morphine and oripavine

morphine has been researched along with oripavine* in 1 studies

Other Studies

1 other study(ies) available for morphine and oripavine

ArticleYear
Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.
    Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21

    A new series of ligands has been synthesized where the cinnamoyl group of the 14-cinnamoylamino morphinones has been introduced to the 7alpha-substituent of the 6,14-bridged oripavine series. In vitro the compounds were mostly low efficacy partial agonists or antagonists with some selectivity for the mu opioid receptor, with evidence of micro efficacy in vivo. The similarity in SAR between these 6,14-bridged oripavines and the 14-cinnamoylamino series suggests a similar mode of interaction with the micro opioid receptor.

    Topics: Analgesics; Animals; Binding, Competitive; CHO Cells; Cinnamates; Cricetinae; Cricetulus; Humans; Ligands; Mice; Molecular Conformation; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Thebaine

2007