morphine and chlornaltrexamine

morphine has been researched along with chlornaltrexamine* in 1 studies

Other Studies

1 other study(ies) available for morphine and chlornaltrexamine

Article	Year
Synthesis and biological activity of analogues of beta-chlornaltrexamine and beta-funaltrexamine at opioid receptors. Journal of medicinal chemistry, 1986, Volume: 29, Issue:10 beta-Chlornaltrexamine and beta-funaltrexamine analogues 4-7 with different length "arms" to which an electrophilic moiety is attached were synthesized in an effort to obtain affinity labels that would selectively and irreversibly block specific opioid receptor types and subtypes. One of the compounds, 4, was a potent, irreversible blocker of opioid receptors in the guinea pig ileum and mouse vas deferens preparations. The results of this study suggest that nucleophiles that are remote from the recognition locus are capable of alkylation by reactive electrophiles. Topics: Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship	1986

Article

Year

Synthesis and biological activity of analogues of beta-chlornaltrexamine and beta-funaltrexamine at opioid receptors.

Journal of medicinal chemistry, 1986, Volume: 29, Issue:10

beta-Chlornaltrexamine and beta-funaltrexamine analogues 4-7 with different length "arms" to which an electrophilic moiety is attached were synthesized in an effort to obtain affinity labels that would selectively and irreversibly block specific opioid receptor types and subtypes. One of the compounds, 4, was a potent, irreversible blocker of opioid receptors in the guinea pig ileum and mouse vas deferens preparations. The results of this study suggest that nucleophiles that are remote from the recognition locus are capable of alkylation by reactive electrophiles.

Topics: Naltrexone; Narcotic Antagonists; Receptors, Opioid; Structure-Activity Relationship

1986