mosapride and td-5108
mosapride has been researched along with td-5108 in 33 studies
Compound Research Comparison
| Studies (mosapride) | Trials (mosapride) | Recent Studies (post-2010) (mosapride) | Studies (td-5108) | Trials (td-5108) | Recent Studies (post-2010) (td-5108) |
|---|---|---|---|---|---|
| 286 | 90 | 142 | 340 | 52 | 216 |
Research
Studies (33)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (33.33) | 29.6817 |
| 2010's | 22 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Cange, L; Finizia, C; Lundell, L; Ruth, M | 1 |
| Asahina, M; Hattori, T; Ito, T; Liu, Z; Odaka, T; Sakakibara, R; Uchiyama, T; Yamaguchi, K; Yamaguchi, T; Yamamoto, T | 1 |
| Fujii, H; Katsui, R; Kojima, Y; Nakagawa, T; Nakajima, Y; Takaki, M | 1 |
| Okamura, K; Sasaki, N; Yamada, H | 1 |
| Odaka, T; Saisho, H; Seza, A; Suzuki, T; Yamaguchi, T | 1 |
| Fujii, H; Katsui, R; Kojima, Y; Nakajima, Y; Takaki, M | 1 |
| Kawatsu, R; Kohmura, Y; Toga, T | 1 |
| Fujii, H; Katsui, R; Kojima, Y; Koyama, F; Kuniyasu, H; Nakajima, Y; Shimizu, J; Takaki, M | 1 |
| Armstrong, SR; Beattie, DT; Humphrey, PP; Marquess, D; Sandlund, C; Shaw, JP; Smith, JA; Taylor, JA | 1 |
| Beattie, DT; Humphrey, PP; Marquess, D; Shaw, JP; Smith, JA; Vickery, RG | 1 |
| Mine, Y; Morikage, K; Oku, S; Shimizu, I; Yoshida, N; Yoshikawa, T | 1 |
| Fujisawa, M; Hori, M; Murata, T; Ozaki, H | 1 |
| Katsui, R; Kuniyasu, H; Matsuyoshi, H; Misawa, H; Obata, K; Okumura, M; Takaki, M; Zhang, GX | 1 |
| Hayashi, SS; Kamei, J; Nakanishi, Y; Ohsawa, M | 1 |
| Fujisawa, M; Hatao, F; Hori, M; Kaminishi, M; Murata, T; Ozaki, H; Seto, Y; Tsuchida, Y | 1 |
| Goto, K; Kawahara, I; Kuniyasu, H; Matsuyoshi, H; Misawa, H; Obata, K; Takaki, M; Zhang, GX | 1 |
| Kaneko, H; Seto, Y; Yoshida, N | 1 |
| Aoki, M; Fukudo, S; Kanazawa, M; Komuro, H; Tana, C; Watanabe, S | 1 |
| Fujii, H; Goto, K; Kawahara, I; Kuniyasu, H; Matsuyoshi, H; Misawa, H; Obata, K; Takaki, M | 1 |
| Lee, JW; Lee, OY; Lee, SE; Sohn, CI; Sung, KW | 1 |
| Detsyk, OI; Skliarov, OIa | 1 |
| Mine, Y; Oku, S; Yoshida, N | 1 |
| Aoki, K; Kamiyama, H; Masuda, K; Terauchi, Y; Togashi, Y | 1 |
| Amano, T; Ariga, H; Shimizu, K; Uchida, M; Yamato, S | 1 |
| Choi, EJ; Park, H; Park, SJ; Yoon, YH | 1 |
| Goto, K; Kawahara, I; Kuniyasu, H; Takaki, M | 1 |
| Amano, T; Ariga, H; Fukudo, S; Kanazawa, M; Kurematsu, A; Masaka, A; Morioka, S; Yamato, S | 1 |
| Goto, K; Inada, H; Kawahara, I; Kuniyasu, H; Misawa, H; Nabekura, J; Takaki, M | 1 |
| Kaji, T; Nonogaki, K | 1 |
| Goto, K; Kawahara, I; Nabekura, J; Takaki, M | 1 |
| Chen, CL; Fabio, P; Hung, JS; Lei, WY; Liu, TT; Orr, WC; Yi, CH | 1 |
| He, Z; Qin, F; Sun, H; Wang, C; Wang, S; Xiong, Z; Zhao, L | 1 |
| He, Z; Li, K; Liu, Z; Song, Y; Wang, S; Yao, J; Zhao, L | 1 |
Reviews
2 review(s) available for mosapride and td-5108
| Article | Year |
|---|---|
Enhancement of the intrinsic defecation reflex by mosapride, a 5-HT4 agonist, in chronically lumbosacral denervated guinea pigs.
