morphine and eseroline

morphine has been researched along with eseroline* in 1 studies

Other Studies

1 other study(ies) available for morphine and eseroline

ArticleYear
Comparison of (-)-eseroline with (+)-eseroline and dihydroseco analogues in antinociceptive assays: confirmation of rubreserine structure by X-ray analysis.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:11

    The enantiomers of eseroline bind to opiate receptors of rat brain membranes with equal affinities and show opiate agonist properties as inhibitors of adenylate cyclase in vitro. However, only (-)-eseroline shows potent narcotic agonist activity in vivo, similar to that of morphine. Neither (-)-noreseroline, (+)-eseroline, nor the open dihydroseco analogue (-)-8 shows analgetic effects in vivo. The structure of rubreserine being a resonance hybrid of an o-quinone with its zwitterionic mesomer is confirmed by solid-state X-ray diffraction analysis.

    Topics: Adenylyl Cyclase Inhibitors; Analgesics; Animals; In Vitro Techniques; Indoles; Physostigmine; Rats; Receptors, Opioid; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction

1986