morphine and mitragynine

morphine has been researched along with mitragynine* in 4 studies

Reviews

1 review(s) available for morphine and mitragynine

ArticleYear
Orally active opioid compounds from a non-poppy source.
    Journal of medicinal chemistry, 2013, Jun-27, Volume: 56, Issue:12

    The basic science and clinical use of morphine and other "opioid" drugs are based almost exclusively on the extracts or analogues of compounds isolated from a single source, the opium poppy (Papaver somniferum). However, it now appears that biological diversity has evolved an alternative source. Specifically, at least two alkaloids isolated from the plant Mitragyna speciosa, mitragynine ((E)-2-[(2S,3S)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[3,2-h]quinolizin-2-yl]-3-methoxyprop-2-enoic acid methyl ester; 9-methoxy coryantheidine; MG) and 7-hydroxymitragynine (7-OH-MG), and several synthetic analogues of these natural products display centrally mediated (supraspinal and spinal) antinociceptive (analgesic) activity in various pain models. Several characteristics of these compounds suggest a classic "opioid" mechanism of action: nanomolar affinity for opioid receptors, competitive interaction with the opioid receptor antagonist naloxone, and two-way analgesic cross-tolerance with morphine. However, other characteristics of the compounds suggest novelty, particularly chemical structure and possible greater separation from side effects. We review the chemical and pharmacological properties of these compounds.

    Topics: Administration, Oral; Analgesics, Opioid; Animals; Humans; Secologanin Tryptamine Alkaloids; Substance-Related Disorders

2013

Other Studies

3 other study(ies) available for morphine and mitragynine

ArticleYear
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.
    Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18

    Mitragynine and 7-hydroxymitragynine (7OH) are the major alkaloids mediating the biological actions of the psychoactive plant kratom. To investigate the structure-activity relationships of mitragynine/7OH templates, we diversified the aromatic ring of the indole at the C9, C10, and C12 positions and investigated their G-protein and arrestin signaling mediated by mu opioid receptors (MOR). Three synthesized lead C9 analogs replacing the 9-OCH

    Topics: Analgesics, Opioid; Animals; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Rats, Sprague-Dawley; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Structure-Activity Relationship

2021
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
    Journal of medicinal chemistry, 2020, 01-09, Volume: 63, Issue:1

    Selected indole-based kratom alkaloids were evaluated for their opioid and adrenergic receptor binding and functional effects, in vivo antinociceptive effects, plasma protein binding, and metabolic stability. Mitragynine, the major alkaloid in

    Topics: Adrenergic Agents; Analgesics; Animals; Blood Proteins; CHO Cells; Cricetulus; Dopamine Agents; Guinea Pigs; Humans; Microsomes, Liver; Rats; Receptors, Adrenergic; Receptors, Opioid; Secologanin Tryptamine Alkaloids

2020
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
    Journal of medicinal chemistry, 2002, Apr-25, Volume: 45, Issue:9

    Mitragynine (1) is a major alkaloidal component in the Thai traditional medicinal herb, Mitragyna speciosa, and has been proven to exhibit analgesic activity mediated by opioid receptors. By utilizing this natural product as a lead compound, synthesis of some derivatives, evaluations of the structure-activity relationship, and surveys of the intrinsic activities and potencies on opioid receptors were performed with guinea pig ileum. The affinities of some compounds for mu-, delta-, and kappa-receptors were determined in a receptor binding assay. The essential structural moieties in the Corynanthe type indole alkaloids for inducing the opioid agonistic activity were also clarified. The oxidative derivatives of mitragynine, i.e., mitragynine pseudoindoxyl (2) and 7-hydroxymitragynine (12), were found as opioid agonists with higher potency than morphine in the experiment with guinea pig ileum. In addition, 2 induced an analgesic activity in the tail flick test in mice.

    Topics: Analgesics; Animals; Brain; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indole Alkaloids; Ligands; Mice; Models, Molecular; Morphine; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Structure-Activity Relationship

2002