Topics: Anal Canal; Animals; Benzamides; Defecation; Denervation; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Lumbosacral Plexus; Morpholines; Rectum; Reflex; Serotonin 5-HT4 Receptor Agonists; Serotonin Receptor Agonists; Stimulation, Chemical | 2006 |
Activation of 5-HT4 receptors facilitates neurogenesis of injured enteric neurons at an anastomosis in the lower gut.
Topics: Anastomosis, Surgical; Animals; Benzamides; Cell Differentiation; Enteric Nervous System; Granulation Tissue; Guinea Pigs; Hirschsprung Disease; Humans; Intestine, Small; Mice; Morpholines; Neural Stem Cells; Neurogenesis; Neurons; Proto-Oncogene Proteins c-ret; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Signal Transduction | 2015 |
Trials
5 trial(s) available for mosapride and td-5108
| Article | Year |
|---|---|
The effect of mosapride on oesophageal motor function and acid reflux in patients with gastro-oesophageal reflux disease.
Topics: Adult; Aged; Benzamides; Cisapride; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Esophagus; Female; Gastroesophageal Reflux; Gastrointestinal Agents; Humans; Hydrogen-Ion Concentration; Male; Manometry; Middle Aged; Morpholines; Peristalsis; Serotonin 5-HT3 Receptor Antagonists; Serotonin 5-HT4 Receptor Agonists | 2003 |
Mosapride citrate, a novel 5-HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients.
Topics: Aged; Benzamides; Colon; Constipation; Female; Functional Laterality; Gastrointestinal Transit; Humans; Male; Middle Aged; Morpholines; Parkinson Disease; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT4 Receptor Agonists; Treatment Outcome; Video Recording | 2005 |
Effect of 5-HT4 receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome.
Topics: Adult; Animals; Benzamides; Colon, Sigmoid; Female; Gastrointestinal Motility; Humans; Irritable Bowel Syndrome; Male; Manometry; Morpholines; Pain Perception; Receptors, Serotonin, 5-HT4; Rectum; Serotonin 5-HT4 Receptor Agonists; Serotonin Plasma Membrane Transport Proteins; Young Adult | 2011 |
Mosapride citrate, a 5-HT₄ receptor agonist, increased the plasma active and total glucagon-like peptide-1 levels in non-diabetic men.
Topics: Adult; Benzamides; Blood Glucose; Gastric Inhibitory Polypeptide; Gastrointestinal Agents; Gastrointestinal Tract; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Humans; Hypoglycemia; Hypoglycemic Agents; Incretins; Insulin; Male; Morpholines; Postprandial Period; Serotonin 5-HT4 Receptor Agonists; Up-Regulation | 2013 |
Effect of 5-hydroxytryptamine receptor 4 agonist mosapride on human gastric accommodation.
Topics: Adult; Benzamides; Cross-Over Studies; Double-Blind Method; Gastrointestinal Motility; Humans; Male; Morpholines; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Stomach; Young Adult | 2015 |
Other Studies
26 other study(ies) available for mosapride and td-5108
| Article | Year |
|---|---|
A 5-HT4 agonist, mosapride, enhances intrinsic rectorectal and rectoanal reflexes after removal of extrinsic nerves in guinea pigs.
Topics: Acute Disease; Anal Canal; Animals; Benzamides; Chronic Disease; Denervation; Disease Models, Animal; Gastrointestinal Agents; Gastrointestinal Motility; Guinea Pigs; Indoles; Male; Morpholines; Rectum; Reflex; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Spinal Cord Injuries; Sulfonamides | 2005 |
Effects of mosapride, a 5-hydroxytryptamine 4 receptor agonist, on electrical activity of the small intestine and cecum in horses.
Topics: Animals; Benzamides; Cecum; Dose-Response Relationship, Drug; Electrophysiology; Gastrointestinal Motility; Horses; Intestine, Small; Morpholines; Serotonin 5-HT4 Receptor Agonists | 2005 |
[Serotonin 5- HT4 receptor agonist (mosapride citrate)].
Topics: Benzamides; Female; Gastrointestinal Agents; Humans; Irritable Bowel Syndrome; Male; Morpholines; Serotonin 5-HT4 Receptor Agonists | 2006 |
The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities.
Topics: Aminopyridines; Arrhythmias, Cardiac; Benzamides; Cell Line; Cisapride; Electrophysiology; Ether-A-Go-Go Potassium Channels; Humans; Imidazoles; Inhibitory Concentration 50; Morpholines; Patch-Clamp Techniques; Serotonin 5-HT4 Receptor Agonists; Serotonin Receptor Agonists | 2007 |
A new possibility for repairing the anal dysfunction by promoting regeneration of the reflex pathways in the enteric nervous system.
