morphine and norbuprenorphine

morphine has been researched along with norbuprenorphine* in 2 studies

Other Studies

2 other study(ies) available for morphine and norbuprenorphine

Article	Year
Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS. Methods in molecular biology (Clifton, N.J.), 2016, Volume: 1383 Buprenorphine (Suboxone, Zubsolv, Buprenex, Butrans, etc.) is an opioid drug that has been used to treat opioid dependence on an outpatient basis, and is also prescribed for managing moderate to severe pain. Pregnant women may be prescribed buprenorphine as part of a treatment plan for opioid addiction. This chapter quantitates buprenorphine and norbuprenorphine in meconium by liquid chromatography tandem mass spectrometry (LC-MS/MS). Topics: Analgesics, Opioid; Buprenorphine; Chromatography, Liquid; Female; Humans; Infant, Newborn; Meconium; Opioid-Related Disorders; Pregnancy; Tandem Mass Spectrometry	2016
Validation and application of a method for the determination of buprenorphine, norbuprenorphine, and their glucuronide conjugates in human meconium. Analytical chemistry, 2008, Jan-01, Volume: 80, Issue:1 A novel liquid chromatography tandem mass spectrometry method for quantification of buprenorphine, norbuprenorphine, and glucuronidated conjugates was developed and validated. Analytes were extracted from meconium using buffer, concentrated by solid-phase extraction and quantified within 13.5 min. In order to determine free and total concentrations, specimens were analyzed with and without enzyme hydrolysis. Calibration was achieved by linear regression with a 1/x weighting factor and deuterated internal standards. All analytes were linear from 20 to 2000 ng/g with a correlation of determination of >0.98. Accuracy was >or=85.7% with intra-assay and interassay imprecisionor=85.0%. There was suppression of ionization by the polar matrix; however, this did not interfere with sensitivity or analyte quantification due to inclusion of deuterated internal standards. Analytes were stable on the autosampler, at room temperature, at 4 degrees C, and when exposed to three freeze/thaw cycles. This sensitive and specific method can be used to monitor in utero buprenorphine exposure and to evaluate correlations, if any, between buprenorphine exposure and neonatal outcomes. Topics: Buprenorphine; Calibration; Chromatography, Liquid; Female; Glucuronides; Humans; Infant; Meconium; Mothers; Opioid-Related Disorders; Pregnancy; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2008

Article

Year

Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS.

Methods in molecular biology (Clifton, N.J.), 2016, Volume: 1383

Buprenorphine (Suboxone, Zubsolv, Buprenex, Butrans, etc.) is an opioid drug that has been used to treat opioid dependence on an outpatient basis, and is also prescribed for managing moderate to severe pain. Pregnant women may be prescribed buprenorphine as part of a treatment plan for opioid addiction. This chapter quantitates buprenorphine and norbuprenorphine in meconium by liquid chromatography tandem mass spectrometry (LC-MS/MS).

Topics: Analgesics, Opioid; Buprenorphine; Chromatography, Liquid; Female; Humans; Infant, Newborn; Meconium; Opioid-Related Disorders; Pregnancy; Tandem Mass Spectrometry

2016

Validation and application of a method for the determination of buprenorphine, norbuprenorphine, and their glucuronide conjugates in human meconium.

Analytical chemistry, 2008, Jan-01, Volume: 80, Issue:1

A novel liquid chromatography tandem mass spectrometry method for quantification of buprenorphine, norbuprenorphine, and glucuronidated conjugates was developed and validated. Analytes were extracted from meconium using buffer, concentrated by solid-phase extraction and quantified within 13.5 min. In order to determine free and total concentrations, specimens were analyzed with and without enzyme hydrolysis. Calibration was achieved by linear regression with a 1/x weighting factor and deuterated internal standards. All analytes were linear from 20 to 2000 ng/g with a correlation of determination of >0.98. Accuracy was >or=85.7% with intra-assay and interassay imprecisionor=85.0%. There was suppression of ionization by the polar matrix; however, this did not interfere with sensitivity or analyte quantification due to inclusion of deuterated internal standards. Analytes were stable on the autosampler, at room temperature, at 4 degrees C, and when exposed to three freeze/thaw cycles. This sensitive and specific method can be used to monitor in utero buprenorphine exposure and to evaluate correlations, if any, between buprenorphine exposure and neonatal outcomes.

Topics: Buprenorphine; Calibration; Chromatography, Liquid; Female; Glucuronides; Humans; Infant; Meconium; Mothers; Opioid-Related Disorders; Pregnancy; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

2008