morphinans has been researched along with metopon* in 22 studies
1 trial(s) available for morphinans and metopon
| Article | Year |
|---|---|
The analgesic connection: the Nathan B. Eddy memorial lecture.
Topics: Analgesia; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Injections, Intramuscular; Morphinans; Morphine; Neoplasms; Palliative Care | 1984 |
21 other study(ies) available for morphinans and metopon
| Article | Year |
|---|---|
Access to 7β-analogs of codeine with mixed μ/δ agonist activity via 6,7-α-epoxide opening.
(-)-Codeine 1 was converted into previously unknown 7β-methyl-7,8-dihydrocodeine/morphine derivatives such as 13 via classical diaxial opening of α-epoxide 3. Several analogs exhibited dual μ/δ-agonist activity. Topics: Animals; Codeine; Epoxy Compounds; Humans; Mice; Models, Molecular; Morphinans; Receptors, Opioid, delta; Receptors, Opioid, mu | 2013 |
Metopon and two unique derivatives: affinity and selectivity for the multiple opioid receptors.
5 beta-Methyl-7,8-dihydromorphinone (metopon), an isomer [6aS-(6a alpha,9a alpha, 10 beta)13aS]-1,10-methano-4-hydroxy-11-methyl- 6,6a,8,9,10,11,12,13-octahydro-[1]-benzopyrano[4,3,e]isoquinoline- 7-(9aH)-one (compound 1) derived from a photochemical rearrangement of 5 beta-methylmorphinone, and [6aS-(6a alpha,9a alpha,10 beta)13aS]-1,10-methano-4-hydroxy-11-methyl- 6,6a,8,9, 10,11,12,13-octahydro-[1]-benzopyrano[4,3,e]-14 beta- (p-nitrocinnamoylamino) isoquinoline-7-(9aH)-one (compound 2) were characterized for opioid receptor affinity, selectivity and analgesic properties. In competition binding assays using bovine striatal membranes, the three compounds inhibited the binding of 0.25 nM [3H][D-Ala2,(Me)-Phe4,Gly(ol)5]enkephalin (DAMGO), a mu-selective peptide, with IC50 values less than 5 nM. All three compounds exhibited lower affinity for delta- and kappa-opioid receptors. In the mouse 55 degrees C warm-water tail-flick assay, both metopon and compound 1 displayed antinociception that lasted for 60 min after i.c.v. injection. Morphine sulfate, metopon and compound 1 produced 50% antinociception with i.c.v. doses of 0.83, 2.0 and 4.0 nmol, respectively. The mu-selective, irreversible opioid receptor antagonist beta-funaltrexamine blocked antinociception induced by metopon and compound 1, while delta- and kappa-opioid receptor selective antagonists did not effect antinociception. These findings demonstrate metopon and its isomer bound with high affinity to the mu-opioid receptor and produced antinociception through this receptor. Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cattle; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Neostriatum; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
Metopon analgesia in the dog.
Topics: Analgesia; Analgesics; Animals; Animals, Newborn; Dogs; Morphinans; Pain | 1954 |
[The new central analgesics].
Topics: Analgesics; Humans; Meperidine; Methadone; Morphinans | 1952 |
Analgesic potency and side action liability in man of heptazone, WIN 1161-2, 6-methyl dihydromorphine, Metopon, levo-isomethadone and pentobarbital sodium, as a further effort to refine methods of evaluation of analgesic drugs.
Topics: Analgesics; Dihydromorphine; Humans; Male; Methadone; Morphinans; Pentobarbital | 1952 |
NEW and nonofficial remedies: metopon hydrochloride.
Topics: Morphinans | 1951 |
Biliary and small intestinal spasm due to synthetic analgesics methadone and methyldihydromorphinone (metopon).
Topics: Analgesics; Biliary Tract; Chemical and Drug Induced Liver Injury; Humans; Intestines; Liver; Methadone; Morphinans; Spasm | 1950 |
On the structure of morphine and its derivative Metopon.
Topics: Morphinans; Morphine | 1950 |
A comparison of the actions of meperidine, Nu-1196, methadone, morphine, Nu-2206, and metopon upon the intestine and uterus.
Topics: Female; Humans; Intestines; Meperidine; Methadone; Morphinans; Morphine; Uterus | 1950 |
Metopon hydrochloride: an experiment in clinical evaluation.
Topics: Morphinans; Morphine | 1949 |
Studies on the identification of narcotics; microchemical reactions for identification of metopon.
Topics: Humans; Morphinans; Narcotics | 1949 |
METOPON hydrochloride, alcohol-dextrose, dextrose vitamin solutions.
Topics: Alcohols; Glucose; Humans; Morphinans; Vitamin A; Vitamins | 1948 |
Pharmacology of metopon and other new analgesic opium derivatives.
Topics: Analgesics; Analgesics, Opioid; Morphinans; Opium | 1948 |
Metopon hydrochloride (methyldihydromorphinone hydrochloride).
Topics: Morphinans | 1948 |
REPORT on metopon hydrochloride.
Topics: Morphinans | 1947 |
METOPON HYDROCHLORIDE (methyldihydromorphinone hydrochloride).
Topics: Morphinans; Morphine | 1947 |
METOPON hydrochloride; (methyldihydromorphinone hydrochloride) statement of Committee on Drug Addiction, National Research Council.
Topics: Humans; Morphinans; National Academy of Sciences, U.S.; Substance-Related Disorders; United States | 1947 |
METOPON hydrochloride (methyldihydromorphinone hydrochloride).
Topics: Morphinans | 1947 |
Metopon.
Topics: Morphinans | 1947 |
METOPON hydrochloride (methyldihydromorphinone hydrochloride).
Topics: Humans; Morphinans; Morphine; North Carolina | 1947 |
METOPON hydrochloride (methyldihydromorphinone hydrochloride).
Topics: Humans; Morphinans; Morphine | 1947 |