Topics: Anal Canal; Anastomosis, Surgical; Animals; Benzamides; Brain-Derived Neurotrophic Factor; Cell Proliferation; Defecation; Dose-Response Relationship, Drug; Enteric Nervous System; Gastrointestinal Agents; Guinea Pigs; Homeodomain Proteins; Immunohistochemistry; Male; Morpholines; Nerve Regeneration; Nerve Tissue Proteins; Neurofilament Proteins; Neuronal Plasticity; Pressure; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-kit; Receptor, trkB; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Recovery of Function; Rectum; Reflex; Serotonin 5-HT4 Receptor Agonists; Serotonin Receptor Agonists; Time Factors; Transcription Factors | 2008 |
The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Benzamides; Cisapride; Colon; Dogs; Dose-Response Relationship, Drug; Esophagus; Female; Gastrointestinal Transit; Guinea Pigs; Indoles; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Serotonin 5-HT4 Receptor Agonists; Serotonin Receptor Agonists | 2008 |
The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.
Topics: Animals; Azabicyclo Compounds; Benzamides; Cell Line; Cisapride; Colon; Cyclic AMP; Esophagus; Ether-A-Go-Go Potassium Channels; Guinea Pigs; Humans; Indoles; Kidney; Morpholines; Protein Binding; Rats; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Serotonin Receptor Agonists | 2008 |
Effect of mosapride citrate hydrate on the colon cleansing action of polyethylene glycol electrolyte lavage solution (PEG-ELS) in guinea pigs.
Topics: Animals; Benzamides; Colon; Colonoscopy; Dose-Response Relationship, Drug; Electrolytes; Gastrointestinal Transit; Guinea Pigs; Male; Morpholines; Polyethylene Glycols; Serotonin 5-HT4 Receptor Agonists; Serotonin Receptor Agonists; Therapeutic Irrigation | 2009 |
The 5-HT4 receptor agonist mosapride attenuates NSAID-induced gastric mucosal damage.
Topics: Acetylcholine; Administration, Oral; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Dose-Response Relationship, Drug; Gastric Mucosa; Indomethacin; Morpholines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin 5-HT4 Receptor Agonists; Serotonin Receptor Agonists; Stomach Ulcer | 2010 |
A 5-HT(4)-receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult.
Topics: Animals; Benzamides; Defecation; Enteric Nervous System; Epithelial Cells; Gastrointestinal Agents; Guinea Pigs; Immunohistochemistry; Indoles; Male; Mesenchymal Stem Cells; Morpholines; Nerve Fibers; Nerve Regeneration; Neural Crest; Neural Pathways; Neuronal Plasticity; Reflex; Serotonin 5-HT4 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists; Stem Cells; Sulfonamides | 2010 |
Effect of chronic pain on morphine-induced respiratory depression in mice.
Topics: Analgesics, Opioid; Animals; Benzamides; Brain Stem; Chronic Disease; Indoles; Ligation; Male; Mice; Mice, Inbred ICR; Morphine; Morpholines; Pain; Peripheral Nervous System Diseases; Receptors, Serotonin, 5-HT4; Respiration; Respiratory Insufficiency; Sciatic Nerve; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Sulfonamides | 2011 |
Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Aminopyridines; Animals; Benzamides; Cholinergic Fibers; Disease Models, Animal; Drug Evaluation, Preclinical; Gastrointestinal Transit; Ileum; Ileus; Imidazoles; Inflammation Mediators; Macrophages; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neutrophil Infiltration; Postoperative Complications; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Tissue Culture Techniques | 2011 |
In vitro enhanced differentiation of neural networks in ES gut-like organ from mouse ES cells by a 5-HT4-receptor activation.
Topics: Animals; Benzamides; Cell Culture Techniques; Cells, Cultured; Embryonic Stem Cells; Gastrointestinal Tract; Mice; Morpholines; Nerve Net; Neurogenesis; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists | 2011 |
Effects of mosapride citrate, a 5-HT4-receptor agonist, on gastric distension-induced visceromotor response in conscious rats.
Topics: Abdominal Pain; Analgesics, Non-Narcotic; Animals; Benzamides; Benzyl Compounds; Dose-Response Relationship, Drug; Dyspepsia; Gastric Dilatation; Gastrointestinal Agents; Gastrointestinal Motility; Granisetron; Male; Morpholines; Random Allocation; Rats; Rats, Wistar; Reflex, Abdominal; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Stomach | 2011 |
Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats.
Topics: Administration, Topical; Anastomosis, Surgical; Animals; Benzamides; Defecation; Fluvoxamine; Guinea Pigs; Male; Morpholines; Nerve Fibers; Neurogenesis; Rats; Rectum; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT4 Receptor Agonists | 2012 |
The effects of 5-HT4 receptor agonist, mosapride citrate, on visceral hypersensitivity in a rat model.
