, LS1
Matsubara, T; Ogawa, A; Oka, T; Otsubo, S1
Hirai, Y; Imamura, K; Kudo, H; Kumasaka, Y; Makino, I; Miyazawa, T; Nakahata, H; Nakamura, T; Takebe, K1
Ganzinger, U; Haberl, H; Haslberger, A; Hitzenberger, G; Schatz, F; Schiel, H1
Ishigami, T; Komeno, T; Konishi, M; Nakamura, M; Uchida, K1
Inazawa, K; Mizojiri, K; Norikura, R; Okabe, H; Sugeno, K; Takashima, A; Tanaka, H; Yoshimori, T; Yukawa, T1
Hayashi, Y; Nakamura, K; Shimada, J1
Coombes, JD; Ings, RM; MacDonald, CM; Turcan, RG1
Akiyoshi, T; Asakawa, S; Igimi, H; Konishi, M; Uchida, K1
Lipsky, JJ2
Black, HR; Buening, MK; Wolen, RL1
Lewis, JC; Lipsky, JJ; Novick, WJ1
Ishigami, T; Komeno, T; Uchida, K1
Smith, GF; Sundboom, JL1

Reviews

1 review(s) available for moxalactam and 1-n-methyl-5-thiotetrazole

ArticleYear
Determinants of antibiotic-associated hypoprothrombinemia.
    Pharmacotherapy, 1987, Volume: 7, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Blood Coagulation; Cephalosporins; Humans; Hypoprothrombinemias; In Vitro Techniques; Moxalactam; Risk; Tetrazoles

1987

Trials

2 trial(s) available for moxalactam and 1-n-methyl-5-thiotetrazole

ArticleYear
[Hemostasis disturbance caused by cephalosporins with an N-methylthiotetrazole side chain. A randomized pilot study].
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:9

    Topics: Aged; Aged, 80 and over; Azoles; Blood Coagulation Disorders; Cefoperazone; Cefotaxime; Cephalosporins; Female; Humans; Male; Moxalactam; Pilot Projects; Protein C; Prothrombin Time; Random Allocation; Tetrazoles; Urinary Tract Infections; Vitamin K Deficiency

1989
Comparison of N-methylthiotetrazole dispositions in healthy volunteers following single intravenous doses of moxalactam, cefoperazone, and cefotetan.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:6

    Topics: Adult; Azoles; Cefoperazone; Cefotetan; Chromatography, High Pressure Liquid; Female; Hematocrit; Humans; Infusions, Intravenous; Male; Moxalactam; Tetrazoles

1989

Other Studies

18 other study(ies) available for moxalactam and 1-n-methyl-5-thiotetrazole

ArticleYear
Detection of antibiotic-induced platelet dysfunction in whole blood using flow cytometry.
    The Journal of antimicrobial chemotherapy, 1992, Volume: 29, Issue:3

    Topics: Adenosine Diphosphate; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Blood Platelet Disorders; Cefotetan; Cefoxitin; Epinephrine; Flow Cytometry; Fluorescein; Fluoresceins; Goats; Humans; Immunoglobulin G; Mice; Moxalactam; P-Selectin; Platelet Activation; Platelet Membrane Glycoproteins; Tetrazoles

1992
Cephalosporin-induced hypoprothrombinemia: possible role for thiol methylation of 1-methyltetrazole-5-thiol and 2-methyl-1,3,4-thiadiazole-5-thiol.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 235, Issue:2

    Topics: Animals; Azoles; Biotransformation; Carbon-Carbon Ligases; Cephalosporins; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Humans; Hypoprothrombinemias; Kidney; Kinetics; Ligases; Male; Methylation; Methyltransferases; Microsomes, Liver; Moxalactam; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Tetrazoles; Thiadiazoles

1985
Effects of beta-lactam antibiotics and N-methyltetrazolethiol on the alcohol-metabolizing system in rats.
    Japanese journal of pharmacology, 1987, Volume: 45, Issue:3

    Topics: Acetaldehyde; Alcohols; Aldehyde Dehydrogenase; Animals; Anti-Bacterial Agents; Azoles; Cefamandole; Ethanol; Histamine H1 Antagonists; Liver; Male; Mitochondria, Liver; Moxalactam; Rats; Rats, Inbred Strains; Subcellular Fractions; Tetrazoles; Time Factors

1987
Kinetics and action of N-methylthiotetrazole in volunteers and patients. Population-based clinical comparisons of antibiotics with and without this moiety.
    American journal of surgery, 1988, May-31, Volume: 155, Issue:5A

    Topics: Azoles; Cefoperazone; Cefotetan; Cephalosporins; Cephamycins; Humans; Hypoprothrombinemias; Moxalactam; Population Surveillance; Risk Factors; Tetrazoles

1988
Pharmacokinetics of latamoxef and N-methyltetrazolethiol in rats associated with the development of disulfiram-like effects.
    Japanese journal of pharmacology, 1987, Volume: 45, Issue:2

    Topics: Acetaldehyde; Aldehyde Dehydrogenase; Animals; Azoles; Bile; Disulfiram; Ethanol; Liver; Male; Moxalactam; Rats; Rats, Inbred Strains; Tetrazoles

1987
[Free methyltetrazolethiol concentrations in men subjected to intravenous administration of cephems with methyltetrazolethiol].
    The Japanese journal of antibiotics, 1987, Volume: 40, Issue:7

