morphinans and nicomorphine

Analgesic effects as well as side effects, circulatory and respiratory parameters of 0.3 mg Buprenorphine (Temgesic) were compared to 10 mg Nicomorphine (Vilan) intramuscularly injected in a double-blind, randomized study for the relief of postoperative pain. Buprenorphine produced an equally potent but longer acting analgesic effect compared to Nicomorphine, although slight delayed. There were only few and slight side effects and no influence on the circulation and the respiration. In the search for a new long-acting and strong analgesic Buprenorphine proved to be superior to Nicomorphine in the control of postoperative pain.

Topics: Adult; Buprenorphine; Double-Blind Method; Female; Humans; Injections, Intramuscular; Male; Morphinans; Morphine Derivatives; Nicotinic Acids; Pain, Postoperative

Nalbuphine and nicomorphine were administered intramusculary in single doses for the relief of moderate to severe pain after abdominal surgery in a group of 40 patients to compare the analgesic effect and clinical tolerance during a 2 hour period. There was no statistically significant difference of the analgesic effect. In both groups SBP, DBP and RR decreased and HR increased significantly after injection but the tolerance of nalbuphine seems to be beter. Nalbuphine is a good choice for postoperative pain.

Topics: Adult; Aged; Blood Pressure; Female; Heart Rate; Humans; Injections, Intramuscular; Male; Middle Aged; Morphinans; Morphine Derivatives; Nalbuphine; Nicotinic Acids; Pain, Postoperative; Respiration