Topics: Animals; Benzamides; Disease Models, Animal; Electromyography; Gastrointestinal Motility; Hypersensitivity; Injections, Intraperitoneal; Male; Morpholines; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Serotonin 5-HT4 Receptor Agonists; Treatment Outcome; Visceral Pain | 2012 |
[The changes of the activity of NO-synthases and oxidative processes under conditions of 5-HT receptors activation in the stomach and large intestine in streptozocin-induced diabetes mellitus].
Topics: Animals; Benzamides; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Gastric Mucosa; Humans; Intestine, Large; Lipid Peroxidation; Male; Morpholines; Muscle, Smooth; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Oxidative Stress; Rats; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Stomach; Streptozocin; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2012 |
Anti-emetic effect of mosapride citrate hydrate, a 5-HT4 receptor agonist, on selective serotonin reuptake inhibitors (SSRIs)-induced emesis in experimental animals.
Topics: Administration, Oral; Afferent Pathways; Animals; Benzamides; Dogs; Dose-Response Relationship, Drug; Gastric Emptying; Male; Morpholines; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT4 Receptor Agonists; Shrews; Stomach; Vagus Nerve; Vomiting | 2013 |
Dual role of mosapride citrate hydrate on the gastric emptying evaluated by the breath test in conscious rats.
Topics: Acetic Acid; Animals; Benzamides; Breath Tests; Carbon Radioisotopes; Depression, Chemical; Dose-Response Relationship, Drug; Gastric Emptying; Indoles; Male; Morpholines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Serotonin 5-HT3 Receptor Antagonists; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Stimulation, Chemical; Sulfonamides | 2013 |
The effects of prucalopride on postoperative ileus in guinea pigs.
Topics: Administration, Oral; Animals; Benzamides; Benzofurans; Charcoal; Colon; Dose-Response Relationship, Drug; Gastrointestinal Motility; Guinea Pigs; Ileus; Indoles; Laparotomy; Male; Morpholines; Postoperative Complications; Serotonin; Serotonin 5-HT4 Receptor Agonists | 2013 |
A protein tyrosine kinase receptor, c-RET signaling pathway contributes to the enteric neurogenesis induced by a 5-HT4 receptor agonist at an anastomosis after transection of the gut in rodents.
Topics: Anastomosis, Surgical; Animals; Benzamides; Enteric Nervous System; Female; Ileum; Indoles; Male; Mice; Mice, Inbred BALB C; Models, Neurological; Morpholines; Neurogenesis; Proto-Oncogene Proteins c-ret; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Serotonin 5-HT4 Receptor Agonists; Signal Transduction; Ubiquitin Thiolesterase; Withanolides | 2015 |
Activation of 5-HT4 receptors facilitates neurogenesis from transplanted neural stem cells in the anastomotic ileum.
Topics: Anastomosis, Surgical; Animals; Antibodies; Benzamides; Fluorescent Dyes; Ileum; Immunohistochemistry; Mice; Mice, Transgenic; Morpholines; Neural Stem Cells; Neurogenesis; Organic Chemicals; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; Ubiquitin Thiolesterase | 2016 |
Mosapride, a selective serotonin 5-HT4 receptor agonist, and alogliptin, a selective dipeptidyl peptidase-4 inhibitor, exert synergic effects on plasma active GLP-1 levels and glucose tolerance in mice.
Topics: Animals; Benzamides; Blood Glucose; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Synergism; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hypoglycemic Agents; Male; Mice; Mice, Inbred C57BL; Morpholines; Piperidines; Serotonin 5-HT4 Receptor Agonists; Uracil | 2015 |
Differences in the Control of Secondary Peristalsis in the Human Esophagus: Influence of the 5-HT4 Receptor versus the TRPV1 Receptor.
Topics: Adult; Benzamides; Capsaicin; Capsicum; Esophagus; Female; Heartburn; Humans; Male; Manometry; Morpholines; Peristalsis; Receptors, Serotonin, 5-HT4; Serotonin 5-HT4 Receptor Agonists; TRPV Cation Channels | 2016 |
Development and validation of a chiral liquid chromatography method for the determination of MP 3950 enantiomers, a high selective 5-HT4 receptor agonist, in rat plasma and its application to stereoselective pharmacokinetic study.
Topics: Animals; Area Under Curve; Benzamides; Chromatography, High Pressure Liquid; Female; Limit of Detection; Male; Morpholines; Rats; Reproducibility of Results; Sensitivity and Specificity; Serotonin 5-HT4 Receptor Agonists; Stereoisomerism | 2016 |
The synthesis and biological evaluation of a new bioactive metabolite of mosapride as a potential gastroprokinetic agent.
Topics: Animals; Benzamides; Gastrointestinal Absorption; Gastrointestinal Agents; Male; Mice; Molecular Structure; Morpholines; Peristalsis; Serotonin 5-HT4 Receptor Agonists; Stereoisomerism | 2019 |