    Topics: Aldehyde Oxidoreductases; Azoles; Biotransformation; Cefmetazole; Cefoperazone; Cephalosporins; Cephamycins; Disulfiram; Humans; Injections, Intravenous; Liver; Liver Cirrhosis; Middle Aged; Moxalactam; Tetrazoles

1987
Comparative pharmacokinetic analysis of latamoxef and CPW 86-363, a novel carboxy-pyrazol-cephalosporin and formation of N-methyl-thiotetrazole.
    International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:3

    Topics: Adult; Azoles; Biotransformation; Blood Coagulation Disorders; Cephalosporins; Humans; Kinetics; Male; Moxalactam; Structure-Activity Relationship; Tetrazoles

1987
Effect of latamoxef on platelet function and prothrombin time in partially nephrectomized rats.
    Japanese journal of pharmacology, 1987, Volume: 43, Issue:1

    Topics: Adenosine Diphosphate; Animals; Blood Platelets; Creatinine; Glomerular Filtration Rate; Male; Moxalactam; Nephrectomy; Prothrombin Time; Rats; Rats, Inbred Strains; Tetrazoles; Vitamin K Deficiency

1987
Disposition of moxalactam and N-methyltetrazolethiol in rats and monkeys.
    Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:8

    Topics: Animals; Azoles; Bile; Feces; Female; Injections, Intravenous; Kinetics; Liver; Macaca fascicularis; Male; Moxalactam; Rats; Rats, Inbred Strains; Species Specificity; Subcellular Fractions; Tetrazoles; Tissue Distribution

1987
Cefmetazole: clinical evaluation of efficacy and safety in Japan.
    Drugs under experimental and clinical research, 1985, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Aldehyde Oxidoreductases; Animals; Azoles; Bacterial Infections; Cefmetazole; Cefoperazone; Cephamycins; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dogs; Drug Evaluation; Ethanol; Humans; In Vitro Techniques; Infant; Japan; Macaca fascicularis; Male; Middle Aged; Moxalactam; Rats; Rats, Inbred Strains; Respiratory Tract Infections; Structure-Activity Relationship; Tetrazoles

1985
Inhibition of the rate of 14CO2 production from [14C]ethanol in rats given beta-lactam antibiotics with disulfiram-like effects.
    Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Bile; Carbon Dioxide; Depression, Chemical; Disulfiram; Ethanol; Kinetics; Male; Models, Biological; Moxalactam; Rats; Rats, Inbred Strains; Tetrazoles

1985
Biliary excretion of latamoxef and N-methyltetrazolethiol in humans and rats.
    Journal of pharmacobio-dynamics, 1985, Volume: 8, Issue:11

    Topics: Animals; Azoles; Bile; Carcinoma; Cholelithiasis; Gallbladder Neoplasms; Humans; Injections, Intravenous; Male; Moxalactam; Pancreatic Neoplasms; Rats; Rats, Inbred Strains; Tetrazoles; Time Factors

1985
N-methyl-thio-tetrazole inhibition of the gamma carboxylation of glutamic acid: possible mechanism for antibiotic-associated hypoprothrombinaemia.
    Lancet (London, England), 1983, Jul-23, Volume: 2, Issue:8343

    Topics: Animals; Anti-Bacterial Agents; Azoles; Bacteria; Biotransformation; Cefamandole; Cefoperazone; Cephalosporins; Cephamycins; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Humans; Hypoprothrombinemias; Intestines; Moxalactam; Prothrombin; Rats; Structure-Activity Relationship; Tetrazoles

1983
Latamoxef, its side chain, and coagulation.
    Lancet (London, England), 1983, Nov-05, Volume: 2, Issue:8358

    Topics: Animals; Azoles; Blood Coagulation; Humans; Male; Moxalactam; Rats; Tetrazoles

1983
Production of hypoprothrombinemia by moxalactam and 1-methyl-5-thiotetrazole in rats.
    Antimicrobial agents and chemotherapy, 1984, Volume: 25, Issue:3

    Topics: Administration, Oral; Animals; Azoles; Cefotaxime; Female; Hypoprothrombinemias; Injections, Intravenous; Moxalactam; Prothrombin Time; Rats; Rats, Inbred Strains; Tetrazoles; Vitamin K Deficiency

1984
Effects of latamoxef and methyltetrazolethiol on gamma-glutamylcarboxylase activity.
    Japanese journal of pharmacology, 1984, Volume: 35, Issue:3

    Topics: Animals; Azoles; Carbon-Carbon Ligases; Ligases; Male; Microsomes, Liver; Moxalactam; Rats; Rats, Inbred Strains; Tetrazoles; Vitamin K Deficiency

1984
Mechanism of the inhibition of the gamma-carboxylation of glutamic acid by N-methylthiotetrazole-containing antibiotics.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:9

    Topics: Animals; Azoles; Disulfides; Glutamates; Glutathione; Microsomes, Liver; Moxalactam; Prothrombin; Rats; Tetrazoles

1984
The effects of 1-methyl-5-thiotetrazole in a rat liver vitamin K-dependent carboxylase assay.
    Thrombosis research, 1984, Mar-15, Volume: 33, Issue:6

    Topics: Animals; Azoles; Carbon-Carbon Ligases; Hemorrhage; Humans; In Vitro Techniques; Ligases; Male; Microsomes, Liver; Moxalactam; Rats; Rats, Inbred Strains; Tetrazoles; Warfarin

1984